Amino acid dipepetide frequency for Streptococcus satellite phage Javan294

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.761AlaAla: 0.761 ± 0.4
0.761AlaCys: 0.761 ± 0.336
2.664AlaAsp: 2.664 ± 1.117
5.708AlaGlu: 5.708 ± 1.441
1.522AlaPhe: 1.522 ± 0.669
3.425AlaGly: 3.425 ± 0.909
1.903AlaHis: 1.903 ± 1.154
7.23AlaIle: 7.23 ± 0.972
4.566AlaLys: 4.566 ± 1.447
6.469AlaLeu: 6.469 ± 1.104
2.283AlaMet: 2.283 ± 1.339
3.805AlaAsn: 3.805 ± 1.12
0.761AlaPro: 0.761 ± 0.389
2.664AlaGln: 2.664 ± 0.967
4.186AlaArg: 4.186 ± 1.803
3.044AlaSer: 3.044 ± 0.593
5.327AlaThr: 5.327 ± 1.555
2.283AlaVal: 2.283 ± 0.705
0.0AlaTrp: 0.0 ± 0.0
4.186AlaTyr: 4.186 ± 1.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.381CysGlu: 0.381 ± 0.37
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.761CysLeu: 0.761 ± 0.481
0.0CysMet: 0.0 ± 0.0
0.381CysAsn: 0.381 ± 0.322
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.761CysArg: 0.761 ± 0.471
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.381CysVal: 0.381 ± 0.31
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.522AspAla: 1.522 ± 0.597
0.0AspCys: 0.0 ± 0.0
2.664AspAsp: 2.664 ± 0.98
4.566AspGlu: 4.566 ± 1.524
3.044AspPhe: 3.044 ± 1.278
1.522AspGly: 1.522 ± 0.756
0.381AspHis: 0.381 ± 0.434
4.186AspIle: 4.186 ± 1.097
7.61AspLys: 7.61 ± 1.239
7.23AspLeu: 7.23 ± 1.7
2.283AspMet: 2.283 ± 0.857
3.425AspAsn: 3.425 ± 0.999
2.283AspPro: 2.283 ± 0.981
1.903AspGln: 1.903 ± 0.765
2.283AspArg: 2.283 ± 0.815
2.283AspSer: 2.283 ± 0.742
4.566AspThr: 4.566 ± 1.021
2.664AspVal: 2.664 ± 0.774
0.0AspTrp: 0.0 ± 0.0
4.566AspTyr: 4.566 ± 0.873
0.0AspXaa: 0.0 ± 0.0
Glu
6.469GluAla: 6.469 ± 1.42
0.381GluCys: 0.381 ± 0.323
5.327GluAsp: 5.327 ± 1.392
7.61GluGlu: 7.61 ± 1.523
3.805GluPhe: 3.805 ± 1.299
4.566GluGly: 4.566 ± 0.945
0.381GluHis: 0.381 ± 0.424
7.61GluIle: 7.61 ± 1.685
6.088GluLys: 6.088 ± 1.388
10.274GluLeu: 10.274 ± 1.508
1.903GluMet: 1.903 ± 0.658
3.425GluAsn: 3.425 ± 1.239
0.761GluPro: 0.761 ± 0.577
3.425GluGln: 3.425 ± 1.128
4.186GluArg: 4.186 ± 1.462
3.425GluSer: 3.425 ± 0.689
3.425GluThr: 3.425 ± 0.745
5.327GluVal: 5.327 ± 1.549
0.761GluTrp: 0.761 ± 0.519
3.425GluTyr: 3.425 ± 1.097
0.0GluXaa: 0.0 ± 0.0
Phe
0.761PheAla: 0.761 ± 0.424
0.0PheCys: 0.0 ± 0.0
3.805PheAsp: 3.805 ± 0.949
1.522PheGlu: 1.522 ± 0.611
0.761PhePhe: 0.761 ± 0.389
1.903PheGly: 1.903 ± 0.545
0.761PheHis: 0.761 ± 0.541
1.522PheIle: 1.522 ± 0.797
4.566PheLys: 4.566 ± 1.452
5.708PheLeu: 5.708 ± 1.882
0.0PheMet: 0.0 ± 0.0
0.761PheAsn: 0.761 ± 0.481
0.761PhePro: 0.761 ± 0.401
0.761PheGln: 0.761 ± 0.619
2.664PheArg: 2.664 ± 0.749
3.044PheSer: 3.044 ± 0.934
3.425PheThr: 3.425 ± 1.029
1.522PheVal: 1.522 ± 0.737
0.761PheTrp: 0.761 ± 0.486
1.522PheTyr: 1.522 ± 0.676
0.0PheXaa: 0.0 ± 0.0
Gly
2.664GlyAla: 2.664 ± 1.042
0.381GlyCys: 0.381 ± 0.322
3.044GlyAsp: 3.044 ± 0.881
3.805GlyGlu: 3.805 ± 1.014
3.805GlyPhe: 3.805 ± 1.002
1.142GlyGly: 1.142 ± 0.612
1.522GlyHis: 1.522 ± 0.839
3.805GlyIle: 3.805 ± 1.74
3.425GlyLys: 3.425 ± 1.096
6.469GlyLeu: 6.469 ± 1.485
0.761GlyMet: 0.761 ± 0.621
1.522GlyAsn: 1.522 ± 0.756
0.381GlyPro: 0.381 ± 0.341
2.283GlyGln: 2.283 ± 1.166
1.522GlyArg: 1.522 ± 0.841
0.381GlySer: 0.381 ± 0.323
2.664GlyThr: 2.664 ± 0.883
2.664GlyVal: 2.664 ± 0.687
2.664GlyTrp: 2.664 ± 0.948
3.805GlyTyr: 3.805 ± 0.674
0.0GlyXaa: 0.0 ± 0.0
His
0.761HisAla: 0.761 ± 0.643
0.0HisCys: 0.0 ± 0.0
0.761HisAsp: 0.761 ± 0.61
1.142HisGlu: 1.142 ± 0.686
1.142HisPhe: 1.142 ± 0.847
1.142HisGly: 1.142 ± 0.436
0.381HisHis: 0.381 ± 0.31
0.761HisIle: 0.761 ± 0.572
0.381HisLys: 0.381 ± 0.484
1.522HisLeu: 1.522 ± 0.661
0.381HisMet: 0.381 ± 0.302
0.761HisAsn: 0.761 ± 0.514
0.761HisPro: 0.761 ± 0.51
1.142HisGln: 1.142 ± 0.64
1.903HisArg: 1.903 ± 0.699
1.142HisSer: 1.142 ± 0.561
1.142HisThr: 1.142 ± 0.74
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.761HisTyr: 0.761 ± 0.666
0.0HisXaa: 0.0 ± 0.0
Ile
4.186IleAla: 4.186 ± 1.021
0.0IleCys: 0.0 ± 0.0
3.044IleAsp: 3.044 ± 0.945
4.947IleGlu: 4.947 ± 1.25
1.142IlePhe: 1.142 ± 0.366
3.425IleGly: 3.425 ± 0.903
0.0IleHis: 0.0 ± 0.0
5.327IleIle: 5.327 ± 1.412
7.23IleLys: 7.23 ± 1.431
5.708IleLeu: 5.708 ± 0.956
1.903IleMet: 1.903 ± 0.847
3.425IleAsn: 3.425 ± 0.944
2.283IlePro: 2.283 ± 0.873
2.664IleGln: 2.664 ± 0.883
3.425IleArg: 3.425 ± 1.786
4.947IleSer: 4.947 ± 0.898
3.425IleThr: 3.425 ± 1.157
2.664IleVal: 2.664 ± 0.733
0.381IleTrp: 0.381 ± 0.31
1.903IleTyr: 1.903 ± 0.961
0.0IleXaa: 0.0 ± 0.0
Lys
10.654LysAla: 10.654 ± 1.802
0.0LysCys: 0.0 ± 0.0
5.708LysAsp: 5.708 ± 1.803
9.132LysGlu: 9.132 ± 1.959
0.761LysPhe: 0.761 ± 0.577
5.327LysGly: 5.327 ± 1.661
2.283LysHis: 2.283 ± 0.791
6.088LysIle: 6.088 ± 1.82
9.513LysLys: 9.513 ± 1.733
10.274LysLeu: 10.274 ± 2.622
1.522LysMet: 1.522 ± 0.578
5.327LysAsn: 5.327 ± 1.113
3.044LysPro: 3.044 ± 0.832
6.469LysGln: 6.469 ± 2.112
7.991LysArg: 7.991 ± 1.808
4.947LysSer: 4.947 ± 1.453
3.805LysThr: 3.805 ± 0.598
2.664LysVal: 2.664 ± 0.611
0.381LysTrp: 0.381 ± 0.322
3.044LysTyr: 3.044 ± 1.186
0.0LysXaa: 0.0 ± 0.0
Leu
8.752LeuAla: 8.752 ± 2.064
0.381LeuCys: 0.381 ± 0.37
6.088LeuAsp: 6.088 ± 1.456
12.177LeuGlu: 12.177 ± 1.942
2.664LeuPhe: 2.664 ± 1.001
6.469LeuGly: 6.469 ± 0.979
1.903LeuHis: 1.903 ± 0.602
3.425LeuIle: 3.425 ± 1.77
12.938LeuLys: 12.938 ± 1.629
10.274LeuLeu: 10.274 ± 1.827
3.805LeuMet: 3.805 ± 0.797
4.566LeuAsn: 4.566 ± 1.119
4.186LeuPro: 4.186 ± 1.544
5.708LeuGln: 5.708 ± 0.785
4.566LeuArg: 4.566 ± 0.846
4.566LeuSer: 4.566 ± 2.0
8.371LeuThr: 8.371 ± 1.755
2.664LeuVal: 2.664 ± 1.03
1.142LeuTrp: 1.142 ± 0.448
4.566LeuTyr: 4.566 ± 1.253
0.0LeuXaa: 0.0 ± 0.0
Met
1.142MetAla: 1.142 ± 0.628
0.0MetCys: 0.0 ± 0.0
1.903MetAsp: 1.903 ± 0.966
2.283MetGlu: 2.283 ± 0.908
0.381MetPhe: 0.381 ± 0.427
1.522MetGly: 1.522 ± 0.618
0.381MetHis: 0.381 ± 0.489
0.381MetIle: 0.381 ± 0.31
1.522MetLys: 1.522 ± 0.706
2.664MetLeu: 2.664 ± 0.777
0.381MetMet: 0.381 ± 0.341
3.044MetAsn: 3.044 ± 1.033
0.0MetPro: 0.0 ± 0.0
0.761MetGln: 0.761 ± 0.643
0.761MetArg: 0.761 ± 0.542
0.381MetSer: 0.381 ± 0.348
3.425MetThr: 3.425 ± 0.892
0.761MetVal: 0.761 ± 0.49
0.0MetTrp: 0.0 ± 0.0
0.761MetTyr: 0.761 ± 0.49
0.0MetXaa: 0.0 ± 0.0
Asn
2.664AsnAla: 2.664 ± 0.923
0.381AsnCys: 0.381 ± 0.31
3.044AsnAsp: 3.044 ± 1.01
3.044AsnGlu: 3.044 ± 0.981
1.522AsnPhe: 1.522 ± 0.797
4.947AsnGly: 4.947 ± 0.916
1.522AsnHis: 1.522 ± 0.67
4.186AsnIle: 4.186 ± 1.303
3.805AsnLys: 3.805 ± 0.936
4.186AsnLeu: 4.186 ± 0.975
0.761AsnMet: 0.761 ± 0.518
2.283AsnAsn: 2.283 ± 1.134
3.425AsnPro: 3.425 ± 1.705
3.425AsnGln: 3.425 ± 0.978
2.283AsnArg: 2.283 ± 1.005
2.283AsnSer: 2.283 ± 0.72
2.664AsnThr: 2.664 ± 1.619
2.283AsnVal: 2.283 ± 0.674
0.0AsnTrp: 0.0 ± 0.0
1.522AsnTyr: 1.522 ± 0.599
0.0AsnXaa: 0.0 ± 0.0
Pro
1.522ProAla: 1.522 ± 0.66
0.0ProCys: 0.0 ± 0.0
2.664ProAsp: 2.664 ± 0.663
3.044ProGlu: 3.044 ± 1.237
1.903ProPhe: 1.903 ± 0.816
1.142ProGly: 1.142 ± 0.64
0.761ProHis: 0.761 ± 0.401
1.142ProIle: 1.142 ± 0.564
4.186ProLys: 4.186 ± 0.998
2.283ProLeu: 2.283 ± 1.531
0.381ProMet: 0.381 ± 0.323
2.664ProAsn: 2.664 ± 1.142
0.0ProPro: 0.0 ± 0.0
0.761ProGln: 0.761 ± 0.511
1.903ProArg: 1.903 ± 0.695
1.142ProSer: 1.142 ± 0.459
1.142ProThr: 1.142 ± 0.503
1.903ProVal: 1.903 ± 0.872
0.0ProTrp: 0.0 ± 0.0
2.283ProTyr: 2.283 ± 0.657
0.0ProXaa: 0.0 ± 0.0
Gln
4.566GlnAla: 4.566 ± 1.436
0.0GlnCys: 0.0 ± 0.0
2.664GlnAsp: 2.664 ± 1.051
3.425GlnGlu: 3.425 ± 1.058
1.903GlnPhe: 1.903 ± 0.565
1.903GlnGly: 1.903 ± 0.885
1.142GlnHis: 1.142 ± 0.621
1.522GlnIle: 1.522 ± 0.878
5.708GlnLys: 5.708 ± 1.498
3.805GlnLeu: 3.805 ± 0.765
0.761GlnMet: 0.761 ± 0.619
1.522GlnAsn: 1.522 ± 0.556
3.044GlnPro: 3.044 ± 1.025
5.708GlnGln: 5.708 ± 0.998
1.522GlnArg: 1.522 ± 0.667
2.664GlnSer: 2.664 ± 1.164
3.044GlnThr: 3.044 ± 1.346
4.186GlnVal: 4.186 ± 1.358
0.761GlnTrp: 0.761 ± 0.431
1.903GlnTyr: 1.903 ± 0.944
0.0GlnXaa: 0.0 ± 0.0
Arg
2.283ArgAla: 2.283 ± 0.572
0.0ArgCys: 0.0 ± 0.0
3.425ArgAsp: 3.425 ± 1.526
4.947ArgGlu: 4.947 ± 1.215
2.664ArgPhe: 2.664 ± 1.021
1.142ArgGly: 1.142 ± 0.587
0.761ArgHis: 0.761 ± 0.519
3.805ArgIle: 3.805 ± 1.183
7.23ArgLys: 7.23 ± 1.975
7.991ArgLeu: 7.991 ± 1.551
0.761ArgMet: 0.761 ± 0.526
2.283ArgAsn: 2.283 ± 0.923
0.761ArgPro: 0.761 ± 0.514
4.947ArgGln: 4.947 ± 1.079
4.566ArgArg: 4.566 ± 1.433
1.142ArgSer: 1.142 ± 0.618
3.044ArgThr: 3.044 ± 1.013
1.142ArgVal: 1.142 ± 0.503
1.142ArgTrp: 1.142 ± 0.633
2.664ArgTyr: 2.664 ± 1.095
0.0ArgXaa: 0.0 ± 0.0
Ser
3.044SerAla: 3.044 ± 1.077
0.381SerCys: 0.381 ± 0.427
2.283SerAsp: 2.283 ± 1.014
3.425SerGlu: 3.425 ± 1.336
1.903SerPhe: 1.903 ± 0.435
2.283SerGly: 2.283 ± 0.617
0.0SerHis: 0.0 ± 0.0
1.903SerIle: 1.903 ± 0.635
4.186SerLys: 4.186 ± 1.086
5.708SerLeu: 5.708 ± 1.185
1.142SerMet: 1.142 ± 0.965
2.283SerAsn: 2.283 ± 0.939
1.903SerPro: 1.903 ± 0.822
1.522SerGln: 1.522 ± 0.645
3.425SerArg: 3.425 ± 1.078
1.142SerSer: 1.142 ± 0.635
2.283SerThr: 2.283 ± 0.761
3.425SerVal: 3.425 ± 1.242
0.381SerTrp: 0.381 ± 0.427
1.522SerTyr: 1.522 ± 0.535
0.0SerXaa: 0.0 ± 0.0
Thr
4.566ThrAla: 4.566 ± 0.989
0.0ThrCys: 0.0 ± 0.0
3.425ThrAsp: 3.425 ± 1.085
3.425ThrGlu: 3.425 ± 1.124
1.903ThrPhe: 1.903 ± 0.617
4.566ThrGly: 4.566 ± 1.111
0.761ThrHis: 0.761 ± 0.519
4.566ThrIle: 4.566 ± 1.067
6.469ThrLys: 6.469 ± 1.894
4.566ThrLeu: 4.566 ± 1.444
1.142ThrMet: 1.142 ± 0.616
2.664ThrAsn: 2.664 ± 1.131
3.425ThrPro: 3.425 ± 1.04
2.664ThrGln: 2.664 ± 1.084
1.903ThrArg: 1.903 ± 1.023
1.903ThrSer: 1.903 ± 0.729
6.469ThrThr: 6.469 ± 1.598
4.947ThrVal: 4.947 ± 1.328
0.381ThrTrp: 0.381 ± 0.438
3.425ThrTyr: 3.425 ± 1.07
0.0ThrXaa: 0.0 ± 0.0
Val
3.044ValAla: 3.044 ± 1.082
0.0ValCys: 0.0 ± 0.0
3.425ValAsp: 3.425 ± 1.436
3.805ValGlu: 3.805 ± 1.707
2.664ValPhe: 2.664 ± 0.977
0.761ValGly: 0.761 ± 0.457
0.761ValHis: 0.761 ± 0.336
2.664ValIle: 2.664 ± 1.067
3.044ValLys: 3.044 ± 0.893
4.947ValLeu: 4.947 ± 1.202
0.381ValMet: 0.381 ± 0.31
1.903ValAsn: 1.903 ± 0.684
1.903ValPro: 1.903 ± 0.701
1.142ValGln: 1.142 ± 0.459
2.664ValArg: 2.664 ± 1.298
3.044ValSer: 3.044 ± 1.415
3.805ValThr: 3.805 ± 1.433
3.425ValVal: 3.425 ± 1.087
0.381ValTrp: 0.381 ± 0.408
2.283ValTyr: 2.283 ± 0.962
0.0ValXaa: 0.0 ± 0.0
Trp
0.761TrpAla: 0.761 ± 0.336
0.0TrpCys: 0.0 ± 0.0
1.142TrpAsp: 1.142 ± 0.622
0.761TrpGlu: 0.761 ± 0.484
0.381TrpPhe: 0.381 ± 0.323
0.761TrpGly: 0.761 ± 0.486
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.903TrpLeu: 1.903 ± 0.935
0.761TrpMet: 0.761 ± 0.511
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.381TrpGln: 0.381 ± 0.427
0.761TrpArg: 0.761 ± 0.61
0.761TrpSer: 0.761 ± 0.4
0.381TrpThr: 0.381 ± 0.31
0.381TrpVal: 0.381 ± 0.489
0.761TrpTrp: 0.761 ± 0.336
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.425TyrAla: 3.425 ± 1.333
0.0TyrCys: 0.0 ± 0.0
1.903TyrAsp: 1.903 ± 0.711
3.425TyrGlu: 3.425 ± 0.895
2.664TyrPhe: 2.664 ± 0.822
0.761TyrGly: 0.761 ± 0.336
0.381TyrHis: 0.381 ± 0.438
1.903TyrIle: 1.903 ± 0.762
6.469TyrLys: 6.469 ± 1.5
6.469TyrLeu: 6.469 ± 1.117
0.761TyrMet: 0.761 ± 0.533
4.186TyrAsn: 4.186 ± 0.992
1.142TyrPro: 1.142 ± 0.759
3.425TyrGln: 3.425 ± 1.06
3.805TyrArg: 3.805 ± 1.276
1.903TyrSer: 1.903 ± 0.502
0.761TyrThr: 0.761 ± 0.512
0.761TyrVal: 0.761 ± 0.4
0.0TyrTrp: 0.0 ± 0.0
1.522TyrTyr: 1.522 ± 0.745
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2629 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski