Amino acid dipepetide frequency for Dishui Lake virophage 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.16AlaCys: 0.16 ± 0.154
3.521AlaAsp: 3.521 ± 0.64
6.241AlaGlu: 6.241 ± 1.42
2.56AlaPhe: 2.56 ± 0.589
5.921AlaGly: 5.921 ± 1.498
0.64AlaHis: 0.64 ± 0.354
2.08AlaIle: 2.08 ± 0.68
6.081AlaLys: 6.081 ± 1.541
5.921AlaLeu: 5.921 ± 0.932
0.96AlaMet: 0.96 ± 0.462
4.001AlaAsn: 4.001 ± 0.577
2.24AlaPro: 2.24 ± 0.58
2.24AlaGln: 2.24 ± 0.838
2.4AlaArg: 2.4 ± 0.648
4.481AlaSer: 4.481 ± 1.479
4.481AlaThr: 4.481 ± 0.96
4.641AlaVal: 4.641 ± 0.998
0.48AlaTrp: 0.48 ± 0.267
3.04AlaTyr: 3.04 ± 0.687
0.0AlaXaa: 0.0 ± 0.0
Cys
0.48CysAla: 0.48 ± 0.22
0.32CysCys: 0.32 ± 0.272
1.12CysAsp: 1.12 ± 0.334
0.8CysGlu: 0.8 ± 0.31
0.32CysPhe: 0.32 ± 0.196
1.44CysGly: 1.44 ± 0.285
0.0CysHis: 0.0 ± 0.0
0.96CysIle: 0.96 ± 0.356
0.48CysLys: 0.48 ± 0.237
1.44CysLeu: 1.44 ± 0.422
0.32CysMet: 0.32 ± 0.164
0.48CysAsn: 0.48 ± 0.235
0.48CysPro: 0.48 ± 0.334
0.0CysGln: 0.0 ± 0.0
0.16CysArg: 0.16 ± 0.16
1.12CysSer: 1.12 ± 0.559
0.0CysThr: 0.0 ± 0.0
0.48CysVal: 0.48 ± 0.237
0.0CysTrp: 0.0 ± 0.0
0.48CysTyr: 0.48 ± 0.279
0.0CysXaa: 0.0 ± 0.0
Asp
3.04AspAla: 3.04 ± 0.574
0.8AspCys: 0.8 ± 0.298
2.56AspAsp: 2.56 ± 0.774
2.56AspGlu: 2.56 ± 0.639
4.961AspPhe: 4.961 ± 0.975
4.321AspGly: 4.321 ± 0.712
0.48AspHis: 0.48 ± 0.268
5.281AspIle: 5.281 ± 0.644
4.961AspLys: 4.961 ± 1.105
5.441AspLeu: 5.441 ± 0.969
0.48AspMet: 0.48 ± 0.25
2.4AspAsn: 2.4 ± 0.512
3.361AspPro: 3.361 ± 0.935
1.12AspGln: 1.12 ± 0.259
2.56AspArg: 2.56 ± 0.921
3.201AspSer: 3.201 ± 0.708
2.56AspThr: 2.56 ± 0.537
3.841AspVal: 3.841 ± 0.744
0.8AspTrp: 0.8 ± 0.349
3.361AspTyr: 3.361 ± 0.765
0.0AspXaa: 0.0 ± 0.0
Glu
3.04GluAla: 3.04 ± 0.9
0.96GluCys: 0.96 ± 0.396
3.681GluAsp: 3.681 ± 0.875
4.641GluGlu: 4.641 ± 1.574
2.08GluPhe: 2.08 ± 0.74
2.56GluGly: 2.56 ± 0.825
0.96GluHis: 0.96 ± 0.392
4.961GluIle: 4.961 ± 0.856
7.521GluLys: 7.521 ± 1.49
5.121GluLeu: 5.121 ± 0.737
2.08GluMet: 2.08 ± 0.813
3.201GluAsn: 3.201 ± 0.558
1.92GluPro: 1.92 ± 0.499
2.72GluGln: 2.72 ± 0.788
2.56GluArg: 2.56 ± 0.624
0.64GluSer: 0.64 ± 0.281
3.521GluThr: 3.521 ± 0.876
3.361GluVal: 3.361 ± 1.092
1.28GluTrp: 1.28 ± 0.503
2.56GluTyr: 2.56 ± 0.519
0.0GluXaa: 0.0 ± 0.0
Phe
2.72PheAla: 2.72 ± 0.614
0.16PheCys: 0.16 ± 0.175
2.56PheAsp: 2.56 ± 0.496
2.72PheGlu: 2.72 ± 0.823
1.12PhePhe: 1.12 ± 0.35
4.001PheGly: 4.001 ± 0.81
0.48PheHis: 0.48 ± 0.228
3.201PheIle: 3.201 ± 0.65
2.4PheLys: 2.4 ± 0.461
3.521PheLeu: 3.521 ± 0.637
0.64PheMet: 0.64 ± 0.281
3.841PheAsn: 3.841 ± 0.897
2.88PhePro: 2.88 ± 0.845
2.08PheGln: 2.08 ± 0.56
1.6PheArg: 1.6 ± 0.484
2.56PheSer: 2.56 ± 0.524
2.72PheThr: 2.72 ± 0.627
3.04PheVal: 3.04 ± 0.773
0.32PheTrp: 0.32 ± 0.209
1.6PheTyr: 1.6 ± 0.482
0.0PheXaa: 0.0 ± 0.0
Gly
4.641GlyAla: 4.641 ± 1.298
0.48GlyCys: 0.48 ± 0.317
4.801GlyAsp: 4.801 ± 0.747
3.201GlyGlu: 3.201 ± 0.95
2.4GlyPhe: 2.4 ± 0.521
6.881GlyGly: 6.881 ± 1.874
0.64GlyHis: 0.64 ± 0.348
3.681GlyIle: 3.681 ± 0.835
5.761GlyLys: 5.761 ± 1.606
5.121GlyLeu: 5.121 ± 0.657
1.76GlyMet: 1.76 ± 0.833
4.321GlyAsn: 4.321 ± 0.765
0.0GlyPro: 0.0 ± 0.0
2.24GlyGln: 2.24 ± 0.649
2.4GlyArg: 2.4 ± 0.515
6.241GlySer: 6.241 ± 1.312
4.161GlyThr: 4.161 ± 1.256
3.201GlyVal: 3.201 ± 0.711
0.8GlyTrp: 0.8 ± 0.368
3.361GlyTyr: 3.361 ± 0.766
0.0GlyXaa: 0.0 ± 0.0
His
0.32HisAla: 0.32 ± 0.267
0.16HisCys: 0.16 ± 0.136
0.64HisAsp: 0.64 ± 0.253
0.48HisGlu: 0.48 ± 0.364
1.92HisPhe: 1.92 ± 0.67
0.32HisGly: 0.32 ± 0.336
0.16HisHis: 0.16 ± 0.165
0.16HisIle: 0.16 ± 0.149
0.16HisLys: 0.16 ± 0.13
1.28HisLeu: 1.28 ± 0.478
0.0HisMet: 0.0 ± 0.0
0.16HisAsn: 0.16 ± 0.175
0.32HisPro: 0.32 ± 0.225
0.64HisGln: 0.64 ± 0.239
1.28HisArg: 1.28 ± 0.481
1.12HisSer: 1.12 ± 0.415
1.12HisThr: 1.12 ± 0.396
0.0HisVal: 0.0 ± 0.0
0.32HisTrp: 0.32 ± 0.23
0.96HisTyr: 0.96 ± 0.338
0.0HisXaa: 0.0 ± 0.0
Ile
2.4IleAla: 2.4 ± 0.641
0.64IleCys: 0.64 ± 0.315
3.361IleAsp: 3.361 ± 0.873
4.161IleGlu: 4.161 ± 1.017
1.76IlePhe: 1.76 ± 0.572
4.161IleGly: 4.161 ± 1.145
1.28IleHis: 1.28 ± 0.346
4.161IleIle: 4.161 ± 0.839
6.881IleLys: 6.881 ± 1.082
4.641IleLeu: 4.641 ± 0.819
0.64IleMet: 0.64 ± 0.295
5.281IleAsn: 5.281 ± 1.274
4.481IlePro: 4.481 ± 1.006
2.88IleGln: 2.88 ± 0.542
2.4IleArg: 2.4 ± 0.541
3.681IleSer: 3.681 ± 1.036
5.761IleThr: 5.761 ± 0.911
3.841IleVal: 3.841 ± 0.535
0.48IleTrp: 0.48 ± 0.235
2.08IleTyr: 2.08 ± 0.736
0.0IleXaa: 0.0 ± 0.0
Lys
5.761LysAla: 5.761 ± 1.346
0.96LysCys: 0.96 ± 0.36
4.321LysAsp: 4.321 ± 1.019
5.921LysGlu: 5.921 ± 1.436
2.88LysPhe: 2.88 ± 0.699
3.841LysGly: 3.841 ± 1.067
2.08LysHis: 2.08 ± 0.567
4.801LysIle: 4.801 ± 1.31
9.281LysLys: 9.281 ± 1.698
6.401LysLeu: 6.401 ± 1.408
3.361LysMet: 3.361 ± 0.698
3.201LysAsn: 3.201 ± 0.642
4.481LysPro: 4.481 ± 1.218
3.04LysGln: 3.04 ± 0.803
3.681LysArg: 3.681 ± 0.863
6.241LysSer: 6.241 ± 1.09
4.801LysThr: 4.801 ± 0.9
3.04LysVal: 3.04 ± 0.634
2.4LysTrp: 2.4 ± 1.128
3.201LysTyr: 3.201 ± 0.87
0.0LysXaa: 0.0 ± 0.0
Leu
3.361LeuAla: 3.361 ± 0.685
0.96LeuCys: 0.96 ± 0.453
4.321LeuAsp: 4.321 ± 0.8
4.161LeuGlu: 4.161 ± 0.9
4.801LeuPhe: 4.801 ± 0.713
4.481LeuGly: 4.481 ± 0.835
0.48LeuHis: 0.48 ± 0.276
5.441LeuIle: 5.441 ± 0.962
9.762LeuLys: 9.762 ± 1.866
6.241LeuLeu: 6.241 ± 1.535
1.92LeuMet: 1.92 ± 0.619
5.761LeuAsn: 5.761 ± 0.982
3.521LeuPro: 3.521 ± 0.903
3.841LeuGln: 3.841 ± 0.461
2.24LeuArg: 2.24 ± 0.505
7.041LeuSer: 7.041 ± 1.106
7.361LeuThr: 7.361 ± 1.155
4.641LeuVal: 4.641 ± 0.764
0.48LeuTrp: 0.48 ± 0.236
3.361LeuTyr: 3.361 ± 0.935
0.0LeuXaa: 0.0 ± 0.0
Met
1.76MetAla: 1.76 ± 0.621
0.16MetCys: 0.16 ± 0.151
1.28MetAsp: 1.28 ± 0.559
2.08MetGlu: 2.08 ± 0.575
0.8MetPhe: 0.8 ± 0.286
1.12MetGly: 1.12 ± 0.348
0.0MetHis: 0.0 ± 0.0
1.44MetIle: 1.44 ± 0.519
1.12MetLys: 1.12 ± 0.297
1.28MetLeu: 1.28 ± 0.602
0.8MetMet: 0.8 ± 0.399
1.6MetAsn: 1.6 ± 0.401
0.64MetPro: 0.64 ± 0.298
0.0MetGln: 0.0 ± 0.0
0.8MetArg: 0.8 ± 0.276
2.72MetSer: 2.72 ± 0.638
2.08MetThr: 2.08 ± 0.555
1.6MetVal: 1.6 ± 0.549
0.0MetTrp: 0.0 ± 0.0
0.32MetTyr: 0.32 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
4.801AsnAla: 4.801 ± 0.989
0.8AsnCys: 0.8 ± 0.283
2.72AsnAsp: 2.72 ± 0.829
2.72AsnGlu: 2.72 ± 0.607
2.56AsnPhe: 2.56 ± 0.532
4.961AsnGly: 4.961 ± 0.821
0.48AsnHis: 0.48 ± 0.227
4.481AsnIle: 4.481 ± 1.009
3.841AsnLys: 3.841 ± 0.757
6.081AsnLeu: 6.081 ± 0.901
1.44AsnMet: 1.44 ± 0.529
4.321AsnAsn: 4.321 ± 1.032
3.361AsnPro: 3.361 ± 0.649
2.24AsnGln: 2.24 ± 0.728
1.28AsnArg: 1.28 ± 0.416
5.921AsnSer: 5.921 ± 0.889
3.841AsnThr: 3.841 ± 0.845
2.88AsnVal: 2.88 ± 0.746
0.8AsnTrp: 0.8 ± 0.357
3.521AsnTyr: 3.521 ± 0.842
0.0AsnXaa: 0.0 ± 0.0
Pro
4.481ProAla: 4.481 ± 0.899
0.32ProCys: 0.32 ± 0.303
2.4ProAsp: 2.4 ± 0.631
2.72ProGlu: 2.72 ± 0.608
1.6ProPhe: 1.6 ± 0.524
0.0ProGly: 0.0 ± 0.0
0.8ProHis: 0.8 ± 0.397
4.161ProIle: 4.161 ± 1.099
4.001ProLys: 4.001 ± 1.118
4.321ProLeu: 4.321 ± 0.797
0.48ProMet: 0.48 ± 0.232
3.201ProAsn: 3.201 ± 0.604
2.08ProPro: 2.08 ± 0.663
0.96ProGln: 0.96 ± 0.487
1.28ProArg: 1.28 ± 0.339
4.161ProSer: 4.161 ± 1.198
3.841ProThr: 3.841 ± 1.014
4.001ProVal: 4.001 ± 0.824
0.0ProTrp: 0.0 ± 0.0
1.44ProTyr: 1.44 ± 0.45
0.0ProXaa: 0.0 ± 0.0
Gln
3.361GlnAla: 3.361 ± 0.686
0.16GlnCys: 0.16 ± 0.141
1.76GlnAsp: 1.76 ± 0.427
1.6GlnGlu: 1.6 ± 0.45
1.44GlnPhe: 1.44 ± 0.488
1.28GlnGly: 1.28 ± 0.458
0.16GlnHis: 0.16 ± 0.149
2.4GlnIle: 2.4 ± 0.633
2.4GlnLys: 2.4 ± 0.686
2.72GlnLeu: 2.72 ± 0.841
1.76GlnMet: 1.76 ± 0.733
1.92GlnAsn: 1.92 ± 0.462
2.24GlnPro: 2.24 ± 0.415
1.6GlnGln: 1.6 ± 0.391
2.4GlnArg: 2.4 ± 0.848
2.4GlnSer: 2.4 ± 0.623
1.28GlnThr: 1.28 ± 0.482
2.88GlnVal: 2.88 ± 0.602
0.16GlnTrp: 0.16 ± 0.136
2.08GlnTyr: 2.08 ± 0.498
0.0GlnXaa: 0.0 ± 0.0
Arg
2.4ArgAla: 2.4 ± 0.627
0.64ArgCys: 0.64 ± 0.287
1.44ArgAsp: 1.44 ± 0.423
3.361ArgGlu: 3.361 ± 0.83
1.76ArgPhe: 1.76 ± 0.468
1.76ArgGly: 1.76 ± 0.601
0.8ArgHis: 0.8 ± 0.325
2.72ArgIle: 2.72 ± 0.95
3.201ArgLys: 3.201 ± 0.811
3.841ArgLeu: 3.841 ± 0.996
1.12ArgMet: 1.12 ± 0.542
2.4ArgAsn: 2.4 ± 0.492
1.76ArgPro: 1.76 ± 0.489
1.12ArgGln: 1.12 ± 0.423
1.44ArgArg: 1.44 ± 0.541
0.8ArgSer: 0.8 ± 0.327
1.92ArgThr: 1.92 ± 0.562
1.12ArgVal: 1.12 ± 0.371
1.12ArgTrp: 1.12 ± 0.385
1.44ArgTyr: 1.44 ± 0.424
0.0ArgXaa: 0.0 ± 0.0
Ser
6.401SerAla: 6.401 ± 1.945
0.8SerCys: 0.8 ± 0.213
2.56SerAsp: 2.56 ± 0.419
2.72SerGlu: 2.72 ± 0.645
2.72SerPhe: 2.72 ± 0.456
6.561SerGly: 6.561 ± 1.264
0.96SerHis: 0.96 ± 0.324
4.161SerIle: 4.161 ± 0.86
3.521SerLys: 3.521 ± 0.795
5.441SerLeu: 5.441 ± 0.88
0.8SerMet: 0.8 ± 0.299
4.961SerAsn: 4.961 ± 0.816
2.72SerPro: 2.72 ± 0.805
4.161SerGln: 4.161 ± 0.892
1.44SerArg: 1.44 ± 0.438
5.601SerSer: 5.601 ± 1.477
4.961SerThr: 4.961 ± 1.476
5.601SerVal: 5.601 ± 0.834
0.8SerTrp: 0.8 ± 0.337
3.361SerTyr: 3.361 ± 0.522
0.0SerXaa: 0.0 ± 0.0
Thr
5.921ThrAla: 5.921 ± 1.582
0.48ThrCys: 0.48 ± 0.242
5.121ThrAsp: 5.121 ± 1.078
3.201ThrGlu: 3.201 ± 0.874
2.24ThrPhe: 2.24 ± 0.626
5.121ThrGly: 5.121 ± 0.794
0.64ThrHis: 0.64 ± 0.344
4.161ThrIle: 4.161 ± 0.729
3.841ThrLys: 3.841 ± 0.734
5.281ThrLeu: 5.281 ± 1.183
1.12ThrMet: 1.12 ± 0.451
5.281ThrAsn: 5.281 ± 1.072
3.04ThrPro: 3.04 ± 0.687
2.88ThrGln: 2.88 ± 0.71
1.76ThrArg: 1.76 ± 0.594
4.961ThrSer: 4.961 ± 1.075
6.241ThrThr: 6.241 ± 1.07
4.001ThrVal: 4.001 ± 0.878
0.48ThrTrp: 0.48 ± 0.205
2.72ThrTyr: 2.72 ± 0.585
0.0ThrXaa: 0.0 ± 0.0
Val
4.321ValAla: 4.321 ± 1.136
0.64ValCys: 0.64 ± 0.336
4.961ValAsp: 4.961 ± 0.974
3.201ValGlu: 3.201 ± 0.9
3.841ValPhe: 3.841 ± 0.99
4.321ValGly: 4.321 ± 0.698
0.0ValHis: 0.0 ± 0.0
3.201ValIle: 3.201 ± 0.69
4.481ValLys: 4.481 ± 0.862
4.481ValLeu: 4.481 ± 0.646
0.96ValMet: 0.96 ± 0.416
3.04ValAsn: 3.04 ± 0.632
4.321ValPro: 4.321 ± 1.198
0.8ValGln: 0.8 ± 0.311
1.44ValArg: 1.44 ± 0.485
4.161ValSer: 4.161 ± 0.754
3.841ValThr: 3.841 ± 0.846
2.88ValVal: 2.88 ± 0.639
0.64ValTrp: 0.64 ± 0.276
1.76ValTyr: 1.76 ± 0.327
0.0ValXaa: 0.0 ± 0.0
Trp
0.8TrpAla: 0.8 ± 0.609
0.64TrpCys: 0.64 ± 0.256
1.44TrpAsp: 1.44 ± 0.486
1.44TrpGlu: 1.44 ± 0.316
0.8TrpPhe: 0.8 ± 0.418
0.48TrpGly: 0.48 ± 0.243
0.0TrpHis: 0.0 ± 0.0
0.64TrpIle: 0.64 ± 0.339
0.96TrpLys: 0.96 ± 0.376
0.32TrpLeu: 0.32 ± 0.218
0.0TrpMet: 0.0 ± 0.0
0.16TrpAsn: 0.16 ± 0.188
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.96TrpArg: 0.96 ± 0.321
0.64TrpSer: 0.64 ± 0.254
0.64TrpThr: 0.64 ± 0.324
1.12TrpVal: 1.12 ± 0.507
0.32TrpTrp: 0.32 ± 0.199
0.96TrpTyr: 0.96 ± 0.256
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.08TyrAla: 2.08 ± 0.613
0.64TyrCys: 0.64 ± 0.339
3.521TyrAsp: 3.521 ± 0.837
1.44TyrGlu: 1.44 ± 0.31
1.6TyrPhe: 1.6 ± 0.353
2.56TyrGly: 2.56 ± 0.505
0.48TyrHis: 0.48 ± 0.218
2.88TyrIle: 2.88 ± 0.7
3.04TyrLys: 3.04 ± 0.815
5.281TyrLeu: 5.281 ± 0.988
0.8TyrMet: 0.8 ± 0.365
3.521TyrAsn: 3.521 ± 0.845
2.4TyrPro: 2.4 ± 0.645
1.44TyrGln: 1.44 ± 0.372
2.08TyrArg: 2.08 ± 0.466
2.56TyrSer: 2.56 ± 0.721
3.361TyrThr: 3.361 ± 0.868
1.12TyrVal: 1.12 ± 0.419
0.64TyrTrp: 0.64 ± 0.231
2.08TyrTyr: 2.08 ± 0.709
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (6250 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski