Amino acid dipepetide frequency for Burkholderia virus DC1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.747AlaAla: 22.747 ± 1.491
0.727AlaCys: 0.727 ± 0.264
6.076AlaAsp: 6.076 ± 0.643
8.517AlaGlu: 8.517 ± 0.77
4.103AlaPhe: 4.103 ± 0.432
11.478AlaGly: 11.478 ± 0.876
1.818AlaHis: 1.818 ± 0.396
5.453AlaIle: 5.453 ± 0.579
5.869AlaLys: 5.869 ± 0.842
10.906AlaLeu: 10.906 ± 0.675
3.791AlaMet: 3.791 ± 0.473
3.895AlaAsn: 3.895 ± 0.627
7.323AlaPro: 7.323 ± 1.169
5.661AlaGln: 5.661 ± 0.789
9.868AlaArg: 9.868 ± 0.783
5.765AlaSer: 5.765 ± 0.64
6.803AlaThr: 6.803 ± 0.505
6.751AlaVal: 6.751 ± 0.689
1.766AlaTrp: 1.766 ± 0.275
2.804AlaTyr: 2.804 ± 0.355
0.0AlaXaa: 0.0 ± 0.0
Cys
0.831CysAla: 0.831 ± 0.254
0.208CysCys: 0.208 ± 0.112
0.312CysAsp: 0.312 ± 0.152
0.623CysGlu: 0.623 ± 0.238
0.156CysPhe: 0.156 ± 0.094
0.364CysGly: 0.364 ± 0.146
0.052CysHis: 0.052 ± 0.051
0.467CysIle: 0.467 ± 0.218
0.312CysLys: 0.312 ± 0.148
0.467CysLeu: 0.467 ± 0.215
0.312CysMet: 0.312 ± 0.16
0.415CysAsn: 0.415 ± 0.159
0.519CysPro: 0.519 ± 0.22
0.26CysGln: 0.26 ± 0.148
0.364CysArg: 0.364 ± 0.146
0.312CysSer: 0.312 ± 0.15
0.312CysThr: 0.312 ± 0.153
0.312CysVal: 0.312 ± 0.167
0.208CysTrp: 0.208 ± 0.114
0.364CysTyr: 0.364 ± 0.155
0.0CysXaa: 0.0 ± 0.0
Asp
9.556AspAla: 9.556 ± 0.84
0.364AspCys: 0.364 ± 0.145
4.986AspAsp: 4.986 ± 0.776
4.57AspGlu: 4.57 ± 0.604
2.441AspPhe: 2.441 ± 0.38
6.388AspGly: 6.388 ± 0.605
1.558AspHis: 1.558 ± 0.399
3.012AspIle: 3.012 ± 0.328
1.974AspLys: 1.974 ± 0.342
4.57AspLeu: 4.57 ± 0.453
1.402AspMet: 1.402 ± 0.258
2.181AspAsn: 2.181 ± 0.313
3.635AspPro: 3.635 ± 0.41
2.181AspGln: 2.181 ± 0.374
4.57AspArg: 4.57 ± 0.498
2.753AspSer: 2.753 ± 0.422
2.804AspThr: 2.804 ± 0.337
3.48AspVal: 3.48 ± 0.355
1.194AspTrp: 1.194 ± 0.318
1.246AspTyr: 1.246 ± 0.231
0.0AspXaa: 0.0 ± 0.0
Glu
7.582GluAla: 7.582 ± 0.734
0.571GluCys: 0.571 ± 0.241
2.597GluAsp: 2.597 ± 0.337
4.051GluGlu: 4.051 ± 0.52
1.87GluPhe: 1.87 ± 0.312
4.259GluGly: 4.259 ± 0.411
2.077GluHis: 2.077 ± 0.359
3.687GluIle: 3.687 ± 0.386
3.012GluLys: 3.012 ± 0.343
7.427GluLeu: 7.427 ± 0.684
1.766GluMet: 1.766 ± 0.446
2.077GluAsn: 2.077 ± 0.277
3.376GluPro: 3.376 ± 0.343
4.155GluGln: 4.155 ± 0.751
6.18GluArg: 6.18 ± 0.567
1.87GluSer: 1.87 ± 0.269
3.687GluThr: 3.687 ± 0.467
3.168GluVal: 3.168 ± 0.398
0.935GluTrp: 0.935 ± 0.212
2.181GluTyr: 2.181 ± 0.309
0.0GluXaa: 0.0 ± 0.0
Phe
4.051PheAla: 4.051 ± 0.454
0.208PheCys: 0.208 ± 0.152
2.389PheAsp: 2.389 ± 0.385
2.129PheGlu: 2.129 ± 0.395
0.935PhePhe: 0.935 ± 0.279
2.441PheGly: 2.441 ± 0.468
0.519PheHis: 0.519 ± 0.14
1.766PheIle: 1.766 ± 0.259
1.091PheLys: 1.091 ± 0.215
1.61PheLeu: 1.61 ± 0.252
1.298PheMet: 1.298 ± 0.232
1.61PheAsn: 1.61 ± 0.242
1.714PhePro: 1.714 ± 0.239
1.143PheGln: 1.143 ± 0.184
1.974PheArg: 1.974 ± 0.389
1.298PheSer: 1.298 ± 0.216
1.662PheThr: 1.662 ± 0.295
2.077PheVal: 2.077 ± 0.382
0.623PheTrp: 0.623 ± 0.193
0.935PheTyr: 0.935 ± 0.287
0.0PheXaa: 0.0 ± 0.0
Gly
9.348GlyAla: 9.348 ± 1.088
0.727GlyCys: 0.727 ± 0.285
6.284GlyAsp: 6.284 ± 0.602
5.09GlyGlu: 5.09 ± 0.498
2.804GlyPhe: 2.804 ± 0.46
7.323GlyGly: 7.323 ± 0.84
1.402GlyHis: 1.402 ± 0.302
3.739GlyIle: 3.739 ± 0.49
4.311GlyLys: 4.311 ± 0.629
4.466GlyLeu: 4.466 ± 0.513
2.493GlyMet: 2.493 ± 0.675
3.012GlyAsn: 3.012 ± 0.422
2.233GlyPro: 2.233 ± 0.292
3.116GlyGln: 3.116 ± 0.439
5.193GlyArg: 5.193 ± 0.638
4.414GlySer: 4.414 ± 0.535
5.869GlyThr: 5.869 ± 0.699
5.09GlyVal: 5.09 ± 0.441
1.194GlyTrp: 1.194 ± 0.22
1.922GlyTyr: 1.922 ± 0.307
0.0GlyXaa: 0.0 ± 0.0
His
2.181HisAla: 2.181 ± 0.468
0.104HisCys: 0.104 ± 0.067
1.246HisAsp: 1.246 ± 0.23
1.402HisGlu: 1.402 ± 0.255
0.779HisPhe: 0.779 ± 0.289
2.025HisGly: 2.025 ± 0.363
0.415HisHis: 0.415 ± 0.146
0.831HisIle: 0.831 ± 0.158
0.779HisLys: 0.779 ± 0.225
1.454HisLeu: 1.454 ± 0.295
0.312HisMet: 0.312 ± 0.122
0.779HisAsn: 0.779 ± 0.258
0.727HisPro: 0.727 ± 0.184
0.364HisGln: 0.364 ± 0.138
1.714HisArg: 1.714 ± 0.346
0.675HisSer: 0.675 ± 0.228
0.779HisThr: 0.779 ± 0.176
1.298HisVal: 1.298 ± 0.315
0.156HisTrp: 0.156 ± 0.077
0.415HisTyr: 0.415 ± 0.151
0.0HisXaa: 0.0 ± 0.0
Ile
6.544IleAla: 6.544 ± 0.49
0.571IleCys: 0.571 ± 0.256
3.48IleAsp: 3.48 ± 0.37
4.051IleGlu: 4.051 ± 0.431
1.558IlePhe: 1.558 ± 0.249
4.207IleGly: 4.207 ± 0.4
0.571IleHis: 0.571 ± 0.15
2.285IleIle: 2.285 ± 0.45
2.337IleLys: 2.337 ± 0.285
1.922IleLeu: 1.922 ± 0.255
0.935IleMet: 0.935 ± 0.226
1.818IleAsn: 1.818 ± 0.326
1.818IlePro: 1.818 ± 0.31
1.454IleGln: 1.454 ± 0.379
2.441IleArg: 2.441 ± 0.314
1.506IleSer: 1.506 ± 0.366
2.493IleThr: 2.493 ± 0.416
3.635IleVal: 3.635 ± 0.453
0.675IleTrp: 0.675 ± 0.249
0.987IleTyr: 0.987 ± 0.232
0.0IleXaa: 0.0 ± 0.0
Lys
6.44LysAla: 6.44 ± 0.579
0.208LysCys: 0.208 ± 0.132
3.012LysAsp: 3.012 ± 0.394
2.856LysGlu: 2.856 ± 0.363
1.039LysPhe: 1.039 ± 0.237
3.012LysGly: 3.012 ± 0.533
0.779LysHis: 0.779 ± 0.193
1.818LysIle: 1.818 ± 0.371
2.597LysLys: 2.597 ± 0.412
3.687LysLeu: 3.687 ± 0.366
1.246LysMet: 1.246 ± 0.235
1.298LysAsn: 1.298 ± 0.319
3.376LysPro: 3.376 ± 0.513
2.493LysGln: 2.493 ± 0.332
3.012LysArg: 3.012 ± 0.416
2.025LysSer: 2.025 ± 0.354
2.129LysThr: 2.129 ± 0.33
3.739LysVal: 3.739 ± 0.417
0.675LysTrp: 0.675 ± 0.175
0.779LysTyr: 0.779 ± 0.158
0.0LysXaa: 0.0 ± 0.0
Leu
9.4LeuAla: 9.4 ± 0.635
0.519LeuCys: 0.519 ± 0.177
5.972LeuAsp: 5.972 ± 0.488
5.245LeuGlu: 5.245 ± 0.405
2.129LeuPhe: 2.129 ± 0.275
4.934LeuGly: 4.934 ± 0.591
1.61LeuHis: 1.61 ± 0.255
3.168LeuIle: 3.168 ± 0.436
4.207LeuLys: 4.207 ± 0.413
5.193LeuLeu: 5.193 ± 0.752
1.454LeuMet: 1.454 ± 0.226
2.96LeuAsn: 2.96 ± 0.36
4.466LeuPro: 4.466 ± 0.722
2.389LeuGln: 2.389 ± 0.312
6.128LeuArg: 6.128 ± 0.598
4.207LeuSer: 4.207 ± 0.557
5.297LeuThr: 5.297 ± 0.523
4.207LeuVal: 4.207 ± 0.482
1.039LeuTrp: 1.039 ± 0.184
2.129LeuTyr: 2.129 ± 0.286
0.0LeuXaa: 0.0 ± 0.0
Met
2.441MetAla: 2.441 ± 0.418
0.208MetCys: 0.208 ± 0.124
1.714MetAsp: 1.714 ± 0.328
0.987MetGlu: 0.987 ± 0.216
0.467MetPhe: 0.467 ± 0.123
2.025MetGly: 2.025 ± 0.324
0.467MetHis: 0.467 ± 0.114
0.623MetIle: 0.623 ± 0.15
1.714MetLys: 1.714 ± 0.261
2.129MetLeu: 2.129 ± 0.393
0.467MetMet: 0.467 ± 0.187
0.883MetAsn: 0.883 ± 0.19
1.922MetPro: 1.922 ± 0.332
0.987MetGln: 0.987 ± 0.221
2.337MetArg: 2.337 ± 0.33
1.922MetSer: 1.922 ± 0.317
1.246MetThr: 1.246 ± 0.303
1.558MetVal: 1.558 ± 0.271
0.623MetTrp: 0.623 ± 0.213
0.415MetTyr: 0.415 ± 0.176
0.0MetXaa: 0.0 ± 0.0
Asn
4.466AsnAla: 4.466 ± 0.472
0.104AsnCys: 0.104 ± 0.079
2.389AsnAsp: 2.389 ± 0.37
2.077AsnGlu: 2.077 ± 0.402
0.779AsnPhe: 0.779 ± 0.189
3.48AsnGly: 3.48 ± 0.44
0.831AsnHis: 0.831 ± 0.194
1.402AsnIle: 1.402 ± 0.237
1.246AsnLys: 1.246 ± 0.255
2.441AsnLeu: 2.441 ± 0.313
0.779AsnMet: 0.779 ± 0.154
1.194AsnAsn: 1.194 ± 0.239
2.285AsnPro: 2.285 ± 0.314
1.246AsnGln: 1.246 ± 0.283
2.077AsnArg: 2.077 ± 0.32
1.402AsnSer: 1.402 ± 0.289
1.454AsnThr: 1.454 ± 0.278
2.493AsnVal: 2.493 ± 0.282
0.519AsnTrp: 0.519 ± 0.113
0.831AsnTyr: 0.831 ± 0.183
0.0AsnXaa: 0.0 ± 0.0
Pro
8.933ProAla: 8.933 ± 1.126
0.364ProCys: 0.364 ± 0.181
3.532ProAsp: 3.532 ± 0.429
4.466ProGlu: 4.466 ± 0.427
1.558ProPhe: 1.558 ± 0.238
4.363ProGly: 4.363 ± 0.718
0.883ProHis: 0.883 ± 0.3
2.233ProIle: 2.233 ± 0.26
1.922ProLys: 1.922 ± 0.32
3.687ProLeu: 3.687 ± 0.446
0.987ProMet: 0.987 ± 0.256
1.714ProAsn: 1.714 ± 0.377
3.739ProPro: 3.739 ± 0.784
2.129ProGln: 2.129 ± 0.351
3.791ProArg: 3.791 ± 0.577
3.272ProSer: 3.272 ± 0.466
2.856ProThr: 2.856 ± 0.323
3.635ProVal: 3.635 ± 0.341
0.467ProTrp: 0.467 ± 0.138
1.194ProTyr: 1.194 ± 0.322
0.0ProXaa: 0.0 ± 0.0
Gln
5.661GlnAla: 5.661 ± 0.637
0.364GlnCys: 0.364 ± 0.17
1.922GlnAsp: 1.922 ± 0.372
2.753GlnGlu: 2.753 ± 0.295
1.35GlnPhe: 1.35 ± 0.2
2.649GlnGly: 2.649 ± 0.469
0.779GlnHis: 0.779 ± 0.164
1.87GlnIle: 1.87 ± 0.469
1.506GlnLys: 1.506 ± 0.215
3.376GlnLeu: 3.376 ± 0.425
1.246GlnMet: 1.246 ± 0.237
1.714GlnAsn: 1.714 ± 0.48
2.804GlnPro: 2.804 ± 0.539
3.376GlnGln: 3.376 ± 0.579
3.583GlnArg: 3.583 ± 0.524
2.181GlnSer: 2.181 ± 0.497
1.818GlnThr: 1.818 ± 0.313
2.337GlnVal: 2.337 ± 0.338
0.156GlnTrp: 0.156 ± 0.07
0.883GlnTyr: 0.883 ± 0.224
0.0GlnXaa: 0.0 ± 0.0
Arg
9.452ArgAla: 9.452 ± 0.636
0.519ArgCys: 0.519 ± 0.216
5.09ArgAsp: 5.09 ± 0.471
5.193ArgGlu: 5.193 ± 0.696
2.96ArgPhe: 2.96 ± 0.391
4.207ArgGly: 4.207 ± 0.484
1.194ArgHis: 1.194 ± 0.356
3.583ArgIle: 3.583 ± 0.431
3.168ArgLys: 3.168 ± 0.354
6.336ArgLeu: 6.336 ± 0.462
2.025ArgMet: 2.025 ± 0.379
2.129ArgAsn: 2.129 ± 0.297
3.22ArgPro: 3.22 ± 0.559
3.272ArgGln: 3.272 ± 0.49
5.349ArgArg: 5.349 ± 0.571
3.012ArgSer: 3.012 ± 0.381
3.687ArgThr: 3.687 ± 0.458
5.297ArgVal: 5.297 ± 0.563
0.935ArgTrp: 0.935 ± 0.19
2.285ArgTyr: 2.285 ± 0.332
0.0ArgXaa: 0.0 ± 0.0
Ser
5.142SerAla: 5.142 ± 0.584
0.104SerCys: 0.104 ± 0.073
2.597SerAsp: 2.597 ± 0.399
2.856SerGlu: 2.856 ± 0.441
1.402SerPhe: 1.402 ± 0.214
5.245SerGly: 5.245 ± 0.484
0.831SerHis: 0.831 ± 0.198
2.389SerIle: 2.389 ± 0.495
2.545SerLys: 2.545 ± 0.283
4.155SerLeu: 4.155 ± 0.406
1.246SerMet: 1.246 ± 0.244
1.35SerAsn: 1.35 ± 0.381
2.96SerPro: 2.96 ± 0.51
1.61SerGln: 1.61 ± 0.306
2.804SerArg: 2.804 ± 0.385
2.181SerSer: 2.181 ± 0.306
3.22SerThr: 3.22 ± 0.405
2.649SerVal: 2.649 ± 0.3
0.519SerTrp: 0.519 ± 0.141
1.091SerTyr: 1.091 ± 0.202
0.0SerXaa: 0.0 ± 0.0
Thr
6.7ThrAla: 6.7 ± 0.677
0.364ThrCys: 0.364 ± 0.166
4.155ThrAsp: 4.155 ± 0.432
3.376ThrGlu: 3.376 ± 0.381
1.974ThrPhe: 1.974 ± 0.279
4.934ThrGly: 4.934 ± 0.656
1.194ThrHis: 1.194 ± 0.279
2.285ThrIle: 2.285 ± 0.392
2.025ThrLys: 2.025 ± 0.282
4.518ThrLeu: 4.518 ± 0.484
1.35ThrMet: 1.35 ± 0.212
1.298ThrAsn: 1.298 ± 0.294
4.155ThrPro: 4.155 ± 0.347
2.545ThrGln: 2.545 ± 0.363
3.376ThrArg: 3.376 ± 0.482
2.545ThrSer: 2.545 ± 0.288
2.597ThrThr: 2.597 ± 0.339
3.843ThrVal: 3.843 ± 0.441
0.571ThrTrp: 0.571 ± 0.217
1.194ThrTyr: 1.194 ± 0.213
0.0ThrXaa: 0.0 ± 0.0
Val
7.063ValAla: 7.063 ± 0.568
0.415ValCys: 0.415 ± 0.186
4.103ValAsp: 4.103 ± 0.322
4.207ValGlu: 4.207 ± 0.47
1.506ValPhe: 1.506 ± 0.292
3.999ValGly: 3.999 ± 0.547
0.883ValHis: 0.883 ± 0.323
2.804ValIle: 2.804 ± 0.434
4.259ValLys: 4.259 ± 0.489
4.726ValLeu: 4.726 ± 0.447
1.143ValMet: 1.143 ± 0.203
1.506ValAsn: 1.506 ± 0.264
3.791ValPro: 3.791 ± 0.452
2.701ValGln: 2.701 ± 0.413
4.622ValArg: 4.622 ± 0.449
3.791ValSer: 3.791 ± 0.421
3.895ValThr: 3.895 ± 0.504
4.051ValVal: 4.051 ± 0.462
0.675ValTrp: 0.675 ± 0.22
1.714ValTyr: 1.714 ± 0.282
0.0ValXaa: 0.0 ± 0.0
Trp
1.298TrpAla: 1.298 ± 0.277
0.208TrpCys: 0.208 ± 0.125
0.779TrpAsp: 0.779 ± 0.223
0.519TrpGlu: 0.519 ± 0.15
0.727TrpPhe: 0.727 ± 0.199
0.935TrpGly: 0.935 ± 0.199
0.26TrpHis: 0.26 ± 0.127
0.883TrpIle: 0.883 ± 0.181
0.519TrpLys: 0.519 ± 0.172
1.714TrpLeu: 1.714 ± 0.395
0.364TrpMet: 0.364 ± 0.147
0.779TrpAsn: 0.779 ± 0.182
0.26TrpPro: 0.26 ± 0.139
0.467TrpGln: 0.467 ± 0.123
1.35TrpArg: 1.35 ± 0.239
0.623TrpSer: 0.623 ± 0.146
0.831TrpThr: 0.831 ± 0.173
0.519TrpVal: 0.519 ± 0.144
0.052TrpTrp: 0.052 ± 0.037
0.312TrpTyr: 0.312 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.285TyrAla: 2.285 ± 0.386
0.312TyrCys: 0.312 ± 0.149
2.233TyrAsp: 2.233 ± 0.245
1.558TyrGlu: 1.558 ± 0.268
0.935TyrPhe: 0.935 ± 0.193
1.766TyrGly: 1.766 ± 0.341
0.312TyrHis: 0.312 ± 0.115
0.987TyrIle: 0.987 ± 0.226
0.831TyrLys: 0.831 ± 0.176
1.87TyrLeu: 1.87 ± 0.259
0.467TyrMet: 0.467 ± 0.124
0.883TyrAsn: 0.883 ± 0.216
1.402TyrPro: 1.402 ± 0.343
0.779TyrGln: 0.779 ± 0.195
2.233TyrArg: 2.233 ± 0.334
1.143TyrSer: 1.143 ± 0.197
1.558TyrThr: 1.558 ± 0.288
1.714TyrVal: 1.714 ± 0.348
0.415TyrTrp: 0.415 ± 0.208
0.779TyrTyr: 0.779 ± 0.189
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (19256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski