Amino acid dipepetide frequency for Planctomycetes bacterium K23_9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.104AlaAla: 11.104 ± 0.094	1.08AlaCys: 1.08 ± 0.027	6.762AlaAsp: 6.762 ± 0.064	5.722AlaGlu: 5.722 ± 0.054	3.306AlaPhe: 3.306 ± 0.036	7.54AlaGly: 7.54 ± 0.072	1.492AlaHis: 1.492 ± 0.027	6.013AlaIle: 6.013 ± 0.056	4.739AlaLys: 4.739 ± 0.064	7.61AlaLeu: 7.61 ± 0.062	2.724AlaMet: 2.724 ± 0.045	3.673AlaAsn: 3.673 ± 0.054	3.807AlaPro: 3.807 ± 0.054	3.323AlaGln: 3.323 ± 0.045	4.651AlaArg: 4.651 ± 0.051	6.915AlaSer: 6.915 ± 0.061	6.237AlaThr: 6.237 ± 0.105	6.828AlaVal: 6.828 ± 0.063	1.239AlaTrp: 1.239 ± 0.026	1.916AlaTyr: 1.916 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.026	0.232CysCys: 0.232 ± 0.012	0.816CysAsp: 0.816 ± 0.024	0.66CysGlu: 0.66 ± 0.021	0.467CysPhe: 0.467 ± 0.017	1.02CysGly: 1.02 ± 0.034	0.434CysHis: 0.434 ± 0.019	0.454CysIle: 0.454 ± 0.013	0.337CysLys: 0.337 ± 0.014	1.09CysLeu: 1.09 ± 0.025	0.211CysMet: 0.211 ± 0.012	0.338CysAsn: 0.338 ± 0.014	0.491CysPro: 0.491 ± 0.016	0.461CysGln: 0.461 ± 0.016	0.72CysArg: 0.72 ± 0.02	0.689CysSer: 0.689 ± 0.019	0.511CysThr: 0.511 ± 0.015	0.857CysVal: 0.857 ± 0.024	0.176CysTrp: 0.176 ± 0.008	0.306CysTyr: 0.306 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.077AspAla: 7.077 ± 0.083	0.632AspCys: 0.632 ± 0.019	5.111AspAsp: 5.111 ± 0.081	4.328AspGlu: 4.328 ± 0.05	2.565AspPhe: 2.565 ± 0.038	5.934AspGly: 5.934 ± 0.11	1.531AspHis: 1.531 ± 0.032	2.654AspIle: 2.654 ± 0.055	2.181AspLys: 2.181 ± 0.04	6.067AspLeu: 6.067 ± 0.063	1.045AspMet: 1.045 ± 0.022	2.039AspAsn: 2.039 ± 0.045	3.612AspPro: 3.612 ± 0.06	3.178AspGln: 3.178 ± 0.037	4.391AspArg: 4.391 ± 0.047	4.505AspSer: 4.505 ± 0.075	3.102AspThr: 3.102 ± 0.079	4.741AspVal: 4.741 ± 0.072	1.087AspTrp: 1.087 ± 0.021	1.628AspTyr: 1.628 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	4.94GluAla: 4.94 ± 0.062	0.477GluCys: 0.477 ± 0.016	2.603GluAsp: 2.603 ± 0.041	2.752GluGlu: 2.752 ± 0.055	2.158GluPhe: 2.158 ± 0.031	3.176GluGly: 3.176 ± 0.047	1.22GluHis: 1.22 ± 0.024	3.526GluIle: 3.526 ± 0.044	2.522GluLys: 2.522 ± 0.04	6.239GluLeu: 6.239 ± 0.066	1.544GluMet: 1.544 ± 0.033	2.043GluAsn: 2.043 ± 0.033	2.47GluPro: 2.47 ± 0.037	2.667GluGln: 2.667 ± 0.039	3.302GluArg: 3.302 ± 0.044	4.744GluSer: 4.744 ± 0.055	3.667GluThr: 3.667 ± 0.043	3.759GluVal: 3.759 ± 0.043	0.6GluTrp: 0.6 ± 0.017	1.24GluTyr: 1.24 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.047PheAla: 4.047 ± 0.047	0.509PheCys: 0.509 ± 0.017	3.189PheAsp: 3.189 ± 0.051	1.935PheGlu: 1.935 ± 0.03	1.473PhePhe: 1.473 ± 0.029	3.298PheGly: 3.298 ± 0.039	0.786PheHis: 0.786 ± 0.02	1.453PheIle: 1.453 ± 0.027	1.105PheLys: 1.105 ± 0.026	3.227PheLeu: 3.227 ± 0.049	0.634PheMet: 0.634 ± 0.018	1.188PheAsn: 1.188 ± 0.031	1.49PhePro: 1.49 ± 0.026	1.414PheGln: 1.414 ± 0.026	2.297PheArg: 2.297 ± 0.038	2.463PheSer: 2.463 ± 0.038	2.004PheThr: 2.004 ± 0.046	2.997PheVal: 2.997 ± 0.036	0.518PheTrp: 0.518 ± 0.018	0.938PheTyr: 0.938 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	5.764GlyAla: 5.764 ± 0.069	0.993GlyCys: 0.993 ± 0.041	5.362GlyAsp: 5.362 ± 0.094	4.331GlyGlu: 4.331 ± 0.046	3.025GlyPhe: 3.025 ± 0.042	6.629GlyGly: 6.629 ± 0.136	1.644GlyHis: 1.644 ± 0.03	3.96GlyIle: 3.96 ± 0.05	3.834GlyLys: 3.834 ± 0.05	6.435GlyLeu: 6.435 ± 0.054	1.867GlyMet: 1.867 ± 0.037	2.981GlyAsn: 2.981 ± 0.076	2.92GlyPro: 2.92 ± 0.044	3.132GlyGln: 3.132 ± 0.045	4.638GlyArg: 4.638 ± 0.053	5.196GlySer: 5.196 ± 0.085	4.687GlyThr: 4.687 ± 0.116	5.397GlyVal: 5.397 ± 0.071	1.178GlyTrp: 1.178 ± 0.028	1.999GlyTyr: 1.999 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.989HisAla: 1.989 ± 0.032	0.338HisCys: 0.338 ± 0.012	1.34HisAsp: 1.34 ± 0.026	1.137HisGlu: 1.137 ± 0.025	0.954HisPhe: 0.954 ± 0.022	1.712HisGly: 1.712 ± 0.032	0.666HisHis: 0.666 ± 0.019	0.805HisIle: 0.805 ± 0.019	0.582HisLys: 0.582 ± 0.018	2.075HisLeu: 2.075 ± 0.038	0.369HisMet: 0.369 ± 0.014	0.648HisAsn: 0.648 ± 0.016	1.269HisPro: 1.269 ± 0.027	0.977HisGln: 0.977 ± 0.022	1.624HisArg: 1.624 ± 0.033	1.389HisSer: 1.389 ± 0.027	0.951HisThr: 0.951 ± 0.024	1.523HisVal: 1.523 ± 0.026	0.414HisTrp: 0.414 ± 0.013	0.619HisTyr: 0.619 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.351IleAla: 6.351 ± 0.058	0.628IleCys: 0.628 ± 0.02	4.667IleAsp: 4.667 ± 0.058	3.678IleGlu: 3.678 ± 0.041	1.423IlePhe: 1.423 ± 0.023	4.377IleGly: 4.377 ± 0.055	1.065IleHis: 1.065 ± 0.021	1.926IleIle: 1.926 ± 0.033	1.772IleLys: 1.772 ± 0.03	3.861IleLeu: 3.861 ± 0.044	0.742IleMet: 0.742 ± 0.022	1.809IleAsn: 1.809 ± 0.037	2.371IlePro: 2.371 ± 0.035	1.989IleGln: 1.989 ± 0.033	3.407IleArg: 3.407 ± 0.041	3.277IleSer: 3.277 ± 0.043	2.891IleThr: 2.891 ± 0.055	4.255IleVal: 4.255 ± 0.044	0.594IleTrp: 0.594 ± 0.016	1.18IleTyr: 1.18 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.336LysAla: 3.336 ± 0.051	0.309LysCys: 0.309 ± 0.012	2.034LysAsp: 2.034 ± 0.036	2.064LysGlu: 2.064 ± 0.041	1.284LysPhe: 1.284 ± 0.027	2.175LysGly: 2.175 ± 0.036	0.945LysHis: 0.945 ± 0.023	2.126LysIle: 2.126 ± 0.039	2.078LysLys: 2.078 ± 0.053	4.032LysLeu: 4.032 ± 0.05	1.06LysMet: 1.06 ± 0.023	1.378LysAsn: 1.378 ± 0.03	2.427LysPro: 2.427 ± 0.041	1.879LysGln: 1.879 ± 0.033	2.741LysArg: 2.741 ± 0.04	2.805LysSer: 2.805 ± 0.044	2.577LysThr: 2.577 ± 0.042	2.531LysVal: 2.531 ± 0.045	0.594LysTrp: 0.594 ± 0.018	0.9LysTyr: 0.9 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	10.033LeuAla: 10.033 ± 0.089	1.119LeuCys: 1.119 ± 0.027	5.751LeuAsp: 5.751 ± 0.05	4.674LeuGlu: 4.674 ± 0.056	3.28LeuPhe: 3.28 ± 0.043	6.61LeuGly: 6.61 ± 0.063	1.857LeuHis: 1.857 ± 0.033	4.938LeuIle: 4.938 ± 0.056	3.512LeuLys: 3.512 ± 0.048	8.887LeuLeu: 8.887 ± 0.105	2.095LeuMet: 2.095 ± 0.037	2.968LeuAsn: 2.968 ± 0.042	5.115LeuPro: 5.115 ± 0.054	3.845LeuGln: 3.845 ± 0.043	5.898LeuArg: 5.898 ± 0.068	6.973LeuSer: 6.973 ± 0.061	5.52LeuThr: 5.52 ± 0.072	6.686LeuVal: 6.686 ± 0.063	1.116LeuTrp: 1.116 ± 0.024	1.887LeuTyr: 1.887 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.091MetAla: 2.091 ± 0.04	0.2MetCys: 0.2 ± 0.009	1.14MetAsp: 1.14 ± 0.026	0.998MetGlu: 0.998 ± 0.024	0.732MetPhe: 0.732 ± 0.021	1.531MetGly: 1.531 ± 0.034	0.507MetHis: 0.507 ± 0.015	1.329MetIle: 1.329 ± 0.029	1.076MetLys: 1.076 ± 0.026	2.278MetLeu: 2.278 ± 0.037	0.632MetMet: 0.632 ± 0.02	0.963MetAsn: 0.963 ± 0.024	1.413MetPro: 1.413 ± 0.026	1.063MetGln: 1.063 ± 0.025	1.47MetArg: 1.47 ± 0.03	1.64MetSer: 1.64 ± 0.028	1.554MetThr: 1.554 ± 0.028	1.482MetVal: 1.482 ± 0.032	0.22MetTrp: 0.22 ± 0.011	0.407MetTyr: 0.407 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.355AsnAla: 3.355 ± 0.046	0.389AsnCys: 0.389 ± 0.014	2.451AsnAsp: 2.451 ± 0.059	2.02AsnGlu: 2.02 ± 0.032	1.185AsnPhe: 1.185 ± 0.026	2.936AsnGly: 2.936 ± 0.065	0.845AsnHis: 0.845 ± 0.021	1.433AsnIle: 1.433 ± 0.031	1.028AsnLys: 1.028 ± 0.025	3.157AsnLeu: 3.157 ± 0.036	0.597AsnMet: 0.597 ± 0.017	1.196AsnAsn: 1.196 ± 0.038	2.038AsnPro: 2.038 ± 0.033	1.69AsnGln: 1.69 ± 0.028	2.453AsnArg: 2.453 ± 0.035	2.198AsnSer: 2.198 ± 0.049	1.761AsnThr: 1.761 ± 0.046	2.604AsnVal: 2.604 ± 0.048	0.578AsnTrp: 0.578 ± 0.017	0.867AsnTyr: 0.867 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.816ProAla: 4.816 ± 0.058	0.353ProCys: 0.353 ± 0.015	3.42ProAsp: 3.42 ± 0.049	3.143ProGlu: 3.143 ± 0.042	1.713ProPhe: 1.713 ± 0.033	3.601ProGly: 3.601 ± 0.044	0.991ProHis: 0.991 ± 0.02	2.742ProIle: 2.742 ± 0.045	2.006ProLys: 2.006 ± 0.035	4.158ProLeu: 4.158 ± 0.049	1.183ProMet: 1.183 ± 0.024	1.96ProAsn: 1.96 ± 0.037	2.532ProPro: 2.532 ± 0.052	1.845ProGln: 1.845 ± 0.032	2.485ProArg: 2.485 ± 0.038	3.722ProSer: 3.722 ± 0.045	3.304ProThr: 3.304 ± 0.052	3.618ProVal: 3.618 ± 0.052	0.645ProTrp: 0.645 ± 0.016	1.049ProTyr: 1.049 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.806GlnAla: 3.806 ± 0.048	0.403GlnCys: 0.403 ± 0.015	1.905GlnAsp: 1.905 ± 0.031	1.812GlnGlu: 1.812 ± 0.031	1.656GlnPhe: 1.656 ± 0.027	2.45GlnGly: 2.45 ± 0.034	0.989GlnHis: 0.989 ± 0.024	2.541GlnIle: 2.541 ± 0.033	1.573GlnLys: 1.573 ± 0.032	4.487GlnLeu: 4.487 ± 0.048	1.038GlnMet: 1.038 ± 0.022	1.413GlnAsn: 1.413 ± 0.026	2.318GlnPro: 2.318 ± 0.044	2.362GlnGln: 2.362 ± 0.043	3.089GlnArg: 3.089 ± 0.043	3.568GlnSer: 3.568 ± 0.049	2.7GlnThr: 2.7 ± 0.037	2.721GlnVal: 2.721 ± 0.039	0.768GlnTrp: 0.768 ± 0.02	1.028GlnTyr: 1.028 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.42ArgAla: 4.42 ± 0.051	0.719ArgCys: 0.719 ± 0.02	3.942ArgAsp: 3.942 ± 0.046	3.511ArgGlu: 3.511 ± 0.058	2.758ArgPhe: 2.758 ± 0.039	4.103ArgGly: 4.103 ± 0.047	1.363ArgHis: 1.363 ± 0.03	3.588ArgIle: 3.588 ± 0.045	2.497ArgLys: 2.497 ± 0.042	6.519ArgLeu: 6.519 ± 0.067	1.726ArgMet: 1.726 ± 0.029	2.075ArgAsn: 2.075 ± 0.034	2.888ArgPro: 2.888 ± 0.039	2.831ArgGln: 2.831 ± 0.042	4.77ArgArg: 4.77 ± 0.067	4.434ArgSer: 4.434 ± 0.057	3.11ArgThr: 3.11 ± 0.04	4.328ArgVal: 4.328 ± 0.051	1.113ArgTrp: 1.113 ± 0.026	1.74ArgTyr: 1.74 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.295SerAla: 6.295 ± 0.064	0.676SerCys: 0.676 ± 0.022	5.079SerAsp: 5.079 ± 0.071	4.036SerGlu: 4.036 ± 0.042	2.508SerPhe: 2.508 ± 0.037	6.032SerGly: 6.032 ± 0.082	1.448SerHis: 1.448 ± 0.031	3.83SerIle: 3.83 ± 0.038	2.562SerLys: 2.562 ± 0.044	6.704SerLeu: 6.704 ± 0.062	1.631SerMet: 1.631 ± 0.033	2.427SerAsn: 2.427 ± 0.041	3.664SerPro: 3.664 ± 0.046	3.093SerGln: 3.093 ± 0.039	4.166SerArg: 4.166 ± 0.05	4.825SerSer: 4.825 ± 0.064	3.968SerThr: 3.968 ± 0.057	5.305SerVal: 5.305 ± 0.059	0.884SerTrp: 0.884 ± 0.02	1.476SerTyr: 1.476 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.636ThrAla: 5.636 ± 0.08	0.555ThrCys: 0.555 ± 0.018	3.986ThrAsp: 3.986 ± 0.083	2.99ThrGlu: 2.99 ± 0.044	2.187ThrPhe: 2.187 ± 0.054	4.795ThrGly: 4.795 ± 0.105	1.183ThrHis: 1.183 ± 0.031	3.546ThrIle: 3.546 ± 0.086	2.128ThrLys: 2.128 ± 0.031	5.634ThrLeu: 5.634 ± 0.067	1.237ThrMet: 1.237 ± 0.027	2.079ThrAsn: 2.079 ± 0.056	3.285ThrPro: 3.285 ± 0.049	2.249ThrGln: 2.249 ± 0.031	3.015ThrArg: 3.015 ± 0.042	3.838ThrSer: 3.838 ± 0.061	3.632ThrThr: 3.632 ± 0.075	4.437ThrVal: 4.437 ± 0.105	0.766ThrTrp: 0.766 ± 0.021	1.368ThrTyr: 1.368 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	7.693ValAla: 7.693 ± 0.066	0.935ValCys: 0.935 ± 0.022	5.43ValAsp: 5.43 ± 0.082	3.854ValGlu: 3.854 ± 0.049	2.722ValPhe: 2.722 ± 0.04	5.341ValGly: 5.341 ± 0.059	1.425ValHis: 1.425 ± 0.026	3.739ValIle: 3.739 ± 0.041	2.37ValLys: 2.37 ± 0.036	6.53ValLeu: 6.53 ± 0.072	1.612ValMet: 1.612 ± 0.027	2.343ValAsn: 2.343 ± 0.046	3.427ValPro: 3.427 ± 0.048	2.709ValGln: 2.709 ± 0.042	4.429ValArg: 4.429 ± 0.047	4.976ValSer: 4.976 ± 0.062	4.421ValThr: 4.421 ± 0.108	5.898ValVal: 5.898 ± 0.061	0.919ValTrp: 0.919 ± 0.021	1.638ValTyr: 1.638 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.029TrpAla: 1.029 ± 0.024	0.186TrpCys: 0.186 ± 0.008	0.766TrpAsp: 0.766 ± 0.02	0.61TrpGlu: 0.61 ± 0.018	0.547TrpPhe: 0.547 ± 0.017	0.837TrpGly: 0.837 ± 0.021	0.414TrpHis: 0.414 ± 0.014	0.862TrpIle: 0.862 ± 0.02	0.692TrpLys: 0.692 ± 0.02	1.512TrpLeu: 1.512 ± 0.029	0.425TrpMet: 0.425 ± 0.015	0.566TrpAsn: 0.566 ± 0.016	0.66TrpPro: 0.66 ± 0.018	0.744TrpGln: 0.744 ± 0.021	0.925TrpArg: 0.925 ± 0.02	0.98TrpSer: 0.98 ± 0.021	0.808TrpThr: 0.808 ± 0.022	0.871TrpVal: 0.871 ± 0.019	0.233TrpTrp: 0.233 ± 0.01	0.34TrpTyr: 0.34 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.119TyrAla: 2.119 ± 0.034	0.316TyrCys: 0.316 ± 0.013	1.653TyrAsp: 1.653 ± 0.048	1.393TyrGlu: 1.393 ± 0.027	1.02TyrPhe: 1.02 ± 0.024	1.873TyrGly: 1.873 ± 0.033	0.577TyrHis: 0.577 ± 0.018	0.795TyrIle: 0.795 ± 0.019	0.681TyrLys: 0.681 ± 0.019	2.262TyrLeu: 2.262 ± 0.034	0.352TyrMet: 0.352 ± 0.012	0.697TyrAsn: 0.697 ± 0.023	1.091TyrPro: 1.091 ± 0.024	1.176TyrGln: 1.176 ± 0.024	1.965TyrArg: 1.965 ± 0.031	1.472TyrSer: 1.472 ± 0.028	1.141TyrThr: 1.141 ± 0.04	1.576TyrVal: 1.576 ± 0.026	0.368TyrTrp: 0.368 ± 0.014	0.643TyrTyr: 0.643 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5858 proteins (2345483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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