Amino acid dipepetide frequency for Viral hemorrhagic septicemia virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.199AlaAla: 3.199 ± 1.712
0.872AlaCys: 0.872 ± 0.344
4.653AlaAsp: 4.653 ± 0.935
3.199AlaGlu: 3.199 ± 1.31
2.035AlaPhe: 2.035 ± 0.644
3.78AlaGly: 3.78 ± 1.214
1.745AlaHis: 1.745 ± 0.899
4.362AlaIle: 4.362 ± 1.084
4.943AlaLys: 4.943 ± 1.32
9.596AlaLeu: 9.596 ± 3.079
2.035AlaMet: 2.035 ± 2.185
0.872AlaAsn: 0.872 ± 0.37
2.035AlaPro: 2.035 ± 0.634
2.908AlaGln: 2.908 ± 1.119
3.489AlaArg: 3.489 ± 1.663
4.362AlaSer: 4.362 ± 1.116
4.943AlaThr: 4.943 ± 0.92
2.617AlaVal: 2.617 ± 0.626
0.582AlaTrp: 0.582 ± 0.322
1.163AlaTyr: 1.163 ± 0.643
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.163CysCys: 1.163 ± 0.946
1.454CysAsp: 1.454 ± 0.56
0.291CysGlu: 0.291 ± 0.588
0.291CysPhe: 0.291 ± 0.161
0.582CysGly: 0.582 ± 0.679
0.0CysHis: 0.0 ± 0.0
0.291CysIle: 0.291 ± 0.336
1.163CysLys: 1.163 ± 0.631
0.872CysLeu: 0.872 ± 0.344
0.872CysMet: 0.872 ± 0.596
0.291CysAsn: 0.291 ± 0.161
1.163CysPro: 1.163 ± 0.599
1.163CysGln: 1.163 ± 0.445
0.291CysArg: 0.291 ± 0.336
2.035CysSer: 2.035 ± 0.561
1.163CysThr: 1.163 ± 0.599
1.454CysVal: 1.454 ± 0.366
0.0CysTrp: 0.0 ± 0.0
0.291CysTyr: 0.291 ± 0.161
0.0CysXaa: 0.0 ± 0.0
Asp
2.617AspAla: 2.617 ± 0.521
0.582AspCys: 0.582 ± 0.3
3.199AspAsp: 3.199 ± 1.533
2.326AspGlu: 2.326 ± 0.694
1.745AspPhe: 1.745 ± 1.017
2.617AspGly: 2.617 ± 0.822
1.163AspHis: 1.163 ± 0.792
4.362AspIle: 4.362 ± 1.116
4.071AspLys: 4.071 ± 1.12
7.27AspLeu: 7.27 ± 0.921
0.872AspMet: 0.872 ± 0.942
2.617AspAsn: 2.617 ± 1.603
2.617AspPro: 2.617 ± 1.504
3.489AspGln: 3.489 ± 1.202
2.326AspArg: 2.326 ± 0.688
3.78AspSer: 3.78 ± 0.73
2.617AspThr: 2.617 ± 0.839
3.199AspVal: 3.199 ± 1.021
0.872AspTrp: 0.872 ± 0.616
1.163AspTyr: 1.163 ± 0.624
0.0AspXaa: 0.0 ± 0.0
Glu
6.106GluAla: 6.106 ± 0.864
1.163GluCys: 1.163 ± 0.445
4.653GluAsp: 4.653 ± 2.059
4.362GluGlu: 4.362 ± 1.581
2.326GluPhe: 2.326 ± 0.695
4.071GluGly: 4.071 ± 1.204
1.163GluHis: 1.163 ± 0.643
3.489GluIle: 3.489 ± 0.802
6.106GluLys: 6.106 ± 1.016
6.979GluLeu: 6.979 ± 1.897
2.617GluMet: 2.617 ± 0.975
2.617GluAsn: 2.617 ± 1.271
2.035GluPro: 2.035 ± 0.349
1.163GluGln: 1.163 ± 0.446
4.071GluArg: 4.071 ± 1.05
5.525GluSer: 5.525 ± 1.751
4.071GluThr: 4.071 ± 0.521
3.199GluVal: 3.199 ± 0.666
1.454GluTrp: 1.454 ± 0.625
1.163GluTyr: 1.163 ± 0.425
0.0GluXaa: 0.0 ± 0.0
Phe
2.035PheAla: 2.035 ± 0.546
0.872PheCys: 0.872 ± 0.344
0.872PheAsp: 0.872 ± 0.509
2.326PheGlu: 2.326 ± 0.786
1.745PhePhe: 1.745 ± 1.053
3.78PheGly: 3.78 ± 0.783
0.872PheHis: 0.872 ± 0.344
1.745PheIle: 1.745 ± 0.399
2.908PheLys: 2.908 ± 0.98
2.908PheLeu: 2.908 ± 1.146
0.0PheMet: 0.0 ± 0.0
0.872PheAsn: 0.872 ± 0.787
1.163PhePro: 1.163 ± 0.445
1.745PheGln: 1.745 ± 0.693
2.617PheArg: 2.617 ± 0.594
3.489PheSer: 3.489 ± 0.44
1.454PheThr: 1.454 ± 0.676
1.745PheVal: 1.745 ± 0.563
0.0PheTrp: 0.0 ± 0.0
0.582PheTyr: 0.582 ± 0.322
0.0PheXaa: 0.0 ± 0.0
Gly
3.78GlyAla: 3.78 ± 1.172
0.582GlyCys: 0.582 ± 0.355
3.489GlyAsp: 3.489 ± 0.682
5.816GlyGlu: 5.816 ± 2.8
1.454GlyPhe: 1.454 ± 1.14
4.943GlyGly: 4.943 ± 1.024
1.745GlyHis: 1.745 ± 1.166
3.78GlyIle: 3.78 ± 0.815
3.199GlyLys: 3.199 ± 0.905
6.979GlyLeu: 6.979 ± 1.318
2.326GlyMet: 2.326 ± 0.805
1.163GlyAsn: 1.163 ± 0.513
3.199GlyPro: 3.199 ± 0.793
2.617GlyGln: 2.617 ± 0.558
3.199GlyArg: 3.199 ± 0.93
4.362GlySer: 4.362 ± 1.497
3.199GlyThr: 3.199 ± 1.395
3.78GlyVal: 3.78 ± 1.121
0.582GlyTrp: 0.582 ± 0.322
2.617GlyTyr: 2.617 ± 1.172
0.0GlyXaa: 0.0 ± 0.0
His
0.872HisAla: 0.872 ± 0.766
0.582HisCys: 0.582 ± 0.3
0.291HisAsp: 0.291 ± 0.336
0.872HisGlu: 0.872 ± 0.616
1.454HisPhe: 1.454 ± 0.551
0.872HisGly: 0.872 ± 0.787
0.582HisHis: 0.582 ± 0.3
2.908HisIle: 2.908 ± 1.328
0.872HisLys: 0.872 ± 0.344
4.362HisLeu: 4.362 ± 1.417
0.291HisMet: 0.291 ± 0.161
0.872HisAsn: 0.872 ± 0.482
2.035HisPro: 2.035 ± 0.923
0.872HisGln: 0.872 ± 0.459
2.326HisArg: 2.326 ± 0.882
0.582HisSer: 0.582 ± 0.3
1.454HisThr: 1.454 ± 0.575
2.035HisVal: 2.035 ± 0.824
0.872HisTrp: 0.872 ± 0.616
1.454HisTyr: 1.454 ± 1.122
0.0HisXaa: 0.0 ± 0.0
Ile
3.78IleAla: 3.78 ± 1.054
0.872IleCys: 0.872 ± 0.482
4.071IleAsp: 4.071 ± 1.479
4.653IleGlu: 4.653 ± 0.578
2.035IlePhe: 2.035 ± 0.948
1.745IleGly: 1.745 ± 1.025
1.745IleHis: 1.745 ± 0.688
5.816IleIle: 5.816 ± 1.21
4.653IleLys: 4.653 ± 1.021
4.653IleLeu: 4.653 ± 1.937
0.872IleMet: 0.872 ± 0.849
1.745IleAsn: 1.745 ± 0.688
4.071IlePro: 4.071 ± 1.251
2.326IleGln: 2.326 ± 0.672
2.908IleArg: 2.908 ± 0.565
4.943IleSer: 4.943 ± 1.239
6.106IleThr: 6.106 ± 0.949
2.326IleVal: 2.326 ± 0.969
1.454IleTrp: 1.454 ± 0.625
1.454IleTyr: 1.454 ± 0.592
0.0IleXaa: 0.0 ± 0.0
Lys
6.688LysAla: 6.688 ± 1.008
0.582LysCys: 0.582 ± 0.499
2.908LysAsp: 2.908 ± 0.58
4.653LysGlu: 4.653 ± 1.455
3.199LysPhe: 3.199 ± 0.442
3.78LysGly: 3.78 ± 0.616
0.582LysHis: 0.582 ± 0.322
3.489LysIle: 3.489 ± 0.799
5.525LysLys: 5.525 ± 2.124
6.979LysLeu: 6.979 ± 0.599
1.745LysMet: 1.745 ± 0.992
1.454LysAsn: 1.454 ± 0.575
1.745LysPro: 1.745 ± 0.992
0.0LysGln: 0.0 ± 0.0
4.653LysArg: 4.653 ± 1.557
3.78LysSer: 3.78 ± 0.666
5.525LysThr: 5.525 ± 1.363
4.071LysVal: 4.071 ± 1.591
1.163LysTrp: 1.163 ± 0.643
2.326LysTyr: 2.326 ± 1.49
0.0LysXaa: 0.0 ± 0.0
Leu
6.688LeuAla: 6.688 ± 1.741
2.617LeuCys: 2.617 ± 1.006
5.816LeuAsp: 5.816 ± 2.683
8.433LeuGlu: 8.433 ± 2.049
4.943LeuPhe: 4.943 ± 1.015
8.433LeuGly: 8.433 ± 1.954
2.617LeuHis: 2.617 ± 0.907
5.234LeuIle: 5.234 ± 1.006
3.78LeuLys: 3.78 ± 1.748
12.794LeuLeu: 12.794 ± 3.106
2.326LeuMet: 2.326 ± 1.072
3.78LeuAsn: 3.78 ± 0.982
4.362LeuPro: 4.362 ± 1.73
4.071LeuGln: 4.071 ± 0.959
4.943LeuArg: 4.943 ± 0.924
9.887LeuSer: 9.887 ± 1.238
7.56LeuThr: 7.56 ± 1.678
7.27LeuVal: 7.27 ± 1.453
0.582LeuTrp: 0.582 ± 0.322
2.035LeuTyr: 2.035 ± 0.557
0.0LeuXaa: 0.0 ± 0.0
Met
2.617MetAla: 2.617 ± 0.915
0.291MetCys: 0.291 ± 0.161
0.582MetAsp: 0.582 ± 0.322
3.199MetGlu: 3.199 ± 0.959
0.872MetPhe: 0.872 ± 0.509
2.035MetGly: 2.035 ± 0.742
0.0MetHis: 0.0 ± 0.0
2.326MetIle: 2.326 ± 0.879
1.745MetLys: 1.745 ± 0.603
0.872MetLeu: 0.872 ± 0.399
0.872MetMet: 0.872 ± 0.749
0.582MetAsn: 0.582 ± 0.322
0.872MetPro: 0.872 ± 0.37
0.291MetGln: 0.291 ± 0.336
2.617MetArg: 2.617 ± 0.901
1.454MetSer: 1.454 ± 1.05
2.035MetThr: 2.035 ± 0.674
1.454MetVal: 1.454 ± 0.804
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.745AsnAla: 1.745 ± 0.847
0.582AsnCys: 0.582 ± 0.689
1.454AsnAsp: 1.454 ± 1.237
1.454AsnGlu: 1.454 ± 0.583
0.582AsnPhe: 0.582 ± 0.355
1.745AsnGly: 1.745 ± 0.998
0.582AsnHis: 0.582 ± 0.672
1.745AsnIle: 1.745 ± 0.46
2.035AsnLys: 2.035 ± 0.865
4.071AsnLeu: 4.071 ± 1.123
0.291AsnMet: 0.291 ± 0.336
1.745AsnAsn: 1.745 ± 0.875
1.745AsnPro: 1.745 ± 0.603
0.872AsnGln: 0.872 ± 0.495
2.908AsnArg: 2.908 ± 1.444
1.745AsnSer: 1.745 ± 0.446
2.617AsnThr: 2.617 ± 1.1
1.163AsnVal: 1.163 ± 0.562
0.291AsnTrp: 0.291 ± 0.161
1.163AsnTyr: 1.163 ± 0.838
0.0AsnXaa: 0.0 ± 0.0
Pro
2.326ProAla: 2.326 ± 1.25
0.582ProCys: 0.582 ± 0.3
2.326ProAsp: 2.326 ± 0.891
3.78ProGlu: 3.78 ± 0.574
1.745ProPhe: 1.745 ± 0.518
2.035ProGly: 2.035 ± 1.21
2.035ProHis: 2.035 ± 0.938
1.745ProIle: 1.745 ± 0.657
4.071ProLys: 4.071 ± 1.318
4.653ProLeu: 4.653 ± 0.968
0.582ProMet: 0.582 ± 0.499
1.454ProAsn: 1.454 ± 0.412
3.78ProPro: 3.78 ± 2.528
0.872ProGln: 0.872 ± 0.399
3.489ProArg: 3.489 ± 1.302
4.362ProSer: 4.362 ± 2.039
2.326ProThr: 2.326 ± 0.796
1.745ProVal: 1.745 ± 0.803
0.582ProTrp: 0.582 ± 0.679
1.454ProTyr: 1.454 ± 0.592
0.0ProXaa: 0.0 ± 0.0
Gln
3.199GlnAla: 3.199 ± 0.976
0.291GlnCys: 0.291 ± 0.161
1.745GlnAsp: 1.745 ± 0.965
3.489GlnGlu: 3.489 ± 0.957
1.163GlnPhe: 1.163 ± 0.445
2.326GlnGly: 2.326 ± 0.672
2.326GlnHis: 2.326 ± 0.842
1.745GlnIle: 1.745 ± 0.542
2.908GlnLys: 2.908 ± 1.013
3.78GlnLeu: 3.78 ± 0.953
1.163GlnMet: 1.163 ± 0.435
0.582GlnAsn: 0.582 ± 0.322
0.872GlnPro: 0.872 ± 0.509
0.582GlnGln: 0.582 ± 0.3
2.326GlnArg: 2.326 ± 0.963
2.617GlnSer: 2.617 ± 0.806
2.326GlnThr: 2.326 ± 0.805
3.199GlnVal: 3.199 ± 0.412
0.291GlnTrp: 0.291 ± 0.161
1.745GlnTyr: 1.745 ± 0.717
0.0GlnXaa: 0.0 ± 0.0
Arg
4.653ArgAla: 4.653 ± 2.342
0.291ArgCys: 0.291 ± 0.336
2.326ArgAsp: 2.326 ± 0.694
5.525ArgGlu: 5.525 ± 1.255
0.872ArgPhe: 0.872 ± 0.482
5.816ArgGly: 5.816 ± 1.138
0.872ArgHis: 0.872 ± 0.495
3.78ArgIle: 3.78 ± 1.395
3.199ArgLys: 3.199 ± 0.554
5.234ArgLeu: 5.234 ± 1.635
1.745ArgMet: 1.745 ± 0.692
1.454ArgAsn: 1.454 ± 0.851
1.745ArgPro: 1.745 ± 1.066
3.489ArgGln: 3.489 ± 0.778
2.617ArgArg: 2.617 ± 0.784
3.78ArgSer: 3.78 ± 1.657
3.199ArgThr: 3.199 ± 0.627
4.362ArgVal: 4.362 ± 0.995
0.291ArgTrp: 0.291 ± 0.161
1.163ArgTyr: 1.163 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
5.234SerAla: 5.234 ± 0.8
0.291SerCys: 0.291 ± 0.336
4.943SerAsp: 4.943 ± 0.947
4.071SerGlu: 4.071 ± 0.797
2.617SerPhe: 2.617 ± 1.425
4.362SerGly: 4.362 ± 1.041
1.745SerHis: 1.745 ± 1.075
4.362SerIle: 4.362 ± 0.854
4.071SerLys: 4.071 ± 0.641
8.433SerLeu: 8.433 ± 2.183
1.163SerMet: 1.163 ± 0.505
2.326SerAsn: 2.326 ± 0.882
4.071SerPro: 4.071 ± 1.693
3.489SerGln: 3.489 ± 0.903
3.199SerArg: 3.199 ± 0.741
5.234SerSer: 5.234 ± 1.103
6.688SerThr: 6.688 ± 1.554
6.397SerVal: 6.397 ± 0.833
1.454SerTrp: 1.454 ± 0.575
2.326SerTyr: 2.326 ± 1.396
0.0SerXaa: 0.0 ± 0.0
Thr
3.199ThrAla: 3.199 ± 0.763
1.454ThrCys: 1.454 ± 0.366
3.199ThrAsp: 3.199 ± 1.118
3.489ThrGlu: 3.489 ± 0.793
2.035ThrPhe: 2.035 ± 0.779
3.78ThrGly: 3.78 ± 1.289
3.489ThrHis: 3.489 ± 1.48
5.525ThrIle: 5.525 ± 1.468
5.234ThrLys: 5.234 ± 1.447
6.688ThrLeu: 6.688 ± 1.573
2.326ThrMet: 2.326 ± 0.695
1.163ThrAsn: 1.163 ± 0.946
2.617ThrPro: 2.617 ± 1.539
4.943ThrGln: 4.943 ± 1.488
4.071ThrArg: 4.071 ± 1.173
7.27ThrSer: 7.27 ± 1.838
3.489ThrThr: 3.489 ± 2.2
2.326ThrVal: 2.326 ± 1.682
1.454ThrTrp: 1.454 ± 0.575
1.745ThrTyr: 1.745 ± 0.82
0.0ThrXaa: 0.0 ± 0.0
Val
2.326ValAla: 2.326 ± 0.614
0.872ValCys: 0.872 ± 0.579
3.489ValAsp: 3.489 ± 1.407
4.362ValGlu: 4.362 ± 0.746
1.454ValPhe: 1.454 ± 0.575
3.199ValGly: 3.199 ± 0.725
2.326ValHis: 2.326 ± 0.694
3.489ValIle: 3.489 ± 0.752
2.035ValLys: 2.035 ± 0.409
6.106ValLeu: 6.106 ± 1.607
0.872ValMet: 0.872 ± 0.355
3.199ValAsn: 3.199 ± 0.566
4.071ValPro: 4.071 ± 0.666
1.745ValGln: 1.745 ± 0.542
3.199ValArg: 3.199 ± 1.35
4.653ValSer: 4.653 ± 1.144
6.106ValThr: 6.106 ± 1.27
3.489ValVal: 3.489 ± 1.336
0.582ValTrp: 0.582 ± 0.322
1.454ValTyr: 1.454 ± 0.575
0.0ValXaa: 0.0 ± 0.0
Trp
0.872TrpAla: 0.872 ± 0.482
0.291TrpCys: 0.291 ± 0.161
0.582TrpAsp: 0.582 ± 0.3
1.454TrpGlu: 1.454 ± 0.804
0.291TrpPhe: 0.291 ± 0.161
1.163TrpGly: 1.163 ± 0.445
0.0TrpHis: 0.0 ± 0.0
0.582TrpIle: 0.582 ± 0.3
1.163TrpLys: 1.163 ± 0.599
0.582TrpLeu: 0.582 ± 0.322
0.582TrpMet: 0.582 ± 0.637
0.872TrpAsn: 0.872 ± 0.344
0.582TrpPro: 0.582 ± 0.3
0.291TrpGln: 0.291 ± 0.336
0.582TrpArg: 0.582 ± 0.322
0.872TrpSer: 0.872 ± 0.616
0.872TrpThr: 0.872 ± 0.482
1.163TrpVal: 1.163 ± 0.445
0.0TrpTrp: 0.0 ± 0.0
0.291TrpTyr: 0.291 ± 0.161
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.454TyrAla: 1.454 ± 1.099
0.0TyrCys: 0.0 ± 0.0
1.454TyrAsp: 1.454 ± 0.613
0.872TyrGlu: 0.872 ± 0.399
0.872TyrPhe: 0.872 ± 0.482
1.745TyrGly: 1.745 ± 1.034
0.872TyrHis: 0.872 ± 0.344
1.454TyrIle: 1.454 ± 0.707
1.163TyrLys: 1.163 ± 0.646
4.362TyrLeu: 4.362 ± 1.17
0.872TyrMet: 0.872 ± 0.509
0.872TyrAsn: 0.872 ± 0.579
1.163TyrPro: 1.163 ± 0.347
1.745TyrGln: 1.745 ± 0.717
0.582TyrArg: 0.582 ± 0.3
1.745TyrSer: 1.745 ± 0.439
1.745TyrThr: 1.745 ± 0.518
2.035TyrVal: 2.035 ± 0.804
0.582TyrTrp: 0.582 ± 0.3
1.745TyrTyr: 1.745 ± 1.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3440 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski