Amino acid dipepetide frequency for Escherichia phage LL11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.006AlaAla: 9.006 ± 1.747
0.429AlaCys: 0.429 ± 0.17
5.575AlaAsp: 5.575 ± 0.728
6.791AlaGlu: 6.791 ± 1.207
3.288AlaPhe: 3.288 ± 0.623
6.576AlaGly: 6.576 ± 0.808
1.43AlaHis: 1.43 ± 0.3
5.218AlaIle: 5.218 ± 0.537
5.289AlaLys: 5.289 ± 0.525
7.219AlaLeu: 7.219 ± 0.532
2.788AlaMet: 2.788 ± 0.456
4.36AlaAsn: 4.36 ± 0.403
3.145AlaPro: 3.145 ± 0.523
4.575AlaGln: 4.575 ± 0.667
5.647AlaArg: 5.647 ± 0.661
5.289AlaSer: 5.289 ± 0.608
4.432AlaThr: 4.432 ± 0.796
7.005AlaVal: 7.005 ± 0.851
1.072AlaTrp: 1.072 ± 0.263
2.931AlaTyr: 2.931 ± 0.391
0.0AlaXaa: 0.0 ± 0.0
Cys
0.572CysAla: 0.572 ± 0.234
0.071CysCys: 0.071 ± 0.066
0.715CysAsp: 0.715 ± 0.248
0.357CysGlu: 0.357 ± 0.189
0.572CysPhe: 0.572 ± 0.198
0.715CysGly: 0.715 ± 0.257
0.286CysHis: 0.286 ± 0.194
0.357CysIle: 0.357 ± 0.168
0.858CysLys: 0.858 ± 0.293
0.786CysLeu: 0.786 ± 0.307
0.572CysMet: 0.572 ± 0.212
0.214CysAsn: 0.214 ± 0.127
0.5CysPro: 0.5 ± 0.211
0.429CysGln: 0.429 ± 0.195
0.858CysArg: 0.858 ± 0.288
0.429CysSer: 0.429 ± 0.208
0.643CysThr: 0.643 ± 0.3
0.786CysVal: 0.786 ± 0.246
0.071CysTrp: 0.071 ± 0.066
0.786CysTyr: 0.786 ± 0.273
0.0CysXaa: 0.0 ± 0.0
Asp
6.576AspAla: 6.576 ± 0.754
0.929AspCys: 0.929 ± 0.311
2.788AspAsp: 2.788 ± 0.676
4.146AspGlu: 4.146 ± 0.602
2.144AspPhe: 2.144 ± 0.387
4.36AspGly: 4.36 ± 0.7
1.001AspHis: 1.001 ± 0.284
3.86AspIle: 3.86 ± 0.472
4.146AspLys: 4.146 ± 0.456
4.789AspLeu: 4.789 ± 0.745
1.43AspMet: 1.43 ± 0.307
2.573AspAsn: 2.573 ± 0.467
2.144AspPro: 2.144 ± 0.336
0.929AspGln: 0.929 ± 0.254
2.788AspArg: 2.788 ± 0.372
3.931AspSer: 3.931 ± 0.573
4.074AspThr: 4.074 ± 0.428
3.931AspVal: 3.931 ± 0.52
1.072AspTrp: 1.072 ± 0.308
1.93AspTyr: 1.93 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
7.434GluAla: 7.434 ± 0.675
1.144GluCys: 1.144 ± 0.364
4.646GluAsp: 4.646 ± 0.575
7.005GluGlu: 7.005 ± 0.857
2.573GluPhe: 2.573 ± 0.381
5.79GluGly: 5.79 ± 0.548
1.501GluHis: 1.501 ± 0.397
3.074GluIle: 3.074 ± 0.39
4.432GluLys: 4.432 ± 0.453
5.575GluLeu: 5.575 ± 0.701
2.144GluMet: 2.144 ± 0.381
1.716GluAsn: 1.716 ± 0.415
1.787GluPro: 1.787 ± 0.33
2.716GluGln: 2.716 ± 0.455
3.288GluArg: 3.288 ± 0.538
3.288GluSer: 3.288 ± 0.513
2.716GluThr: 2.716 ± 0.422
6.219GluVal: 6.219 ± 0.699
1.644GluTrp: 1.644 ± 0.327
1.787GluTyr: 1.787 ± 0.251
0.0GluXaa: 0.0 ± 0.0
Phe
2.502PheAla: 2.502 ± 0.46
0.214PheCys: 0.214 ± 0.133
3.288PheAsp: 3.288 ± 0.456
3.217PheGlu: 3.217 ± 0.463
1.287PhePhe: 1.287 ± 0.375
2.645PheGly: 2.645 ± 0.466
0.643PheHis: 0.643 ± 0.224
2.287PheIle: 2.287 ± 0.258
2.645PheLys: 2.645 ± 0.468
3.145PheLeu: 3.145 ± 0.51
1.43PheMet: 1.43 ± 0.295
1.93PheAsn: 1.93 ± 0.374
1.144PhePro: 1.144 ± 0.242
1.001PheGln: 1.001 ± 0.201
1.573PheArg: 1.573 ± 0.311
2.287PheSer: 2.287 ± 0.432
2.073PheThr: 2.073 ± 0.352
1.43PheVal: 1.43 ± 0.347
0.214PheTrp: 0.214 ± 0.126
0.786PheTyr: 0.786 ± 0.232
0.0PheXaa: 0.0 ± 0.0
Gly
6.147GlyAla: 6.147 ± 0.61
0.929GlyCys: 0.929 ± 0.297
4.646GlyAsp: 4.646 ± 0.645
5.004GlyGlu: 5.004 ± 0.536
2.931GlyPhe: 2.931 ± 0.647
5.361GlyGly: 5.361 ± 0.582
1.93GlyHis: 1.93 ± 0.38
4.575GlyIle: 4.575 ± 0.54
5.861GlyLys: 5.861 ± 0.962
5.647GlyLeu: 5.647 ± 0.782
1.573GlyMet: 1.573 ± 0.311
3.074GlyAsn: 3.074 ± 0.574
0.214GlyPro: 0.214 ± 0.117
3.645GlyGln: 3.645 ± 0.461
4.146GlyArg: 4.146 ± 0.417
6.004GlySer: 6.004 ± 0.909
4.646GlyThr: 4.646 ± 0.673
5.647GlyVal: 5.647 ± 0.914
1.501GlyTrp: 1.501 ± 0.248
3.217GlyTyr: 3.217 ± 0.396
0.0GlyXaa: 0.0 ± 0.0
His
1.501HisAla: 1.501 ± 0.252
0.214HisCys: 0.214 ± 0.145
1.716HisAsp: 1.716 ± 0.426
1.001HisGlu: 1.001 ± 0.301
1.144HisPhe: 1.144 ± 0.228
1.716HisGly: 1.716 ± 0.316
0.5HisHis: 0.5 ± 0.209
1.287HisIle: 1.287 ± 0.287
1.573HisLys: 1.573 ± 0.393
2.287HisLeu: 2.287 ± 0.378
0.572HisMet: 0.572 ± 0.285
0.929HisAsn: 0.929 ± 0.239
0.643HisPro: 0.643 ± 0.225
0.643HisGln: 0.643 ± 0.237
1.43HisArg: 1.43 ± 0.419
0.715HisSer: 0.715 ± 0.237
0.858HisThr: 0.858 ± 0.204
1.501HisVal: 1.501 ± 0.337
0.071HisTrp: 0.071 ± 0.066
1.001HisTyr: 1.001 ± 0.299
0.0HisXaa: 0.0 ± 0.0
Ile
5.004IleAla: 5.004 ± 0.487
0.286IleCys: 0.286 ± 0.145
3.717IleAsp: 3.717 ± 0.537
3.645IleGlu: 3.645 ± 0.5
1.644IlePhe: 1.644 ± 0.526
4.289IleGly: 4.289 ± 0.489
1.287IleHis: 1.287 ± 0.351
3.217IleIle: 3.217 ± 0.585
3.788IleLys: 3.788 ± 0.494
4.074IleLeu: 4.074 ± 0.47
1.501IleMet: 1.501 ± 0.378
2.216IleAsn: 2.216 ± 0.386
2.001IlePro: 2.001 ± 0.328
2.144IleGln: 2.144 ± 0.349
3.217IleArg: 3.217 ± 0.406
3.074IleSer: 3.074 ± 0.457
2.859IleThr: 2.859 ± 0.517
3.36IleVal: 3.36 ± 0.416
1.001IleTrp: 1.001 ± 0.23
1.43IleTyr: 1.43 ± 0.39
0.0IleXaa: 0.0 ± 0.0
Lys
7.577LysAla: 7.577 ± 0.823
0.786LysCys: 0.786 ± 0.217
3.217LysAsp: 3.217 ± 0.631
4.646LysGlu: 4.646 ± 0.567
1.573LysPhe: 1.573 ± 0.293
5.861LysGly: 5.861 ± 0.779
1.787LysHis: 1.787 ± 0.472
3.145LysIle: 3.145 ± 0.516
3.86LysLys: 3.86 ± 0.697
6.29LysLeu: 6.29 ± 0.673
1.358LysMet: 1.358 ± 0.274
2.216LysAsn: 2.216 ± 0.415
3.217LysPro: 3.217 ± 0.545
2.573LysGln: 2.573 ± 0.436
3.931LysArg: 3.931 ± 0.449
3.503LysSer: 3.503 ± 0.429
2.43LysThr: 2.43 ± 0.335
3.86LysVal: 3.86 ± 0.62
0.715LysTrp: 0.715 ± 0.223
2.502LysTyr: 2.502 ± 0.44
0.0LysXaa: 0.0 ± 0.0
Leu
6.076LeuAla: 6.076 ± 0.98
0.929LeuCys: 0.929 ± 0.26
5.289LeuAsp: 5.289 ± 0.572
5.361LeuGlu: 5.361 ± 0.466
2.502LeuPhe: 2.502 ± 0.572
5.718LeuGly: 5.718 ± 0.676
1.287LeuHis: 1.287 ± 0.368
4.646LeuIle: 4.646 ± 0.696
5.289LeuLys: 5.289 ± 0.597
5.075LeuLeu: 5.075 ± 0.516
2.502LeuMet: 2.502 ± 0.423
3.788LeuAsn: 3.788 ± 0.422
3.074LeuPro: 3.074 ± 0.455
4.003LeuGln: 4.003 ± 0.679
4.36LeuArg: 4.36 ± 0.774
5.289LeuSer: 5.289 ± 0.782
4.718LeuThr: 4.718 ± 0.655
6.147LeuVal: 6.147 ± 0.695
0.715LeuTrp: 0.715 ± 0.249
2.859LeuTyr: 2.859 ± 0.385
0.0LeuXaa: 0.0 ± 0.0
Met
3.288MetAla: 3.288 ± 0.497
0.214MetCys: 0.214 ± 0.113
1.001MetAsp: 1.001 ± 0.252
2.001MetGlu: 2.001 ± 0.386
0.858MetPhe: 0.858 ± 0.284
2.001MetGly: 2.001 ± 0.656
0.429MetHis: 0.429 ± 0.199
1.287MetIle: 1.287 ± 0.309
1.573MetLys: 1.573 ± 0.287
3.074MetLeu: 3.074 ± 0.377
0.572MetMet: 0.572 ± 0.209
1.215MetAsn: 1.215 ± 0.225
1.287MetPro: 1.287 ± 0.239
1.93MetGln: 1.93 ± 0.453
1.716MetArg: 1.716 ± 0.418
2.216MetSer: 2.216 ± 0.291
1.716MetThr: 1.716 ± 0.374
1.858MetVal: 1.858 ± 0.321
0.214MetTrp: 0.214 ± 0.104
0.643MetTyr: 0.643 ± 0.229
0.0MetXaa: 0.0 ± 0.0
Asn
3.217AsnAla: 3.217 ± 0.503
0.5AsnCys: 0.5 ± 0.248
2.287AsnAsp: 2.287 ± 0.334
2.216AsnGlu: 2.216 ± 0.495
1.787AsnPhe: 1.787 ± 0.254
3.002AsnGly: 3.002 ± 0.457
0.929AsnHis: 0.929 ± 0.325
2.216AsnIle: 2.216 ± 0.511
3.074AsnLys: 3.074 ± 0.384
3.36AsnLeu: 3.36 ± 0.51
1.144AsnMet: 1.144 ± 0.295
3.431AsnAsn: 3.431 ± 0.811
1.93AsnPro: 1.93 ± 0.338
1.858AsnGln: 1.858 ± 0.368
2.716AsnArg: 2.716 ± 0.451
2.001AsnSer: 2.001 ± 0.37
2.931AsnThr: 2.931 ± 0.568
3.645AsnVal: 3.645 ± 0.598
0.858AsnTrp: 0.858 ± 0.255
2.001AsnTyr: 2.001 ± 0.39
0.0AsnXaa: 0.0 ± 0.0
Pro
3.145ProAla: 3.145 ± 0.534
0.357ProCys: 0.357 ± 0.161
2.716ProAsp: 2.716 ± 0.434
3.217ProGlu: 3.217 ± 0.469
1.287ProPhe: 1.287 ± 0.274
1.144ProGly: 1.144 ± 0.266
0.786ProHis: 0.786 ± 0.264
1.215ProIle: 1.215 ± 0.258
2.216ProLys: 2.216 ± 0.324
2.216ProLeu: 2.216 ± 0.339
1.215ProMet: 1.215 ± 0.193
1.573ProAsn: 1.573 ± 0.363
1.072ProPro: 1.072 ± 0.213
1.287ProGln: 1.287 ± 0.25
1.001ProArg: 1.001 ± 0.224
2.43ProSer: 2.43 ± 0.398
1.93ProThr: 1.93 ± 0.471
3.145ProVal: 3.145 ± 0.545
0.643ProTrp: 0.643 ± 0.185
1.43ProTyr: 1.43 ± 0.333
0.0ProXaa: 0.0 ± 0.0
Gln
5.575GlnAla: 5.575 ± 0.6
0.357GlnCys: 0.357 ± 0.143
1.858GlnAsp: 1.858 ± 0.307
2.144GlnGlu: 2.144 ± 0.423
1.716GlnPhe: 1.716 ± 0.325
3.288GlnGly: 3.288 ± 0.468
0.786GlnHis: 0.786 ± 0.213
2.359GlnIle: 2.359 ± 0.373
1.287GlnLys: 1.287 ± 0.243
3.074GlnLeu: 3.074 ± 0.471
1.93GlnMet: 1.93 ± 0.397
1.716GlnAsn: 1.716 ± 0.481
0.858GlnPro: 0.858 ± 0.248
2.573GlnGln: 2.573 ± 0.32
2.216GlnArg: 2.216 ± 0.366
2.359GlnSer: 2.359 ± 0.54
2.073GlnThr: 2.073 ± 0.367
2.859GlnVal: 2.859 ± 0.44
0.572GlnTrp: 0.572 ± 0.209
1.858GlnTyr: 1.858 ± 0.364
0.0GlnXaa: 0.0 ± 0.0
Arg
5.218ArgAla: 5.218 ± 1.018
0.572ArgCys: 0.572 ± 0.218
3.145ArgAsp: 3.145 ± 0.378
4.217ArgGlu: 4.217 ± 0.637
1.93ArgPhe: 1.93 ± 0.316
4.789ArgGly: 4.789 ± 0.559
1.501ArgHis: 1.501 ± 0.344
3.145ArgIle: 3.145 ± 0.457
3.503ArgLys: 3.503 ± 0.524
4.861ArgLeu: 4.861 ± 0.525
2.073ArgMet: 2.073 ± 0.396
2.645ArgAsn: 2.645 ± 0.349
1.287ArgPro: 1.287 ± 0.352
2.216ArgGln: 2.216 ± 0.435
2.859ArgArg: 2.859 ± 0.402
1.716ArgSer: 1.716 ± 0.355
2.359ArgThr: 2.359 ± 0.464
3.645ArgVal: 3.645 ± 0.359
0.643ArgTrp: 0.643 ± 0.197
1.93ArgTyr: 1.93 ± 0.402
0.0ArgXaa: 0.0 ± 0.0
Ser
4.36SerAla: 4.36 ± 0.703
0.715SerCys: 0.715 ± 0.251
3.931SerAsp: 3.931 ± 0.719
4.36SerGlu: 4.36 ± 0.618
2.144SerPhe: 2.144 ± 0.438
6.219SerGly: 6.219 ± 0.751
1.144SerHis: 1.144 ± 0.272
2.716SerIle: 2.716 ± 0.4
3.288SerLys: 3.288 ± 0.467
4.932SerLeu: 4.932 ± 0.673
1.858SerMet: 1.858 ± 0.336
3.002SerAsn: 3.002 ± 0.629
1.43SerPro: 1.43 ± 0.344
2.716SerGln: 2.716 ± 0.333
3.288SerArg: 3.288 ± 0.416
4.146SerSer: 4.146 ± 0.769
3.002SerThr: 3.002 ± 0.588
3.931SerVal: 3.931 ± 0.386
0.858SerTrp: 0.858 ± 0.213
2.001SerTyr: 2.001 ± 0.366
0.0SerXaa: 0.0 ± 0.0
Thr
3.574ThrAla: 3.574 ± 0.631
0.5ThrCys: 0.5 ± 0.206
3.002ThrAsp: 3.002 ± 0.688
3.788ThrGlu: 3.788 ± 0.554
2.931ThrPhe: 2.931 ± 0.57
4.503ThrGly: 4.503 ± 0.511
1.215ThrHis: 1.215 ± 0.316
3.145ThrIle: 3.145 ± 0.531
4.217ThrLys: 4.217 ± 0.591
4.432ThrLeu: 4.432 ± 0.658
0.786ThrMet: 0.786 ± 0.226
2.216ThrAsn: 2.216 ± 0.451
2.716ThrPro: 2.716 ± 0.396
1.573ThrGln: 1.573 ± 0.344
2.502ThrArg: 2.502 ± 0.439
3.36ThrSer: 3.36 ± 0.7
2.859ThrThr: 2.859 ± 0.367
3.931ThrVal: 3.931 ± 0.68
0.572ThrTrp: 0.572 ± 0.189
1.644ThrTyr: 1.644 ± 0.368
0.0ThrXaa: 0.0 ± 0.0
Val
6.862ValAla: 6.862 ± 0.589
0.643ValCys: 0.643 ± 0.232
3.717ValAsp: 3.717 ± 0.428
4.217ValGlu: 4.217 ± 0.612
2.073ValPhe: 2.073 ± 0.3
4.503ValGly: 4.503 ± 0.603
1.573ValHis: 1.573 ± 0.352
3.717ValIle: 3.717 ± 0.472
5.075ValLys: 5.075 ± 0.475
4.718ValLeu: 4.718 ± 0.693
2.287ValMet: 2.287 ± 0.369
3.717ValAsn: 3.717 ± 0.443
3.36ValPro: 3.36 ± 0.455
3.002ValGln: 3.002 ± 0.479
4.432ValArg: 4.432 ± 0.686
4.932ValSer: 4.932 ± 0.445
4.718ValThr: 4.718 ± 0.549
4.789ValVal: 4.789 ± 0.711
0.429ValTrp: 0.429 ± 0.147
1.93ValTyr: 1.93 ± 0.384
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.256
0.429TrpCys: 0.429 ± 0.157
0.5TrpAsp: 0.5 ± 0.175
1.215TrpGlu: 1.215 ± 0.268
0.357TrpPhe: 0.357 ± 0.18
0.715TrpGly: 0.715 ± 0.166
0.429TrpHis: 0.429 ± 0.163
0.286TrpIle: 0.286 ± 0.131
1.144TrpLys: 1.144 ± 0.354
0.858TrpLeu: 0.858 ± 0.229
0.429TrpMet: 0.429 ± 0.172
0.715TrpAsn: 0.715 ± 0.232
1.144TrpPro: 1.144 ± 0.268
0.715TrpGln: 0.715 ± 0.186
0.5TrpArg: 0.5 ± 0.175
0.929TrpSer: 0.929 ± 0.328
0.572TrpThr: 0.572 ± 0.201
1.072TrpVal: 1.072 ± 0.268
0.143TrpTrp: 0.143 ± 0.086
0.214TrpTyr: 0.214 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.503TyrAla: 3.503 ± 0.435
0.357TyrCys: 0.357 ± 0.129
1.787TyrAsp: 1.787 ± 0.327
2.001TyrGlu: 2.001 ± 0.274
1.001TyrPhe: 1.001 ± 0.296
3.503TyrGly: 3.503 ± 0.697
0.858TyrHis: 0.858 ± 0.307
2.001TyrIle: 2.001 ± 0.279
1.93TyrLys: 1.93 ± 0.235
3.217TyrLeu: 3.217 ± 0.545
0.858TyrMet: 0.858 ± 0.242
1.858TyrAsn: 1.858 ± 0.416
1.072TyrPro: 1.072 ± 0.282
0.929TyrGln: 0.929 ± 0.32
1.787TyrArg: 1.787 ± 0.407
2.144TyrSer: 2.144 ± 0.438
1.858TyrThr: 1.858 ± 0.352
1.93TyrVal: 1.93 ± 0.342
0.286TyrTrp: 0.286 ± 0.181
0.858TyrTyr: 0.858 ± 0.287
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (13991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski