Amino acid dipepetide frequency for Burkholderia multivorans (strain ATCC 17616 / 249)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.156AlaAla: 21.156 ± 0.196	1.487AlaCys: 1.487 ± 0.033	7.501AlaAsp: 7.501 ± 0.073	6.129AlaGlu: 6.129 ± 0.073	4.658AlaPhe: 4.658 ± 0.054	10.944AlaGly: 10.944 ± 0.1	3.316AlaHis: 3.316 ± 0.047	6.091AlaIle: 6.091 ± 0.056	3.737AlaLys: 3.737 ± 0.054	15.882AlaLeu: 15.882 ± 0.139	3.416AlaMet: 3.416 ± 0.042	3.182AlaAsn: 3.182 ± 0.053	6.853AlaPro: 6.853 ± 0.087	5.537AlaGln: 5.537 ± 0.068	10.63AlaArg: 10.63 ± 0.114	7.34AlaSer: 7.34 ± 0.078	6.757AlaThr: 6.757 ± 0.066	9.164AlaVal: 9.164 ± 0.081	1.878AlaTrp: 1.878 ± 0.038	2.881AlaTyr: 2.881 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.416CysAla: 1.416 ± 0.028	0.141CysCys: 0.141 ± 0.01	0.564CysAsp: 0.564 ± 0.016	0.451CysGlu: 0.451 ± 0.015	0.328CysPhe: 0.328 ± 0.013	1.001CysGly: 1.001 ± 0.027	0.256CysHis: 0.256 ± 0.012	0.39CysIle: 0.39 ± 0.014	0.181CysLys: 0.181 ± 0.01	0.729CysLeu: 0.729 ± 0.02	0.199CysMet: 0.199 ± 0.01	0.205CysAsn: 0.205 ± 0.012	0.469CysPro: 0.469 ± 0.019	0.196CysGln: 0.196 ± 0.01	0.658CysArg: 0.658 ± 0.02	0.453CysSer: 0.453 ± 0.017	0.498CysThr: 0.498 ± 0.017	0.813CysVal: 0.813 ± 0.023	0.126CysTrp: 0.126 ± 0.009	0.245CysTyr: 0.245 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	10.067AspAla: 10.067 ± 0.098	0.452AspCys: 0.452 ± 0.015	3.833AspAsp: 3.833 ± 0.053	3.476AspGlu: 3.476 ± 0.045	1.843AspPhe: 1.843 ± 0.029	5.192AspGly: 5.192 ± 0.068	1.094AspHis: 1.094 ± 0.027	2.344AspIle: 2.344 ± 0.034	1.463AspLys: 1.463 ± 0.029	4.923AspLeu: 4.923 ± 0.056	1.122AspMet: 1.122 ± 0.026	1.132AspAsn: 1.132 ± 0.027	3.141AspPro: 3.141 ± 0.043	1.353AspGln: 1.353 ± 0.029	3.845AspArg: 3.845 ± 0.044	2.15AspSer: 2.15 ± 0.031	3.238AspThr: 3.238 ± 0.049	4.827AspVal: 4.827 ± 0.058	0.976AspTrp: 0.976 ± 0.024	1.54AspTyr: 1.54 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.968GluAla: 5.968 ± 0.067	0.384GluCys: 0.384 ± 0.018	1.816GluAsp: 1.816 ± 0.036	1.906GluGlu: 1.906 ± 0.038	1.65GluPhe: 1.65 ± 0.033	2.955GluGly: 2.955 ± 0.05	1.392GluHis: 1.392 ± 0.029	2.644GluIle: 2.644 ± 0.042	1.531GluLys: 1.531 ± 0.031	5.129GluLeu: 5.129 ± 0.049	1.07GluMet: 1.07 ± 0.023	1.164GluAsn: 1.164 ± 0.028	2.576GluPro: 2.576 ± 0.038	2.203GluGln: 2.203 ± 0.039	5.219GluArg: 5.219 ± 0.066	2.186GluSer: 2.186 ± 0.038	2.56GluThr: 2.56 ± 0.043	3.066GluVal: 3.066 ± 0.056	0.725GluTrp: 0.725 ± 0.019	1.081GluTyr: 1.081 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	5.028PheAla: 5.028 ± 0.06	0.368PheCys: 0.368 ± 0.013	2.822PheAsp: 2.822 ± 0.036	1.904PheGlu: 1.904 ± 0.032	1.38PhePhe: 1.38 ± 0.032	3.729PheGly: 3.729 ± 0.039	0.76PheHis: 0.76 ± 0.019	1.402PheIle: 1.402 ± 0.026	0.876PheLys: 0.876 ± 0.023	2.761PheLeu: 2.761 ± 0.045	0.732PheMet: 0.732 ± 0.021	1.049PheAsn: 1.049 ± 0.026	1.548PhePro: 1.548 ± 0.028	0.874PheGln: 0.874 ± 0.02	2.107PheArg: 2.107 ± 0.031	2.02PheSer: 2.02 ± 0.032	1.873PheThr: 1.873 ± 0.035	3.308PheVal: 3.308 ± 0.047	0.519PheTrp: 0.519 ± 0.017	0.93PheTyr: 0.93 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.457GlyAla: 10.457 ± 0.143	0.882GlyCys: 0.882 ± 0.022	4.232GlyAsp: 4.232 ± 0.051	3.989GlyGlu: 3.989 ± 0.048	3.376GlyPhe: 3.376 ± 0.044	6.965GlyGly: 6.965 ± 0.124	1.846GlyHis: 1.846 ± 0.034	4.283GlyIle: 4.283 ± 0.052	2.905GlyLys: 2.905 ± 0.043	7.806GlyLeu: 7.806 ± 0.072	2.091GlyMet: 2.091 ± 0.036	2.155GlyAsn: 2.155 ± 0.052	2.971GlyPro: 2.971 ± 0.047	2.415GlyGln: 2.415 ± 0.038	5.69GlyArg: 5.69 ± 0.067	4.307GlySer: 4.307 ± 0.083	4.976GlyThr: 4.976 ± 0.14	6.684GlyVal: 6.684 ± 0.069	1.454GlyTrp: 1.454 ± 0.03	2.452GlyTyr: 2.452 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	3.635HisAla: 3.635 ± 0.054	0.254HisCys: 0.254 ± 0.012	1.519HisAsp: 1.519 ± 0.03	1.07HisGlu: 1.07 ± 0.024	0.903HisPhe: 0.903 ± 0.024	2.267HisGly: 2.267 ± 0.035	0.618HisHis: 0.618 ± 0.02	0.781HisIle: 0.781 ± 0.021	0.448HisLys: 0.448 ± 0.016	2.1HisLeu: 2.1 ± 0.031	0.453HisMet: 0.453 ± 0.015	0.468HisAsn: 0.468 ± 0.018	1.484HisPro: 1.484 ± 0.027	0.57HisGln: 0.57 ± 0.019	1.696HisArg: 1.696 ± 0.029	0.919HisSer: 0.919 ± 0.021	1.094HisThr: 1.094 ± 0.028	1.88HisVal: 1.88 ± 0.037	0.4HisTrp: 0.4 ± 0.016	0.671HisTyr: 0.671 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.603IleAla: 7.603 ± 0.069	0.391IleCys: 0.391 ± 0.013	3.659IleAsp: 3.659 ± 0.041	3.012IleGlu: 3.012 ± 0.041	1.26IlePhe: 1.26 ± 0.031	4.867IleGly: 4.867 ± 0.063	0.819IleHis: 0.819 ± 0.023	1.289IleIle: 1.289 ± 0.03	1.133IleLys: 1.133 ± 0.027	3.041IleLeu: 3.041 ± 0.043	0.68IleMet: 0.68 ± 0.021	1.203IleAsn: 1.203 ± 0.03	1.977IlePro: 1.977 ± 0.037	1.074IleGln: 1.074 ± 0.027	2.838IleArg: 2.838 ± 0.036	2.023IleSer: 2.023 ± 0.035	2.143IleThr: 2.143 ± 0.04	4.756IleVal: 4.756 ± 0.055	0.464IleTrp: 0.464 ± 0.016	0.968IleTyr: 0.968 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.337LysAla: 3.337 ± 0.052	0.151LysCys: 0.151 ± 0.009	1.292LysAsp: 1.292 ± 0.028	1.202LysGlu: 1.202 ± 0.028	0.801LysPhe: 0.801 ± 0.022	1.921LysGly: 1.921 ± 0.036	0.657LysHis: 0.657 ± 0.019	1.433LysIle: 1.433 ± 0.031	1.109LysLys: 1.109 ± 0.038	3.166LysLeu: 3.166 ± 0.046	0.669LysMet: 0.669 ± 0.02	0.736LysAsn: 0.736 ± 0.024	1.893LysPro: 1.893 ± 0.03	1.187LysGln: 1.187 ± 0.026	2.376LysArg: 2.376 ± 0.038	1.524LysSer: 1.524 ± 0.029	1.703LysThr: 1.703 ± 0.029	2.101LysVal: 2.101 ± 0.042	0.362LysTrp: 0.362 ± 0.014	0.66LysTyr: 0.66 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.696LeuAla: 14.696 ± 0.121	0.987LeuCys: 0.987 ± 0.025	6.485LeuAsp: 6.485 ± 0.066	4.571LeuGlu: 4.571 ± 0.05	3.6LeuPhe: 3.6 ± 0.046	8.163LeuGly: 8.163 ± 0.096	2.252LeuHis: 2.252 ± 0.04	4.436LeuIle: 4.436 ± 0.054	3.191LeuLys: 3.191 ± 0.043	9.801LeuLeu: 9.801 ± 0.102	2.122LeuMet: 2.122 ± 0.042	2.607LeuAsn: 2.607 ± 0.048	5.913LeuPro: 5.913 ± 0.051	3.036LeuGln: 3.036 ± 0.04	7.24LeuArg: 7.24 ± 0.069	5.962LeuSer: 5.962 ± 0.094	5.444LeuThr: 5.444 ± 0.054	7.529LeuVal: 7.529 ± 0.074	1.128LeuTrp: 1.128 ± 0.029	2.21LeuTyr: 2.21 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.25MetAla: 2.25 ± 0.038	0.18MetCys: 0.18 ± 0.009	0.871MetAsp: 0.871 ± 0.023	0.774MetGlu: 0.774 ± 0.018	0.744MetPhe: 0.744 ± 0.022	1.359MetGly: 1.359 ± 0.031	0.543MetHis: 0.543 ± 0.016	1.075MetIle: 1.075 ± 0.021	0.995MetLys: 0.995 ± 0.022	2.592MetLeu: 2.592 ± 0.043	0.574MetMet: 0.574 ± 0.019	0.838MetAsn: 0.838 ± 0.016	1.439MetPro: 1.439 ± 0.028	0.995MetGln: 0.995 ± 0.023	1.862MetArg: 1.862 ± 0.032	1.652MetSer: 1.652 ± 0.03	1.684MetThr: 1.684 ± 0.029	1.343MetVal: 1.343 ± 0.026	0.211MetTrp: 0.211 ± 0.011	0.391MetTyr: 0.391 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.41AsnAla: 3.41 ± 0.046	0.233AsnCys: 0.233 ± 0.011	1.411AsnAsp: 1.411 ± 0.029	1.134AsnGlu: 1.134 ± 0.022	0.868AsnPhe: 0.868 ± 0.021	2.503AsnGly: 2.503 ± 0.051	0.487AsnHis: 0.487 ± 0.018	0.987AsnIle: 0.987 ± 0.023	0.577AsnLys: 0.577 ± 0.02	2.555AsnLeu: 2.555 ± 0.047	0.471AsnMet: 0.471 ± 0.016	0.69AsnAsn: 0.69 ± 0.027	1.687AsnPro: 1.687 ± 0.04	0.774AsnGln: 0.774 ± 0.021	1.837AsnArg: 1.837 ± 0.031	1.084AsnSer: 1.084 ± 0.044	1.333AsnThr: 1.333 ± 0.036	2.152AsnVal: 2.152 ± 0.039	0.397AsnTrp: 0.397 ± 0.014	0.684AsnTyr: 0.684 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.642ProAla: 7.642 ± 0.089	0.355ProCys: 0.355 ± 0.013	3.698ProAsp: 3.698 ± 0.053	2.764ProGlu: 2.764 ± 0.048	1.985ProPhe: 1.985 ± 0.029	4.18ProGly: 4.18 ± 0.054	1.355ProHis: 1.355 ± 0.028	2.097ProIle: 2.097 ± 0.033	1.391ProLys: 1.391 ± 0.027	5.323ProLeu: 5.323 ± 0.065	1.103ProMet: 1.103 ± 0.026	1.409ProAsn: 1.409 ± 0.029	2.766ProPro: 2.766 ± 0.05	1.75ProGln: 1.75 ± 0.035	3.191ProArg: 3.191 ± 0.046	2.904ProSer: 2.904 ± 0.046	2.657ProThr: 2.657 ± 0.047	4.448ProVal: 4.448 ± 0.049	0.677ProTrp: 0.677 ± 0.02	1.257ProTyr: 1.257 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.253GlnAla: 4.253 ± 0.052	0.283GlnCys: 0.283 ± 0.012	1.256GlnAsp: 1.256 ± 0.027	1.145GlnGlu: 1.145 ± 0.028	1.176GlnPhe: 1.176 ± 0.027	2.163GlnGly: 2.163 ± 0.036	0.886GlnHis: 0.886 ± 0.02	1.805GlnIle: 1.805 ± 0.032	0.956GlnLys: 0.956 ± 0.023	3.56GlnLeu: 3.56 ± 0.046	0.937GlnMet: 0.937 ± 0.021	0.78GlnAsn: 0.78 ± 0.022	2.107GlnPro: 2.107 ± 0.035	1.725GlnGln: 1.725 ± 0.042	3.007GlnArg: 3.007 ± 0.044	1.769GlnSer: 1.769 ± 0.031	1.794GlnThr: 1.794 ± 0.032	2.28GlnVal: 2.28 ± 0.036	0.534GlnTrp: 0.534 ± 0.018	0.886GlnTyr: 0.886 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.905ArgAla: 9.905 ± 0.1	0.653ArgCys: 0.653 ± 0.019	4.788ArgAsp: 4.788 ± 0.068	4.04ArgGlu: 4.04 ± 0.055	3.073ArgPhe: 3.073 ± 0.037	4.961ArgGly: 4.961 ± 0.059	2.104ArgHis: 2.104 ± 0.034	3.936ArgIle: 3.936 ± 0.047	1.928ArgLys: 1.928 ± 0.029	7.421ArgLeu: 7.421 ± 0.068	1.899ArgMet: 1.899 ± 0.035	1.822ArgAsn: 1.822 ± 0.031	3.449ArgPro: 3.449 ± 0.049	2.46ArgGln: 2.46 ± 0.042	6.166ArgArg: 6.166 ± 0.073	3.296ArgSer: 3.296 ± 0.043	3.881ArgThr: 3.881 ± 0.052	5.74ArgVal: 5.74 ± 0.06	1.139ArgTrp: 1.139 ± 0.026	2.202ArgTyr: 2.202 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.7SerAla: 6.7 ± 0.085	0.444SerCys: 0.444 ± 0.019	2.685SerAsp: 2.685 ± 0.035	2.02SerGlu: 2.02 ± 0.037	1.972SerPhe: 1.972 ± 0.037	5.078SerGly: 5.078 ± 0.096	1.11SerHis: 1.11 ± 0.025	2.554SerIle: 2.554 ± 0.046	1.382SerLys: 1.382 ± 0.03	5.369SerLeu: 5.369 ± 0.067	1.201SerMet: 1.201 ± 0.026	1.409SerAsn: 1.409 ± 0.031	2.788SerPro: 2.788 ± 0.04	1.526SerGln: 1.526 ± 0.03	3.547SerArg: 3.547 ± 0.038	2.9SerSer: 2.9 ± 0.103	3.022SerThr: 3.022 ± 0.115	4.082SerVal: 4.082 ± 0.051	0.683SerTrp: 0.683 ± 0.019	1.22SerTyr: 1.22 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.147ThrAla: 6.147 ± 0.076	0.435ThrCys: 0.435 ± 0.015	2.776ThrAsp: 2.776 ± 0.047	2.113ThrGlu: 2.113 ± 0.043	2.051ThrPhe: 2.051 ± 0.036	4.876ThrGly: 4.876 ± 0.115	1.266ThrHis: 1.266 ± 0.026	2.685ThrIle: 2.685 ± 0.043	1.191ThrLys: 1.191 ± 0.027	6.724ThrLeu: 6.724 ± 0.084	1.147ThrMet: 1.147 ± 0.023	1.296ThrAsn: 1.296 ± 0.037	3.613ThrPro: 3.613 ± 0.055	1.796ThrGln: 1.796 ± 0.03	3.737ThrArg: 3.737 ± 0.05	2.938ThrSer: 2.938 ± 0.09	2.907ThrThr: 2.907 ± 0.057	4.508ThrVal: 4.508 ± 0.055	0.689ThrTrp: 0.689 ± 0.021	1.322ThrTyr: 1.322 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.507ValAla: 10.507 ± 0.081	0.823ValCys: 0.823 ± 0.02	4.724ValAsp: 4.724 ± 0.052	3.942ValGlu: 3.942 ± 0.048	2.732ValPhe: 2.732 ± 0.043	5.75ValGly: 5.75 ± 0.064	1.545ValHis: 1.545 ± 0.026	3.457ValIle: 3.457 ± 0.047	2.33ValLys: 2.33 ± 0.041	7.913ValLeu: 7.913 ± 0.072	1.709ValMet: 1.709 ± 0.033	2.112ValAsn: 2.112 ± 0.042	4.323ValPro: 4.323 ± 0.07	2.356ValGln: 2.356 ± 0.037	5.631ValArg: 5.631 ± 0.056	4.384ValSer: 4.384 ± 0.051	4.594ValThr: 4.594 ± 0.07	6.304ValVal: 6.304 ± 0.06	0.992ValTrp: 0.992 ± 0.026	1.754ValTyr: 1.754 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.259TrpAla: 1.259 ± 0.027	0.159TrpCys: 0.159 ± 0.01	0.599TrpAsp: 0.599 ± 0.017	0.455TrpGlu: 0.455 ± 0.016	0.595TrpPhe: 0.595 ± 0.019	0.871TrpGly: 0.871 ± 0.025	0.41TrpHis: 0.41 ± 0.014	0.732TrpIle: 0.732 ± 0.022	0.393TrpLys: 0.393 ± 0.012	2.04TrpLeu: 2.04 ± 0.033	0.355TrpMet: 0.355 ± 0.013	0.413TrpAsn: 0.413 ± 0.014	0.693TrpPro: 0.693 ± 0.021	0.675TrpGln: 0.675 ± 0.02	1.37TrpArg: 1.37 ± 0.029	0.759TrpSer: 0.759 ± 0.022	0.736TrpThr: 0.736 ± 0.022	0.927TrpVal: 0.927 ± 0.023	0.229TrpTrp: 0.229 ± 0.011	0.321TrpTyr: 0.321 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.103TyrAla: 3.103 ± 0.044	0.258TyrCys: 0.258 ± 0.011	1.48TyrAsp: 1.48 ± 0.031	1.129TyrGlu: 1.129 ± 0.023	0.993TyrPhe: 0.993 ± 0.025	2.191TyrGly: 2.191 ± 0.033	0.515TyrHis: 0.515 ± 0.015	0.778TyrIle: 0.778 ± 0.024	0.564TyrLys: 0.564 ± 0.018	2.538TyrLeu: 2.538 ± 0.043	0.422TyrMet: 0.422 ± 0.015	0.608TyrAsn: 0.608 ± 0.018	1.262TyrPro: 1.262 ± 0.028	0.798TyrGln: 0.798 ± 0.024	2.211TyrArg: 2.211 ± 0.031	1.122TyrSer: 1.122 ± 0.027	1.323TyrThr: 1.323 ± 0.029	1.97TyrVal: 1.97 ± 0.032	0.409TyrTrp: 0.409 ± 0.012	0.676TyrTyr: 0.676 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6040 proteins (1951710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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