Amino acid dipepetide frequency for Microviridae sp. ct0DW36

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.299AlaAla: 8.299 ± 3.154
1.383AlaCys: 1.383 ± 1.281
6.916AlaAsp: 6.916 ± 2.276
4.149AlaGlu: 4.149 ± 1.425
3.458AlaPhe: 3.458 ± 1.291
6.224AlaGly: 6.224 ± 1.696
2.075AlaHis: 2.075 ± 0.953
0.692AlaIle: 0.692 ± 0.966
2.075AlaLys: 2.075 ± 1.33
2.075AlaLeu: 2.075 ± 1.552
5.533AlaMet: 5.533 ± 1.586
6.224AlaAsn: 6.224 ± 3.387
2.766AlaPro: 2.766 ± 2.344
3.458AlaGln: 3.458 ± 1.647
9.682AlaArg: 9.682 ± 2.594
4.841AlaSer: 4.841 ± 2.384
4.149AlaThr: 4.149 ± 3.103
9.682AlaVal: 9.682 ± 2.873
0.0AlaTrp: 0.0 ± 0.0
2.766AlaTyr: 2.766 ± 0.815
0.0AlaXaa: 0.0 ± 0.0
Cys
0.692CysAla: 0.692 ± 0.517
0.0CysCys: 0.0 ± 0.0
1.383CysAsp: 1.383 ± 0.793
0.0CysGlu: 0.0 ± 0.0
0.692CysPhe: 0.692 ± 0.64
0.692CysGly: 0.692 ± 0.64
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.383CysLeu: 1.383 ± 0.946
0.692CysMet: 0.692 ± 0.64
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.692CysGln: 0.692 ± 0.966
1.383CysArg: 1.383 ± 1.164
2.766CysSer: 2.766 ± 2.076
0.0CysThr: 0.0 ± 0.0
2.075CysVal: 2.075 ± 1.921
0.0CysTrp: 0.0 ± 0.0
0.692CysTyr: 0.692 ± 0.64
0.0CysXaa: 0.0 ± 0.0
Asp
6.224AspAla: 6.224 ± 1.575
0.692AspCys: 0.692 ± 0.64
4.841AspAsp: 4.841 ± 3.649
4.149AspGlu: 4.149 ± 1.664
3.458AspPhe: 3.458 ± 1.678
1.383AspGly: 1.383 ± 1.034
2.766AspHis: 2.766 ± 1.166
2.075AspIle: 2.075 ± 1.253
0.692AspLys: 0.692 ± 1.068
4.841AspLeu: 4.841 ± 1.133
2.075AspMet: 2.075 ± 1.156
2.766AspAsn: 2.766 ± 0.975
3.458AspPro: 3.458 ± 0.773
2.075AspGln: 2.075 ± 0.833
1.383AspArg: 1.383 ± 0.793
8.299AspSer: 8.299 ± 3.608
4.149AspThr: 4.149 ± 2.019
4.841AspVal: 4.841 ± 1.321
0.692AspTrp: 0.692 ± 0.64
4.841AspTyr: 4.841 ± 2.228
0.0AspXaa: 0.0 ± 0.0
Glu
1.383GluAla: 1.383 ± 0.686
0.692GluCys: 0.692 ± 0.831
2.075GluAsp: 2.075 ± 0.953
0.0GluGlu: 0.0 ± 0.0
2.766GluPhe: 2.766 ± 1.311
0.692GluGly: 0.692 ± 0.517
2.075GluHis: 2.075 ± 1.18
4.149GluIle: 4.149 ± 1.083
1.383GluLys: 1.383 ± 1.636
3.458GluLeu: 3.458 ± 1.164
0.692GluMet: 0.692 ± 0.94
0.692GluAsn: 0.692 ± 0.966
0.0GluPro: 0.0 ± 0.0
2.075GluGln: 2.075 ± 0.953
2.766GluArg: 2.766 ± 0.832
2.766GluSer: 2.766 ± 1.505
1.383GluThr: 1.383 ± 1.281
2.075GluVal: 2.075 ± 0.833
0.692GluTrp: 0.692 ± 0.517
3.458GluTyr: 3.458 ± 1.745
0.0GluXaa: 0.0 ± 0.0
Phe
2.075PheAla: 2.075 ± 1.552
1.383PheCys: 1.383 ± 1.021
4.149PheAsp: 4.149 ± 1.719
1.383PheGlu: 1.383 ± 1.054
1.383PhePhe: 1.383 ± 1.005
4.841PheGly: 4.841 ± 1.74
2.075PheHis: 2.075 ± 0.655
0.692PheIle: 0.692 ± 0.517
2.075PheLys: 2.075 ± 1.125
2.075PheLeu: 2.075 ± 0.874
2.075PheMet: 2.075 ± 0.941
5.533PheAsn: 5.533 ± 1.808
0.0PhePro: 0.0 ± 0.0
1.383PheGln: 1.383 ± 0.686
2.766PheArg: 2.766 ± 0.975
3.458PheSer: 3.458 ± 2.64
2.766PheThr: 2.766 ± 2.069
4.841PheVal: 4.841 ± 2.156
0.692PheTrp: 0.692 ± 0.64
4.149PheTyr: 4.149 ± 1.08
0.0PheXaa: 0.0 ± 0.0
Gly
3.458GlyAla: 3.458 ± 1.565
0.692GlyCys: 0.692 ± 0.64
2.075GlyAsp: 2.075 ± 1.18
3.458GlyGlu: 3.458 ± 1.745
3.458GlyPhe: 3.458 ± 1.745
5.533GlyGly: 5.533 ± 2.644
2.075GlyHis: 2.075 ± 2.18
3.458GlyIle: 3.458 ± 1.835
3.458GlyLys: 3.458 ± 1.413
6.224GlyLeu: 6.224 ± 2.366
0.0GlyMet: 0.0 ± 0.0
2.766GlyAsn: 2.766 ± 1.644
2.766GlyPro: 2.766 ± 1.225
2.766GlyGln: 2.766 ± 1.067
3.458GlyArg: 3.458 ± 2.627
4.841GlySer: 4.841 ± 1.534
6.916GlyThr: 6.916 ± 3.627
2.075GlyVal: 2.075 ± 1.05
0.692GlyTrp: 0.692 ± 1.068
2.766GlyTyr: 2.766 ± 1.4
0.0GlyXaa: 0.0 ± 0.0
His
1.383HisAla: 1.383 ± 0.838
0.692HisCys: 0.692 ± 0.517
1.383HisAsp: 1.383 ± 0.626
1.383HisGlu: 1.383 ± 1.281
3.458HisPhe: 3.458 ± 1.883
3.458HisGly: 3.458 ± 2.311
0.0HisHis: 0.0 ± 0.0
2.075HisIle: 2.075 ± 1.841
0.692HisLys: 0.692 ± 1.108
2.766HisLeu: 2.766 ± 1.235
0.0HisMet: 0.0 ± 0.0
1.383HisAsn: 1.383 ± 1.034
2.766HisPro: 2.766 ± 1.892
0.692HisGln: 0.692 ± 0.831
1.383HisArg: 1.383 ± 1.034
3.458HisSer: 3.458 ± 2.087
0.0HisThr: 0.0 ± 0.0
0.692HisVal: 0.692 ± 0.64
0.0HisTrp: 0.0 ± 0.0
2.766HisTyr: 2.766 ± 1.584
0.0HisXaa: 0.0 ± 0.0
Ile
4.149IleAla: 4.149 ± 2.209
0.692IleCys: 0.692 ± 0.966
2.075IleAsp: 2.075 ± 0.655
0.692IleGlu: 0.692 ± 1.108
1.383IlePhe: 1.383 ± 0.946
4.149IleGly: 4.149 ± 1.083
2.075IleHis: 2.075 ± 1.18
2.075IleIle: 2.075 ± 1.261
0.0IleLys: 0.0 ± 0.0
2.766IleLeu: 2.766 ± 1.918
0.0IleMet: 0.0 ± 0.0
2.766IleAsn: 2.766 ± 1.311
2.075IlePro: 2.075 ± 1.05
2.075IleGln: 2.075 ± 0.953
2.075IleArg: 2.075 ± 0.833
2.766IleSer: 2.766 ± 2.441
4.149IleThr: 4.149 ± 1.697
3.458IleVal: 3.458 ± 0.924
0.692IleTrp: 0.692 ± 0.517
1.383IleTyr: 1.383 ± 1.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.383LysAla: 1.383 ± 1.23
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
0.692LysGlu: 0.692 ± 0.517
4.841LysPhe: 4.841 ± 2.91
0.692LysGly: 0.692 ± 0.517
0.0LysHis: 0.0 ± 0.0
2.766LysIle: 2.766 ± 1.8
2.766LysLys: 2.766 ± 1.606
5.533LysLeu: 5.533 ± 1.135
0.0LysMet: 0.0 ± 0.0
1.383LysAsn: 1.383 ± 1.662
0.692LysPro: 0.692 ± 0.517
0.692LysGln: 0.692 ± 1.068
4.149LysArg: 4.149 ± 1.864
4.149LysSer: 4.149 ± 1.028
4.149LysThr: 4.149 ± 2.705
2.075LysVal: 2.075 ± 1.156
0.0LysTrp: 0.0 ± 0.0
1.383LysTyr: 1.383 ± 1.005
0.0LysXaa: 0.0 ± 0.0
Leu
7.607LeuAla: 7.607 ± 1.848
0.0LeuCys: 0.0 ± 0.0
2.075LeuAsp: 2.075 ± 0.874
4.841LeuGlu: 4.841 ± 1.444
4.841LeuPhe: 4.841 ± 1.534
4.149LeuGly: 4.149 ± 1.478
0.692LeuHis: 0.692 ± 1.108
3.458LeuIle: 3.458 ± 1.221
2.075LeuLys: 2.075 ± 1.834
4.149LeuLeu: 4.149 ± 1.86
1.383LeuMet: 1.383 ± 0.603
6.916LeuAsn: 6.916 ± 2.029
4.841LeuPro: 4.841 ± 1.375
2.766LeuGln: 2.766 ± 1.225
3.458LeuArg: 3.458 ± 1.273
5.533LeuSer: 5.533 ± 1.415
4.149LeuThr: 4.149 ± 1.113
4.149LeuVal: 4.149 ± 2.354
0.692LeuTrp: 0.692 ± 0.64
2.075LeuTyr: 2.075 ± 1.156
0.0LeuXaa: 0.0 ± 0.0
Met
3.458MetAla: 3.458 ± 1.089
0.0MetCys: 0.0 ± 0.0
2.075MetAsp: 2.075 ± 1.05
0.692MetGlu: 0.692 ± 0.676
0.692MetPhe: 0.692 ± 0.966
0.0MetGly: 0.0 ± 0.0
1.383MetHis: 1.383 ± 0.626
0.692MetIle: 0.692 ± 0.966
1.383MetLys: 1.383 ± 0.626
0.0MetLeu: 0.0 ± 0.0
0.692MetMet: 0.692 ± 0.517
0.692MetAsn: 0.692 ± 1.068
1.383MetPro: 1.383 ± 0.626
1.383MetGln: 1.383 ± 0.838
4.149MetArg: 4.149 ± 2.029
2.766MetSer: 2.766 ± 1.528
2.766MetThr: 2.766 ± 1.496
0.692MetVal: 0.692 ± 0.831
0.692MetTrp: 0.692 ± 0.517
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.149AsnAla: 4.149 ± 2.525
3.458AsnCys: 3.458 ± 1.133
0.692AsnAsp: 0.692 ± 0.831
3.458AsnGlu: 3.458 ± 1.088
2.075AsnPhe: 2.075 ± 0.953
2.766AsnGly: 2.766 ± 0.954
1.383AsnHis: 1.383 ± 0.626
2.766AsnIle: 2.766 ± 1.556
2.075AsnLys: 2.075 ± 1.54
4.149AsnLeu: 4.149 ± 2.424
1.383AsnMet: 1.383 ± 0.838
0.692AsnAsn: 0.692 ± 0.966
1.383AsnPro: 1.383 ± 1.356
1.383AsnGln: 1.383 ± 1.005
4.149AsnArg: 4.149 ± 0.809
2.075AsnSer: 2.075 ± 1.534
1.383AsnThr: 1.383 ± 2.137
2.075AsnVal: 2.075 ± 1.514
0.692AsnTrp: 0.692 ± 0.517
2.766AsnTyr: 2.766 ± 1.246
0.0AsnXaa: 0.0 ± 0.0
Pro
4.149ProAla: 4.149 ± 2.276
0.692ProCys: 0.692 ± 1.108
4.149ProAsp: 4.149 ± 1.748
2.766ProGlu: 2.766 ± 1.166
1.383ProPhe: 1.383 ± 1.204
4.841ProGly: 4.841 ± 0.807
2.766ProHis: 2.766 ± 1.398
4.149ProIle: 4.149 ± 1.076
0.692ProLys: 0.692 ± 0.64
1.383ProLeu: 1.383 ± 1.034
0.692ProMet: 0.692 ± 0.517
0.692ProAsn: 0.692 ± 1.068
2.075ProPro: 2.075 ± 1.011
2.766ProGln: 2.766 ± 1.118
1.383ProArg: 1.383 ± 1.035
4.149ProSer: 4.149 ± 1.425
3.458ProThr: 3.458 ± 1.912
5.533ProVal: 5.533 ± 2.655
0.692ProTrp: 0.692 ± 0.517
0.692ProTyr: 0.692 ± 0.517
0.0ProXaa: 0.0 ± 0.0
Gln
6.916GlnAla: 6.916 ± 1.782
0.692GlnCys: 0.692 ± 1.108
2.766GlnAsp: 2.766 ± 1.209
1.383GlnGlu: 1.383 ± 0.686
0.0GlnPhe: 0.0 ± 0.0
2.075GlnGly: 2.075 ± 1.552
0.0GlnHis: 0.0 ± 0.0
2.075GlnIle: 2.075 ± 1.54
3.458GlnLys: 3.458 ± 1.294
2.075GlnLeu: 2.075 ± 1.921
0.0GlnMet: 0.0 ± 0.0
2.766GlnAsn: 2.766 ± 1.629
2.766GlnPro: 2.766 ± 1.557
1.383GlnGln: 1.383 ± 0.626
2.766GlnArg: 2.766 ± 1.372
3.458GlnSer: 3.458 ± 1.624
2.766GlnThr: 2.766 ± 1.593
2.075GlnVal: 2.075 ± 0.655
0.692GlnTrp: 0.692 ± 0.64
0.692GlnTyr: 0.692 ± 0.676
0.0GlnXaa: 0.0 ± 0.0
Arg
6.916ArgAla: 6.916 ± 1.337
1.383ArgCys: 1.383 ± 1.281
6.224ArgAsp: 6.224 ± 2.153
0.0ArgGlu: 0.0 ± 0.0
2.766ArgPhe: 2.766 ± 2.501
2.766ArgGly: 2.766 ± 1.208
3.458ArgHis: 3.458 ± 1.202
2.075ArgIle: 2.075 ± 2.324
2.075ArgLys: 2.075 ± 1.534
6.224ArgLeu: 6.224 ± 1.847
2.075ArgMet: 2.075 ± 1.105
0.692ArgAsn: 0.692 ± 1.108
4.841ArgPro: 4.841 ± 2.119
5.533ArgGln: 5.533 ± 1.761
3.458ArgArg: 3.458 ± 2.042
6.224ArgSer: 6.224 ± 1.841
3.458ArgThr: 3.458 ± 1.802
3.458ArgVal: 3.458 ± 1.216
2.075ArgTrp: 2.075 ± 0.833
3.458ArgTyr: 3.458 ± 1.527
0.0ArgXaa: 0.0 ± 0.0
Ser
11.757SerAla: 11.757 ± 1.756
0.692SerCys: 0.692 ± 1.068
8.299SerAsp: 8.299 ± 3.271
0.692SerGlu: 0.692 ± 0.517
3.458SerPhe: 3.458 ± 2.19
3.458SerGly: 3.458 ± 2.555
2.766SerHis: 2.766 ± 1.491
2.075SerIle: 2.075 ± 0.655
6.916SerLys: 6.916 ± 2.443
4.841SerLeu: 4.841 ± 1.539
3.458SerMet: 3.458 ± 2.846
2.075SerAsn: 2.075 ± 1.175
4.149SerPro: 4.149 ± 1.907
2.766SerGln: 2.766 ± 1.4
7.607SerArg: 7.607 ± 4.402
8.99SerSer: 8.99 ± 3.768
8.299SerThr: 8.299 ± 3.01
6.916SerVal: 6.916 ± 1.787
0.692SerTrp: 0.692 ± 0.517
1.383SerTyr: 1.383 ± 0.686
0.0SerXaa: 0.0 ± 0.0
Thr
5.533ThrAla: 5.533 ± 1.583
0.0ThrCys: 0.0 ± 0.0
4.841ThrAsp: 4.841 ± 2.444
2.766ThrGlu: 2.766 ± 1.208
2.766ThrPhe: 2.766 ± 1.453
6.916ThrGly: 6.916 ± 2.064
2.075ThrHis: 2.075 ± 1.715
1.383ThrIle: 1.383 ± 0.686
2.075ThrLys: 2.075 ± 1.24
6.916ThrLeu: 6.916 ± 1.871
0.692ThrMet: 0.692 ± 0.517
1.383ThrAsn: 1.383 ± 0.686
4.841ThrPro: 4.841 ± 0.854
1.383ThrGln: 1.383 ± 1.352
3.458ThrArg: 3.458 ± 1.12
12.448ThrSer: 12.448 ± 5.001
4.149ThrThr: 4.149 ± 2.383
1.383ThrVal: 1.383 ± 1.281
0.0ThrTrp: 0.0 ± 0.0
2.766ThrTyr: 2.766 ± 2.348
0.0ThrXaa: 0.0 ± 0.0
Val
4.841ValAla: 4.841 ± 1.118
0.0ValCys: 0.0 ± 0.0
4.841ValAsp: 4.841 ± 1.472
1.383ValGlu: 1.383 ± 0.946
3.458ValPhe: 3.458 ± 1.133
3.458ValGly: 3.458 ± 1.527
0.692ValHis: 0.692 ± 0.64
4.841ValIle: 4.841 ± 1.74
1.383ValLys: 1.383 ± 1.005
4.149ValLeu: 4.149 ± 1.86
1.383ValMet: 1.383 ± 0.626
2.766ValAsn: 2.766 ± 1.099
6.224ValPro: 6.224 ± 1.977
1.383ValGln: 1.383 ± 0.838
5.533ValArg: 5.533 ± 1.765
4.841ValSer: 4.841 ± 3.425
6.224ValThr: 6.224 ± 1.964
6.224ValVal: 6.224 ± 1.602
0.692ValTrp: 0.692 ± 0.517
2.075ValTyr: 2.075 ± 1.156
0.0ValXaa: 0.0 ± 0.0
Trp
0.692TrpAla: 0.692 ± 0.64
0.0TrpCys: 0.0 ± 0.0
1.383TrpAsp: 1.383 ± 1.034
0.0TrpGlu: 0.0 ± 0.0
0.692TrpPhe: 0.692 ± 0.517
1.383TrpGly: 1.383 ± 1.174
0.692TrpHis: 0.692 ± 0.517
0.0TrpIle: 0.0 ± 0.0
0.692TrpLys: 0.692 ± 0.64
1.383TrpLeu: 1.383 ± 0.838
0.0TrpMet: 0.0 ± 0.0
0.692TrpAsn: 0.692 ± 0.517
1.383TrpPro: 1.383 ± 1.034
1.383TrpGln: 1.383 ± 0.793
0.0TrpArg: 0.0 ± 0.0
0.692TrpSer: 0.692 ± 0.517
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.383TyrAla: 1.383 ± 1.034
0.0TyrCys: 0.0 ± 0.0
3.458TyrAsp: 3.458 ± 2.279
2.075TyrGlu: 2.075 ± 1.156
2.766TyrPhe: 2.766 ± 2.069
3.458TyrGly: 3.458 ± 1.164
1.383TyrHis: 1.383 ± 1.021
0.0TyrIle: 0.0 ± 0.0
1.383TyrLys: 1.383 ± 0.626
3.458TyrLeu: 3.458 ± 1.929
2.075TyrMet: 2.075 ± 1.253
2.075TyrAsn: 2.075 ± 0.874
0.692TyrPro: 0.692 ± 0.64
2.766TyrGln: 2.766 ± 1.372
4.149TyrArg: 4.149 ± 1.764
2.766TyrSer: 2.766 ± 2.115
3.458TyrThr: 3.458 ± 1.84
2.075TyrVal: 2.075 ± 0.847
0.692TyrTrp: 0.692 ± 0.517
1.383TyrTyr: 1.383 ± 1.281
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski