Amino acid dipepetide frequency for Wolfiporia cocos (strain MD-104) (Brown rot fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.374AlaAla: 10.374 ± 0.083	1.249AlaCys: 1.249 ± 0.016	4.816AlaAsp: 4.816 ± 0.03	5.625AlaGlu: 5.625 ± 0.065	3.272AlaPhe: 3.272 ± 0.03	6.057AlaGly: 6.057 ± 0.045	2.531AlaHis: 2.531 ± 0.023	4.28AlaIle: 4.28 ± 0.031	3.708AlaLys: 3.708 ± 0.032	9.105AlaLeu: 9.105 ± 0.048	2.099AlaMet: 2.099 ± 0.023	2.76AlaAsn: 2.76 ± 0.024	6.05AlaPro: 6.05 ± 0.054	3.853AlaGln: 3.853 ± 0.027	6.65AlaArg: 6.65 ± 0.048	8.188AlaSer: 8.188 ± 0.046	5.571AlaThr: 5.571 ± 0.043	5.877AlaVal: 5.877 ± 0.043	1.229AlaTrp: 1.229 ± 0.014	2.398AlaTyr: 2.398 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.221CysAla: 1.221 ± 0.016	0.265CysCys: 0.265 ± 0.009	0.663CysAsp: 0.663 ± 0.013	0.623CysGlu: 0.623 ± 0.01	0.471CysPhe: 0.471 ± 0.01	0.983CysGly: 0.983 ± 0.015	0.358CysHis: 0.358 ± 0.008	0.727CysIle: 0.727 ± 0.012	0.502CysLys: 0.502 ± 0.012	1.253CysLeu: 1.253 ± 0.018	0.309CysMet: 0.309 ± 0.008	0.421CysAsn: 0.421 ± 0.01	0.795CysPro: 0.795 ± 0.014	0.43CysGln: 0.43 ± 0.009	0.859CysArg: 0.859 ± 0.014	0.986CysSer: 0.986 ± 0.014	0.824CysThr: 0.824 ± 0.014	0.875CysVal: 0.875 ± 0.016	0.208CysTrp: 0.208 ± 0.006	0.345CysTyr: 0.345 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.647AspAla: 5.647 ± 0.04	0.65AspCys: 0.65 ± 0.012	4.159AspAsp: 4.159 ± 0.041	4.427AspGlu: 4.427 ± 0.044	1.891AspPhe: 1.891 ± 0.019	3.988AspGly: 3.988 ± 0.035	1.19AspHis: 1.19 ± 0.015	2.964AspIle: 2.964 ± 0.027	2.009AspLys: 2.009 ± 0.025	4.737AspLeu: 4.737 ± 0.033	1.262AspMet: 1.262 ± 0.015	1.635AspAsn: 1.635 ± 0.021	3.358AspPro: 3.358 ± 0.031	1.586AspGln: 1.586 ± 0.019	3.032AspArg: 3.032 ± 0.031	3.858AspSer: 3.858 ± 0.032	2.929AspThr: 2.929 ± 0.023	4.105AspVal: 4.105 ± 0.033	0.895AspTrp: 0.895 ± 0.013	1.472AspTyr: 1.472 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.263GluAla: 5.263 ± 0.042	0.69GluCys: 0.69 ± 0.014	4.164GluAsp: 4.164 ± 0.04	5.545GluGlu: 5.545 ± 0.071	1.786GluPhe: 1.786 ± 0.021	3.703GluGly: 3.703 ± 0.029	1.575GluHis: 1.575 ± 0.018	2.777GluIle: 2.777 ± 0.024	2.928GluLys: 2.928 ± 0.031	5.419GluLeu: 5.419 ± 0.036	1.372GluMet: 1.372 ± 0.017	1.831GluAsn: 1.831 ± 0.02	2.778GluPro: 2.778 ± 0.026	2.483GluGln: 2.483 ± 0.028	4.456GluArg: 4.456 ± 0.044	3.867GluSer: 3.867 ± 0.032	3.069GluThr: 3.069 ± 0.029	3.781GluVal: 3.781 ± 0.06	0.985GluTrp: 0.985 ± 0.015	1.602GluTyr: 1.602 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.143PheAla: 3.143 ± 0.029	0.53PheCys: 0.53 ± 0.011	2.116PheAsp: 2.116 ± 0.02	1.894PheGlu: 1.894 ± 0.021	1.349PhePhe: 1.349 ± 0.019	2.507PheGly: 2.507 ± 0.031	0.84PheHis: 0.84 ± 0.013	1.605PheIle: 1.605 ± 0.019	1.293PheLys: 1.293 ± 0.015	3.224PheLeu: 3.224 ± 0.027	0.763PheMet: 0.763 ± 0.012	1.182PheAsn: 1.182 ± 0.018	1.9PhePro: 1.9 ± 0.021	1.105PheGln: 1.105 ± 0.015	1.852PheArg: 1.852 ± 0.02	2.833PheSer: 2.833 ± 0.025	1.982PheThr: 1.982 ± 0.018	2.411PheVal: 2.411 ± 0.023	0.542PheTrp: 0.542 ± 0.012	1.003PheTyr: 1.003 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.778GlyAla: 5.778 ± 0.047	0.876GlyCys: 0.876 ± 0.014	3.414GlyAsp: 3.414 ± 0.03	3.622GlyGlu: 3.622 ± 0.037	2.284GlyPhe: 2.284 ± 0.024	5.155GlyGly: 5.155 ± 0.05	1.719GlyHis: 1.719 ± 0.019	3.11GlyIle: 3.11 ± 0.026	3.073GlyLys: 3.073 ± 0.031	5.434GlyLeu: 5.434 ± 0.034	1.529GlyMet: 1.529 ± 0.022	2.072GlyAsn: 2.072 ± 0.023	3.329GlyPro: 3.329 ± 0.031	2.284GlyGln: 2.284 ± 0.024	4.403GlyArg: 4.403 ± 0.038	5.428GlySer: 5.428 ± 0.042	4.056GlyThr: 4.056 ± 0.032	4.233GlyVal: 4.233 ± 0.029	1.104GlyTrp: 1.104 ± 0.018	1.858GlyTyr: 1.858 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	2.553HisAla: 2.553 ± 0.025	0.365HisCys: 0.365 ± 0.01	1.363HisAsp: 1.363 ± 0.017	1.344HisGlu: 1.344 ± 0.018	0.889HisPhe: 0.889 ± 0.015	1.691HisGly: 1.691 ± 0.02	0.825HisHis: 0.825 ± 0.018	1.386HisIle: 1.386 ± 0.016	0.91HisLys: 0.91 ± 0.013	2.489HisLeu: 2.489 ± 0.023	0.532HisMet: 0.532 ± 0.011	0.834HisAsn: 0.834 ± 0.011	1.918HisPro: 1.918 ± 0.021	0.9HisGln: 0.9 ± 0.015	1.777HisArg: 1.777 ± 0.021	2.116HisSer: 2.116 ± 0.025	1.55HisThr: 1.55 ± 0.019	1.68HisVal: 1.68 ± 0.018	0.345HisTrp: 0.345 ± 0.008	0.693HisTyr: 0.693 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.366IleAla: 4.366 ± 0.032	0.763IleCys: 0.763 ± 0.012	2.703IleAsp: 2.703 ± 0.028	2.61IleGlu: 2.61 ± 0.024	1.732IlePhe: 1.732 ± 0.02	2.889IleGly: 2.889 ± 0.03	1.18IleHis: 1.18 ± 0.015	2.322IleIle: 2.322 ± 0.026	1.852IleLys: 1.852 ± 0.02	4.366IleLeu: 4.366 ± 0.032	1.021IleMet: 1.021 ± 0.017	1.513IleAsn: 1.513 ± 0.018	3.149IlePro: 3.149 ± 0.029	1.632IleGln: 1.632 ± 0.021	2.811IleArg: 2.811 ± 0.026	3.631IleSer: 3.631 ± 0.03	2.71IleThr: 2.71 ± 0.024	3.329IleVal: 3.329 ± 0.031	0.734IleTrp: 0.734 ± 0.014	1.261IleTyr: 1.261 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.965LysAla: 3.965 ± 0.038	0.461LysCys: 0.461 ± 0.009	2.209LysAsp: 2.209 ± 0.022	2.869LysGlu: 2.869 ± 0.029	1.177LysPhe: 1.177 ± 0.017	2.617LysGly: 2.617 ± 0.028	1.04LysHis: 1.04 ± 0.016	1.852LysIle: 1.852 ± 0.02	2.572LysLys: 2.572 ± 0.037	3.612LysLeu: 3.612 ± 0.03	0.866LysMet: 0.866 ± 0.014	1.229LysAsn: 1.229 ± 0.017	2.307LysPro: 2.307 ± 0.024	1.619LysGln: 1.619 ± 0.019	3.29LysArg: 3.29 ± 0.03	2.858LysSer: 2.858 ± 0.031	2.278LysThr: 2.278 ± 0.021	2.454LysVal: 2.454 ± 0.028	0.608LysTrp: 0.608 ± 0.012	1.119LysTyr: 1.119 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.661LeuAla: 8.661 ± 0.048	1.324LeuCys: 1.324 ± 0.018	5.043LeuAsp: 5.043 ± 0.033	5.31LeuGlu: 5.31 ± 0.038	3.229LeuPhe: 3.229 ± 0.026	5.504LeuGly: 5.504 ± 0.037	2.587LeuHis: 2.587 ± 0.022	3.757LeuIle: 3.757 ± 0.032	3.655LeuLys: 3.655 ± 0.032	8.726LeuLeu: 8.726 ± 0.056	1.794LeuMet: 1.794 ± 0.017	2.901LeuAsn: 2.901 ± 0.025	6.157LeuPro: 6.157 ± 0.04	3.765LeuGln: 3.765 ± 0.031	6.461LeuArg: 6.461 ± 0.044	7.662LeuSer: 7.662 ± 0.053	5.106LeuThr: 5.106 ± 0.03	5.685LeuVal: 5.685 ± 0.041	1.234LeuTrp: 1.234 ± 0.017	2.477LeuTyr: 2.477 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.94MetAla: 1.94 ± 0.021	0.277MetCys: 0.277 ± 0.009	1.19MetAsp: 1.19 ± 0.016	1.241MetGlu: 1.241 ± 0.017	0.739MetPhe: 0.739 ± 0.013	1.308MetGly: 1.308 ± 0.015	0.621MetHis: 0.621 ± 0.013	0.907MetIle: 0.907 ± 0.014	0.854MetLys: 0.854 ± 0.015	2.031MetLeu: 2.031 ± 0.02	0.524MetMet: 0.524 ± 0.009	0.739MetAsn: 0.739 ± 0.013	1.377MetPro: 1.377 ± 0.017	0.953MetGln: 0.953 ± 0.012	1.475MetArg: 1.475 ± 0.017	2.071MetSer: 2.071 ± 0.019	1.248MetThr: 1.248 ± 0.016	1.249MetVal: 1.249 ± 0.014	0.315MetTrp: 0.315 ± 0.008	0.567MetTyr: 0.567 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.251AsnAla: 3.251 ± 0.028	0.379AsnCys: 0.379 ± 0.009	1.673AsnAsp: 1.673 ± 0.02	1.708AsnGlu: 1.708 ± 0.019	1.082AsnPhe: 1.082 ± 0.015	2.397AsnGly: 2.397 ± 0.026	0.718AsnHis: 0.718 ± 0.01	1.769AsnIle: 1.769 ± 0.019	1.218AsnLys: 1.218 ± 0.018	2.762AsnLeu: 2.762 ± 0.028	0.755AsnMet: 0.755 ± 0.013	1.065AsnAsn: 1.065 ± 0.018	2.073AsnPro: 2.073 ± 0.022	0.989AsnGln: 0.989 ± 0.016	1.667AsnArg: 1.667 ± 0.02	2.241AsnSer: 2.241 ± 0.022	1.827AsnThr: 1.827 ± 0.022	2.346AsnVal: 2.346 ± 0.025	0.453AsnTrp: 0.453 ± 0.01	0.854AsnTyr: 0.854 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.517ProAla: 6.517 ± 0.056	0.589ProCys: 0.589 ± 0.012	3.386ProAsp: 3.386 ± 0.027	3.677ProGlu: 3.677 ± 0.023	1.953ProPhe: 1.953 ± 0.018	3.826ProGly: 3.826 ± 0.035	1.682ProHis: 1.682 ± 0.022	2.596ProIle: 2.596 ± 0.022	2.175ProLys: 2.175 ± 0.024	5.368ProLeu: 5.368 ± 0.037	1.153ProMet: 1.153 ± 0.016	1.916ProAsn: 1.916 ± 0.02	6.618ProPro: 6.618 ± 0.074	2.452ProGln: 2.452 ± 0.026	4.078ProArg: 4.078 ± 0.041	6.893ProSer: 6.893 ± 0.05	4.254ProThr: 4.254 ± 0.038	3.939ProVal: 3.939 ± 0.031	0.72ProTrp: 0.72 ± 0.014	1.661ProTyr: 1.661 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.559GlnAla: 3.559 ± 0.031	0.502GlnCys: 0.502 ± 0.011	1.963GlnAsp: 1.963 ± 0.02	2.279GlnGlu: 2.279 ± 0.022	1.165GlnPhe: 1.165 ± 0.016	2.162GlnGly: 2.162 ± 0.024	1.072GlnHis: 1.072 ± 0.019	1.722GlnIle: 1.722 ± 0.019	1.498GlnLys: 1.498 ± 0.019	3.523GlnLeu: 3.523 ± 0.028	0.848GlnMet: 0.848 ± 0.014	1.246GlnAsn: 1.246 ± 0.018	2.464GlnPro: 2.464 ± 0.026	1.957GlnGln: 1.957 ± 0.033	2.724GlnArg: 2.724 ± 0.025	2.937GlnSer: 2.937 ± 0.028	2.217GlnThr: 2.217 ± 0.023	2.156GlnVal: 2.156 ± 0.022	0.569GlnTrp: 0.569 ± 0.011	1.12GlnTyr: 1.12 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	6.39ArgAla: 6.39 ± 0.045	0.893ArgCys: 0.893 ± 0.016	3.518ArgAsp: 3.518 ± 0.033	4.16ArgGlu: 4.16 ± 0.034	2.117ArgPhe: 2.117 ± 0.021	4.0ArgGly: 4.0 ± 0.036	1.785ArgHis: 1.785 ± 0.023	3.101ArgIle: 3.101 ± 0.026	3.242ArgLys: 3.242 ± 0.029	5.979ArgLeu: 5.979 ± 0.037	1.503ArgMet: 1.503 ± 0.018	2.019ArgAsn: 2.019 ± 0.019	4.109ArgPro: 4.109 ± 0.037	2.519ArgGln: 2.519 ± 0.025	6.046ArgArg: 6.046 ± 0.053	5.272ArgSer: 5.272 ± 0.042	3.962ArgThr: 3.962 ± 0.033	4.004ArgVal: 4.004 ± 0.026	1.059ArgTrp: 1.059 ± 0.013	1.721ArgTyr: 1.721 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	8.069SerAla: 8.069 ± 0.051	0.961SerCys: 0.961 ± 0.015	4.266SerAsp: 4.266 ± 0.034	4.003SerGlu: 4.003 ± 0.032	2.77SerPhe: 2.77 ± 0.027	5.539SerGly: 5.539 ± 0.038	2.06SerHis: 2.06 ± 0.025	3.676SerIle: 3.676 ± 0.031	3.01SerLys: 3.01 ± 0.028	7.33SerLeu: 7.33 ± 0.046	1.782SerMet: 1.782 ± 0.019	2.462SerAsn: 2.462 ± 0.026	6.133SerPro: 6.133 ± 0.058	3.062SerGln: 3.062 ± 0.028	5.33SerArg: 5.33 ± 0.039	9.167SerSer: 9.167 ± 0.08	5.669SerThr: 5.669 ± 0.046	5.089SerVal: 5.089 ± 0.039	1.027SerTrp: 1.027 ± 0.014	1.936SerTyr: 1.936 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.57ThrAla: 5.57 ± 0.038	0.762ThrCys: 0.762 ± 0.012	2.808ThrAsp: 2.808 ± 0.025	2.923ThrGlu: 2.923 ± 0.03	2.23ThrPhe: 2.23 ± 0.025	3.759ThrGly: 3.759 ± 0.03	1.521ThrHis: 1.521 ± 0.018	2.939ThrIle: 2.939 ± 0.026	2.141ThrLys: 2.141 ± 0.019	5.645ThrLeu: 5.645 ± 0.033	1.188ThrMet: 1.188 ± 0.017	1.816ThrAsn: 1.816 ± 0.018	4.541ThrPro: 4.541 ± 0.039	2.041ThrGln: 2.041 ± 0.023	3.616ThrArg: 3.616 ± 0.029	5.456ThrSer: 5.456 ± 0.036	3.926ThrThr: 3.926 ± 0.036	3.923ThrVal: 3.923 ± 0.03	0.822ThrTrp: 0.822 ± 0.013	1.629ThrTyr: 1.629 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.858ValAla: 5.858 ± 0.043	0.956ValCys: 0.956 ± 0.015	3.79ValAsp: 3.79 ± 0.027	3.85ValGlu: 3.85 ± 0.037	2.375ValPhe: 2.375 ± 0.025	3.906ValGly: 3.906 ± 0.035	1.76ValHis: 1.76 ± 0.02	2.994ValIle: 2.994 ± 0.026	2.626ValLys: 2.626 ± 0.025	6.174ValLeu: 6.174 ± 0.038	1.361ValMet: 1.361 ± 0.019	2.052ValAsn: 2.052 ± 0.023	4.201ValPro: 4.201 ± 0.033	2.557ValGln: 2.557 ± 0.024	4.153ValArg: 4.153 ± 0.03	4.829ValSer: 4.829 ± 0.038	3.563ValThr: 3.563 ± 0.032	4.599ValVal: 4.599 ± 0.034	0.998ValTrp: 0.998 ± 0.016	1.785ValTyr: 1.785 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.158TrpAla: 1.158 ± 0.016	0.228TrpCys: 0.228 ± 0.006	0.927TrpAsp: 0.927 ± 0.014	0.883TrpGlu: 0.883 ± 0.015	0.518TrpPhe: 0.518 ± 0.01	0.861TrpGly: 0.861 ± 0.013	0.377TrpHis: 0.377 ± 0.009	0.719TrpIle: 0.719 ± 0.011	0.728TrpLys: 0.728 ± 0.011	1.368TrpLeu: 1.368 ± 0.018	0.367TrpMet: 0.367 ± 0.009	0.558TrpAsn: 0.558 ± 0.012	0.641TrpPro: 0.641 ± 0.011	0.554TrpGln: 0.554 ± 0.011	1.092TrpArg: 1.092 ± 0.014	1.064TrpSer: 1.064 ± 0.015	0.9TrpThr: 0.9 ± 0.013	0.882TrpVal: 0.882 ± 0.012	0.277TrpTrp: 0.277 ± 0.009	0.428TrpTyr: 0.428 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.409TyrAla: 2.409 ± 0.023	0.4TyrCys: 0.4 ± 0.009	1.622TyrAsp: 1.622 ± 0.021	1.483TyrGlu: 1.483 ± 0.02	1.047TyrPhe: 1.047 ± 0.015	1.907TyrGly: 1.907 ± 0.02	0.719TyrHis: 0.719 ± 0.012	1.37TyrIle: 1.37 ± 0.017	1.007TyrLys: 1.007 ± 0.014	2.494TyrLeu: 2.494 ± 0.026	0.597TyrMet: 0.597 ± 0.012	0.978TyrAsn: 0.978 ± 0.015	1.558TyrPro: 1.558 ± 0.02	0.942TyrGln: 0.942 ± 0.013	1.624TyrArg: 1.624 ± 0.02	1.984TyrSer: 1.984 ± 0.024	1.614TyrThr: 1.614 ± 0.019	1.769TyrVal: 1.769 ± 0.02	0.406TyrTrp: 0.406 ± 0.01	0.879TyrTyr: 0.879 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12197 proteins (4997340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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