Amino acid dipepetide frequency for Neptunomonas marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.166AlaAla: 11.166 ± 0.145	1.085AlaCys: 1.085 ± 0.036	5.573AlaAsp: 5.573 ± 0.082	6.738AlaGlu: 6.738 ± 0.097	3.668AlaPhe: 3.668 ± 0.055	7.246AlaGly: 7.246 ± 0.091	2.048AlaHis: 2.048 ± 0.042	5.967AlaIle: 5.967 ± 0.073	4.349AlaLys: 4.349 ± 0.06	11.974AlaLeu: 11.974 ± 0.121	2.744AlaMet: 2.744 ± 0.044	3.33AlaAsn: 3.33 ± 0.061	3.828AlaPro: 3.828 ± 0.079	5.059AlaGln: 5.059 ± 0.076	4.948AlaArg: 4.948 ± 0.067	5.797AlaSer: 5.797 ± 0.076	4.937AlaThr: 4.937 ± 0.076	7.123AlaVal: 7.123 ± 0.092	1.145AlaTrp: 1.145 ± 0.034	2.435AlaTyr: 2.435 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.03	0.178CysCys: 0.178 ± 0.014	0.579CysAsp: 0.579 ± 0.021	0.678CysGlu: 0.678 ± 0.028	0.419CysPhe: 0.419 ± 0.021	0.921CysGly: 0.921 ± 0.031	0.332CysHis: 0.332 ± 0.019	0.525CysIle: 0.525 ± 0.022	0.362CysLys: 0.362 ± 0.021	0.935CysLeu: 0.935 ± 0.029	0.235CysMet: 0.235 ± 0.018	0.347CysAsn: 0.347 ± 0.018	0.456CysPro: 0.456 ± 0.022	0.428CysGln: 0.428 ± 0.021	0.521CysArg: 0.521 ± 0.022	0.663CysSer: 0.663 ± 0.024	0.527CysThr: 0.527 ± 0.022	0.716CysVal: 0.716 ± 0.024	0.141CysTrp: 0.141 ± 0.012	0.332CysTyr: 0.332 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.503AspAla: 5.503 ± 0.08	0.507AspCys: 0.507 ± 0.022	3.12AspAsp: 3.12 ± 0.055	3.91AspGlu: 3.91 ± 0.061	2.06AspPhe: 2.06 ± 0.043	3.784AspGly: 3.784 ± 0.07	1.268AspHis: 1.268 ± 0.032	3.662AspIle: 3.662 ± 0.057	2.464AspLys: 2.464 ± 0.055	5.564AspLeu: 5.564 ± 0.075	1.361AspMet: 1.361 ± 0.037	1.94AspAsn: 1.94 ± 0.044	2.325AspPro: 2.325 ± 0.049	2.551AspGln: 2.551 ± 0.049	2.739AspArg: 2.739 ± 0.06	3.115AspSer: 3.115 ± 0.051	2.853AspThr: 2.853 ± 0.059	3.944AspVal: 3.944 ± 0.071	0.824AspTrp: 0.824 ± 0.027	1.821AspTyr: 1.821 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.598GluAla: 6.598 ± 0.09	0.499GluCys: 0.499 ± 0.023	2.763GluAsp: 2.763 ± 0.064	3.933GluGlu: 3.933 ± 0.077	2.094GluPhe: 2.094 ± 0.046	4.065GluGly: 4.065 ± 0.07	1.726GluHis: 1.726 ± 0.043	3.557GluIle: 3.557 ± 0.059	3.081GluLys: 3.081 ± 0.056	7.148GluLeu: 7.148 ± 0.08	1.718GluMet: 1.718 ± 0.038	2.137GluAsn: 2.137 ± 0.042	2.402GluPro: 2.402 ± 0.049	4.311GluGln: 4.311 ± 0.066	4.305GluArg: 4.305 ± 0.066	3.504GluSer: 3.504 ± 0.064	3.177GluThr: 3.177 ± 0.058	4.609GluVal: 4.609 ± 0.078	0.745GluTrp: 0.745 ± 0.031	1.573GluTyr: 1.573 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.804PheAla: 3.804 ± 0.07	0.513PheCys: 0.513 ± 0.021	2.502PheAsp: 2.502 ± 0.045	2.353PheGlu: 2.353 ± 0.048	1.613PhePhe: 1.613 ± 0.044	3.129PheGly: 3.129 ± 0.061	0.772PheHis: 0.772 ± 0.023	2.309PheIle: 2.309 ± 0.051	1.637PheLys: 1.637 ± 0.04	3.425PheLeu: 3.425 ± 0.063	0.858PheMet: 0.858 ± 0.027	1.49PheAsn: 1.49 ± 0.035	1.45PhePro: 1.45 ± 0.039	1.229PheGln: 1.229 ± 0.032	1.655PheArg: 1.655 ± 0.041	2.999PheSer: 2.999 ± 0.054	2.173PheThr: 2.173 ± 0.049	2.706PheVal: 2.706 ± 0.049	0.525PheTrp: 0.525 ± 0.022	1.223PheTyr: 1.223 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.233GlyAla: 6.233 ± 0.08	0.959GlyCys: 0.959 ± 0.031	3.905GlyAsp: 3.905 ± 0.063	4.431GlyGlu: 4.431 ± 0.066	3.337GlyPhe: 3.337 ± 0.059	5.073GlyGly: 5.073 ± 0.083	1.654GlyHis: 1.654 ± 0.043	4.421GlyIle: 4.421 ± 0.069	3.439GlyLys: 3.439 ± 0.063	7.266GlyLeu: 7.266 ± 0.092	2.06GlyMet: 2.06 ± 0.046	2.305GlyAsn: 2.305 ± 0.05	1.878GlyPro: 1.878 ± 0.045	2.95GlyGln: 2.95 ± 0.051	3.686GlyArg: 3.686 ± 0.067	4.188GlySer: 4.188 ± 0.072	3.465GlyThr: 3.465 ± 0.06	5.738GlyVal: 5.738 ± 0.076	1.054GlyTrp: 1.054 ± 0.03	2.404GlyTyr: 2.404 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.995HisAla: 1.995 ± 0.041	0.321HisCys: 0.321 ± 0.016	1.215HisAsp: 1.215 ± 0.032	1.292HisGlu: 1.292 ± 0.034	1.06HisPhe: 1.06 ± 0.031	1.579HisGly: 1.579 ± 0.04	0.788HisHis: 0.788 ± 0.032	1.316HisIle: 1.316 ± 0.035	0.828HisLys: 0.828 ± 0.027	2.456HisLeu: 2.456 ± 0.049	0.519HisMet: 0.519 ± 0.019	0.774HisAsn: 0.774 ± 0.026	1.285HisPro: 1.285 ± 0.033	1.205HisGln: 1.205 ± 0.034	1.235HisArg: 1.235 ± 0.037	1.317HisSer: 1.317 ± 0.037	1.164HisThr: 1.164 ± 0.036	1.409HisVal: 1.409 ± 0.036	0.37HisTrp: 0.37 ± 0.018	0.803HisTyr: 0.803 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.433IleAla: 6.433 ± 0.081	0.658IleCys: 0.658 ± 0.025	3.87IleAsp: 3.87 ± 0.062	4.219IleGlu: 4.219 ± 0.059	1.905IlePhe: 1.905 ± 0.048	4.196IleGly: 4.196 ± 0.064	1.13IleHis: 1.13 ± 0.035	2.835IleIle: 2.835 ± 0.057	2.578IleLys: 2.578 ± 0.057	4.765IleLeu: 4.765 ± 0.078	1.143IleMet: 1.143 ± 0.032	2.421IleAsn: 2.421 ± 0.045	2.519IlePro: 2.519 ± 0.055	2.029IleGln: 2.029 ± 0.048	3.022IleArg: 3.022 ± 0.053	4.059IleSer: 4.059 ± 0.066	3.376IleThr: 3.376 ± 0.064	3.868IleVal: 3.868 ± 0.07	0.573IleTrp: 0.573 ± 0.024	1.548IleTyr: 1.548 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.626LysAla: 4.626 ± 0.074	0.244LysCys: 0.244 ± 0.016	2.145LysAsp: 2.145 ± 0.05	2.768LysGlu: 2.768 ± 0.053	1.085LysPhe: 1.085 ± 0.035	2.908LysGly: 2.908 ± 0.058	1.03LysHis: 1.03 ± 0.033	2.143LysIle: 2.143 ± 0.04	2.14LysLys: 2.14 ± 0.058	4.354LysLeu: 4.354 ± 0.063	1.096LysMet: 1.096 ± 0.035	1.367LysAsn: 1.367 ± 0.04	2.235LysPro: 2.235 ± 0.046	2.334LysGln: 2.334 ± 0.05	2.944LysArg: 2.944 ± 0.053	2.492LysSer: 2.492 ± 0.041	2.396LysThr: 2.396 ± 0.05	3.131LysVal: 3.131 ± 0.051	0.395LysTrp: 0.395 ± 0.02	0.957LysTyr: 0.957 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.491LeuAla: 11.491 ± 0.118	1.091LeuCys: 1.091 ± 0.034	5.969LeuAsp: 5.969 ± 0.089	6.595LeuGlu: 6.595 ± 0.083	4.234LeuPhe: 4.234 ± 0.071	7.385LeuGly: 7.385 ± 0.09	2.225LeuHis: 2.225 ± 0.052	5.963LeuIle: 5.963 ± 0.094	4.784LeuLys: 4.784 ± 0.069	11.453LeuLeu: 11.453 ± 0.165	2.735LeuMet: 2.735 ± 0.055	4.059LeuAsn: 4.059 ± 0.061	5.229LeuPro: 5.229 ± 0.074	4.229LeuGln: 4.229 ± 0.075	5.493LeuArg: 5.493 ± 0.075	7.617LeuSer: 7.617 ± 0.081	5.849LeuThr: 5.849 ± 0.073	7.367LeuVal: 7.367 ± 0.096	1.1LeuTrp: 1.1 ± 0.033	2.558LeuTyr: 2.558 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.677MetAla: 2.677 ± 0.05	0.191MetCys: 0.191 ± 0.013	1.229MetAsp: 1.229 ± 0.035	1.322MetGlu: 1.322 ± 0.04	0.831MetPhe: 0.831 ± 0.031	1.782MetGly: 1.782 ± 0.043	0.493MetHis: 0.493 ± 0.023	1.451MetIle: 1.451 ± 0.041	1.249MetLys: 1.249 ± 0.04	2.8MetLeu: 2.8 ± 0.052	0.731MetMet: 0.731 ± 0.028	0.881MetAsn: 0.881 ± 0.028	1.251MetPro: 1.251 ± 0.035	1.212MetGln: 1.212 ± 0.037	1.447MetArg: 1.447 ± 0.033	1.958MetSer: 1.958 ± 0.042	1.458MetThr: 1.458 ± 0.037	1.697MetVal: 1.697 ± 0.037	0.213MetTrp: 0.213 ± 0.013	0.422MetTyr: 0.422 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.273AsnAla: 3.273 ± 0.058	0.37AsnCys: 0.37 ± 0.018	1.938AsnAsp: 1.938 ± 0.039	2.086AsnGlu: 2.086 ± 0.043	1.177AsnPhe: 1.177 ± 0.033	2.615AsnGly: 2.615 ± 0.067	0.788AsnHis: 0.788 ± 0.026	2.049AsnIle: 2.049 ± 0.048	1.408AsnLys: 1.408 ± 0.032	3.347AsnLeu: 3.347 ± 0.054	0.845AsnMet: 0.845 ± 0.028	1.306AsnAsn: 1.306 ± 0.035	1.955AsnPro: 1.955 ± 0.048	1.621AsnGln: 1.621 ± 0.042	2.011AsnArg: 2.011 ± 0.043	2.001AsnSer: 2.001 ± 0.049	2.005AsnThr: 2.005 ± 0.045	2.166AsnVal: 2.166 ± 0.043	0.458AsnTrp: 0.458 ± 0.02	1.053AsnTyr: 1.053 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.302ProAla: 4.302 ± 0.065	0.338ProCys: 0.338 ± 0.018	2.756ProAsp: 2.756 ± 0.05	3.523ProGlu: 3.523 ± 0.058	1.775ProPhe: 1.775 ± 0.042	2.621ProGly: 2.621 ± 0.059	0.963ProHis: 0.963 ± 0.032	2.336ProIle: 2.336 ± 0.043	1.808ProLys: 1.808 ± 0.04	4.562ProLeu: 4.562 ± 0.072	1.045ProMet: 1.045 ± 0.034	1.543ProAsn: 1.543 ± 0.044	1.473ProPro: 1.473 ± 0.037	1.783ProGln: 1.783 ± 0.04	1.735ProArg: 1.735 ± 0.042	2.578ProSer: 2.578 ± 0.049	2.259ProThr: 2.259 ± 0.048	3.487ProVal: 3.487 ± 0.056	0.549ProTrp: 0.549 ± 0.026	1.203ProTyr: 1.203 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.989GlnAla: 4.989 ± 0.07	0.34GlnCys: 0.34 ± 0.019	1.936GlnAsp: 1.936 ± 0.042	2.546GlnGlu: 2.546 ± 0.051	1.646GlnPhe: 1.646 ± 0.041	3.084GlnGly: 3.084 ± 0.052	1.311GlnHis: 1.311 ± 0.034	2.328GlnIle: 2.328 ± 0.048	1.661GlnLys: 1.661 ± 0.043	5.848GlnLeu: 5.848 ± 0.092	1.187GlnMet: 1.187 ± 0.031	1.37GlnAsn: 1.37 ± 0.034	2.167GlnPro: 2.167 ± 0.05	3.292GlnGln: 3.292 ± 0.072	3.086GlnArg: 3.086 ± 0.062	2.624GlnSer: 2.624 ± 0.05	2.331GlnThr: 2.331 ± 0.044	3.353GlnVal: 3.353 ± 0.053	0.685GlnTrp: 0.685 ± 0.024	1.14GlnTyr: 1.14 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.628ArgAla: 4.628 ± 0.062	0.57ArgCys: 0.57 ± 0.024	2.974ArgAsp: 2.974 ± 0.049	3.553ArgGlu: 3.553 ± 0.057	2.602ArgPhe: 2.602 ± 0.045	3.125ArgGly: 3.125 ± 0.057	1.334ArgHis: 1.334 ± 0.037	3.478ArgIle: 3.478 ± 0.058	2.382ArgLys: 2.382 ± 0.045	5.984ArgLeu: 5.984 ± 0.078	1.477ArgMet: 1.477 ± 0.036	1.848ArgAsn: 1.848 ± 0.04	1.931ArgPro: 1.931 ± 0.043	2.568ArgGln: 2.568 ± 0.054	3.124ArgArg: 3.124 ± 0.054	3.279ArgSer: 3.279 ± 0.052	2.449ArgThr: 2.449 ± 0.046	3.88ArgVal: 3.88 ± 0.066	0.843ArgTrp: 0.843 ± 0.029	2.03ArgTyr: 2.03 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.279SerAla: 6.279 ± 0.076	0.644SerCys: 0.644 ± 0.026	3.507SerAsp: 3.507 ± 0.054	3.906SerGlu: 3.906 ± 0.064	2.598SerPhe: 2.598 ± 0.055	5.109SerGly: 5.109 ± 0.081	1.517SerHis: 1.517 ± 0.038	3.385SerIle: 3.385 ± 0.058	2.398SerLys: 2.398 ± 0.047	6.702SerLeu: 6.702 ± 0.093	1.583SerMet: 1.583 ± 0.038	2.01SerAsn: 2.01 ± 0.056	2.489SerPro: 2.489 ± 0.051	2.715SerGln: 2.715 ± 0.052	3.279SerArg: 3.279 ± 0.062	4.03SerSer: 4.03 ± 0.068	3.093SerThr: 3.093 ± 0.058	4.52SerVal: 4.52 ± 0.062	0.817SerTrp: 0.817 ± 0.031	1.873SerTyr: 1.873 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.204ThrAla: 5.204 ± 0.075	0.479ThrCys: 0.479 ± 0.02	2.894ThrAsp: 2.894 ± 0.051	3.215ThrGlu: 3.215 ± 0.052	1.926ThrPhe: 1.926 ± 0.04	4.061ThrGly: 4.061 ± 0.068	1.199ThrHis: 1.199 ± 0.036	2.773ThrIle: 2.773 ± 0.045	1.715ThrLys: 1.715 ± 0.036	6.62ThrLeu: 6.62 ± 0.083	1.07ThrMet: 1.07 ± 0.033	1.579ThrAsn: 1.579 ± 0.043	3.007ThrPro: 3.007 ± 0.056	2.498ThrGln: 2.498 ± 0.043	2.624ThrArg: 2.624 ± 0.049	2.979ThrSer: 2.979 ± 0.056	2.833ThrThr: 2.833 ± 0.06	3.688ThrVal: 3.688 ± 0.066	0.557ThrTrp: 0.557 ± 0.023	1.414ThrTyr: 1.414 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.768ValAla: 7.768 ± 0.096	0.787ValCys: 0.787 ± 0.029	4.284ValAsp: 4.284 ± 0.065	4.648ValGlu: 4.648 ± 0.072	2.594ValPhe: 2.594 ± 0.053	5.04ValGly: 5.04 ± 0.071	1.293ValHis: 1.293 ± 0.036	4.546ValIle: 4.546 ± 0.074	3.095ValLys: 3.095 ± 0.064	7.277ValLeu: 7.277 ± 0.081	1.975ValMet: 1.975 ± 0.039	2.503ValAsn: 2.503 ± 0.044	2.898ValPro: 2.898 ± 0.049	2.407ValGln: 2.407 ± 0.045	3.417ValArg: 3.417 ± 0.05	4.815ValSer: 4.815 ± 0.068	4.139ValThr: 4.139 ± 0.071	5.935ValVal: 5.935 ± 0.083	0.779ValTrp: 0.779 ± 0.028	1.759ValTyr: 1.759 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.899TrpAla: 0.899 ± 0.029	0.161TrpCys: 0.161 ± 0.012	0.64TrpAsp: 0.64 ± 0.027	0.656TrpGlu: 0.656 ± 0.025	0.541TrpPhe: 0.541 ± 0.02	0.774TrpGly: 0.774 ± 0.026	0.334TrpHis: 0.334 ± 0.019	0.607TrpIle: 0.607 ± 0.023	0.437TrpLys: 0.437 ± 0.023	1.772TrpLeu: 1.772 ± 0.046	0.32TrpMet: 0.32 ± 0.017	0.408TrpAsn: 0.408 ± 0.02	0.533TrpPro: 0.533 ± 0.023	0.851TrpGln: 0.851 ± 0.031	0.819TrpArg: 0.819 ± 0.028	0.765TrpSer: 0.765 ± 0.029	0.449TrpThr: 0.449 ± 0.021	0.95TrpVal: 0.95 ± 0.03	0.16TrpTrp: 0.16 ± 0.014	0.297TrpTyr: 0.297 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.324TyrAla: 2.324 ± 0.046	0.328TyrCys: 0.328 ± 0.018	1.516TyrAsp: 1.516 ± 0.038	1.573TyrGlu: 1.573 ± 0.039	1.198TyrPhe: 1.198 ± 0.035	1.951TyrGly: 1.951 ± 0.041	0.725TyrHis: 0.725 ± 0.026	1.497TyrIle: 1.497 ± 0.041	0.974TyrLys: 0.974 ± 0.029	3.169TyrLeu: 3.169 ± 0.053	0.596TyrMet: 0.596 ± 0.024	0.856TyrAsn: 0.856 ± 0.029	1.33TyrPro: 1.33 ± 0.034	1.65TyrGln: 1.65 ± 0.035	1.973TyrArg: 1.973 ± 0.048	1.673TyrSer: 1.673 ± 0.041	1.399TyrThr: 1.399 ± 0.036	1.673TyrVal: 1.673 ± 0.038	0.438TyrTrp: 0.438 ± 0.019	0.865TyrTyr: 0.865 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3482 proteins (1104039 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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