Amino acid dipepetide frequency for Bacteriovorax sp. DB6_IX

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.018AlaAla: 4.018 ± 0.096
0.713AlaCys: 0.713 ± 0.026
3.044AlaAsp: 3.044 ± 0.065
3.488AlaGlu: 3.488 ± 0.075
2.874AlaPhe: 2.874 ± 0.059
4.077AlaGly: 4.077 ± 0.096
1.343AlaHis: 1.343 ± 0.044
4.532AlaIle: 4.532 ± 0.075
5.447AlaLys: 5.447 ± 0.114
6.343AlaLeu: 6.343 ± 0.096
1.703AlaMet: 1.703 ± 0.046
3.045AlaAsn: 3.045 ± 0.075
2.058AlaPro: 2.058 ± 0.056
2.535AlaGln: 2.535 ± 0.06
2.4AlaArg: 2.4 ± 0.056
4.212AlaSer: 4.212 ± 0.082
3.291AlaThr: 3.291 ± 0.06
3.45AlaVal: 3.45 ± 0.064
0.525AlaTrp: 0.525 ± 0.023
2.01AlaTyr: 2.01 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.628CysAla: 0.628 ± 0.031
0.114CysCys: 0.114 ± 0.014
0.742CysAsp: 0.742 ± 0.03
0.691CysGlu: 0.691 ± 0.029
0.609CysPhe: 0.609 ± 0.023
0.778CysGly: 0.778 ± 0.031
0.396CysHis: 0.396 ± 0.022
0.612CysIle: 0.612 ± 0.03
0.57CysLys: 0.57 ± 0.027
1.147CysLeu: 1.147 ± 0.044
0.279CysMet: 0.279 ± 0.018
0.4CysAsn: 0.4 ± 0.021
0.515CysPro: 0.515 ± 0.026
0.452CysGln: 0.452 ± 0.023
0.44CysArg: 0.44 ± 0.021
0.869CysSer: 0.869 ± 0.035
0.547CysThr: 0.547 ± 0.03
0.591CysVal: 0.591 ± 0.022
0.111CysTrp: 0.111 ± 0.012
0.37CysTyr: 0.37 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
2.947AspAla: 2.947 ± 0.066
0.595AspCys: 0.595 ± 0.025
3.09AspAsp: 3.09 ± 0.076
4.321AspGlu: 4.321 ± 0.081
3.551AspPhe: 3.551 ± 0.06
3.451AspGly: 3.451 ± 0.082
1.276AspHis: 1.276 ± 0.038
4.748AspIle: 4.748 ± 0.075
4.334AspLys: 4.334 ± 0.077
6.053AspLeu: 6.053 ± 0.084
1.307AspMet: 1.307 ± 0.037
2.591AspAsn: 2.591 ± 0.053
1.833AspPro: 1.833 ± 0.044
2.087AspGln: 2.087 ± 0.051
2.259AspArg: 2.259 ± 0.048
3.697AspSer: 3.697 ± 0.073
2.261AspThr: 2.261 ± 0.063
3.266AspVal: 3.266 ± 0.071
0.582AspTrp: 0.582 ± 0.025
2.697AspTyr: 2.697 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.209GluAla: 4.209 ± 0.091
0.61GluCys: 0.61 ± 0.027
4.185GluAsp: 4.185 ± 0.083
5.698GluGlu: 5.698 ± 0.103
3.461GluPhe: 3.461 ± 0.058
3.865GluGly: 3.865 ± 0.076
1.208GluHis: 1.208 ± 0.04
5.744GluIle: 5.744 ± 0.085
6.467GluLys: 6.467 ± 0.108
7.534GluLeu: 7.534 ± 0.105
1.927GluMet: 1.927 ± 0.053
4.104GluAsn: 4.104 ± 0.07
1.336GluPro: 1.336 ± 0.043
2.275GluGln: 2.275 ± 0.055
3.194GluArg: 3.194 ± 0.071
4.552GluSer: 4.552 ± 0.067
3.35GluThr: 3.35 ± 0.065
4.995GluVal: 4.995 ± 0.085
0.563GluTrp: 0.563 ± 0.026
2.462GluTyr: 2.462 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.9PheAla: 2.9 ± 0.063
0.629PheCys: 0.629 ± 0.03
3.225PheAsp: 3.225 ± 0.063
3.491PheGlu: 3.491 ± 0.067
2.787PhePhe: 2.787 ± 0.074
3.17PheGly: 3.17 ± 0.062
1.154PheHis: 1.154 ± 0.034
3.574PheIle: 3.574 ± 0.071
4.143PheLys: 4.143 ± 0.076
4.826PheLeu: 4.826 ± 0.094
1.221PheMet: 1.221 ± 0.04
2.782PheAsn: 2.782 ± 0.059
1.651PhePro: 1.651 ± 0.041
1.562PheGln: 1.562 ± 0.051
1.734PheArg: 1.734 ± 0.046
4.277PheSer: 4.277 ± 0.084
2.597PheThr: 2.597 ± 0.058
3.031PheVal: 3.031 ± 0.069
0.529PheTrp: 0.529 ± 0.025
2.117PheTyr: 2.117 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.214GlyAla: 4.214 ± 0.084
0.704GlyCys: 0.704 ± 0.031
3.369GlyAsp: 3.369 ± 0.069
4.149GlyGlu: 4.149 ± 0.068
3.066GlyPhe: 3.066 ± 0.071
4.298GlyGly: 4.298 ± 0.233
1.695GlyHis: 1.695 ± 0.044
4.573GlyIle: 4.573 ± 0.074
4.958GlyLys: 4.958 ± 0.085
6.111GlyLeu: 6.111 ± 0.099
1.683GlyMet: 1.683 ± 0.055
2.813GlyAsn: 2.813 ± 0.08
1.714GlyPro: 1.714 ± 0.041
2.177GlyGln: 2.177 ± 0.058
2.546GlyArg: 2.546 ± 0.066
4.056GlySer: 4.056 ± 0.141
3.43GlyThr: 3.43 ± 0.12
4.361GlyVal: 4.361 ± 0.076
0.49GlyTrp: 0.49 ± 0.022
2.131GlyTyr: 2.131 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.152HisAla: 1.152 ± 0.033
0.266HisCys: 0.266 ± 0.018
1.083HisAsp: 1.083 ± 0.037
1.434HisGlu: 1.434 ± 0.048
1.211HisPhe: 1.211 ± 0.036
1.379HisGly: 1.379 ± 0.04
0.618HisHis: 0.618 ± 0.029
1.472HisIle: 1.472 ± 0.037
1.358HisLys: 1.358 ± 0.038
2.04HisLeu: 2.04 ± 0.051
0.537HisMet: 0.537 ± 0.026
0.916HisAsn: 0.916 ± 0.032
0.958HisPro: 0.958 ± 0.037
0.744HisGln: 0.744 ± 0.031
0.884HisArg: 0.884 ± 0.036
1.397HisSer: 1.397 ± 0.036
0.89HisThr: 0.89 ± 0.033
1.044HisVal: 1.044 ± 0.037
0.207HisTrp: 0.207 ± 0.017
0.904HisTyr: 0.904 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
4.257IleAla: 4.257 ± 0.08
0.811IleCys: 0.811 ± 0.03
4.581IleAsp: 4.581 ± 0.074
5.525IleGlu: 5.525 ± 0.085
3.738IlePhe: 3.738 ± 0.077
4.506IleGly: 4.506 ± 0.081
1.57IleHis: 1.57 ± 0.046
4.902IleIle: 4.902 ± 0.093
5.678IleLys: 5.678 ± 0.083
7.056IleLeu: 7.056 ± 0.094
1.396IleMet: 1.396 ± 0.042
3.835IleAsn: 3.835 ± 0.07
2.864IlePro: 2.864 ± 0.059
2.53IleGln: 2.53 ± 0.055
2.741IleArg: 2.741 ± 0.051
5.753IleSer: 5.753 ± 0.1
3.587IleThr: 3.587 ± 0.079
4.343IleVal: 4.343 ± 0.066
0.578IleTrp: 0.578 ± 0.026
2.557IleTyr: 2.557 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.031LysAla: 5.031 ± 0.09
0.694LysCys: 0.694 ± 0.032
4.977LysAsp: 4.977 ± 0.081
6.69LysGlu: 6.69 ± 0.102
3.575LysPhe: 3.575 ± 0.065
4.483LysGly: 4.483 ± 0.069
1.26LysHis: 1.26 ± 0.039
6.08LysIle: 6.08 ± 0.093
8.595LysLys: 8.595 ± 0.16
7.515LysLeu: 7.515 ± 0.105
2.095LysMet: 2.095 ± 0.052
4.841LysAsn: 4.841 ± 0.081
2.058LysPro: 2.058 ± 0.051
2.198LysGln: 2.198 ± 0.054
3.648LysArg: 3.648 ± 0.075
5.787LysSer: 5.787 ± 0.087
4.327LysThr: 4.327 ± 0.075
5.59LysVal: 5.59 ± 0.089
0.72LysTrp: 0.72 ± 0.031
3.068LysTyr: 3.068 ± 0.062
0.001LysXaa: 0.001 ± 0.001
Leu
6.31LeuAla: 6.31 ± 0.091
1.091LeuCys: 1.091 ± 0.041
5.581LeuAsp: 5.581 ± 0.091
7.365LeuGlu: 7.365 ± 0.108
4.736LeuPhe: 4.736 ± 0.09
6.355LeuGly: 6.355 ± 0.104
1.658LeuHis: 1.658 ± 0.045
6.726LeuIle: 6.726 ± 0.109
8.655LeuLys: 8.655 ± 0.106
8.712LeuLeu: 8.712 ± 0.124
2.345LeuMet: 2.345 ± 0.057
5.181LeuAsn: 5.181 ± 0.083
3.32LeuPro: 3.32 ± 0.062
2.612LeuGln: 2.612 ± 0.048
3.908LeuArg: 3.908 ± 0.067
8.082LeuSer: 8.082 ± 0.101
5.067LeuThr: 5.067 ± 0.079
5.764LeuVal: 5.764 ± 0.086
0.773LeuTrp: 0.773 ± 0.029
3.005LeuTyr: 3.005 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.168MetAla: 2.168 ± 0.057
0.223MetCys: 0.223 ± 0.018
1.282MetAsp: 1.282 ± 0.038
1.487MetGlu: 1.487 ± 0.036
0.847MetPhe: 0.847 ± 0.032
1.759MetGly: 1.759 ± 0.053
0.353MetHis: 0.353 ± 0.02
1.711MetIle: 1.711 ± 0.042
2.532MetLys: 2.532 ± 0.053
1.874MetLeu: 1.874 ± 0.047
0.684MetMet: 0.684 ± 0.029
1.46MetAsn: 1.46 ± 0.042
0.86MetPro: 0.86 ± 0.032
0.657MetGln: 0.657 ± 0.028
1.135MetArg: 1.135 ± 0.032
1.843MetSer: 1.843 ± 0.043
1.551MetThr: 1.551 ± 0.048
1.33MetVal: 1.33 ± 0.045
0.177MetTrp: 0.177 ± 0.014
0.524MetTyr: 0.524 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.58AsnAla: 2.58 ± 0.062
0.578AsnCys: 0.578 ± 0.029
2.615AsnAsp: 2.615 ± 0.059
3.392AsnGlu: 3.392 ± 0.065
2.976AsnPhe: 2.976 ± 0.059
3.067AsnGly: 3.067 ± 0.091
1.099AsnHis: 1.099 ± 0.034
4.159AsnIle: 4.159 ± 0.066
3.97AsnLys: 3.97 ± 0.08
5.116AsnLeu: 5.116 ± 0.083
1.199AsnMet: 1.199 ± 0.039
2.421AsnAsn: 2.421 ± 0.061
2.137AsnPro: 2.137 ± 0.044
1.811AsnGln: 1.811 ± 0.046
2.099AsnArg: 2.099 ± 0.049
3.65AsnSer: 3.65 ± 0.075
2.425AsnThr: 2.425 ± 0.059
2.608AsnVal: 2.608 ± 0.059
0.557AsnTrp: 0.557 ± 0.028
2.291AsnTyr: 2.291 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.913ProAla: 1.913 ± 0.05
0.326ProCys: 0.326 ± 0.019
1.653ProAsp: 1.653 ± 0.045
2.647ProGlu: 2.647 ± 0.061
1.81ProPhe: 1.81 ± 0.045
1.944ProGly: 1.944 ± 0.049
0.682ProHis: 0.682 ± 0.029
2.43ProIle: 2.43 ± 0.055
2.467ProLys: 2.467 ± 0.056
3.12ProLeu: 3.12 ± 0.057
0.751ProMet: 0.751 ± 0.029
1.564ProAsn: 1.564 ± 0.045
0.743ProPro: 0.743 ± 0.039
1.181ProGln: 1.181 ± 0.033
1.157ProArg: 1.157 ± 0.035
2.193ProSer: 2.193 ± 0.053
1.766ProThr: 1.766 ± 0.05
2.268ProVal: 2.268 ± 0.057
0.34ProTrp: 0.34 ± 0.022
1.261ProTyr: 1.261 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.363GlnAla: 2.363 ± 0.061
0.331GlnCys: 0.331 ± 0.022
1.883GlnAsp: 1.883 ± 0.047
2.456GlnGlu: 2.456 ± 0.062
1.538GlnPhe: 1.538 ± 0.043
2.019GlnGly: 2.019 ± 0.045
0.518GlnHis: 0.518 ± 0.021
2.45GlnIle: 2.45 ± 0.057
3.024GlnLys: 3.024 ± 0.072
3.0GlnLeu: 3.0 ± 0.066
0.965GlnMet: 0.965 ± 0.034
1.723GlnAsn: 1.723 ± 0.05
0.628GlnPro: 0.628 ± 0.029
1.063GlnGln: 1.063 ± 0.039
1.672GlnArg: 1.672 ± 0.052
2.251GlnSer: 2.251 ± 0.055
1.749GlnThr: 1.749 ± 0.044
2.355GlnVal: 2.355 ± 0.054
0.318GlnTrp: 0.318 ± 0.018
1.155GlnTyr: 1.155 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.588ArgAla: 2.588 ± 0.055
0.364ArgCys: 0.364 ± 0.02
2.444ArgAsp: 2.444 ± 0.055
3.238ArgGlu: 3.238 ± 0.061
2.025ArgPhe: 2.025 ± 0.055
2.359ArgGly: 2.359 ± 0.052
0.792ArgHis: 0.792 ± 0.031
3.023ArgIle: 3.023 ± 0.066
3.161ArgLys: 3.161 ± 0.066
3.738ArgLeu: 3.738 ± 0.079
1.052ArgMet: 1.052 ± 0.035
2.037ArgAsn: 2.037 ± 0.051
1.42ArgPro: 1.42 ± 0.039
1.163ArgGln: 1.163 ± 0.036
1.855ArgArg: 1.855 ± 0.05
2.63ArgSer: 2.63 ± 0.06
1.931ArgThr: 1.931 ± 0.051
2.795ArgVal: 2.795 ± 0.057
0.358ArgTrp: 0.358 ± 0.024
1.555ArgTyr: 1.555 ± 0.047
0.001ArgXaa: 0.001 ± 0.001
Ser
4.072SerAla: 4.072 ± 0.094
1.033SerCys: 1.033 ± 0.041
3.796SerAsp: 3.796 ± 0.062
4.792SerGlu: 4.792 ± 0.075
4.439SerPhe: 4.439 ± 0.067
4.741SerGly: 4.741 ± 0.149
1.631SerHis: 1.631 ± 0.042
4.878SerIle: 4.878 ± 0.086
5.588SerLys: 5.588 ± 0.086
7.75SerLeu: 7.75 ± 0.111
1.679SerMet: 1.679 ± 0.046
3.213SerAsn: 3.213 ± 0.066
2.28SerPro: 2.28 ± 0.058
2.829SerGln: 2.829 ± 0.063
2.694SerArg: 2.694 ± 0.054
5.649SerSer: 5.649 ± 0.117
3.482SerThr: 3.482 ± 0.091
4.178SerVal: 4.178 ± 0.078
0.794SerTrp: 0.794 ± 0.03
2.88SerTyr: 2.88 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
3.145ThrAla: 3.145 ± 0.088
0.552ThrCys: 0.552 ± 0.034
2.758ThrAsp: 2.758 ± 0.057
3.133ThrGlu: 3.133 ± 0.064
2.563ThrPhe: 2.563 ± 0.062
3.522ThrGly: 3.522 ± 0.088
1.054ThrHis: 1.054 ± 0.038
3.691ThrIle: 3.691 ± 0.08
3.84ThrLys: 3.84 ± 0.076
5.126ThrLeu: 5.126 ± 0.075
1.078ThrMet: 1.078 ± 0.031
2.516ThrAsn: 2.516 ± 0.074
2.188ThrPro: 2.188 ± 0.051
1.818ThrGln: 1.818 ± 0.044
1.853ThrArg: 1.853 ± 0.039
3.551ThrSer: 3.551 ± 0.086
2.878ThrThr: 2.878 ± 0.083
3.122ThrVal: 3.122 ± 0.074
0.487ThrTrp: 0.487 ± 0.026
1.881ThrTyr: 1.881 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.11ValAla: 4.11 ± 0.068
0.688ValCys: 0.688 ± 0.027
3.946ValAsp: 3.946 ± 0.073
4.731ValGlu: 4.731 ± 0.079
3.012ValPhe: 3.012 ± 0.066
3.902ValGly: 3.902 ± 0.076
1.128ValHis: 1.128 ± 0.035
4.419ValIle: 4.419 ± 0.07
4.953ValLys: 4.953 ± 0.087
5.612ValLeu: 5.612 ± 0.081
1.432ValMet: 1.432 ± 0.043
2.969ValAsn: 2.969 ± 0.062
1.977ValPro: 1.977 ± 0.048
1.883ValGln: 1.883 ± 0.05
2.282ValArg: 2.282 ± 0.057
4.629ValSer: 4.629 ± 0.076
3.3ValThr: 3.3 ± 0.073
4.023ValVal: 4.023 ± 0.085
0.479ValTrp: 0.479 ± 0.023
1.907ValTyr: 1.907 ± 0.047
0.001ValXaa: 0.001 ± 0.001
Trp
0.58TrpAla: 0.58 ± 0.027
0.103TrpCys: 0.103 ± 0.011
0.526TrpAsp: 0.526 ± 0.023
0.562TrpGlu: 0.562 ± 0.027
0.43TrpPhe: 0.43 ± 0.021
0.677TrpGly: 0.677 ± 0.029
0.231TrpHis: 0.231 ± 0.014
0.599TrpIle: 0.599 ± 0.026
0.706TrpLys: 0.706 ± 0.029
0.822TrpLeu: 0.822 ± 0.03
0.273TrpMet: 0.273 ± 0.019
0.513TrpAsn: 0.513 ± 0.025
0.316TrpPro: 0.316 ± 0.018
0.344TrpGln: 0.344 ± 0.022
0.346TrpArg: 0.346 ± 0.02
0.655TrpSer: 0.655 ± 0.027
0.481TrpThr: 0.481 ± 0.027
0.517TrpVal: 0.517 ± 0.025
0.122TrpTrp: 0.122 ± 0.012
0.3TrpTyr: 0.3 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.925TyrAla: 1.925 ± 0.049
0.434TyrCys: 0.434 ± 0.025
2.167TyrAsp: 2.167 ± 0.044
2.452TyrGlu: 2.452 ± 0.052
2.152TyrPhe: 2.152 ± 0.057
2.186TyrGly: 2.186 ± 0.057
0.829TyrHis: 0.829 ± 0.032
2.485TyrIle: 2.485 ± 0.059
2.785TyrLys: 2.785 ± 0.065
3.752TyrLeu: 3.752 ± 0.066
0.848TyrMet: 0.848 ± 0.032
1.827TyrAsn: 1.827 ± 0.047
1.36TyrPro: 1.36 ± 0.043
1.538TyrGln: 1.538 ± 0.047
1.68TyrArg: 1.68 ± 0.048
2.666TyrSer: 2.666 ± 0.06
1.847TyrThr: 1.847 ± 0.049
1.754TyrVal: 1.754 ± 0.04
0.391TyrTrp: 0.391 ± 0.02
1.501TyrTyr: 1.501 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.002XaaArg: 0.002 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3188 proteins (893457 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski