Amino acid dipepetide frequency for Lucifera butyrica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.176AlaAla: 11.176 ± 0.133
1.042AlaCys: 1.042 ± 0.029
4.484AlaAsp: 4.484 ± 0.06
5.686AlaGlu: 5.686 ± 0.069
3.206AlaPhe: 3.206 ± 0.043
8.902AlaGly: 8.902 ± 0.117
1.388AlaHis: 1.388 ± 0.031
6.21AlaIle: 6.21 ± 0.081
4.989AlaLys: 4.989 ± 0.062
8.532AlaLeu: 8.532 ± 0.085
2.615AlaMet: 2.615 ± 0.037
3.217AlaAsn: 3.217 ± 0.054
2.69AlaPro: 2.69 ± 0.047
3.194AlaGln: 3.194 ± 0.055
4.186AlaArg: 4.186 ± 0.058
4.191AlaSer: 4.191 ± 0.062
4.133AlaThr: 4.133 ± 0.062
8.113AlaVal: 8.113 ± 0.083
0.868AlaTrp: 0.868 ± 0.029
2.633AlaTyr: 2.633 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.859CysAla: 0.859 ± 0.025
0.248CysCys: 0.248 ± 0.015
0.537CysAsp: 0.537 ± 0.023
0.612CysGlu: 0.612 ± 0.019
0.511CysPhe: 0.511 ± 0.017
1.292CysGly: 1.292 ± 0.033
0.29CysHis: 0.29 ± 0.015
0.803CysIle: 0.803 ± 0.024
0.529CysLys: 0.529 ± 0.02
1.16CysLeu: 1.16 ± 0.032
0.314CysMet: 0.314 ± 0.015
0.455CysAsn: 0.455 ± 0.021
0.692CysPro: 0.692 ± 0.026
0.444CysGln: 0.444 ± 0.018
0.791CysArg: 0.791 ± 0.024
0.791CysSer: 0.791 ± 0.026
0.606CysThr: 0.606 ± 0.021
0.714CysVal: 0.714 ± 0.022
0.118CysTrp: 0.118 ± 0.009
0.381CysTyr: 0.381 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.795AspAla: 3.795 ± 0.054
0.656AspCys: 0.656 ± 0.024
2.024AspAsp: 2.024 ± 0.041
2.962AspGlu: 2.962 ± 0.05
2.194AspPhe: 2.194 ± 0.038
3.549AspGly: 3.549 ± 0.054
0.846AspHis: 0.846 ± 0.025
3.885AspIle: 3.885 ± 0.056
2.899AspLys: 2.899 ± 0.047
4.603AspLeu: 4.603 ± 0.056
1.422AspMet: 1.422 ± 0.034
1.936AspAsn: 1.936 ± 0.038
1.946AspPro: 1.946 ± 0.04
1.508AspGln: 1.508 ± 0.034
2.668AspArg: 2.668 ± 0.04
2.462AspSer: 2.462 ± 0.047
2.415AspThr: 2.415 ± 0.036
3.464AspVal: 3.464 ± 0.053
0.645AspTrp: 0.645 ± 0.023
2.007AspTyr: 2.007 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
5.321GluAla: 5.321 ± 0.063
0.6GluCys: 0.6 ± 0.021
2.594GluAsp: 2.594 ± 0.042
4.548GluGlu: 4.548 ± 0.066
2.142GluPhe: 2.142 ± 0.041
3.473GluGly: 3.473 ± 0.053
1.127GluHis: 1.127 ± 0.025
4.875GluIle: 4.875 ± 0.062
4.759GluLys: 4.759 ± 0.066
6.352GluLeu: 6.352 ± 0.076
1.959GluMet: 1.959 ± 0.038
2.86GluAsn: 2.86 ± 0.047
2.058GluPro: 2.058 ± 0.034
2.923GluGln: 2.923 ± 0.048
3.476GluArg: 3.476 ± 0.053
2.599GluSer: 2.599 ± 0.046
3.22GluThr: 3.22 ± 0.051
4.119GluVal: 4.119 ± 0.049
0.608GluTrp: 0.608 ± 0.023
2.069GluTyr: 2.069 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.484PheAla: 3.484 ± 0.047
0.614PheCys: 0.614 ± 0.022
2.093PheAsp: 2.093 ± 0.039
1.901PheGlu: 1.901 ± 0.041
1.924PhePhe: 1.924 ± 0.043
3.147PheGly: 3.147 ± 0.056
0.795PheHis: 0.795 ± 0.023
3.034PheIle: 3.034 ± 0.055
1.825PheLys: 1.825 ± 0.041
4.199PheLeu: 4.199 ± 0.073
1.02PheMet: 1.02 ± 0.028
1.659PheAsn: 1.659 ± 0.035
1.617PhePro: 1.617 ± 0.033
1.327PheGln: 1.327 ± 0.032
1.88PheArg: 1.88 ± 0.036
2.823PheSer: 2.823 ± 0.044
2.398PheThr: 2.398 ± 0.036
2.736PheVal: 2.736 ± 0.05
0.498PheTrp: 0.498 ± 0.02
1.398PheTyr: 1.398 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
6.059GlyAla: 6.059 ± 0.085
1.146GlyCys: 1.146 ± 0.031
3.332GlyAsp: 3.332 ± 0.053
4.255GlyGlu: 4.255 ± 0.058
3.364GlyPhe: 3.364 ± 0.056
5.787GlyGly: 5.787 ± 0.086
1.467GlyHis: 1.467 ± 0.035
6.476GlyIle: 6.476 ± 0.079
4.862GlyLys: 4.862 ± 0.056
7.501GlyLeu: 7.501 ± 0.074
2.428GlyMet: 2.428 ± 0.044
3.01GlyAsn: 3.01 ± 0.051
2.204GlyPro: 2.204 ± 0.04
2.865GlyGln: 2.865 ± 0.051
3.818GlyArg: 3.818 ± 0.051
4.181GlySer: 4.181 ± 0.059
4.374GlyThr: 4.374 ± 0.068
5.558GlyVal: 5.558 ± 0.055
0.866GlyTrp: 0.866 ± 0.027
2.988GlyTyr: 2.988 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.404HisAla: 1.404 ± 0.031
0.358HisCys: 0.358 ± 0.016
0.863HisAsp: 0.863 ± 0.027
0.913HisGlu: 0.913 ± 0.025
0.919HisPhe: 0.919 ± 0.026
1.459HisGly: 1.459 ± 0.039
0.489HisHis: 0.489 ± 0.022
1.418HisIle: 1.418 ± 0.029
0.919HisLys: 0.919 ± 0.031
1.79HisLeu: 1.79 ± 0.032
0.477HisMet: 0.477 ± 0.016
0.831HisAsn: 0.831 ± 0.024
1.016HisPro: 1.016 ± 0.026
0.634HisGln: 0.634 ± 0.021
0.961HisArg: 0.961 ± 0.027
1.132HisSer: 1.132 ± 0.025
1.046HisThr: 1.046 ± 0.029
1.145HisVal: 1.145 ± 0.027
0.259HisTrp: 0.259 ± 0.014
0.779HisTyr: 0.779 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.932IleAla: 6.932 ± 0.086
0.851IleCys: 0.851 ± 0.025
3.693IleAsp: 3.693 ± 0.051
4.041IleGlu: 4.041 ± 0.056
2.775IlePhe: 2.775 ± 0.052
5.495IleGly: 5.495 ± 0.071
1.526IleHis: 1.526 ± 0.034
5.095IleIle: 5.095 ± 0.07
3.878IleLys: 3.878 ± 0.055
7.17IleLeu: 7.17 ± 0.073
1.824IleMet: 1.824 ± 0.035
3.006IleAsn: 3.006 ± 0.054
3.349IlePro: 3.349 ± 0.045
2.463IleGln: 2.463 ± 0.042
3.591IleArg: 3.591 ± 0.06
4.173IleSer: 4.173 ± 0.053
4.318IleThr: 4.318 ± 0.055
5.14IleVal: 5.14 ± 0.061
0.658IleTrp: 0.658 ± 0.024
2.189IleTyr: 2.189 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.92LysAla: 4.92 ± 0.058
0.488LysCys: 0.488 ± 0.021
2.711LysAsp: 2.711 ± 0.047
4.394LysGlu: 4.394 ± 0.061
1.666LysPhe: 1.666 ± 0.031
3.421LysGly: 3.421 ± 0.049
0.9LysHis: 0.9 ± 0.025
4.407LysIle: 4.407 ± 0.058
3.895LysLys: 3.895 ± 0.058
5.264LysLeu: 5.264 ± 0.062
1.862LysMet: 1.862 ± 0.034
2.681LysAsn: 2.681 ± 0.045
2.185LysPro: 2.185 ± 0.041
2.384LysGln: 2.384 ± 0.045
2.66LysArg: 2.66 ± 0.045
2.648LysSer: 2.648 ± 0.045
3.22LysThr: 3.22 ± 0.047
4.231LysVal: 4.231 ± 0.055
0.547LysTrp: 0.547 ± 0.02
1.946LysTyr: 1.946 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
10.291LeuAla: 10.291 ± 0.099
1.196LeuCys: 1.196 ± 0.026
4.685LeuAsp: 4.685 ± 0.052
5.673LeuGlu: 5.673 ± 0.064
4.315LeuPhe: 4.315 ± 0.063
7.292LeuGly: 7.292 ± 0.083
1.756LeuHis: 1.756 ± 0.034
6.411LeuIle: 6.411 ± 0.057
5.688LeuLys: 5.688 ± 0.064
10.343LeuLeu: 10.343 ± 0.098
2.39LeuMet: 2.39 ± 0.037
4.012LeuAsn: 4.012 ± 0.06
4.641LeuPro: 4.641 ± 0.057
3.708LeuGln: 3.708 ± 0.053
4.642LeuArg: 4.642 ± 0.064
6.227LeuSer: 6.227 ± 0.078
5.959LeuThr: 5.959 ± 0.068
6.806LeuVal: 6.806 ± 0.082
0.959LeuTrp: 0.959 ± 0.022
2.905LeuTyr: 2.905 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.783MetAla: 2.783 ± 0.047
0.216MetCys: 0.216 ± 0.011
1.445MetAsp: 1.445 ± 0.032
1.856MetGlu: 1.856 ± 0.036
0.904MetPhe: 0.904 ± 0.023
1.997MetGly: 1.997 ± 0.04
0.477MetHis: 0.477 ± 0.017
1.861MetIle: 1.861 ± 0.039
1.74MetLys: 1.74 ± 0.033
2.729MetLeu: 2.729 ± 0.044
0.69MetMet: 0.69 ± 0.022
1.209MetAsn: 1.209 ± 0.035
1.275MetPro: 1.275 ± 0.031
1.081MetGln: 1.081 ± 0.027
1.25MetArg: 1.25 ± 0.027
1.482MetSer: 1.482 ± 0.032
1.549MetThr: 1.549 ± 0.034
1.981MetVal: 1.981 ± 0.041
0.192MetTrp: 0.192 ± 0.011
0.666MetTyr: 0.666 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.065AsnAla: 3.065 ± 0.053
0.539AsnCys: 0.539 ± 0.021
1.75AsnAsp: 1.75 ± 0.036
2.213AsnGlu: 2.213 ± 0.041
1.58AsnPhe: 1.58 ± 0.034
3.084AsnGly: 3.084 ± 0.051
0.821AsnHis: 0.821 ± 0.024
3.139AsnIle: 3.139 ± 0.05
2.16AsnLys: 2.16 ± 0.04
4.175AsnLeu: 4.175 ± 0.054
1.09AsnMet: 1.09 ± 0.03
1.721AsnAsn: 1.721 ± 0.042
2.241AsnPro: 2.241 ± 0.039
1.69AsnGln: 1.69 ± 0.038
2.187AsnArg: 2.187 ± 0.043
2.195AsnSer: 2.195 ± 0.044
2.204AsnThr: 2.204 ± 0.047
2.744AsnVal: 2.744 ± 0.046
0.506AsnTrp: 0.506 ± 0.022
1.5AsnTyr: 1.5 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
4.184ProAla: 4.184 ± 0.066
0.443ProCys: 0.443 ± 0.019
2.528ProAsp: 2.528 ± 0.043
3.143ProGlu: 3.143 ± 0.044
1.734ProPhe: 1.734 ± 0.035
3.479ProGly: 3.479 ± 0.053
0.826ProHis: 0.826 ± 0.024
2.223ProIle: 2.223 ± 0.046
1.692ProLys: 1.692 ± 0.036
3.906ProLeu: 3.906 ± 0.048
0.891ProMet: 0.891 ± 0.026
1.351ProAsn: 1.351 ± 0.03
1.551ProPro: 1.551 ± 0.038
1.493ProGln: 1.493 ± 0.03
1.606ProArg: 1.606 ± 0.036
1.94ProSer: 1.94 ± 0.036
1.719ProThr: 1.719 ± 0.033
4.113ProVal: 4.113 ± 0.057
0.463ProTrp: 0.463 ± 0.017
1.374ProTyr: 1.374 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.783GlnAla: 3.783 ± 0.049
0.406GlnCys: 0.406 ± 0.018
1.847GlnAsp: 1.847 ± 0.04
2.882GlnGlu: 2.882 ± 0.051
1.382GlnPhe: 1.382 ± 0.028
2.697GlnGly: 2.697 ± 0.038
0.671GlnHis: 0.671 ± 0.024
2.691GlnIle: 2.691 ± 0.041
2.388GlnLys: 2.388 ± 0.041
3.47GlnLeu: 3.47 ± 0.053
1.064GlnMet: 1.064 ± 0.028
1.638GlnAsn: 1.638 ± 0.035
1.425GlnPro: 1.425 ± 0.033
1.852GlnGln: 1.852 ± 0.044
1.738GlnArg: 1.738 ± 0.039
1.945GlnSer: 1.945 ± 0.035
2.089GlnThr: 2.089 ± 0.039
2.723GlnVal: 2.723 ± 0.042
0.393GlnTrp: 0.393 ± 0.018
1.407GlnTyr: 1.407 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.293ArgAla: 3.293 ± 0.049
0.585ArgCys: 0.585 ± 0.02
2.357ArgAsp: 2.357 ± 0.046
3.985ArgGlu: 3.985 ± 0.061
2.041ArgPhe: 2.041 ± 0.043
2.96ArgGly: 2.96 ± 0.052
1.088ArgHis: 1.088 ± 0.026
3.719ArgIle: 3.719 ± 0.051
2.834ArgLys: 2.834 ± 0.045
5.226ArgLeu: 5.226 ± 0.071
1.467ArgMet: 1.467 ± 0.03
2.069ArgAsn: 2.069 ± 0.034
1.944ArgPro: 1.944 ± 0.031
2.81ArgGln: 2.81 ± 0.053
2.874ArgArg: 2.874 ± 0.051
2.412ArgSer: 2.412 ± 0.04
2.36ArgThr: 2.36 ± 0.04
3.211ArgVal: 3.211 ± 0.043
0.544ArgTrp: 0.544 ± 0.018
1.875ArgTyr: 1.875 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.388SerAla: 4.388 ± 0.058
0.674SerCys: 0.674 ± 0.022
2.371SerAsp: 2.371 ± 0.044
2.766SerGlu: 2.766 ± 0.05
2.518SerPhe: 2.518 ± 0.044
4.732SerGly: 4.732 ± 0.068
1.127SerHis: 1.127 ± 0.026
3.789SerIle: 3.789 ± 0.053
2.482SerLys: 2.482 ± 0.042
5.941SerLeu: 5.941 ± 0.067
1.551SerMet: 1.551 ± 0.032
1.962SerAsn: 1.962 ± 0.04
2.284SerPro: 2.284 ± 0.035
2.11SerGln: 2.11 ± 0.038
3.056SerArg: 3.056 ± 0.043
3.105SerSer: 3.105 ± 0.056
2.671SerThr: 2.671 ± 0.048
3.883SerVal: 3.883 ± 0.053
0.605SerTrp: 0.605 ± 0.021
1.891SerTyr: 1.891 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.685ThrAla: 5.685 ± 0.066
0.541ThrCys: 0.541 ± 0.021
2.576ThrAsp: 2.576 ± 0.044
3.016ThrGlu: 3.016 ± 0.039
2.125ThrPhe: 2.125 ± 0.035
5.417ThrGly: 5.417 ± 0.064
0.897ThrHis: 0.897 ± 0.023
3.675ThrIle: 3.675 ± 0.059
2.442ThrLys: 2.442 ± 0.047
5.305ThrLeu: 5.305 ± 0.056
1.347ThrMet: 1.347 ± 0.03
1.944ThrAsn: 1.944 ± 0.041
2.468ThrPro: 2.468 ± 0.042
1.62ThrGln: 1.62 ± 0.031
2.279ThrArg: 2.279 ± 0.043
2.662ThrSer: 2.662 ± 0.053
2.785ThrThr: 2.785 ± 0.054
4.915ThrVal: 4.915 ± 0.064
0.461ThrTrp: 0.461 ± 0.018
1.608ThrTyr: 1.608 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
6.726ValAla: 6.726 ± 0.087
0.948ValCys: 0.948 ± 0.026
3.755ValAsp: 3.755 ± 0.046
4.315ValGlu: 4.315 ± 0.052
3.047ValPhe: 3.047 ± 0.05
4.919ValGly: 4.919 ± 0.065
1.302ValHis: 1.302 ± 0.028
5.584ValIle: 5.584 ± 0.069
4.257ValLys: 4.257 ± 0.06
7.457ValLeu: 7.457 ± 0.079
1.971ValMet: 1.971 ± 0.04
3.096ValAsn: 3.096 ± 0.047
3.114ValPro: 3.114 ± 0.048
2.331ValGln: 2.331 ± 0.047
3.519ValArg: 3.519 ± 0.047
4.448ValSer: 4.448 ± 0.052
4.45ValThr: 4.45 ± 0.064
5.628ValVal: 5.628 ± 0.074
0.717ValTrp: 0.717 ± 0.024
2.386ValTyr: 2.386 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.698TrpAla: 0.698 ± 0.024
0.116TrpCys: 0.116 ± 0.009
0.504TrpAsp: 0.504 ± 0.02
0.642TrpGlu: 0.642 ± 0.023
0.467TrpPhe: 0.467 ± 0.019
0.799TrpGly: 0.799 ± 0.023
0.258TrpHis: 0.258 ± 0.014
0.627TrpIle: 0.627 ± 0.02
0.511TrpLys: 0.511 ± 0.019
1.293TrpLeu: 1.293 ± 0.03
0.255TrpMet: 0.255 ± 0.014
0.478TrpAsn: 0.478 ± 0.02
0.386TrpPro: 0.386 ± 0.019
0.655TrpGln: 0.655 ± 0.021
0.592TrpArg: 0.592 ± 0.022
0.568TrpSer: 0.568 ± 0.021
0.494TrpThr: 0.494 ± 0.021
0.637TrpVal: 0.637 ± 0.021
0.163TrpTrp: 0.163 ± 0.011
0.351TrpTyr: 0.351 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.607TyrAla: 2.607 ± 0.04
0.484TyrCys: 0.484 ± 0.018
1.736TyrAsp: 1.736 ± 0.036
1.881TyrGlu: 1.881 ± 0.035
1.557TyrPhe: 1.557 ± 0.037
2.639TyrGly: 2.639 ± 0.045
0.76TyrHis: 0.76 ± 0.023
2.245TyrIle: 2.245 ± 0.04
1.681TyrLys: 1.681 ± 0.037
3.483TyrLeu: 3.483 ± 0.051
0.745TyrMet: 0.745 ± 0.025
1.465TyrAsn: 1.465 ± 0.033
1.569TyrPro: 1.569 ± 0.032
1.402TyrGln: 1.402 ± 0.03
1.878TyrArg: 1.878 ± 0.036
1.922TyrSer: 1.922 ± 0.037
1.759TyrThr: 1.759 ± 0.035
2.111TyrVal: 2.111 ± 0.036
0.426TyrTrp: 0.426 ± 0.017
1.316TyrTyr: 1.316 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5043 proteins (1511077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski