Amino acid dipepetide frequency for Paraburkholderia caffeinilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.749AlaAla: 17.749 ± 0.154	1.235AlaCys: 1.235 ± 0.025	6.603AlaAsp: 6.603 ± 0.066	6.148AlaGlu: 6.148 ± 0.069	4.33AlaPhe: 4.33 ± 0.053	10.516AlaGly: 10.516 ± 0.101	2.844AlaHis: 2.844 ± 0.044	5.832AlaIle: 5.832 ± 0.067	3.774AlaLys: 3.774 ± 0.055	14.097AlaLeu: 14.097 ± 0.131	3.301AlaMet: 3.301 ± 0.043	3.51AlaAsn: 3.51 ± 0.059	5.734AlaPro: 5.734 ± 0.076	5.304AlaGln: 5.304 ± 0.07	8.553AlaArg: 8.553 ± 0.081	7.624AlaSer: 7.624 ± 0.08	6.591AlaThr: 6.591 ± 0.07	8.874AlaVal: 8.874 ± 0.078	1.634AlaTrp: 1.634 ± 0.035	2.742AlaTyr: 2.742 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.17CysAla: 1.17 ± 0.028	0.099CysCys: 0.099 ± 0.007	0.516CysAsp: 0.516 ± 0.02	0.496CysGlu: 0.496 ± 0.017	0.34CysPhe: 0.34 ± 0.013	0.976CysGly: 0.976 ± 0.024	0.239CysHis: 0.239 ± 0.012	0.395CysIle: 0.395 ± 0.016	0.227CysLys: 0.227 ± 0.013	0.787CysLeu: 0.787 ± 0.021	0.198CysMet: 0.198 ± 0.011	0.251CysAsn: 0.251 ± 0.012	0.404CysPro: 0.404 ± 0.018	0.199CysGln: 0.199 ± 0.011	0.566CysArg: 0.566 ± 0.019	0.497CysSer: 0.497 ± 0.016	0.466CysThr: 0.466 ± 0.017	0.797CysVal: 0.797 ± 0.02	0.119CysTrp: 0.119 ± 0.009	0.216CysTyr: 0.216 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.548AspAla: 7.548 ± 0.068	0.441AspCys: 0.441 ± 0.017	2.999AspAsp: 2.999 ± 0.047	3.353AspGlu: 3.353 ± 0.047	1.953AspPhe: 1.953 ± 0.032	4.468AspGly: 4.468 ± 0.051	1.156AspHis: 1.156 ± 0.028	2.501AspIle: 2.501 ± 0.038	1.599AspLys: 1.599 ± 0.035	5.2AspLeu: 5.2 ± 0.064	1.128AspMet: 1.128 ± 0.024	1.368AspAsn: 1.368 ± 0.029	2.852AspPro: 2.852 ± 0.05	1.66AspGln: 1.66 ± 0.036	3.243AspArg: 3.243 ± 0.048	2.618AspSer: 2.618 ± 0.04	2.893AspThr: 2.893 ± 0.038	4.342AspVal: 4.342 ± 0.051	0.867AspTrp: 0.867 ± 0.022	1.542AspTyr: 1.542 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.621GluAla: 6.621 ± 0.077	0.398GluCys: 0.398 ± 0.016	2.065GluAsp: 2.065 ± 0.037	2.413GluGlu: 2.413 ± 0.047	1.773GluPhe: 1.773 ± 0.036	3.397GluGly: 3.397 ± 0.053	1.456GluHis: 1.456 ± 0.031	2.777GluIle: 2.777 ± 0.044	1.748GluLys: 1.748 ± 0.038	5.362GluLeu: 5.362 ± 0.069	1.193GluMet: 1.193 ± 0.028	1.422GluAsn: 1.422 ± 0.026	2.539GluPro: 2.539 ± 0.041	2.429GluGln: 2.429 ± 0.041	4.778GluArg: 4.778 ± 0.058	2.631GluSer: 2.631 ± 0.035	2.902GluThr: 2.902 ± 0.048	3.563GluVal: 3.563 ± 0.053	0.745GluTrp: 0.745 ± 0.023	1.166GluTyr: 1.166 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.736PheAla: 4.736 ± 0.064	0.417PheCys: 0.417 ± 0.014	2.747PheAsp: 2.747 ± 0.042	2.035PheGlu: 2.035 ± 0.032	1.482PhePhe: 1.482 ± 0.034	3.76PheGly: 3.76 ± 0.054	0.758PheHis: 0.758 ± 0.021	1.69PheIle: 1.69 ± 0.031	1.014PheLys: 1.014 ± 0.023	2.962PheLeu: 2.962 ± 0.043	0.84PheMet: 0.84 ± 0.023	1.238PheAsn: 1.238 ± 0.03	1.644PhePro: 1.644 ± 0.03	1.007PheGln: 1.007 ± 0.023	1.958PheArg: 1.958 ± 0.033	2.369PheSer: 2.369 ± 0.037	2.057PheThr: 2.057 ± 0.033	3.205PheVal: 3.205 ± 0.046	0.519PheTrp: 0.519 ± 0.017	0.998PheTyr: 0.998 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.488GlyAla: 9.488 ± 0.088	0.832GlyCys: 0.832 ± 0.024	3.967GlyAsp: 3.967 ± 0.049	4.31GlyGlu: 4.31 ± 0.053	3.489GlyPhe: 3.489 ± 0.047	6.894GlyGly: 6.894 ± 0.106	1.936GlyHis: 1.936 ± 0.042	4.394GlyIle: 4.394 ± 0.056	3.268GlyLys: 3.268 ± 0.05	7.987GlyLeu: 7.987 ± 0.064	2.225GlyMet: 2.225 ± 0.035	2.521GlyAsn: 2.521 ± 0.063	2.851GlyPro: 2.851 ± 0.043	2.818GlyGln: 2.818 ± 0.047	4.989GlyArg: 4.989 ± 0.061	4.811GlySer: 4.811 ± 0.08	4.775GlyThr: 4.775 ± 0.087	6.83GlyVal: 6.83 ± 0.073	1.362GlyTrp: 1.362 ± 0.033	2.435GlyTyr: 2.435 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	3.068HisAla: 3.068 ± 0.046	0.238HisCys: 0.238 ± 0.012	1.372HisAsp: 1.372 ± 0.029	1.223HisGlu: 1.223 ± 0.027	0.994HisPhe: 0.994 ± 0.025	2.154HisGly: 2.154 ± 0.041	0.633HisHis: 0.633 ± 0.021	0.946HisIle: 0.946 ± 0.02	0.548HisLys: 0.548 ± 0.018	2.156HisLeu: 2.156 ± 0.033	0.521HisMet: 0.521 ± 0.017	0.534HisAsn: 0.534 ± 0.02	1.403HisPro: 1.403 ± 0.028	0.649HisGln: 0.649 ± 0.019	1.503HisArg: 1.503 ± 0.03	1.088HisSer: 1.088 ± 0.028	1.113HisThr: 1.113 ± 0.026	1.76HisVal: 1.76 ± 0.032	0.385HisTrp: 0.385 ± 0.016	0.701HisTyr: 0.701 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.158IleAla: 7.158 ± 0.066	0.465IleCys: 0.465 ± 0.017	3.493IleAsp: 3.493 ± 0.044	3.315IleGlu: 3.315 ± 0.04	1.513IlePhe: 1.513 ± 0.029	4.879IleGly: 4.879 ± 0.065	0.904IleHis: 0.904 ± 0.024	1.63IleIle: 1.63 ± 0.034	1.421IleLys: 1.421 ± 0.038	3.374IleLeu: 3.374 ± 0.047	0.817IleMet: 0.817 ± 0.024	1.472IleAsn: 1.472 ± 0.033	2.171IlePro: 2.171 ± 0.037	1.288IleGln: 1.288 ± 0.028	2.788IleArg: 2.788 ± 0.037	2.607IleSer: 2.607 ± 0.044	2.484IleThr: 2.484 ± 0.051	4.516IleVal: 4.516 ± 0.057	0.513IleTrp: 0.513 ± 0.015	1.09IleTyr: 1.09 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.634LysAla: 3.634 ± 0.05	0.164LysCys: 0.164 ± 0.011	1.515LysAsp: 1.515 ± 0.038	1.434LysGlu: 1.434 ± 0.033	0.9LysPhe: 0.9 ± 0.024	2.156LysGly: 2.156 ± 0.035	0.688LysHis: 0.688 ± 0.02	1.615LysIle: 1.615 ± 0.033	1.257LysLys: 1.257 ± 0.03	3.463LysLeu: 3.463 ± 0.049	0.791LysMet: 0.791 ± 0.021	0.913LysAsn: 0.913 ± 0.023	1.974LysPro: 1.974 ± 0.036	1.338LysGln: 1.338 ± 0.029	2.328LysArg: 2.328 ± 0.038	1.739LysSer: 1.739 ± 0.032	1.921LysThr: 1.921 ± 0.035	2.398LysVal: 2.398 ± 0.046	0.377LysTrp: 0.377 ± 0.013	0.701LysTyr: 0.701 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.709LeuAla: 13.709 ± 0.101	1.016LeuCys: 1.016 ± 0.023	5.933LeuAsp: 5.933 ± 0.065	4.967LeuGlu: 4.967 ± 0.063	3.646LeuPhe: 3.646 ± 0.05	8.26LeuGly: 8.26 ± 0.081	2.26LeuHis: 2.26 ± 0.039	4.857LeuIle: 4.857 ± 0.063	3.457LeuLys: 3.457 ± 0.044	9.81LeuLeu: 9.81 ± 0.102	2.219LeuMet: 2.219 ± 0.04	2.932LeuAsn: 2.932 ± 0.049	5.731LeuPro: 5.731 ± 0.058	3.367LeuGln: 3.367 ± 0.047	6.839LeuArg: 6.839 ± 0.065	6.468LeuSer: 6.468 ± 0.067	5.821LeuThr: 5.821 ± 0.065	7.391LeuVal: 7.391 ± 0.079	1.118LeuTrp: 1.118 ± 0.027	2.153LeuTyr: 2.153 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.459MetAla: 2.459 ± 0.038	0.182MetCys: 0.182 ± 0.009	0.95MetAsp: 0.95 ± 0.022	0.946MetGlu: 0.946 ± 0.023	0.785MetPhe: 0.785 ± 0.021	1.536MetGly: 1.536 ± 0.034	0.561MetHis: 0.561 ± 0.019	1.128MetIle: 1.128 ± 0.028	1.043MetLys: 1.043 ± 0.024	2.721MetLeu: 2.721 ± 0.037	0.61MetMet: 0.61 ± 0.019	0.971MetAsn: 0.971 ± 0.024	1.4MetPro: 1.4 ± 0.03	1.022MetGln: 1.022 ± 0.026	1.746MetArg: 1.746 ± 0.034	1.744MetSer: 1.744 ± 0.032	1.692MetThr: 1.692 ± 0.033	1.566MetVal: 1.566 ± 0.034	0.211MetTrp: 0.211 ± 0.011	0.405MetTyr: 0.405 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.768AsnAla: 3.768 ± 0.071	0.273AsnCys: 0.273 ± 0.012	1.527AsnAsp: 1.527 ± 0.032	1.359AsnGlu: 1.359 ± 0.036	1.038AsnPhe: 1.038 ± 0.025	2.791AsnGly: 2.791 ± 0.054	0.562AsnHis: 0.562 ± 0.019	1.335AsnIle: 1.335 ± 0.034	0.72AsnLys: 0.72 ± 0.023	2.868AsnLeu: 2.868 ± 0.048	0.582AsnMet: 0.582 ± 0.017	0.89AsnAsn: 0.89 ± 0.034	1.914AsnPro: 1.914 ± 0.037	0.962AsnGln: 0.962 ± 0.029	1.816AsnArg: 1.816 ± 0.031	1.475AsnSer: 1.475 ± 0.042	1.61AsnThr: 1.61 ± 0.036	2.369AsnVal: 2.369 ± 0.042	0.437AsnTrp: 0.437 ± 0.017	0.785AsnTyr: 0.785 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.559ProAla: 6.559 ± 0.074	0.333ProCys: 0.333 ± 0.014	3.069ProAsp: 3.069 ± 0.043	2.898ProGlu: 2.898 ± 0.044	1.972ProPhe: 1.972 ± 0.034	4.048ProGly: 4.048 ± 0.05	1.278ProHis: 1.278 ± 0.028	2.106ProIle: 2.106 ± 0.037	1.432ProLys: 1.432 ± 0.03	5.2ProLeu: 5.2 ± 0.051	1.113ProMet: 1.113 ± 0.023	1.478ProAsn: 1.478 ± 0.034	2.371ProPro: 2.371 ± 0.042	1.915ProGln: 1.915 ± 0.037	2.745ProArg: 2.745 ± 0.048	2.824ProSer: 2.824 ± 0.043	2.578ProThr: 2.578 ± 0.045	4.321ProVal: 4.321 ± 0.054	0.606ProTrp: 0.606 ± 0.017	1.24ProTyr: 1.24 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.558GlnAla: 4.558 ± 0.054	0.281GlnCys: 0.281 ± 0.014	1.353GlnAsp: 1.353 ± 0.028	1.327GlnGlu: 1.327 ± 0.028	1.365GlnPhe: 1.365 ± 0.03	2.552GlnGly: 2.552 ± 0.044	0.942GlnHis: 0.942 ± 0.025	2.065GlnIle: 2.065 ± 0.037	1.135GlnLys: 1.135 ± 0.027	3.791GlnLeu: 3.791 ± 0.049	1.047GlnMet: 1.047 ± 0.024	0.977GlnAsn: 0.977 ± 0.026	2.023GlnPro: 2.023 ± 0.037	2.018GlnGln: 2.018 ± 0.052	2.837GlnArg: 2.837 ± 0.048	2.106GlnSer: 2.106 ± 0.038	2.126GlnThr: 2.126 ± 0.038	2.5GlnVal: 2.5 ± 0.041	0.555GlnTrp: 0.555 ± 0.022	0.937GlnTyr: 0.937 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.836ArgAla: 7.836 ± 0.077	0.535ArgCys: 0.535 ± 0.018	3.7ArgAsp: 3.7 ± 0.05	4.106ArgGlu: 4.106 ± 0.06	2.959ArgPhe: 2.959 ± 0.041	4.517ArgGly: 4.517 ± 0.05	1.772ArgHis: 1.772 ± 0.035	3.585ArgIle: 3.585 ± 0.044	2.041ArgLys: 2.041 ± 0.035	6.96ArgLeu: 6.96 ± 0.073	1.749ArgMet: 1.749 ± 0.033	1.935ArgAsn: 1.935 ± 0.035	2.845ArgPro: 2.845 ± 0.043	2.452ArgGln: 2.452 ± 0.039	4.973ArgArg: 4.973 ± 0.061	3.45ArgSer: 3.45 ± 0.05	3.356ArgThr: 3.356 ± 0.039	5.139ArgVal: 5.139 ± 0.053	0.989ArgTrp: 0.989 ± 0.021	1.933ArgTyr: 1.933 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.186SerAla: 7.186 ± 0.083	0.415SerCys: 0.415 ± 0.016	2.818SerAsp: 2.818 ± 0.036	2.641SerGlu: 2.641 ± 0.041	2.294SerPhe: 2.294 ± 0.037	5.525SerGly: 5.525 ± 0.085	1.261SerHis: 1.261 ± 0.023	2.944SerIle: 2.944 ± 0.041	1.705SerLys: 1.705 ± 0.036	5.937SerLeu: 5.937 ± 0.072	1.389SerMet: 1.389 ± 0.029	1.766SerAsn: 1.766 ± 0.032	2.834SerPro: 2.834 ± 0.042	1.914SerGln: 1.914 ± 0.036	3.599SerArg: 3.599 ± 0.048	3.659SerSer: 3.659 ± 0.059	3.348SerThr: 3.348 ± 0.051	4.535SerVal: 4.535 ± 0.056	0.735SerTrp: 0.735 ± 0.023	1.381SerTyr: 1.381 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.259ThrAla: 6.259 ± 0.08	0.423ThrCys: 0.423 ± 0.017	2.703ThrAsp: 2.703 ± 0.042	2.424ThrGlu: 2.424 ± 0.038	2.064ThrPhe: 2.064 ± 0.038	4.95ThrGly: 4.95 ± 0.072	1.284ThrHis: 1.284 ± 0.028	2.654ThrIle: 2.654 ± 0.042	1.294ThrLys: 1.294 ± 0.03	6.737ThrLeu: 6.737 ± 0.069	1.259ThrMet: 1.259 ± 0.027	1.417ThrAsn: 1.417 ± 0.039	3.55ThrPro: 3.55 ± 0.047	2.037ThrGln: 2.037 ± 0.03	3.583ThrArg: 3.583 ± 0.043	3.188ThrSer: 3.188 ± 0.05	3.048ThrThr: 3.048 ± 0.058	4.542ThrVal: 4.542 ± 0.06	0.69ThrTrp: 0.69 ± 0.02	1.332ThrTyr: 1.332 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.484ValAla: 9.484 ± 0.083	0.807ValCys: 0.807 ± 0.024	4.353ValAsp: 4.353 ± 0.058	4.262ValGlu: 4.262 ± 0.055	2.939ValPhe: 2.939 ± 0.039	5.712ValGly: 5.712 ± 0.068	1.514ValHis: 1.514 ± 0.032	3.894ValIle: 3.894 ± 0.053	2.565ValLys: 2.565 ± 0.044	8.053ValLeu: 8.053 ± 0.093	1.87ValMet: 1.87 ± 0.028	2.349ValAsn: 2.349 ± 0.042	3.968ValPro: 3.968 ± 0.054	2.538ValGln: 2.538 ± 0.039	4.972ValArg: 4.972 ± 0.058	4.824ValSer: 4.824 ± 0.055	4.645ValThr: 4.645 ± 0.067	6.329ValVal: 6.329 ± 0.071	0.985ValTrp: 0.985 ± 0.024	1.693ValTyr: 1.693 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.163TrpAla: 1.163 ± 0.028	0.139TrpCys: 0.139 ± 0.009	0.603TrpAsp: 0.603 ± 0.017	0.485TrpGlu: 0.485 ± 0.017	0.574TrpPhe: 0.574 ± 0.02	0.878TrpGly: 0.878 ± 0.021	0.411TrpHis: 0.411 ± 0.014	0.707TrpIle: 0.707 ± 0.024	0.419TrpLys: 0.419 ± 0.016	1.917TrpLeu: 1.917 ± 0.04	0.366TrpMet: 0.366 ± 0.015	0.469TrpAsn: 0.469 ± 0.016	0.618TrpPro: 0.618 ± 0.017	0.655TrpGln: 0.655 ± 0.021	1.154TrpArg: 1.154 ± 0.027	0.784TrpSer: 0.784 ± 0.018	0.698TrpThr: 0.698 ± 0.021	0.878TrpVal: 0.878 ± 0.021	0.231TrpTrp: 0.231 ± 0.012	0.323TrpTyr: 0.323 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.841TyrAla: 2.841 ± 0.04	0.264TyrCys: 0.264 ± 0.011	1.446TyrAsp: 1.446 ± 0.033	1.236TyrGlu: 1.236 ± 0.034	1.025TyrPhe: 1.025 ± 0.023	2.212TyrGly: 2.212 ± 0.033	0.531TyrHis: 0.531 ± 0.016	0.847TyrIle: 0.847 ± 0.022	0.64TyrLys: 0.64 ± 0.021	2.571TyrLeu: 2.571 ± 0.036	0.459TyrMet: 0.459 ± 0.015	0.669TyrAsn: 0.669 ± 0.02	1.258TyrPro: 1.258 ± 0.024	0.922TyrGln: 0.922 ± 0.023	1.863TyrArg: 1.863 ± 0.036	1.377TyrSer: 1.377 ± 0.032	1.316TyrThr: 1.316 ± 0.03	1.901TyrVal: 1.901 ± 0.034	0.396TyrTrp: 0.396 ± 0.013	0.673TyrTyr: 0.673 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5423 proteins (1771409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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