Amino acid dipepetide frequency for Metarhizium album (strain ARSEF 1941)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.976AlaAla: 10.976 ± 0.097	1.174AlaCys: 1.174 ± 0.018	4.888AlaAsp: 4.888 ± 0.037	5.381AlaGlu: 5.381 ± 0.06	3.145AlaPhe: 3.145 ± 0.029	6.553AlaGly: 6.553 ± 0.048	1.979AlaHis: 1.979 ± 0.022	3.986AlaIle: 3.986 ± 0.036	4.264AlaLys: 4.264 ± 0.038	8.028AlaLeu: 8.028 ± 0.054	2.161AlaMet: 2.161 ± 0.024	3.051AlaAsn: 3.051 ± 0.033	5.114AlaPro: 5.114 ± 0.048	3.581AlaGln: 3.581 ± 0.035	5.844AlaArg: 5.844 ± 0.04	7.962AlaSer: 7.962 ± 0.049	5.488AlaThr: 5.488 ± 0.042	6.177AlaVal: 6.177 ± 0.048	1.251AlaTrp: 1.251 ± 0.02	2.117AlaTyr: 2.117 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.052CysAla: 1.052 ± 0.02	0.246CysCys: 0.246 ± 0.008	0.687CysAsp: 0.687 ± 0.012	0.615CysGlu: 0.615 ± 0.013	0.527CysPhe: 0.527 ± 0.012	0.991CysGly: 0.991 ± 0.019	0.346CysHis: 0.346 ± 0.01	0.651CysIle: 0.651 ± 0.014	0.521CysLys: 0.521 ± 0.013	1.296CysLeu: 1.296 ± 0.019	0.26CysMet: 0.26 ± 0.009	0.442CysAsn: 0.442 ± 0.013	0.705CysPro: 0.705 ± 0.013	0.465CysGln: 0.465 ± 0.013	0.849CysArg: 0.849 ± 0.015	0.946CysSer: 0.946 ± 0.016	0.687CysThr: 0.687 ± 0.015	0.826CysVal: 0.826 ± 0.015	0.2CysTrp: 0.2 ± 0.009	0.33CysTyr: 0.33 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.586AspAla: 5.586 ± 0.041	0.691AspCys: 0.691 ± 0.013	4.879AspAsp: 4.879 ± 0.055	4.709AspGlu: 4.709 ± 0.047	2.177AspPhe: 2.177 ± 0.025	4.775AspGly: 4.775 ± 0.039	1.258AspHis: 1.258 ± 0.02	2.777AspIle: 2.777 ± 0.027	2.653AspLys: 2.653 ± 0.034	4.896AspLeu: 4.896 ± 0.041	1.435AspMet: 1.435 ± 0.019	1.826AspAsn: 1.826 ± 0.022	3.138AspPro: 3.138 ± 0.032	1.906AspGln: 1.906 ± 0.024	3.266AspArg: 3.266 ± 0.04	4.188AspSer: 4.188 ± 0.037	2.837AspThr: 2.837 ± 0.024	4.117AspVal: 4.117 ± 0.032	0.858AspTrp: 0.858 ± 0.015	1.513AspTyr: 1.513 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.819GluAla: 5.819 ± 0.05	0.625GluCys: 0.625 ± 0.012	4.04GluAsp: 4.04 ± 0.038	4.827GluGlu: 4.827 ± 0.06	1.864GluPhe: 1.864 ± 0.021	3.487GluGly: 3.487 ± 0.033	1.42GluHis: 1.42 ± 0.019	2.631GluIle: 2.631 ± 0.031	3.356GluLys: 3.356 ± 0.038	5.197GluLeu: 5.197 ± 0.048	1.444GluMet: 1.444 ± 0.02	2.055GluAsn: 2.055 ± 0.025	2.926GluPro: 2.926 ± 0.03	2.482GluGln: 2.482 ± 0.034	3.983GluArg: 3.983 ± 0.042	4.191GluSer: 4.191 ± 0.042	3.352GluThr: 3.352 ± 0.033	3.362GluVal: 3.362 ± 0.03	0.818GluTrp: 0.818 ± 0.013	1.535GluTyr: 1.535 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.086PheAla: 3.086 ± 0.033	0.537PheCys: 0.537 ± 0.012	2.253PheAsp: 2.253 ± 0.024	2.014PheGlu: 2.014 ± 0.025	1.487PhePhe: 1.487 ± 0.02	2.774PheGly: 2.774 ± 0.033	0.863PheHis: 0.863 ± 0.014	1.575PheIle: 1.575 ± 0.021	1.452PheLys: 1.452 ± 0.022	3.196PheLeu: 3.196 ± 0.034	0.755PheMet: 0.755 ± 0.015	1.323PheAsn: 1.323 ± 0.018	1.823PhePro: 1.823 ± 0.023	1.317PheGln: 1.317 ± 0.019	2.011PheArg: 2.011 ± 0.024	2.769PheSer: 2.769 ± 0.028	1.911PheThr: 1.911 ± 0.027	2.398PheVal: 2.398 ± 0.027	0.594PheTrp: 0.594 ± 0.013	0.986PheTyr: 0.986 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.921GlyAla: 5.921 ± 0.048	0.904GlyCys: 0.904 ± 0.018	4.019GlyAsp: 4.019 ± 0.037	3.792GlyGlu: 3.792 ± 0.033	2.693GlyPhe: 2.693 ± 0.034	6.186GlyGly: 6.186 ± 0.068	1.917GlyHis: 1.917 ± 0.024	3.344GlyIle: 3.344 ± 0.035	3.409GlyLys: 3.409 ± 0.034	6.15GlyLeu: 6.15 ± 0.044	1.62GlyMet: 1.62 ± 0.021	2.561GlyAsn: 2.561 ± 0.032	3.695GlyPro: 3.695 ± 0.039	2.819GlyGln: 2.819 ± 0.034	4.85GlyArg: 4.85 ± 0.044	5.986GlySer: 5.986 ± 0.05	4.005GlyThr: 4.005 ± 0.039	4.461GlyVal: 4.461 ± 0.035	1.152GlyTrp: 1.152 ± 0.016	1.984GlyTyr: 1.984 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.033HisAla: 2.033 ± 0.022	0.346HisCys: 0.346 ± 0.01	1.519HisAsp: 1.519 ± 0.022	1.377HisGlu: 1.377 ± 0.019	0.854HisPhe: 0.854 ± 0.015	1.99HisGly: 1.99 ± 0.026	0.951HisHis: 0.951 ± 0.021	1.101HisIle: 1.101 ± 0.016	0.95HisLys: 0.95 ± 0.014	2.267HisLeu: 2.267 ± 0.026	0.534HisMet: 0.534 ± 0.012	0.779HisAsn: 0.779 ± 0.015	1.629HisPro: 1.629 ± 0.021	1.093HisGln: 1.093 ± 0.02	1.649HisArg: 1.649 ± 0.024	1.757HisSer: 1.757 ± 0.022	1.162HisThr: 1.162 ± 0.017	1.718HisVal: 1.718 ± 0.022	0.321HisTrp: 0.321 ± 0.008	0.624HisTyr: 0.624 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.787IleAla: 3.787 ± 0.032	0.675IleCys: 0.675 ± 0.014	2.598IleAsp: 2.598 ± 0.026	2.463IleGlu: 2.463 ± 0.029	1.714IlePhe: 1.714 ± 0.026	2.867IleGly: 2.867 ± 0.028	1.11IleHis: 1.11 ± 0.017	2.042IleIle: 2.042 ± 0.027	2.05IleLys: 2.05 ± 0.022	4.086IleLeu: 4.086 ± 0.039	0.971IleMet: 0.971 ± 0.015	1.559IleAsn: 1.559 ± 0.021	2.665IlePro: 2.665 ± 0.025	1.734IleGln: 1.734 ± 0.02	2.749IleArg: 2.749 ± 0.027	3.443IleSer: 3.443 ± 0.026	2.398IleThr: 2.398 ± 0.028	2.953IleVal: 2.953 ± 0.03	0.645IleTrp: 0.645 ± 0.013	1.172IleTyr: 1.172 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.378LysAla: 4.378 ± 0.04	0.479LysCys: 0.479 ± 0.013	2.74LysAsp: 2.74 ± 0.036	2.993LysGlu: 2.993 ± 0.035	1.439LysPhe: 1.439 ± 0.019	2.878LysGly: 2.878 ± 0.03	1.138LysHis: 1.138 ± 0.015	2.085LysIle: 2.085 ± 0.026	3.307LysLys: 3.307 ± 0.101	4.063LysLeu: 4.063 ± 0.037	1.026LysMet: 1.026 ± 0.018	1.626LysAsn: 1.626 ± 0.024	2.68LysPro: 2.68 ± 0.034	1.865LysGln: 1.865 ± 0.027	3.46LysArg: 3.46 ± 0.038	3.456LysSer: 3.456 ± 0.035	2.802LysThr: 2.802 ± 0.026	2.693LysVal: 2.693 ± 0.027	0.63LysTrp: 0.63 ± 0.013	1.277LysTyr: 1.277 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.333LeuAla: 8.333 ± 0.057	1.243LeuCys: 1.243 ± 0.02	5.411LeuAsp: 5.411 ± 0.039	5.216LeuGlu: 5.216 ± 0.048	3.112LeuPhe: 3.112 ± 0.034	6.183LeuGly: 6.183 ± 0.051	2.158LeuHis: 2.158 ± 0.021	3.427LeuIle: 3.427 ± 0.036	3.914LeuLys: 3.914 ± 0.041	8.174LeuLeu: 8.174 ± 0.075	1.783LeuMet: 1.783 ± 0.022	2.892LeuAsn: 2.892 ± 0.03	5.366LeuPro: 5.366 ± 0.038	3.721LeuGln: 3.721 ± 0.037	6.117LeuArg: 6.117 ± 0.041	7.078LeuSer: 7.078 ± 0.05	4.554LeuThr: 4.554 ± 0.036	5.794LeuVal: 5.794 ± 0.051	1.152LeuTrp: 1.152 ± 0.019	2.184LeuTyr: 2.184 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.449MetAla: 2.449 ± 0.026	0.259MetCys: 0.259 ± 0.008	1.348MetAsp: 1.348 ± 0.019	1.275MetGlu: 1.275 ± 0.018	0.703MetPhe: 0.703 ± 0.013	1.5MetGly: 1.5 ± 0.02	0.465MetHis: 0.465 ± 0.011	0.883MetIle: 0.883 ± 0.016	0.974MetLys: 0.974 ± 0.016	1.894MetLeu: 1.894 ± 0.024	0.604MetMet: 0.604 ± 0.013	0.747MetAsn: 0.747 ± 0.014	1.376MetPro: 1.376 ± 0.019	0.893MetGln: 0.893 ± 0.016	1.345MetArg: 1.345 ± 0.016	1.896MetSer: 1.896 ± 0.022	1.355MetThr: 1.355 ± 0.02	1.313MetVal: 1.313 ± 0.019	0.272MetTrp: 0.272 ± 0.009	0.529MetTyr: 0.529 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.013AsnAla: 3.013 ± 0.029	0.436AsnCys: 0.436 ± 0.01	1.884AsnAsp: 1.884 ± 0.021	1.843AsnGlu: 1.843 ± 0.025	1.286AsnPhe: 1.286 ± 0.017	2.84AsnGly: 2.84 ± 0.037	0.83AsnHis: 0.83 ± 0.016	1.752AsnIle: 1.752 ± 0.022	1.564AsnLys: 1.564 ± 0.021	3.044AsnLeu: 3.044 ± 0.03	0.855AsnMet: 0.855 ± 0.014	1.327AsnAsn: 1.327 ± 0.021	2.188AsnPro: 2.188 ± 0.025	1.232AsnGln: 1.232 ± 0.02	1.967AsnArg: 1.967 ± 0.021	2.528AsnSer: 2.528 ± 0.028	1.938AsnThr: 1.938 ± 0.029	2.269AsnVal: 2.269 ± 0.024	0.495AsnTrp: 0.495 ± 0.011	0.919AsnTyr: 0.919 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.776ProAla: 5.776 ± 0.051	0.612ProCys: 0.612 ± 0.012	3.376ProAsp: 3.376 ± 0.03	3.673ProGlu: 3.673 ± 0.03	1.958ProPhe: 1.958 ± 0.025	4.485ProGly: 4.485 ± 0.048	1.366ProHis: 1.366 ± 0.02	2.168ProIle: 2.168 ± 0.024	2.524ProLys: 2.524 ± 0.027	4.634ProLeu: 4.634 ± 0.041	1.057ProMet: 1.057 ± 0.017	1.994ProAsn: 1.994 ± 0.024	5.527ProPro: 5.527 ± 0.089	2.44ProGln: 2.44 ± 0.034	3.96ProArg: 3.96 ± 0.042	5.953ProSer: 5.953 ± 0.048	3.713ProThr: 3.713 ± 0.042	3.756ProVal: 3.756 ± 0.028	0.761ProTrp: 0.761 ± 0.014	1.354ProTyr: 1.354 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.679GlnAla: 3.679 ± 0.034	0.43GlnCys: 0.43 ± 0.011	2.281GlnAsp: 2.281 ± 0.025	2.271GlnGlu: 2.271 ± 0.026	1.206GlnPhe: 1.206 ± 0.019	2.604GlnGly: 2.604 ± 0.031	1.191GlnHis: 1.191 ± 0.022	1.686GlnIle: 1.686 ± 0.019	1.87GlnLys: 1.87 ± 0.025	3.452GlnLeu: 3.452 ± 0.036	0.897GlnMet: 0.897 ± 0.02	1.399GlnAsn: 1.399 ± 0.027	2.65GlnPro: 2.65 ± 0.038	2.582GlnGln: 2.582 ± 0.075	2.853GlnArg: 2.853 ± 0.029	3.087GlnSer: 3.087 ± 0.031	2.26GlnThr: 2.26 ± 0.025	2.379GlnVal: 2.379 ± 0.025	0.547GlnTrp: 0.547 ± 0.011	1.073GlnTyr: 1.073 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.558ArgAla: 5.558 ± 0.048	0.799ArgCys: 0.799 ± 0.017	3.913ArgAsp: 3.913 ± 0.046	4.016ArgGlu: 4.016 ± 0.038	2.162ArgPhe: 2.162 ± 0.024	4.364ArgGly: 4.364 ± 0.038	1.88ArgHis: 1.88 ± 0.023	2.821ArgIle: 2.821 ± 0.027	3.457ArgLys: 3.457 ± 0.037	5.999ArgLeu: 5.999 ± 0.044	1.399ArgMet: 1.399 ± 0.017	2.301ArgAsn: 2.301 ± 0.022	4.057ArgPro: 4.057 ± 0.041	2.999ArgGln: 2.999 ± 0.026	6.217ArgArg: 6.217 ± 0.068	5.039ArgSer: 5.039 ± 0.041	3.383ArgThr: 3.383 ± 0.03	3.679ArgVal: 3.679 ± 0.029	0.94ArgTrp: 0.94 ± 0.016	1.632ArgTyr: 1.632 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.06SerAla: 7.06 ± 0.047	0.937SerCys: 0.937 ± 0.015	4.274SerAsp: 4.274 ± 0.038	3.965SerGlu: 3.965 ± 0.037	2.824SerPhe: 2.824 ± 0.028	5.689SerGly: 5.689 ± 0.054	1.991SerHis: 1.991 ± 0.026	3.537SerIle: 3.537 ± 0.035	3.593SerLys: 3.593 ± 0.033	7.066SerLeu: 7.066 ± 0.052	1.734SerMet: 1.734 ± 0.022	2.755SerAsn: 2.755 ± 0.032	5.718SerPro: 5.718 ± 0.055	3.335SerGln: 3.335 ± 0.031	5.669SerArg: 5.669 ± 0.044	8.481SerSer: 8.481 ± 0.081	5.136SerThr: 5.136 ± 0.042	4.724SerVal: 4.724 ± 0.037	1.101SerTrp: 1.101 ± 0.017	1.897SerTyr: 1.897 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.426ThrAla: 5.426 ± 0.042	0.759ThrCys: 0.759 ± 0.014	2.776ThrAsp: 2.776 ± 0.028	2.919ThrGlu: 2.919 ± 0.031	1.972ThrPhe: 1.972 ± 0.023	4.168ThrGly: 4.168 ± 0.049	1.223ThrHis: 1.223 ± 0.017	2.643ThrIle: 2.643 ± 0.025	2.484ThrLys: 2.484 ± 0.025	4.85ThrLeu: 4.85 ± 0.039	1.197ThrMet: 1.197 ± 0.018	1.855ThrAsn: 1.855 ± 0.022	4.14ThrPro: 4.14 ± 0.04	1.964ThrGln: 1.964 ± 0.022	3.425ThrArg: 3.425 ± 0.03	5.071ThrSer: 5.071 ± 0.042	3.946ThrThr: 3.946 ± 0.049	3.657ThrVal: 3.657 ± 0.038	0.818ThrTrp: 0.818 ± 0.015	1.447ThrTyr: 1.447 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.94ValAla: 5.94 ± 0.047	0.911ValCys: 0.911 ± 0.016	4.076ValAsp: 4.076 ± 0.038	3.845ValGlu: 3.845 ± 0.032	2.435ValPhe: 2.435 ± 0.031	4.292ValGly: 4.292 ± 0.036	1.487ValHis: 1.487 ± 0.019	2.728ValIle: 2.728 ± 0.029	2.906ValLys: 2.906 ± 0.031	5.748ValLeu: 5.748 ± 0.044	1.371ValMet: 1.371 ± 0.015	2.178ValAsn: 2.178 ± 0.021	3.775ValPro: 3.775 ± 0.036	2.417ValGln: 2.417 ± 0.026	3.806ValArg: 3.806 ± 0.029	4.78ValSer: 4.78 ± 0.038	3.519ValThr: 3.519 ± 0.031	4.733ValVal: 4.733 ± 0.049	0.835ValTrp: 0.835 ± 0.016	1.678ValTyr: 1.678 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.182TrpAla: 1.182 ± 0.017	0.194TrpCys: 0.194 ± 0.006	0.915TrpAsp: 0.915 ± 0.015	0.804TrpGlu: 0.804 ± 0.015	0.5TrpPhe: 0.5 ± 0.011	0.876TrpGly: 0.876 ± 0.017	0.38TrpHis: 0.38 ± 0.01	0.672TrpIle: 0.672 ± 0.013	0.739TrpLys: 0.739 ± 0.014	1.301TrpLeu: 1.301 ± 0.02	0.36TrpMet: 0.36 ± 0.012	0.57TrpAsn: 0.57 ± 0.013	0.628TrpPro: 0.628 ± 0.014	0.558TrpGln: 0.558 ± 0.012	0.99TrpArg: 0.99 ± 0.015	1.019TrpSer: 1.019 ± 0.016	0.891TrpThr: 0.891 ± 0.015	0.835TrpVal: 0.835 ± 0.015	0.284TrpTrp: 0.284 ± 0.009	0.374TrpTyr: 0.374 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.065TyrAla: 2.065 ± 0.025	0.385TyrCys: 0.385 ± 0.01	1.606TyrAsp: 1.606 ± 0.037	1.413TyrGlu: 1.413 ± 0.022	1.067TyrPhe: 1.067 ± 0.017	1.965TyrGly: 1.965 ± 0.026	0.704TyrHis: 0.704 ± 0.013	1.172TyrIle: 1.172 ± 0.016	1.027TyrLys: 1.027 ± 0.016	2.469TyrLeu: 2.469 ± 0.027	0.617TyrMet: 0.617 ± 0.012	0.971TyrAsn: 0.971 ± 0.015	1.288TyrPro: 1.288 ± 0.021	0.993TyrGln: 0.993 ± 0.016	1.604TyrArg: 1.604 ± 0.021	1.857TyrSer: 1.857 ± 0.02	1.404TyrThr: 1.404 ± 0.021	1.618TyrVal: 1.618 ± 0.021	0.397TyrTrp: 0.397 ± 0.009	0.817TyrTyr: 0.817 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8389 proteins (4223730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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