Amino acid dipepetide frequency for Trichinella pseudospiralis (Parasitic roundworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.406AlaAla: 5.406 ± 0.043	1.548AlaCys: 1.548 ± 0.018	3.583AlaAsp: 3.583 ± 0.024	4.526AlaGlu: 4.526 ± 0.031	2.812AlaPhe: 2.812 ± 0.024	3.317AlaGly: 3.317 ± 0.029	1.303AlaHis: 1.303 ± 0.014	3.473AlaIle: 3.473 ± 0.025	3.723AlaLys: 3.723 ± 0.026	6.311AlaLeu: 6.311 ± 0.037	1.585AlaMet: 1.585 ± 0.019	2.937AlaAsn: 2.937 ± 0.022	2.252AlaPro: 2.252 ± 0.024	2.213AlaGln: 2.213 ± 0.017	2.836AlaArg: 2.836 ± 0.023	5.149AlaSer: 5.149 ± 0.032	3.446AlaThr: 3.446 ± 0.024	4.965AlaVal: 4.965 ± 0.026	0.657AlaTrp: 0.657 ± 0.009	1.859AlaTyr: 1.859 ± 0.021	0.001AlaXaa: 0.001 ± 0.0
Cys	1.417CysAla: 1.417 ± 0.014	0.921CysCys: 0.921 ± 0.016	1.399CysAsp: 1.399 ± 0.024	1.521CysGlu: 1.521 ± 0.022	1.334CysPhe: 1.334 ± 0.015	1.451CysGly: 1.451 ± 0.018	0.693CysHis: 0.693 ± 0.013	1.595CysIle: 1.595 ± 0.022	1.55CysLys: 1.55 ± 0.02	2.688CysLeu: 2.688 ± 0.026	0.576CysMet: 0.576 ± 0.009	1.279CysAsn: 1.279 ± 0.016	1.27CysPro: 1.27 ± 0.026	1.134CysGln: 1.134 ± 0.016	1.577CysArg: 1.577 ± 0.023	2.487CysSer: 2.487 ± 0.026	1.399CysThr: 1.399 ± 0.018	1.542CysVal: 1.542 ± 0.018	0.366CysTrp: 0.366 ± 0.009	0.799CysTyr: 0.799 ± 0.012	0.002CysXaa: 0.002 ± 0.0
Asp	3.288AspAla: 3.288 ± 0.023	1.406AspCys: 1.406 ± 0.022	3.995AspAsp: 3.995 ± 0.04	4.279AspGlu: 4.279 ± 0.033	2.422AspPhe: 2.422 ± 0.023	3.154AspGly: 3.154 ± 0.033	1.192AspHis: 1.192 ± 0.014	2.798AspIle: 2.798 ± 0.021	2.608AspLys: 2.608 ± 0.021	4.732AspLeu: 4.732 ± 0.026	1.191AspMet: 1.191 ± 0.013	2.347AspAsn: 2.347 ± 0.021	2.037AspPro: 2.037 ± 0.021	2.079AspGln: 2.079 ± 0.021	2.678AspArg: 2.678 ± 0.02	4.234AspSer: 4.234 ± 0.026	2.129AspThr: 2.129 ± 0.016	3.742AspVal: 3.742 ± 0.025	0.692AspTrp: 0.692 ± 0.012	1.664AspTyr: 1.664 ± 0.017	0.001AspXaa: 0.001 ± 0.0
Glu	3.864GluAla: 3.864 ± 0.029	1.43GluCys: 1.43 ± 0.024	3.278GluAsp: 3.278 ± 0.025	5.691GluGlu: 5.691 ± 0.053	2.491GluPhe: 2.491 ± 0.022	2.344GluGly: 2.344 ± 0.025	1.458GluHis: 1.458 ± 0.017	3.965GluIle: 3.965 ± 0.031	5.057GluLys: 5.057 ± 0.036	5.986GluLeu: 5.986 ± 0.04	1.937GluMet: 1.937 ± 0.019	4.108GluAsn: 4.108 ± 0.027	2.083GluPro: 2.083 ± 0.021	3.098GluGln: 3.098 ± 0.027	3.528GluArg: 3.528 ± 0.03	4.49GluSer: 4.49 ± 0.03	3.275GluThr: 3.275 ± 0.022	3.52GluVal: 3.52 ± 0.027	0.666GluTrp: 0.666 ± 0.012	1.804GluTyr: 1.804 ± 0.017	0.001GluXaa: 0.001 ± 0.001
Phe	2.812PheAla: 2.812 ± 0.023	1.414PheCys: 1.414 ± 0.018	2.606PheAsp: 2.606 ± 0.021	2.685PheGlu: 2.685 ± 0.018	2.269PhePhe: 2.269 ± 0.021	2.57PheGly: 2.57 ± 0.022	1.232PheHis: 1.232 ± 0.015	2.65PheIle: 2.65 ± 0.025	2.277PheLys: 2.277 ± 0.022	4.476PheLeu: 4.476 ± 0.037	0.915PheMet: 0.915 ± 0.014	2.13PheAsn: 2.13 ± 0.02	1.856PhePro: 1.856 ± 0.019	1.935PheGln: 1.935 ± 0.016	2.255PheArg: 2.255 ± 0.016	3.9PheSer: 3.9 ± 0.026	2.417PheThr: 2.417 ± 0.02	3.076PheVal: 3.076 ± 0.025	0.618PheTrp: 0.618 ± 0.011	1.765PheTyr: 1.765 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	2.72GlyAla: 2.72 ± 0.024	1.289GlyCys: 1.289 ± 0.019	2.615GlyAsp: 2.615 ± 0.025	2.89GlyGlu: 2.89 ± 0.028	2.303GlyPhe: 2.303 ± 0.022	3.173GlyGly: 3.173 ± 0.039	1.228GlyHis: 1.228 ± 0.015	3.02GlyIle: 3.02 ± 0.025	3.377GlyLys: 3.377 ± 0.023	4.166GlyLeu: 4.166 ± 0.035	1.246GlyMet: 1.246 ± 0.015	2.507GlyAsn: 2.507 ± 0.021	1.748GlyPro: 1.748 ± 0.033	2.069GlyGln: 2.069 ± 0.021	3.021GlyArg: 3.021 ± 0.028	4.175GlySer: 4.175 ± 0.029	2.568GlyThr: 2.568 ± 0.02	2.97GlyVal: 2.97 ± 0.022	0.624GlyTrp: 0.624 ± 0.01	1.797GlyTyr: 1.797 ± 0.022	0.004GlyXaa: 0.004 ± 0.001
His	1.406HisAla: 1.406 ± 0.016	0.912HisCys: 0.912 ± 0.014	1.02HisAsp: 1.02 ± 0.013	1.199HisGlu: 1.199 ± 0.015	1.349HisPhe: 1.349 ± 0.015	1.306HisGly: 1.306 ± 0.016	0.911HisHis: 0.911 ± 0.016	1.283HisIle: 1.283 ± 0.016	0.999HisLys: 0.999 ± 0.012	2.692HisLeu: 2.692 ± 0.022	0.523HisMet: 0.523 ± 0.01	0.994HisAsn: 0.994 ± 0.012	1.199HisPro: 1.199 ± 0.013	1.095HisGln: 1.095 ± 0.014	1.507HisArg: 1.507 ± 0.016	2.023HisSer: 2.023 ± 0.017	1.018HisThr: 1.018 ± 0.014	1.544HisVal: 1.544 ± 0.015	0.367HisTrp: 0.367 ± 0.007	0.893HisTyr: 0.893 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.806IleAla: 3.806 ± 0.025	1.715IleCys: 1.715 ± 0.02	2.988IleAsp: 2.988 ± 0.023	3.408IleGlu: 3.408 ± 0.024	2.836IlePhe: 2.836 ± 0.027	2.923IleGly: 2.923 ± 0.024	1.301IleHis: 1.301 ± 0.015	3.181IleIle: 3.181 ± 0.028	2.88IleLys: 2.88 ± 0.025	5.481IleLeu: 5.481 ± 0.039	1.218IleMet: 1.218 ± 0.013	2.52IleAsn: 2.52 ± 0.022	2.557IlePro: 2.557 ± 0.021	2.2IleGln: 2.2 ± 0.021	3.119IleArg: 3.119 ± 0.024	4.699IleSer: 4.699 ± 0.029	2.847IleThr: 2.847 ± 0.025	3.68IleVal: 3.68 ± 0.023	0.701IleTrp: 0.701 ± 0.011	1.928IleTyr: 1.928 ± 0.018	0.001IleXaa: 0.001 ± 0.0
Lys	3.691LysAla: 3.691 ± 0.028	1.538LysCys: 1.538 ± 0.018	2.727LysAsp: 2.727 ± 0.023	4.097LysGlu: 4.097 ± 0.034	2.513LysPhe: 2.513 ± 0.02	2.306LysGly: 2.306 ± 0.028	1.502LysHis: 1.502 ± 0.017	3.624LysIle: 3.624 ± 0.028	4.536LysLys: 4.536 ± 0.043	6.288LysLeu: 6.288 ± 0.036	1.77LysMet: 1.77 ± 0.017	3.221LysAsn: 3.221 ± 0.024	2.461LysPro: 2.461 ± 0.028	2.919LysGln: 2.919 ± 0.025	3.836LysArg: 3.836 ± 0.028	4.565LysSer: 4.565 ± 0.032	2.976LysThr: 2.976 ± 0.025	3.429LysVal: 3.429 ± 0.023	0.734LysTrp: 0.734 ± 0.012	1.899LysTyr: 1.899 ± 0.016	0.001LysXaa: 0.001 ± 0.0
Leu	6.082LeuAla: 6.082 ± 0.031	2.556LeuCys: 2.556 ± 0.026	4.67LeuAsp: 4.67 ± 0.03	5.864LeuGlu: 5.864 ± 0.042	4.656LeuPhe: 4.656 ± 0.036	3.915LeuGly: 3.915 ± 0.028	2.718LeuHis: 2.718 ± 0.02	5.499LeuIle: 5.499 ± 0.035	6.824LeuLys: 6.824 ± 0.04	11.057LeuLeu: 11.057 ± 0.061	2.347LeuMet: 2.347 ± 0.02	5.208LeuAsn: 5.208 ± 0.03	4.819LeuPro: 4.819 ± 0.032	4.618LeuGln: 4.618 ± 0.03	5.403LeuArg: 5.403 ± 0.04	7.742LeuSer: 7.742 ± 0.038	5.031LeuThr: 5.031 ± 0.031	5.469LeuVal: 5.469 ± 0.034	1.105LeuTrp: 1.105 ± 0.013	3.018LeuTyr: 3.018 ± 0.022	0.002LeuXaa: 0.002 ± 0.001
Met	1.62MetAla: 1.62 ± 0.017	0.516MetCys: 0.516 ± 0.009	1.281MetAsp: 1.281 ± 0.012	1.637MetGlu: 1.637 ± 0.016	1.028MetPhe: 1.028 ± 0.013	0.908MetGly: 0.908 ± 0.013	0.666MetHis: 0.666 ± 0.009	1.363MetIle: 1.363 ± 0.015	1.778MetLys: 1.778 ± 0.017	2.546MetLeu: 2.546 ± 0.021	0.719MetMet: 0.719 ± 0.01	1.362MetAsn: 1.362 ± 0.017	1.146MetPro: 1.146 ± 0.014	1.188MetGln: 1.188 ± 0.016	1.254MetArg: 1.254 ± 0.014	1.771MetSer: 1.771 ± 0.015	1.282MetThr: 1.282 ± 0.014	1.403MetVal: 1.403 ± 0.015	0.24MetTrp: 0.24 ± 0.006	0.667MetTyr: 0.667 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.328AsnAla: 3.328 ± 0.023	1.476AsnCys: 1.476 ± 0.018	2.821AsnAsp: 2.821 ± 0.024	3.322AsnGlu: 3.322 ± 0.025	2.527AsnPhe: 2.527 ± 0.021	2.971AsnGly: 2.971 ± 0.024	1.035AsnHis: 1.035 ± 0.012	2.761AsnIle: 2.761 ± 0.024	2.56AsnLys: 2.56 ± 0.021	4.683AsnLeu: 4.683 ± 0.027	1.148AsnMet: 1.148 ± 0.013	3.114AsnAsn: 3.114 ± 0.041	1.941AsnPro: 1.941 ± 0.019	1.819AsnGln: 1.819 ± 0.019	2.596AsnArg: 2.596 ± 0.021	4.269AsnSer: 4.269 ± 0.031	2.229AsnThr: 2.229 ± 0.019	3.479AsnVal: 3.479 ± 0.024	0.612AsnTrp: 0.612 ± 0.01	1.747AsnTyr: 1.747 ± 0.019	0.001AsnXaa: 0.001 ± 0.0
Pro	2.776ProAla: 2.776 ± 0.025	0.967ProCys: 0.967 ± 0.017	2.208ProAsp: 2.208 ± 0.021	2.619ProGlu: 2.619 ± 0.024	1.936ProPhe: 1.936 ± 0.02	2.398ProGly: 2.398 ± 0.064	0.873ProHis: 0.873 ± 0.014	2.097ProIle: 2.097 ± 0.018	2.337ProLys: 2.337 ± 0.02	3.959ProLeu: 3.959 ± 0.03	0.947ProMet: 0.947 ± 0.011	2.018ProAsn: 2.018 ± 0.016	2.765ProPro: 2.765 ± 0.038	1.504ProGln: 1.504 ± 0.022	1.83ProArg: 1.83 ± 0.021	3.727ProSer: 3.727 ± 0.03	2.515ProThr: 2.515 ± 0.023	3.091ProVal: 3.091 ± 0.021	0.472ProTrp: 0.472 ± 0.009	1.373ProTyr: 1.373 ± 0.017	0.002ProXaa: 0.002 ± 0.0
Gln	2.617GlnAla: 2.617 ± 0.024	1.224GlnCys: 1.224 ± 0.019	1.519GlnAsp: 1.519 ± 0.016	2.266GlnGlu: 2.266 ± 0.021	1.981GlnPhe: 1.981 ± 0.017	1.48GlnGly: 1.48 ± 0.015	1.221GlnHis: 1.221 ± 0.015	2.411GlnIle: 2.411 ± 0.02	2.517GlnLys: 2.517 ± 0.02	4.932GlnLeu: 4.932 ± 0.033	1.202GlnMet: 1.202 ± 0.013	2.096GlnAsn: 2.096 ± 0.02	1.874GlnPro: 1.874 ± 0.022	3.798GlnGln: 3.798 ± 0.075	2.584GlnArg: 2.584 ± 0.021	3.296GlnSer: 3.296 ± 0.026	2.075GlnThr: 2.075 ± 0.019	2.067GlnVal: 2.067 ± 0.019	0.585GlnTrp: 0.585 ± 0.009	1.3GlnTyr: 1.3 ± 0.014	0.001GlnXaa: 0.001 ± 0.0
Arg	2.869ArgAla: 2.869 ± 0.022	1.655ArgCys: 1.655 ± 0.023	2.383ArgAsp: 2.383 ± 0.019	2.972ArgGlu: 2.972 ± 0.022	2.489ArgPhe: 2.489 ± 0.021	2.393ArgGly: 2.393 ± 0.024	1.493ArgHis: 1.493 ± 0.016	3.186ArgIle: 3.186 ± 0.024	3.633ArgLys: 3.633 ± 0.026	5.753ArgLeu: 5.753 ± 0.036	1.454ArgMet: 1.454 ± 0.015	2.679ArgAsn: 2.679 ± 0.022	2.224ArgPro: 2.224 ± 0.021	2.52ArgGln: 2.52 ± 0.022	4.341ArgArg: 4.341 ± 0.037	4.246ArgSer: 4.246 ± 0.038	2.636ArgThr: 2.636 ± 0.024	2.882ArgVal: 2.882 ± 0.022	0.795ArgTrp: 0.795 ± 0.011	1.709ArgTyr: 1.709 ± 0.015	0.001ArgXaa: 0.001 ± 0.0
Ser	5.428SerAla: 5.428 ± 0.03	2.106SerCys: 2.106 ± 0.023	4.5SerAsp: 4.5 ± 0.03	4.97SerGlu: 4.97 ± 0.035	3.557SerPhe: 3.557 ± 0.027	4.472SerGly: 4.472 ± 0.029	1.643SerHis: 1.643 ± 0.015	4.159SerIle: 4.159 ± 0.026	4.679SerLys: 4.679 ± 0.027	7.574SerLeu: 7.574 ± 0.039	1.861SerMet: 1.861 ± 0.016	4.152SerAsn: 4.152 ± 0.027	3.423SerPro: 3.423 ± 0.035	2.82SerGln: 2.82 ± 0.026	4.123SerArg: 4.123 ± 0.031	9.332SerSer: 9.332 ± 0.07	5.108SerThr: 5.108 ± 0.03	5.716SerVal: 5.716 ± 0.032	0.907SerTrp: 0.907 ± 0.012	2.206SerTyr: 2.206 ± 0.02	0.003SerXaa: 0.003 ± 0.001
Thr	4.115ThrAla: 4.115 ± 0.03	1.348ThrCys: 1.348 ± 0.02	2.77ThrAsp: 2.77 ± 0.023	3.142ThrGlu: 3.142 ± 0.024	2.372ThrPhe: 2.372 ± 0.02	2.847ThrGly: 2.847 ± 0.021	0.919ThrHis: 0.919 ± 0.011	2.861ThrIle: 2.861 ± 0.021	2.718ThrLys: 2.718 ± 0.023	4.997ThrLeu: 4.997 ± 0.03	1.24ThrMet: 1.24 ± 0.014	2.431ThrAsn: 2.431 ± 0.021	2.266ThrPro: 2.266 ± 0.022	1.454ThrGln: 1.454 ± 0.014	2.117ThrArg: 2.117 ± 0.019	4.455ThrSer: 4.455 ± 0.031	3.783ThrThr: 3.783 ± 0.039	4.393ThrVal: 4.393 ± 0.029	0.555ThrTrp: 0.555 ± 0.01	1.405ThrTyr: 1.405 ± 0.015	0.001ThrXaa: 0.001 ± 0.0
Val	4.185ValAla: 4.185 ± 0.028	1.668ValCys: 1.668 ± 0.025	4.072ValAsp: 4.072 ± 0.025	4.58ValGlu: 4.58 ± 0.029	2.65ValPhe: 2.65 ± 0.023	3.354ValGly: 3.354 ± 0.023	1.737ValHis: 1.737 ± 0.014	3.598ValIle: 3.598 ± 0.025	3.88ValLys: 3.88 ± 0.028	5.868ValLeu: 5.868 ± 0.034	1.426ValMet: 1.426 ± 0.015	3.092ValAsn: 3.092 ± 0.02	2.641ValPro: 2.641 ± 0.022	2.82ValGln: 2.82 ± 0.022	3.221ValArg: 3.221 ± 0.025	4.695ValSer: 4.695 ± 0.025	3.24ValThr: 3.24 ± 0.023	4.603ValVal: 4.603 ± 0.033	0.722ValTrp: 0.722 ± 0.011	1.92ValTyr: 1.92 ± 0.018	0.002ValXaa: 0.002 ± 0.0
Trp	0.585TrpAla: 0.585 ± 0.01	0.293TrpCys: 0.293 ± 0.007	0.565TrpAsp: 0.565 ± 0.01	0.576TrpGlu: 0.576 ± 0.009	0.562TrpPhe: 0.562 ± 0.01	0.386TrpGly: 0.386 ± 0.009	0.333TrpHis: 0.333 ± 0.006	0.81TrpIle: 0.81 ± 0.012	0.967TrpLys: 0.967 ± 0.012	1.317TrpLeu: 1.317 ± 0.016	0.348TrpMet: 0.348 ± 0.007	0.756TrpAsn: 0.756 ± 0.01	0.48TrpPro: 0.48 ± 0.008	0.545TrpGln: 0.545 ± 0.01	0.704TrpArg: 0.704 ± 0.011	0.999TrpSer: 0.999 ± 0.014	0.712TrpThr: 0.712 ± 0.011	0.512TrpVal: 0.512 ± 0.009	0.183TrpTrp: 0.183 ± 0.006	0.433TrpTyr: 0.433 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.883TyrAla: 1.883 ± 0.017	1.016TyrCys: 1.016 ± 0.014	1.668TyrAsp: 1.668 ± 0.018	1.827TyrGlu: 1.827 ± 0.019	1.769TyrPhe: 1.769 ± 0.02	1.844TyrGly: 1.844 ± 0.019	0.78TyrHis: 0.78 ± 0.011	1.654TyrIle: 1.654 ± 0.017	1.732TyrLys: 1.732 ± 0.02	3.093TyrLeu: 3.093 ± 0.023	0.721TyrMet: 0.721 ± 0.008	1.491TyrAsn: 1.491 ± 0.017	1.369TyrPro: 1.369 ± 0.015	1.219TyrGln: 1.219 ± 0.012	1.782TyrArg: 1.782 ± 0.019	2.485TyrSer: 2.485 ± 0.021	1.501TyrThr: 1.501 ± 0.015	1.89TyrVal: 1.89 ± 0.019	0.463TyrTrp: 0.463 ± 0.01	1.266TyrTyr: 1.266 ± 0.017	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.483XaaXaa: 0.483 ± 0.042

Statistics based on 14914 proteins (6968983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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