Amino acid dipepetide frequency for Sulfolobus virus Kamchatka 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.188AlaCys: 0.188 ± 0.18
1.125AlaAsp: 1.125 ± 0.521
3.563AlaGlu: 3.563 ± 0.726
4.314AlaPhe: 4.314 ± 1.018
2.626AlaGly: 2.626 ± 0.815
0.563AlaHis: 0.563 ± 0.295
4.126AlaIle: 4.126 ± 0.854
4.689AlaLys: 4.689 ± 1.027
7.877AlaLeu: 7.877 ± 1.31
1.313AlaMet: 1.313 ± 0.534
3.188AlaAsn: 3.188 ± 0.98
3.001AlaPro: 3.001 ± 0.556
2.063AlaGln: 2.063 ± 0.594
2.438AlaArg: 2.438 ± 0.716
2.813AlaSer: 2.813 ± 0.688
2.063AlaThr: 2.063 ± 0.497
3.938AlaVal: 3.938 ± 0.843
1.313AlaTrp: 1.313 ± 0.459
2.626AlaTyr: 2.626 ± 0.906
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.188CysAsp: 0.188 ± 0.209
0.188CysGlu: 0.188 ± 0.173
0.188CysPhe: 0.188 ± 0.232
0.563CysGly: 0.563 ± 0.334
0.0CysHis: 0.0 ± 0.0
0.188CysIle: 0.188 ± 0.18
0.188CysLys: 0.188 ± 0.186
1.5CysLeu: 1.5 ± 0.579
0.375CysMet: 0.375 ± 0.268
0.188CysAsn: 0.188 ± 0.185
1.125CysPro: 1.125 ± 0.566
0.0CysGln: 0.0 ± 0.0
0.563CysArg: 0.563 ± 0.388
0.0CysSer: 0.0 ± 0.0
0.375CysThr: 0.375 ± 0.259
0.938CysVal: 0.938 ± 0.331
0.188CysTrp: 0.188 ± 0.148
0.188CysTyr: 0.188 ± 0.185
0.0CysXaa: 0.0 ± 0.0
Asp
1.688AspAla: 1.688 ± 0.602
0.0AspCys: 0.0 ± 0.0
1.5AspAsp: 1.5 ± 0.681
3.188AspGlu: 3.188 ± 1.133
1.5AspPhe: 1.5 ± 0.468
4.689AspGly: 4.689 ± 0.911
0.75AspHis: 0.75 ± 0.382
1.313AspIle: 1.313 ± 0.421
3.188AspLys: 3.188 ± 0.842
2.813AspLeu: 2.813 ± 0.765
0.938AspMet: 0.938 ± 0.456
0.938AspAsn: 0.938 ± 0.539
1.313AspPro: 1.313 ± 0.6
0.375AspGln: 0.375 ± 0.274
0.938AspArg: 0.938 ± 0.401
1.688AspSer: 1.688 ± 0.612
1.313AspThr: 1.313 ± 0.497
2.438AspVal: 2.438 ± 0.605
0.188AspTrp: 0.188 ± 0.209
3.188AspTyr: 3.188 ± 0.602
0.0AspXaa: 0.0 ± 0.0
Glu
3.751GluAla: 3.751 ± 0.955
0.75GluCys: 0.75 ± 0.422
1.875GluAsp: 1.875 ± 0.74
7.689GluGlu: 7.689 ± 1.772
2.626GluPhe: 2.626 ± 0.863
3.376GluGly: 3.376 ± 0.693
0.563GluHis: 0.563 ± 0.36
4.501GluIle: 4.501 ± 0.823
4.689GluLys: 4.689 ± 1.051
7.127GluLeu: 7.127 ± 1.548
2.063GluMet: 2.063 ± 0.646
3.188GluAsn: 3.188 ± 0.945
0.75GluPro: 0.75 ± 0.329
1.875GluGln: 1.875 ± 0.678
3.001GluArg: 3.001 ± 0.738
1.875GluSer: 1.875 ± 0.645
2.626GluThr: 2.626 ± 0.751
6.939GluVal: 6.939 ± 1.8
0.75GluTrp: 0.75 ± 0.315
2.063GluTyr: 2.063 ± 0.492
0.0GluXaa: 0.0 ± 0.0
Phe
2.626PheAla: 2.626 ± 0.61
0.188PheCys: 0.188 ± 0.209
2.251PheAsp: 2.251 ± 0.828
2.438PheGlu: 2.438 ± 0.64
1.688PhePhe: 1.688 ± 0.528
2.251PheGly: 2.251 ± 0.615
0.938PheHis: 0.938 ± 0.369
3.188PheIle: 3.188 ± 0.905
1.875PheLys: 1.875 ± 0.618
4.876PheLeu: 4.876 ± 0.965
0.75PheMet: 0.75 ± 0.279
1.5PheAsn: 1.5 ± 0.466
2.063PhePro: 2.063 ± 0.707
0.938PheGln: 0.938 ± 0.43
1.688PheArg: 1.688 ± 0.702
4.501PheSer: 4.501 ± 0.887
4.501PheThr: 4.501 ± 0.903
3.751PheVal: 3.751 ± 0.575
0.375PheTrp: 0.375 ± 0.215
5.064PheTyr: 5.064 ± 1.163
0.0PheXaa: 0.0 ± 0.0
Gly
3.751GlyAla: 3.751 ± 0.932
0.188GlyCys: 0.188 ± 0.21
1.5GlyAsp: 1.5 ± 0.575
2.251GlyGlu: 2.251 ± 0.699
3.376GlyPhe: 3.376 ± 0.73
4.126GlyGly: 4.126 ± 0.949
0.563GlyHis: 0.563 ± 0.354
5.626GlyIle: 5.626 ± 0.935
5.064GlyLys: 5.064 ± 0.979
9.002GlyLeu: 9.002 ± 1.276
1.313GlyMet: 1.313 ± 0.513
3.001GlyAsn: 3.001 ± 0.582
2.063GlyPro: 2.063 ± 0.779
2.251GlyGln: 2.251 ± 0.755
2.626GlyArg: 2.626 ± 0.742
4.876GlySer: 4.876 ± 1.175
3.938GlyThr: 3.938 ± 1.086
3.938GlyVal: 3.938 ± 1.021
1.5GlyTrp: 1.5 ± 0.554
3.188GlyTyr: 3.188 ± 0.902
0.0GlyXaa: 0.0 ± 0.0
His
0.563HisAla: 0.563 ± 0.318
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.938HisPhe: 0.938 ± 0.308
0.563HisGly: 0.563 ± 0.312
0.563HisHis: 0.563 ± 0.309
0.75HisIle: 0.75 ± 0.33
0.563HisLys: 0.563 ± 0.327
1.5HisLeu: 1.5 ± 0.568
0.375HisMet: 0.375 ± 0.245
0.75HisAsn: 0.75 ± 0.296
0.188HisPro: 0.188 ± 0.174
0.375HisGln: 0.375 ± 0.237
0.75HisArg: 0.75 ± 0.502
0.75HisSer: 0.75 ± 0.429
0.563HisThr: 0.563 ± 0.38
1.125HisVal: 1.125 ± 0.627
0.0HisTrp: 0.0 ± 0.0
1.125HisTyr: 1.125 ± 0.52
0.0HisXaa: 0.0 ± 0.0
Ile
6.377IleAla: 6.377 ± 1.344
0.375IleCys: 0.375 ± 0.265
3.188IleAsp: 3.188 ± 0.573
4.501IleGlu: 4.501 ± 1.011
3.751IlePhe: 3.751 ± 0.974
6.002IleGly: 6.002 ± 1.105
0.563IleHis: 0.563 ± 0.373
6.564IleIle: 6.564 ± 1.142
3.938IleLys: 3.938 ± 1.192
6.752IleLeu: 6.752 ± 1.385
0.938IleMet: 0.938 ± 0.363
3.001IleAsn: 3.001 ± 1.105
2.813IlePro: 2.813 ± 0.95
1.125IleGln: 1.125 ± 0.358
4.126IleArg: 4.126 ± 0.9
6.189IleSer: 6.189 ± 1.348
5.064IleThr: 5.064 ± 1.091
7.689IleVal: 7.689 ± 1.634
0.75IleTrp: 0.75 ± 0.402
2.626IleTyr: 2.626 ± 0.455
0.0IleXaa: 0.0 ± 0.0
Lys
3.751LysAla: 3.751 ± 0.994
0.563LysCys: 0.563 ± 0.259
2.626LysAsp: 2.626 ± 0.722
6.564LysGlu: 6.564 ± 1.678
3.001LysPhe: 3.001 ± 0.8
3.001LysGly: 3.001 ± 0.763
0.938LysHis: 0.938 ± 0.358
4.876LysIle: 4.876 ± 1.132
6.939LysLys: 6.939 ± 2.221
8.44LysLeu: 8.44 ± 1.629
0.938LysMet: 0.938 ± 0.377
2.813LysAsn: 2.813 ± 0.705
3.376LysPro: 3.376 ± 1.068
3.376LysGln: 3.376 ± 1.147
3.376LysArg: 3.376 ± 0.942
4.126LysSer: 4.126 ± 1.072
4.501LysThr: 4.501 ± 1.368
5.814LysVal: 5.814 ± 1.251
0.938LysTrp: 0.938 ± 0.418
3.376LysTyr: 3.376 ± 0.951
0.0LysXaa: 0.0 ± 0.0
Leu
6.377LeuAla: 6.377 ± 0.965
0.375LeuCys: 0.375 ± 0.276
3.751LeuAsp: 3.751 ± 0.847
4.876LeuGlu: 4.876 ± 1.224
5.814LeuPhe: 5.814 ± 1.082
6.377LeuGly: 6.377 ± 1.438
1.688LeuHis: 1.688 ± 0.602
9.19LeuIle: 9.19 ± 1.867
9.002LeuLys: 9.002 ± 1.591
12.566LeuLeu: 12.566 ± 2.443
3.001LeuMet: 3.001 ± 0.724
5.439LeuAsn: 5.439 ± 1.217
4.314LeuPro: 4.314 ± 0.821
3.376LeuGln: 3.376 ± 0.782
6.377LeuArg: 6.377 ± 1.504
6.939LeuSer: 6.939 ± 1.076
8.627LeuThr: 8.627 ± 0.935
6.002LeuVal: 6.002 ± 1.194
1.125LeuTrp: 1.125 ± 0.478
5.626LeuTyr: 5.626 ± 1.032
0.0LeuXaa: 0.0 ± 0.0
Met
1.125MetAla: 1.125 ± 0.439
0.188MetCys: 0.188 ± 0.213
0.938MetAsp: 0.938 ± 0.498
1.5MetGlu: 1.5 ± 0.382
0.938MetPhe: 0.938 ± 0.324
2.063MetGly: 2.063 ± 0.474
0.188MetHis: 0.188 ± 0.172
0.938MetIle: 0.938 ± 0.432
2.438MetLys: 2.438 ± 0.797
1.5MetLeu: 1.5 ± 0.945
1.313MetMet: 1.313 ± 0.529
0.938MetAsn: 0.938 ± 0.453
0.75MetPro: 0.75 ± 0.339
0.375MetGln: 0.375 ± 0.321
0.75MetArg: 0.75 ± 0.453
1.313MetSer: 1.313 ± 0.466
0.938MetThr: 0.938 ± 0.373
1.875MetVal: 1.875 ± 0.7
0.375MetTrp: 0.375 ± 0.228
0.563MetTyr: 0.563 ± 0.315
0.0MetXaa: 0.0 ± 0.0
Asn
2.813AsnAla: 2.813 ± 0.666
0.375AsnCys: 0.375 ± 0.248
2.063AsnAsp: 2.063 ± 0.724
2.251AsnGlu: 2.251 ± 0.778
1.688AsnPhe: 1.688 ± 0.63
4.126AsnGly: 4.126 ± 1.275
0.563AsnHis: 0.563 ± 0.353
3.751AsnIle: 3.751 ± 0.9
2.251AsnLys: 2.251 ± 0.755
3.938AsnLeu: 3.938 ± 0.812
0.563AsnMet: 0.563 ± 0.306
3.563AsnAsn: 3.563 ± 1.113
3.376AsnPro: 3.376 ± 0.861
1.688AsnGln: 1.688 ± 0.497
1.688AsnArg: 1.688 ± 0.718
3.188AsnSer: 3.188 ± 1.141
3.938AsnThr: 3.938 ± 1.051
3.751AsnVal: 3.751 ± 1.043
0.563AsnTrp: 0.563 ± 0.295
4.314AsnTyr: 4.314 ± 1.202
0.0AsnXaa: 0.0 ± 0.0
Pro
1.875ProAla: 1.875 ± 0.499
0.0ProCys: 0.0 ± 0.0
1.688ProAsp: 1.688 ± 0.687
1.875ProGlu: 1.875 ± 0.626
2.438ProPhe: 2.438 ± 0.585
1.688ProGly: 1.688 ± 0.817
0.188ProHis: 0.188 ± 0.185
3.563ProIle: 3.563 ± 1.18
3.376ProLys: 3.376 ± 1.005
2.813ProLeu: 2.813 ± 1.043
0.563ProMet: 0.563 ± 0.308
2.251ProAsn: 2.251 ± 0.699
4.314ProPro: 4.314 ± 1.465
1.313ProGln: 1.313 ± 0.451
0.938ProArg: 0.938 ± 0.455
3.563ProSer: 3.563 ± 0.833
2.438ProThr: 2.438 ± 0.667
2.626ProVal: 2.626 ± 0.6
0.75ProTrp: 0.75 ± 0.446
3.001ProTyr: 3.001 ± 0.985
0.0ProXaa: 0.0 ± 0.0
Gln
1.125GlnAla: 1.125 ± 0.405
0.188GlnCys: 0.188 ± 0.204
0.375GlnAsp: 0.375 ± 0.259
1.875GlnGlu: 1.875 ± 0.445
1.125GlnPhe: 1.125 ± 0.416
1.875GlnGly: 1.875 ± 0.588
0.75GlnHis: 0.75 ± 0.516
4.126GlnIle: 4.126 ± 0.906
2.438GlnLys: 2.438 ± 0.549
2.438GlnLeu: 2.438 ± 0.685
0.375GlnMet: 0.375 ± 0.234
0.938GlnAsn: 0.938 ± 0.406
0.563GlnPro: 0.563 ± 0.247
0.938GlnGln: 0.938 ± 0.477
0.563GlnArg: 0.563 ± 0.388
2.251GlnSer: 2.251 ± 0.747
2.251GlnThr: 2.251 ± 0.568
2.251GlnVal: 2.251 ± 0.648
0.938GlnTrp: 0.938 ± 0.371
1.875GlnTyr: 1.875 ± 0.401
0.0GlnXaa: 0.0 ± 0.0
Arg
1.5ArgAla: 1.5 ± 0.409
1.313ArgCys: 1.313 ± 0.472
2.626ArgAsp: 2.626 ± 0.783
3.001ArgGlu: 3.001 ± 0.839
1.5ArgPhe: 1.5 ± 0.543
3.188ArgGly: 3.188 ± 0.971
0.563ArgHis: 0.563 ± 0.338
2.438ArgIle: 2.438 ± 0.628
5.251ArgLys: 5.251 ± 1.208
4.126ArgLeu: 4.126 ± 0.901
0.75ArgMet: 0.75 ± 0.387
2.626ArgAsn: 2.626 ± 0.727
0.938ArgPro: 0.938 ± 0.441
1.875ArgGln: 1.875 ± 0.465
2.626ArgArg: 2.626 ± 0.857
0.938ArgSer: 0.938 ± 0.48
1.313ArgThr: 1.313 ± 0.425
2.813ArgVal: 2.813 ± 0.789
0.188ArgTrp: 0.188 ± 0.232
1.313ArgTyr: 1.313 ± 0.581
0.0ArgXaa: 0.0 ± 0.0
Ser
4.689SerAla: 4.689 ± 0.623
0.188SerCys: 0.188 ± 0.18
2.063SerAsp: 2.063 ± 0.493
3.563SerGlu: 3.563 ± 0.844
3.376SerPhe: 3.376 ± 0.752
5.626SerGly: 5.626 ± 1.361
0.563SerHis: 0.563 ± 0.389
5.626SerIle: 5.626 ± 1.474
3.563SerLys: 3.563 ± 1.145
6.377SerLeu: 6.377 ± 1.106
0.75SerMet: 0.75 ± 0.301
4.876SerAsn: 4.876 ± 1.489
2.251SerPro: 2.251 ± 0.636
1.688SerGln: 1.688 ± 0.715
1.313SerArg: 1.313 ± 0.443
5.251SerSer: 5.251 ± 1.119
3.001SerThr: 3.001 ± 0.658
4.501SerVal: 4.501 ± 0.966
0.375SerTrp: 0.375 ± 0.285
4.876SerTyr: 4.876 ± 1.046
0.0SerXaa: 0.0 ± 0.0
Thr
3.376ThrAla: 3.376 ± 0.818
0.188ThrCys: 0.188 ± 0.186
1.688ThrAsp: 1.688 ± 0.549
4.126ThrGlu: 4.126 ± 0.876
2.251ThrPhe: 2.251 ± 0.73
3.751ThrGly: 3.751 ± 1.198
0.375ThrHis: 0.375 ± 0.26
6.189ThrIle: 6.189 ± 1.338
3.751ThrLys: 3.751 ± 0.767
7.689ThrLeu: 7.689 ± 1.485
1.688ThrMet: 1.688 ± 0.447
2.813ThrAsn: 2.813 ± 0.797
2.813ThrPro: 2.813 ± 0.51
1.5ThrGln: 1.5 ± 0.697
1.313ThrArg: 1.313 ± 0.523
4.314ThrSer: 4.314 ± 0.769
5.814ThrThr: 5.814 ± 1.514
4.501ThrVal: 4.501 ± 0.94
0.75ThrTrp: 0.75 ± 0.378
5.814ThrTyr: 5.814 ± 1.334
0.0ThrXaa: 0.0 ± 0.0
Val
3.376ValAla: 3.376 ± 0.809
1.125ValCys: 1.125 ± 0.644
2.626ValAsp: 2.626 ± 0.887
5.251ValGlu: 5.251 ± 1.136
1.875ValPhe: 1.875 ± 0.642
4.501ValGly: 4.501 ± 0.889
0.375ValHis: 0.375 ± 0.26
4.689ValIle: 4.689 ± 0.872
6.377ValLys: 6.377 ± 1.31
8.815ValLeu: 8.815 ± 1.227
1.313ValMet: 1.313 ± 0.545
4.126ValAsn: 4.126 ± 1.151
2.626ValPro: 2.626 ± 0.665
1.688ValGln: 1.688 ± 0.448
3.188ValArg: 3.188 ± 0.73
6.564ValSer: 6.564 ± 1.443
6.752ValThr: 6.752 ± 1.92
4.126ValVal: 4.126 ± 0.97
0.938ValTrp: 0.938 ± 0.473
4.314ValTyr: 4.314 ± 0.666
0.0ValXaa: 0.0 ± 0.0
Trp
0.563TrpAla: 0.563 ± 0.278
0.0TrpCys: 0.0 ± 0.0
0.375TrpAsp: 0.375 ± 0.236
0.75TrpGlu: 0.75 ± 0.312
1.125TrpPhe: 1.125 ± 0.433
0.75TrpGly: 0.75 ± 0.319
0.375TrpHis: 0.375 ± 0.248
0.75TrpIle: 0.75 ± 0.438
0.75TrpLys: 0.75 ± 0.312
2.251TrpLeu: 2.251 ± 0.673
0.563TrpMet: 0.563 ± 0.369
0.375TrpAsn: 0.375 ± 0.259
0.375TrpPro: 0.375 ± 0.264
0.188TrpGln: 0.188 ± 0.199
0.563TrpArg: 0.563 ± 0.281
0.375TrpSer: 0.375 ± 0.248
0.563TrpThr: 0.563 ± 0.317
0.938TrpVal: 0.938 ± 0.359
0.188TrpTrp: 0.188 ± 0.209
1.5TrpTyr: 1.5 ± 0.708
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.501TyrAla: 4.501 ± 0.838
0.75TyrCys: 0.75 ± 0.349
1.5TyrAsp: 1.5 ± 0.48
2.626TyrGlu: 2.626 ± 0.699
3.938TyrPhe: 3.938 ± 0.784
3.001TyrGly: 3.001 ± 0.835
0.375TyrHis: 0.375 ± 0.205
4.126TyrIle: 4.126 ± 1.016
3.001TyrLys: 3.001 ± 0.892
8.44TyrLeu: 8.44 ± 1.174
0.938TyrMet: 0.938 ± 0.385
3.938TyrAsn: 3.938 ± 1.341
2.251TyrPro: 2.251 ± 0.724
2.251TyrGln: 2.251 ± 0.808
2.063TyrArg: 2.063 ± 0.52
3.001TyrSer: 3.001 ± 0.657
4.126TyrThr: 4.126 ± 1.08
4.689TyrVal: 4.689 ± 0.92
1.125TyrTrp: 1.125 ± 0.482
3.001TyrTyr: 3.001 ± 0.948
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 31 proteins (5333 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski