Amino acid dipepetide frequency for Heterocephalus glaber (Naked mole rat)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.345AlaAla: 6.345 ± 0.043	1.49AlaCys: 1.49 ± 0.016	2.843AlaAsp: 2.843 ± 0.019	4.713AlaGlu: 4.713 ± 0.034	2.775AlaPhe: 2.775 ± 0.024	4.656AlaGly: 4.656 ± 0.028	1.627AlaHis: 1.627 ± 0.014	2.846AlaIle: 2.846 ± 0.021	3.374AlaLys: 3.374 ± 0.028	7.409AlaLeu: 7.409 ± 0.044	1.549AlaMet: 1.549 ± 0.014	1.967AlaAsn: 1.967 ± 0.015	4.109AlaPro: 4.109 ± 0.033	3.31AlaGln: 3.31 ± 0.027	3.625AlaArg: 3.625 ± 0.023	5.68AlaSer: 5.68 ± 0.027	3.63AlaThr: 3.63 ± 0.028	4.784AlaVal: 4.784 ± 0.026	0.841AlaTrp: 0.841 ± 0.009	1.552AlaTyr: 1.552 ± 0.015	0.006AlaXaa: 0.006 ± 0.001
Cys	1.352CysAla: 1.352 ± 0.015	0.664CysCys: 0.664 ± 0.012	1.072CysAsp: 1.072 ± 0.013	1.272CysGlu: 1.272 ± 0.017	0.905CysPhe: 0.905 ± 0.012	1.881CysGly: 1.881 ± 0.026	0.722CysHis: 0.722 ± 0.01	0.987CysIle: 0.987 ± 0.013	1.228CysLys: 1.228 ± 0.018	2.255CysLeu: 2.255 ± 0.019	0.478CysMet: 0.478 ± 0.009	0.793CysAsn: 0.793 ± 0.01	1.433CysPro: 1.433 ± 0.02	1.116CysGln: 1.116 ± 0.016	1.305CysArg: 1.305 ± 0.014	2.126CysSer: 2.126 ± 0.019	1.186CysThr: 1.186 ± 0.013	1.378CysVal: 1.378 ± 0.017	0.321CysTrp: 0.321 ± 0.006	0.616CysTyr: 0.616 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	2.777AspAla: 2.777 ± 0.019	1.073AspCys: 1.073 ± 0.014	2.507AspAsp: 2.507 ± 0.026	3.298AspGlu: 3.298 ± 0.028	2.092AspPhe: 2.092 ± 0.015	3.134AspGly: 3.134 ± 0.025	1.144AspHis: 1.144 ± 0.01	2.583AspIle: 2.583 ± 0.019	2.457AspLys: 2.457 ± 0.02	4.965AspLeu: 4.965 ± 0.023	1.136AspMet: 1.136 ± 0.013	1.621AspAsn: 1.621 ± 0.016	2.925AspPro: 2.925 ± 0.019	1.823AspGln: 1.823 ± 0.019	2.415AspArg: 2.415 ± 0.019	4.14AspSer: 4.14 ± 0.026	2.521AspThr: 2.521 ± 0.018	2.997AspVal: 2.997 ± 0.022	0.639AspTrp: 0.639 ± 0.01	1.413AspTyr: 1.413 ± 0.015	0.002AspXaa: 0.002 ± 0.0
Glu	5.269GluAla: 5.269 ± 0.037	1.395GluCys: 1.395 ± 0.022	4.411GluAsp: 4.411 ± 0.029	8.06GluGlu: 8.06 ± 0.08	2.044GluPhe: 2.044 ± 0.016	4.244GluGly: 4.244 ± 0.033	1.537GluHis: 1.537 ± 0.013	3.04GluIle: 3.04 ± 0.026	5.323GluLys: 5.323 ± 0.048	6.365GluLeu: 6.365 ± 0.042	1.637GluMet: 1.637 ± 0.015	2.985GluAsn: 2.985 ± 0.026	3.181GluPro: 3.181 ± 0.029	3.133GluGln: 3.133 ± 0.027	3.823GluArg: 3.823 ± 0.029	4.182GluSer: 4.182 ± 0.027	3.226GluThr: 3.226 ± 0.02	4.215GluVal: 4.215 ± 0.03	0.687GluTrp: 0.687 ± 0.01	1.52GluTyr: 1.52 ± 0.019	0.003GluXaa: 0.003 ± 0.001
Phe	1.988PheAla: 1.988 ± 0.017	1.067PheCys: 1.067 ± 0.013	1.64PheAsp: 1.64 ± 0.013	1.953PheGlu: 1.953 ± 0.014	1.776PhePhe: 1.776 ± 0.017	2.247PheGly: 2.247 ± 0.018	1.085PheHis: 1.085 ± 0.012	1.933PheIle: 1.933 ± 0.018	1.744PheLys: 1.744 ± 0.016	4.384PheLeu: 4.384 ± 0.032	0.818PheMet: 0.818 ± 0.012	1.292PheAsn: 1.292 ± 0.013	2.015PhePro: 2.015 ± 0.018	1.806PheGln: 1.806 ± 0.013	1.938PheArg: 1.938 ± 0.017	3.577PheSer: 3.577 ± 0.023	2.07PheThr: 2.07 ± 0.017	2.233PheVal: 2.233 ± 0.018	0.503PheTrp: 0.503 ± 0.008	1.267PheTyr: 1.267 ± 0.012	0.002PheXaa: 0.002 ± 0.0
Gly	4.478GlyAla: 4.478 ± 0.03	1.38GlyCys: 1.38 ± 0.016	3.102GlyAsp: 3.102 ± 0.022	4.121GlyGlu: 4.121 ± 0.036	2.458GlyPhe: 2.458 ± 0.02	4.685GlyGly: 4.685 ± 0.036	1.771GlyHis: 1.771 ± 0.017	2.724GlyIle: 2.724 ± 0.021	3.848GlyLys: 3.848 ± 0.029	6.098GlyLeu: 6.098 ± 0.034	1.282GlyMet: 1.282 ± 0.013	2.371GlyAsn: 2.371 ± 0.024	4.301GlyPro: 4.301 ± 0.053	2.843GlyGln: 2.843 ± 0.023	3.704GlyArg: 3.704 ± 0.031	5.735GlySer: 5.735 ± 0.035	3.639GlyThr: 3.639 ± 0.025	3.571GlyVal: 3.571 ± 0.022	0.807GlyTrp: 0.807 ± 0.011	1.688GlyTyr: 1.688 ± 0.015	0.008GlyXaa: 0.008 ± 0.001
His	1.348HisAla: 1.348 ± 0.014	0.781HisCys: 0.781 ± 0.011	0.848HisAsp: 0.848 ± 0.01	1.355HisGlu: 1.355 ± 0.014	1.177HisPhe: 1.177 ± 0.012	1.584HisGly: 1.584 ± 0.015	0.877HisHis: 0.877 ± 0.014	1.289HisIle: 1.289 ± 0.012	1.259HisLys: 1.259 ± 0.012	3.066HisLeu: 3.066 ± 0.027	0.631HisMet: 0.631 ± 0.008	0.85HisAsn: 0.85 ± 0.01	1.766HisPro: 1.766 ± 0.064	1.376HisGln: 1.376 ± 0.015	1.647HisArg: 1.647 ± 0.015	2.383HisSer: 2.383 ± 0.027	1.703HisThr: 1.703 ± 0.023	1.5HisVal: 1.5 ± 0.012	0.366HisTrp: 0.366 ± 0.007	0.853HisTyr: 0.853 ± 0.01	0.001HisXaa: 0.001 ± 0.0
Ile	2.497IleAla: 2.497 ± 0.019	1.183IleCys: 1.183 ± 0.014	1.912IleAsp: 1.912 ± 0.017	2.473IleGlu: 2.473 ± 0.024	1.977IlePhe: 1.977 ± 0.019	2.164IleGly: 2.164 ± 0.019	1.446IleHis: 1.446 ± 0.018	2.422IleIle: 2.422 ± 0.02	2.516IleLys: 2.516 ± 0.02	4.741IleLeu: 4.741 ± 0.027	1.044IleMet: 1.044 ± 0.01	1.744IleAsn: 1.744 ± 0.015	2.572IlePro: 2.572 ± 0.018	2.234IleGln: 2.234 ± 0.018	2.306IleArg: 2.306 ± 0.017	3.748IleSer: 3.748 ± 0.023	2.526IleThr: 2.526 ± 0.022	2.508IleVal: 2.508 ± 0.019	0.517IleTrp: 0.517 ± 0.008	1.493IleTyr: 1.493 ± 0.017	0.002IleXaa: 0.002 ± 0.0
Lys	4.191LysAla: 4.191 ± 0.029	1.122LysCys: 1.122 ± 0.015	3.072LysAsp: 3.072 ± 0.024	5.038LysGlu: 5.038 ± 0.046	1.709LysPhe: 1.709 ± 0.015	3.255LysGly: 3.255 ± 0.035	1.406LysHis: 1.406 ± 0.014	2.703LysIle: 2.703 ± 0.024	4.707LysLys: 4.707 ± 0.042	5.095LysLeu: 5.095 ± 0.032	1.464LysMet: 1.464 ± 0.015	2.301LysAsn: 2.301 ± 0.018	3.086LysPro: 3.086 ± 0.028	2.61LysGln: 2.61 ± 0.023	3.135LysArg: 3.135 ± 0.023	3.781LysSer: 3.781 ± 0.032	3.018LysThr: 3.018 ± 0.021	3.461LysVal: 3.461 ± 0.03	0.596LysTrp: 0.596 ± 0.009	1.529LysTyr: 1.529 ± 0.015	0.002LysXaa: 0.002 ± 0.0
Leu	7.107LeuAla: 7.107 ± 0.046	2.346LeuCys: 2.346 ± 0.021	4.76LeuAsp: 4.76 ± 0.027	7.036LeuGlu: 7.036 ± 0.05	3.548LeuPhe: 3.548 ± 0.028	6.235LeuGly: 6.235 ± 0.034	2.909LeuHis: 2.909 ± 0.02	4.002LeuIle: 4.002 ± 0.024	5.682LeuLys: 5.682 ± 0.039	11.199LeuLeu: 11.199 ± 0.064	2.09LeuMet: 2.09 ± 0.016	3.393LeuAsn: 3.393 ± 0.02	5.997LeuPro: 5.997 ± 0.039	5.851LeuGln: 5.851 ± 0.034	5.923LeuArg: 5.923 ± 0.037	8.225LeuSer: 8.225 ± 0.033	5.145LeuThr: 5.145 ± 0.026	5.835LeuVal: 5.835 ± 0.036	1.208LeuTrp: 1.208 ± 0.014	2.567LeuTyr: 2.567 ± 0.019	0.007LeuXaa: 0.007 ± 0.001
Met	2.01MetAla: 2.01 ± 0.015	0.426MetCys: 0.426 ± 0.007	1.248MetAsp: 1.248 ± 0.012	1.837MetGlu: 1.837 ± 0.016	0.756MetPhe: 0.756 ± 0.009	1.344MetGly: 1.344 ± 0.017	0.475MetHis: 0.475 ± 0.008	0.865MetIle: 0.865 ± 0.01	1.433MetLys: 1.433 ± 0.014	2.083MetLeu: 2.083 ± 0.016	0.563MetMet: 0.563 ± 0.008	0.888MetAsn: 0.888 ± 0.01	1.081MetPro: 1.081 ± 0.015	0.932MetGln: 0.932 ± 0.011	1.029MetArg: 1.029 ± 0.011	1.6MetSer: 1.6 ± 0.014	1.113MetThr: 1.113 ± 0.011	1.476MetVal: 1.476 ± 0.013	0.245MetTrp: 0.245 ± 0.004	0.7MetTyr: 0.7 ± 0.011	0.001MetXaa: 0.001 ± 0.0
Asn	1.939AsnAla: 1.939 ± 0.018	0.821AsnCys: 0.821 ± 0.011	1.421AsnAsp: 1.421 ± 0.015	2.1AsnGlu: 2.1 ± 0.019	1.468AsnPhe: 1.468 ± 0.014	2.264AsnGly: 2.264 ± 0.02	1.005AsnHis: 1.005 ± 0.061	2.026AsnIle: 2.026 ± 0.017	2.181AsnLys: 2.181 ± 0.019	3.715AsnLeu: 3.715 ± 0.022	0.898AsnMet: 0.898 ± 0.013	1.477AsnAsn: 1.477 ± 0.065	2.175AsnPro: 2.175 ± 0.014	1.586AsnGln: 1.586 ± 0.016	1.715AsnArg: 1.715 ± 0.013	3.076AsnSer: 3.076 ± 0.103	1.866AsnThr: 1.866 ± 0.017	2.144AsnVal: 2.144 ± 0.017	0.443AsnTrp: 0.443 ± 0.007	1.065AsnTyr: 1.065 ± 0.012	0.001AsnXaa: 0.001 ± 0.0
Pro	4.666ProAla: 4.666 ± 0.036	1.216ProCys: 1.216 ± 0.017	2.709ProAsp: 2.709 ± 0.018	4.443ProGlu: 4.443 ± 0.03	1.982ProPhe: 1.982 ± 0.018	5.266ProGly: 5.266 ± 0.068	1.446ProHis: 1.446 ± 0.014	1.813ProIle: 1.813 ± 0.017	2.833ProLys: 2.833 ± 0.039	5.403ProLeu: 5.403 ± 0.031	1.149ProMet: 1.149 ± 0.012	1.773ProAsn: 1.773 ± 0.044	5.462ProPro: 5.462 ± 0.061	2.79ProGln: 2.79 ± 0.021	3.309ProArg: 3.309 ± 0.025	5.481ProSer: 5.481 ± 0.033	2.983ProThr: 2.983 ± 0.024	3.805ProVal: 3.805 ± 0.027	0.733ProTrp: 0.733 ± 0.01	1.546ProTyr: 1.546 ± 0.021	0.008ProXaa: 0.008 ± 0.001
Gln	3.574GlnAla: 3.574 ± 0.025	1.048GlnCys: 1.048 ± 0.018	2.352GlnAsp: 2.352 ± 0.018	3.872GlnGlu: 3.872 ± 0.032	1.342GlnPhe: 1.342 ± 0.013	2.983GlnGly: 2.983 ± 0.024	1.302GlnHis: 1.302 ± 0.014	1.977GlnIle: 1.977 ± 0.018	2.917GlnLys: 2.917 ± 0.024	4.811GlnLeu: 4.811 ± 0.033	1.104GlnMet: 1.104 ± 0.011	1.785GlnAsn: 1.785 ± 0.015	2.739GlnPro: 2.739 ± 0.024	2.863GlnGln: 2.863 ± 0.031	2.898GlnArg: 2.898 ± 0.025	3.073GlnSer: 3.073 ± 0.024	2.229GlnThr: 2.229 ± 0.016	2.966GlnVal: 2.966 ± 0.026	0.557GlnTrp: 0.557 ± 0.009	1.119GlnTyr: 1.119 ± 0.011	0.003GlnXaa: 0.003 ± 0.001
Arg	3.906ArgAla: 3.906 ± 0.028	1.207ArgCys: 1.207 ± 0.016	2.676ArgAsp: 2.676 ± 0.022	3.866ArgGlu: 3.866 ± 0.027	1.797ArgPhe: 1.797 ± 0.014	3.57ArgGly: 3.57 ± 0.029	1.526ArgHis: 1.526 ± 0.019	2.328ArgIle: 2.328 ± 0.015	3.66ArgLys: 3.66 ± 0.028	5.229ArgLeu: 5.229 ± 0.032	1.161ArgMet: 1.161 ± 0.011	2.073ArgAsn: 2.073 ± 0.016	3.149ArgPro: 3.149 ± 0.023	2.541ArgGln: 2.541 ± 0.021	4.045ArgArg: 4.045 ± 0.032	4.053ArgSer: 4.053 ± 0.032	2.766ArgThr: 2.766 ± 0.021	3.185ArgVal: 3.185 ± 0.023	0.692ArgTrp: 0.692 ± 0.008	1.449ArgTyr: 1.449 ± 0.013	0.007ArgXaa: 0.007 ± 0.001
Ser	5.236SerAla: 5.236 ± 0.028	1.938SerCys: 1.938 ± 0.019	3.796SerAsp: 3.796 ± 0.026	5.056SerGlu: 5.056 ± 0.032	3.13SerPhe: 3.13 ± 0.018	5.57SerGly: 5.57 ± 0.031	2.25SerHis: 2.25 ± 0.04	3.184SerIle: 3.184 ± 0.018	3.932SerLys: 3.932 ± 0.025	8.291SerLeu: 8.291 ± 0.048	1.644SerMet: 1.644 ± 0.012	2.636SerAsn: 2.636 ± 0.101	5.747SerPro: 5.747 ± 0.042	3.814SerGln: 3.814 ± 0.028	4.377SerArg: 4.377 ± 0.032	9.041SerSer: 9.041 ± 0.061	4.51SerThr: 4.51 ± 0.029	4.947SerVal: 4.947 ± 0.027	1.107SerTrp: 1.107 ± 0.012	2.175SerTyr: 2.175 ± 0.018	0.005SerXaa: 0.005 ± 0.001
Thr	3.752ThrAla: 3.752 ± 0.025	1.381ThrCys: 1.381 ± 0.017	2.381ThrAsp: 2.381 ± 0.016	3.506ThrGlu: 3.506 ± 0.022	2.144ThrPhe: 2.144 ± 0.016	3.617ThrGly: 3.617 ± 0.025	1.434ThrHis: 1.434 ± 0.019	2.39ThrIle: 2.39 ± 0.019	2.627ThrLys: 2.627 ± 0.019	5.376ThrLeu: 5.376 ± 0.028	1.141ThrMet: 1.141 ± 0.011	1.67ThrAsn: 1.67 ± 0.014	3.464ThrPro: 3.464 ± 0.028	2.322ThrGln: 2.322 ± 0.017	2.44ThrArg: 2.44 ± 0.017	4.486ThrSer: 4.486 ± 0.028	2.873ThrThr: 2.873 ± 0.029	3.969ThrVal: 3.969 ± 0.028	0.705ThrTrp: 0.705 ± 0.011	1.427ThrTyr: 1.427 ± 0.015	0.002ThrXaa: 0.002 ± 0.0
Val	4.421ValAla: 4.421 ± 0.024	1.582ValCys: 1.582 ± 0.017	2.945ValAsp: 2.945 ± 0.022	3.804ValGlu: 3.804 ± 0.026	2.49ValPhe: 2.49 ± 0.021	3.478ValGly: 3.478 ± 0.02	1.63ValHis: 1.63 ± 0.012	2.98ValIle: 2.98 ± 0.022	3.266ValLys: 3.266 ± 0.028	6.585ValLeu: 6.585 ± 0.035	1.371ValMet: 1.371 ± 0.013	2.187ValAsn: 2.187 ± 0.02	3.762ValPro: 3.762 ± 0.031	2.796ValGln: 2.796 ± 0.022	2.992ValArg: 2.992 ± 0.019	4.864ValSer: 4.864 ± 0.035	3.882ValThr: 3.882 ± 0.032	4.12ValVal: 4.12 ± 0.027	0.743ValTrp: 0.743 ± 0.01	1.644ValTyr: 1.644 ± 0.015	0.002ValXaa: 0.002 ± 0.0
Trp	0.868TrpAla: 0.868 ± 0.01	0.252TrpCys: 0.252 ± 0.006	0.672TrpAsp: 0.672 ± 0.009	0.811TrpGlu: 0.811 ± 0.01	0.457TrpPhe: 0.457 ± 0.007	0.783TrpGly: 0.783 ± 0.011	0.315TrpHis: 0.315 ± 0.006	0.533TrpIle: 0.533 ± 0.01	0.833TrpLys: 0.833 ± 0.01	1.242TrpLeu: 1.242 ± 0.012	0.307TrpMet: 0.307 ± 0.005	0.524TrpAsn: 0.524 ± 0.008	0.563TrpPro: 0.563 ± 0.007	0.545TrpGln: 0.545 ± 0.008	0.735TrpArg: 0.735 ± 0.011	0.868TrpSer: 0.868 ± 0.01	0.67TrpThr: 0.67 ± 0.01	0.756TrpVal: 0.756 ± 0.01	0.198TrpTrp: 0.198 ± 0.004	0.334TrpTyr: 0.334 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.4TyrAla: 1.4 ± 0.013	0.716TyrCys: 0.716 ± 0.009	1.296TyrAsp: 1.296 ± 0.011	1.667TyrGlu: 1.667 ± 0.015	1.308TyrPhe: 1.308 ± 0.012	1.646TyrGly: 1.646 ± 0.016	0.755TyrHis: 0.755 ± 0.01	1.398TyrIle: 1.398 ± 0.017	1.457TyrLys: 1.457 ± 0.017	2.747TyrLeu: 2.747 ± 0.024	0.636TyrMet: 0.636 ± 0.008	1.054TyrAsn: 1.054 ± 0.012	1.281TyrPro: 1.281 ± 0.014	1.222TyrGln: 1.222 ± 0.013	1.518TyrArg: 1.518 ± 0.014	2.261TyrSer: 2.261 ± 0.019	1.546TyrThr: 1.546 ± 0.015	1.692TyrVal: 1.692 ± 0.017	0.356TyrTrp: 0.356 ± 0.009	0.923TyrTyr: 0.923 ± 0.012	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.003XaaGlu: 0.003 ± 0.001	0.003XaaPhe: 0.003 ± 0.0	0.006XaaGly: 0.006 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.007XaaLeu: 0.007 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.007XaaPro: 0.007 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.006XaaArg: 0.006 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	1.89XaaXaa: 1.89 ± 0.191

Statistics based on 21449 proteins (10466552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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