Amino acid dipepetide frequency for Xanthomonas phage phiXv2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.433AlaAla: 17.433 ± 4.684
3.698AlaCys: 3.698 ± 1.268
4.226AlaAsp: 4.226 ± 1.028
6.339AlaGlu: 6.339 ± 1.573
3.17AlaPhe: 3.17 ± 1.501
10.037AlaGly: 10.037 ± 2.739
2.113AlaHis: 2.113 ± 1.056
4.226AlaIle: 4.226 ± 1.502
5.283AlaLys: 5.283 ± 2.044
12.15AlaLeu: 12.15 ± 3.077
3.17AlaMet: 3.17 ± 1.164
1.585AlaAsn: 1.585 ± 0.795
4.226AlaPro: 4.226 ± 1.431
3.698AlaGln: 3.698 ± 2.081
10.565AlaArg: 10.565 ± 2.273
7.924AlaSer: 7.924 ± 2.056
4.754AlaThr: 4.754 ± 1.159
8.452AlaVal: 8.452 ± 2.507
3.17AlaTrp: 3.17 ± 1.191
2.113AlaTyr: 2.113 ± 0.68
0.0AlaXaa: 0.0 ± 0.0
Cys
2.641CysAla: 2.641 ± 1.698
0.528CysCys: 0.528 ± 0.701
1.585CysAsp: 1.585 ± 1.176
0.528CysGlu: 0.528 ± 0.518
0.528CysPhe: 0.528 ± 0.483
1.585CysGly: 1.585 ± 0.73
0.0CysHis: 0.0 ± 0.0
1.057CysIle: 1.057 ± 0.546
1.585CysLys: 1.585 ± 0.989
0.0CysLeu: 0.0 ± 0.0
1.057CysMet: 1.057 ± 0.947
0.528CysAsn: 0.528 ± 0.607
2.641CysPro: 2.641 ± 1.688
0.528CysGln: 0.528 ± 0.536
0.528CysArg: 0.528 ± 0.483
2.113CysSer: 2.113 ± 1.06
1.057CysThr: 1.057 ± 0.511
1.585CysVal: 1.585 ± 0.959
0.528CysTrp: 0.528 ± 0.536
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.867AspAla: 6.867 ± 1.219
0.0AspCys: 0.0 ± 0.0
1.057AspAsp: 1.057 ± 0.965
2.641AspGlu: 2.641 ± 1.585
3.698AspPhe: 3.698 ± 2.17
16.376AspGly: 16.376 ± 10.437
0.528AspHis: 0.528 ± 0.536
2.113AspIle: 2.113 ± 1.24
0.0AspLys: 0.0 ± 0.0
3.698AspLeu: 3.698 ± 1.499
0.0AspMet: 0.0 ± 0.0
2.113AspAsn: 2.113 ± 1.07
3.17AspPro: 3.17 ± 1.155
3.17AspGln: 3.17 ± 0.973
5.283AspArg: 5.283 ± 1.894
1.057AspSer: 1.057 ± 0.511
3.698AspThr: 3.698 ± 1.113
3.17AspVal: 3.17 ± 0.885
0.0AspTrp: 0.0 ± 0.0
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
3.17GluAla: 3.17 ± 1.497
0.0GluCys: 0.0 ± 0.0
1.057GluAsp: 1.057 ± 1.012
1.585GluGlu: 1.585 ± 0.913
2.641GluPhe: 2.641 ± 1.025
5.283GluGly: 5.283 ± 1.657
0.0GluHis: 0.0 ± 0.0
1.057GluIle: 1.057 ± 0.908
3.698GluLys: 3.698 ± 1.454
4.754GluLeu: 4.754 ± 1.545
0.528GluMet: 0.528 ± 0.607
1.057GluAsn: 1.057 ± 0.813
0.528GluPro: 0.528 ± 0.518
2.113GluGln: 2.113 ± 0.834
2.113GluArg: 2.113 ± 1.786
3.698GluSer: 3.698 ± 1.27
0.528GluThr: 0.528 ± 0.454
2.113GluVal: 2.113 ± 0.995
1.057GluTrp: 1.057 ± 0.715
0.528GluTyr: 0.528 ± 0.407
0.0GluXaa: 0.0 ± 0.0
Phe
2.641PheAla: 2.641 ± 0.858
0.528PheCys: 0.528 ± 0.454
2.113PheAsp: 2.113 ± 1.3
0.528PheGlu: 0.528 ± 0.407
2.641PhePhe: 2.641 ± 1.108
3.17PheGly: 3.17 ± 1.807
1.585PheHis: 1.585 ± 0.657
1.057PheIle: 1.057 ± 0.511
2.113PheLys: 2.113 ± 0.75
2.113PheLeu: 2.113 ± 1.424
1.585PheMet: 1.585 ± 1.061
3.17PheAsn: 3.17 ± 1.087
3.17PhePro: 3.17 ± 1.357
1.057PheGln: 1.057 ± 0.66
2.641PheArg: 2.641 ± 1.856
1.585PheSer: 1.585 ± 1.448
3.698PheThr: 3.698 ± 1.098
3.17PheVal: 3.17 ± 1.886
1.057PheTrp: 1.057 ± 0.511
2.641PheTyr: 2.641 ± 1.005
0.0PheXaa: 0.0 ± 0.0
Gly
10.565GlyAla: 10.565 ± 2.149
1.585GlyCys: 1.585 ± 0.89
12.678GlyAsp: 12.678 ± 8.748
4.226GlyGlu: 4.226 ± 1.768
3.17GlyPhe: 3.17 ± 1.618
18.489GlyGly: 18.489 ± 8.418
1.057GlyHis: 1.057 ± 0.722
3.17GlyIle: 3.17 ± 0.967
4.754GlyLys: 4.754 ± 1.688
4.754GlyLeu: 4.754 ± 1.778
4.754GlyMet: 4.754 ± 1.738
0.528GlyAsn: 0.528 ± 0.675
3.698GlyPro: 3.698 ± 1.981
3.17GlyGln: 3.17 ± 0.967
5.283GlyArg: 5.283 ± 1.395
9.509GlySer: 9.509 ± 4.064
4.226GlyThr: 4.226 ± 1.647
5.811GlyVal: 5.811 ± 1.687
3.17GlyTrp: 3.17 ± 1.189
2.113GlyTyr: 2.113 ± 0.862
0.0GlyXaa: 0.0 ± 0.0
His
1.057HisAla: 1.057 ± 0.715
1.057HisCys: 1.057 ± 0.644
1.057HisAsp: 1.057 ± 0.628
0.528HisGlu: 0.528 ± 0.407
1.057HisPhe: 1.057 ± 0.733
1.585HisGly: 1.585 ± 0.956
0.0HisHis: 0.0 ± 0.0
1.057HisIle: 1.057 ± 0.813
0.0HisLys: 0.0 ± 0.0
1.057HisLeu: 1.057 ± 0.636
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.057HisPro: 1.057 ± 0.628
0.0HisGln: 0.0 ± 0.0
1.585HisArg: 1.585 ± 0.872
0.528HisSer: 0.528 ± 0.407
1.057HisThr: 1.057 ± 0.636
2.113HisVal: 2.113 ± 0.86
0.0HisTrp: 0.0 ± 0.0
1.585HisTyr: 1.585 ± 0.877
0.0HisXaa: 0.0 ± 0.0
Ile
5.283IleAla: 5.283 ± 1.417
0.0IleCys: 0.0 ± 0.0
3.17IleAsp: 3.17 ± 1.311
2.641IleGlu: 2.641 ± 1.284
1.585IlePhe: 1.585 ± 0.804
4.754IleGly: 4.754 ± 1.885
0.528IleHis: 0.528 ± 0.536
1.057IleIle: 1.057 ± 1.013
0.0IleLys: 0.0 ± 0.0
3.17IleLeu: 3.17 ± 1.563
1.585IleMet: 1.585 ± 0.924
1.057IleAsn: 1.057 ± 0.546
1.057IlePro: 1.057 ± 0.636
1.057IleGln: 1.057 ± 0.511
3.698IleArg: 3.698 ± 1.102
0.528IleSer: 0.528 ± 0.536
1.585IleThr: 1.585 ± 0.977
1.585IleVal: 1.585 ± 1.055
0.528IleTrp: 0.528 ± 0.675
1.585IleTyr: 1.585 ± 0.677
0.0IleXaa: 0.0 ± 0.0
Lys
3.698LysAla: 3.698 ± 1.327
0.528LysCys: 0.528 ± 0.518
3.17LysAsp: 3.17 ± 1.498
1.057LysGlu: 1.057 ± 0.928
2.113LysPhe: 2.113 ± 0.582
4.226LysGly: 4.226 ± 1.302
1.585LysHis: 1.585 ± 0.924
2.113LysIle: 2.113 ± 1.188
3.17LysLys: 3.17 ± 1.14
2.641LysLeu: 2.641 ± 0.89
0.528LysMet: 0.528 ± 0.519
2.641LysAsn: 2.641 ± 1.284
2.641LysPro: 2.641 ± 1.325
0.528LysGln: 0.528 ± 0.518
2.641LysArg: 2.641 ± 1.408
3.17LysSer: 3.17 ± 0.869
1.585LysThr: 1.585 ± 0.977
3.698LysVal: 3.698 ± 1.735
1.585LysTrp: 1.585 ± 0.767
1.057LysTyr: 1.057 ± 0.511
0.0LysXaa: 0.0 ± 0.0
Leu
8.98LeuAla: 8.98 ± 1.855
2.641LeuCys: 2.641 ± 1.523
3.17LeuAsp: 3.17 ± 1.728
1.057LeuGlu: 1.057 ± 0.926
2.113LeuPhe: 2.113 ± 0.75
4.226LeuGly: 4.226 ± 1.14
1.585LeuHis: 1.585 ± 0.633
1.057LeuIle: 1.057 ± 0.644
2.113LeuLys: 2.113 ± 0.862
5.283LeuLeu: 5.283 ± 2.997
1.057LeuMet: 1.057 ± 0.709
0.528LeuAsn: 0.528 ± 0.407
2.641LeuPro: 2.641 ± 1.3
2.113LeuGln: 2.113 ± 1.202
6.339LeuArg: 6.339 ± 1.422
5.811LeuSer: 5.811 ± 1.495
9.509LeuThr: 9.509 ± 2.856
5.811LeuVal: 5.811 ± 1.414
3.17LeuTrp: 3.17 ± 1.546
3.17LeuTyr: 3.17 ± 1.08
0.0LeuXaa: 0.0 ± 0.0
Met
3.17MetAla: 3.17 ± 1.454
0.528MetCys: 0.528 ± 0.483
1.057MetAsp: 1.057 ± 0.69
0.0MetGlu: 0.0 ± 0.0
0.528MetPhe: 0.528 ± 0.701
0.528MetGly: 0.528 ± 0.701
0.528MetHis: 0.528 ± 0.407
1.585MetIle: 1.585 ± 1.045
1.585MetLys: 1.585 ± 0.875
2.641MetLeu: 2.641 ± 0.989
1.057MetMet: 1.057 ± 0.663
0.0MetAsn: 0.0 ± 0.0
1.585MetPro: 1.585 ± 1.211
2.113MetGln: 2.113 ± 1.189
2.641MetArg: 2.641 ± 1.426
1.585MetSer: 1.585 ± 0.976
2.113MetThr: 2.113 ± 0.972
1.585MetVal: 1.585 ± 0.74
0.528MetTrp: 0.528 ± 0.675
1.585MetTyr: 1.585 ± 0.656
0.0MetXaa: 0.0 ± 0.0
Asn
3.698AsnAla: 3.698 ± 1.604
0.528AsnCys: 0.528 ± 0.454
1.585AsnAsp: 1.585 ± 1.313
1.057AsnGlu: 1.057 ± 0.813
1.585AsnPhe: 1.585 ± 0.947
1.585AsnGly: 1.585 ± 1.22
0.528AsnHis: 0.528 ± 0.407
0.528AsnIle: 0.528 ± 0.607
3.17AsnLys: 3.17 ± 0.988
0.528AsnLeu: 0.528 ± 0.536
1.057AsnMet: 1.057 ± 0.636
1.585AsnAsn: 1.585 ± 0.89
0.528AsnPro: 0.528 ± 0.518
0.0AsnGln: 0.0 ± 0.0
2.113AsnArg: 2.113 ± 0.936
0.528AsnSer: 0.528 ± 0.483
2.641AsnThr: 2.641 ± 1.263
1.057AsnVal: 1.057 ± 0.813
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
7.924ProAla: 7.924 ± 2.514
1.057ProCys: 1.057 ± 0.951
4.754ProAsp: 4.754 ± 1.407
1.057ProGlu: 1.057 ± 0.836
0.528ProPhe: 0.528 ± 0.627
3.698ProGly: 3.698 ± 1.288
1.057ProHis: 1.057 ± 0.908
1.585ProIle: 1.585 ± 0.804
2.113ProLys: 2.113 ± 1.145
4.226ProLeu: 4.226 ± 1.297
2.113ProMet: 2.113 ± 1.268
0.528ProAsn: 0.528 ± 0.407
3.698ProPro: 3.698 ± 1.307
0.0ProGln: 0.0 ± 0.0
2.641ProArg: 2.641 ± 1.274
3.698ProSer: 3.698 ± 1.186
1.057ProThr: 1.057 ± 0.908
4.226ProVal: 4.226 ± 1.71
2.113ProTrp: 2.113 ± 0.966
0.528ProTyr: 0.528 ± 0.627
0.0ProXaa: 0.0 ± 0.0
Gln
3.698GlnAla: 3.698 ± 1.718
0.528GlnCys: 0.528 ± 0.536
1.585GlnAsp: 1.585 ± 0.87
2.113GlnGlu: 2.113 ± 0.9
0.0GlnPhe: 0.0 ± 0.0
2.113GlnGly: 2.113 ± 0.972
0.0GlnHis: 0.0 ± 0.0
0.528GlnIle: 0.528 ± 0.454
1.057GlnLys: 1.057 ± 0.511
1.585GlnLeu: 1.585 ± 0.596
0.528GlnMet: 0.528 ± 0.407
1.057GlnAsn: 1.057 ± 0.653
2.641GlnPro: 2.641 ± 1.32
1.585GlnGln: 1.585 ± 1.429
4.226GlnArg: 4.226 ± 1.647
2.641GlnSer: 2.641 ± 1.297
1.585GlnThr: 1.585 ± 0.889
2.113GlnVal: 2.113 ± 1.263
1.585GlnTrp: 1.585 ± 0.87
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
8.452ArgAla: 8.452 ± 1.772
0.0ArgCys: 0.0 ± 0.0
3.17ArgAsp: 3.17 ± 1.25
6.339ArgGlu: 6.339 ± 3.056
1.585ArgPhe: 1.585 ± 0.692
4.754ArgGly: 4.754 ± 1.937
0.0ArgHis: 0.0 ± 0.0
3.698ArgIle: 3.698 ± 1.02
2.641ArgLys: 2.641 ± 1.194
8.98ArgLeu: 8.98 ± 1.577
2.641ArgMet: 2.641 ± 1.13
1.057ArgAsn: 1.057 ± 0.623
1.585ArgPro: 1.585 ± 0.743
0.528ArgGln: 0.528 ± 0.518
5.811ArgArg: 5.811 ± 3.378
4.226ArgSer: 4.226 ± 1.931
4.226ArgThr: 4.226 ± 1.321
4.754ArgVal: 4.754 ± 1.684
2.113ArgTrp: 2.113 ± 1.484
3.17ArgTyr: 3.17 ± 0.838
0.0ArgXaa: 0.0 ± 0.0
Ser
7.396SerAla: 7.396 ± 1.37
2.113SerCys: 2.113 ± 1.437
6.339SerAsp: 6.339 ± 2.538
1.585SerGlu: 1.585 ± 0.836
3.698SerPhe: 3.698 ± 1.679
7.924SerGly: 7.924 ± 2.666
0.0SerHis: 0.0 ± 0.0
1.057SerIle: 1.057 ± 0.78
4.754SerLys: 4.754 ± 1.125
4.226SerLeu: 4.226 ± 1.044
0.0SerMet: 0.0 ± 0.0
1.057SerAsn: 1.057 ± 0.546
4.226SerPro: 4.226 ± 1.321
0.528SerGln: 0.528 ± 0.407
1.585SerArg: 1.585 ± 1.296
4.754SerSer: 4.754 ± 1.912
3.698SerThr: 3.698 ± 1.363
6.339SerVal: 6.339 ± 1.187
0.0SerTrp: 0.0 ± 0.0
1.057SerTyr: 1.057 ± 0.589
0.0SerXaa: 0.0 ± 0.0
Thr
6.867ThrAla: 6.867 ± 1.968
3.17ThrCys: 3.17 ± 1.464
0.528ThrAsp: 0.528 ± 0.483
1.585ThrGlu: 1.585 ± 0.877
2.641ThrPhe: 2.641 ± 0.945
5.283ThrGly: 5.283 ± 2.431
1.585ThrHis: 1.585 ± 0.923
2.641ThrIle: 2.641 ± 1.087
2.113ThrLys: 2.113 ± 1.2
2.641ThrLeu: 2.641 ± 0.89
0.528ThrMet: 0.528 ± 0.47
1.057ThrAsn: 1.057 ± 0.813
3.698ThrPro: 3.698 ± 1.855
4.754ThrGln: 4.754 ± 1.946
2.113ThrArg: 2.113 ± 1.015
2.641ThrSer: 2.641 ± 1.321
4.754ThrThr: 4.754 ± 1.946
5.811ThrVal: 5.811 ± 1.666
0.0ThrTrp: 0.0 ± 0.0
2.641ThrTyr: 2.641 ± 0.914
0.0ThrXaa: 0.0 ± 0.0
Val
10.565ValAla: 10.565 ± 2.137
0.0ValCys: 0.0 ± 0.0
3.17ValAsp: 3.17 ± 1.316
1.057ValGlu: 1.057 ± 0.546
3.17ValPhe: 3.17 ± 1.356
9.509ValGly: 9.509 ± 1.501
2.641ValHis: 2.641 ± 0.817
4.754ValIle: 4.754 ± 1.645
1.585ValLys: 1.585 ± 0.931
5.283ValLeu: 5.283 ± 2.037
3.17ValMet: 3.17 ± 1.625
1.585ValAsn: 1.585 ± 0.967
3.17ValPro: 3.17 ± 0.656
2.641ValGln: 2.641 ± 0.907
4.754ValArg: 4.754 ± 0.937
2.113ValSer: 2.113 ± 0.87
4.226ValThr: 4.226 ± 0.96
5.811ValVal: 5.811 ± 1.126
3.17ValTrp: 3.17 ± 1.372
1.585ValTyr: 1.585 ± 0.596
0.0ValXaa: 0.0 ± 0.0
Trp
2.113TrpAla: 2.113 ± 1.321
1.585TrpCys: 1.585 ± 1.419
1.585TrpAsp: 1.585 ± 1.339
0.0TrpGlu: 0.0 ± 0.0
2.641TrpPhe: 2.641 ± 1.786
0.528TrpGly: 0.528 ± 0.701
0.528TrpHis: 0.528 ± 0.607
1.057TrpIle: 1.057 ± 0.813
1.585TrpLys: 1.585 ± 1.362
1.057TrpLeu: 1.057 ± 1.351
1.057TrpMet: 1.057 ± 0.799
1.057TrpAsn: 1.057 ± 0.59
1.585TrpPro: 1.585 ± 0.877
0.528TrpGln: 0.528 ± 0.675
2.113TrpArg: 2.113 ± 1.467
2.641TrpSer: 2.641 ± 0.943
0.528TrpThr: 0.528 ± 0.407
2.113TrpVal: 2.113 ± 0.848
1.585TrpTrp: 1.585 ± 0.935
0.528TrpTyr: 0.528 ± 0.454
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.113TyrAla: 2.113 ± 0.571
0.528TyrCys: 0.528 ± 0.638
1.585TyrAsp: 1.585 ± 1.22
1.585TyrGlu: 1.585 ± 0.824
3.17TyrPhe: 3.17 ± 1.533
1.585TyrGly: 1.585 ± 0.889
0.528TyrHis: 0.528 ± 0.454
1.057TyrIle: 1.057 ± 0.898
1.057TyrLys: 1.057 ± 0.59
1.585TyrLeu: 1.585 ± 1.02
0.0TyrMet: 0.0 ± 0.0
2.113TyrAsn: 2.113 ± 1.4
1.057TyrPro: 1.057 ± 0.644
1.057TyrGln: 1.057 ± 0.69
1.057TyrArg: 1.057 ± 0.511
1.585TyrSer: 1.585 ± 0.657
0.528TyrThr: 0.528 ± 0.407
2.641TyrVal: 2.641 ± 0.858
1.057TyrTrp: 1.057 ± 0.836
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (1894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski