Amino acid dipepetide frequency for CRESS virus sp. ctWOo3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.074AlaAla: 1.074 ± 0.654
1.074AlaCys: 1.074 ± 1.785
3.222AlaAsp: 3.222 ± 1.478
2.148AlaGlu: 2.148 ± 1.308
3.222AlaPhe: 3.222 ± 0.712
5.371AlaGly: 5.371 ± 3.082
1.074AlaHis: 1.074 ± 0.654
2.148AlaIle: 2.148 ± 0.544
3.222AlaLys: 3.222 ± 1.962
2.148AlaLeu: 2.148 ± 1.559
0.0AlaMet: 0.0 ± 0.0
3.222AlaAsn: 3.222 ± 1.962
5.371AlaPro: 5.371 ± 1.87
0.0AlaGln: 0.0 ± 0.0
4.296AlaArg: 4.296 ± 5.055
3.222AlaSer: 3.222 ± 2.909
3.222AlaThr: 3.222 ± 1.962
1.074AlaVal: 1.074 ± 0.654
0.0AlaTrp: 0.0 ± 0.0
2.148AlaTyr: 2.148 ± 1.308
0.0AlaXaa: 0.0 ± 0.0
Cys
2.148CysAla: 2.148 ± 1.559
0.0CysCys: 0.0 ± 0.0
1.074CysAsp: 1.074 ± 0.97
1.074CysGlu: 1.074 ± 0.654
0.0CysPhe: 0.0 ± 0.0
1.074CysGly: 1.074 ± 0.654
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.074CysLeu: 1.074 ± 0.654
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.074CysPro: 1.074 ± 0.97
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.074CysSer: 1.074 ± 0.97
0.0CysThr: 0.0 ± 0.0
1.074CysVal: 1.074 ± 0.97
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.0AspCys: 0.0 ± 0.0
8.593AspAsp: 8.593 ± 2.283
1.074AspGlu: 1.074 ± 1.785
5.371AspPhe: 5.371 ± 1.086
2.148AspGly: 2.148 ± 1.559
0.0AspHis: 0.0 ± 0.0
2.148AspIle: 2.148 ± 1.559
3.222AspLys: 3.222 ± 1.43
8.593AspLeu: 8.593 ± 2.762
3.222AspMet: 3.222 ± 0.712
2.148AspAsn: 2.148 ± 1.308
8.593AspPro: 8.593 ± 2.762
1.074AspGln: 1.074 ± 0.654
5.371AspArg: 5.371 ± 2.708
5.371AspSer: 5.371 ± 1.086
6.445AspThr: 6.445 ± 1.356
5.371AspVal: 5.371 ± 3.345
0.0AspTrp: 0.0 ± 0.0
4.296AspTyr: 4.296 ± 4.006
0.0AspXaa: 0.0 ± 0.0
Glu
3.222GluAla: 3.222 ± 0.712
0.0GluCys: 0.0 ± 0.0
4.296GluAsp: 4.296 ± 3.362
4.296GluGlu: 4.296 ± 2.382
2.148GluPhe: 2.148 ± 0.544
1.074GluGly: 1.074 ± 1.785
0.0GluHis: 0.0 ± 0.0
4.296GluIle: 4.296 ± 1.954
3.222GluLys: 3.222 ± 1.591
2.148GluLeu: 2.148 ± 0.544
2.148GluMet: 2.148 ± 1.559
6.445GluAsn: 6.445 ± 2.054
1.074GluPro: 1.074 ± 1.785
2.148GluGln: 2.148 ± 1.308
2.148GluArg: 2.148 ± 0.544
2.148GluSer: 2.148 ± 0.544
4.296GluThr: 4.296 ± 1.255
4.296GluVal: 4.296 ± 1.255
0.0GluTrp: 0.0 ± 0.0
1.074GluTyr: 1.074 ± 0.654
0.0GluXaa: 0.0 ± 0.0
Phe
2.148PheAla: 2.148 ± 1.559
0.0PheCys: 0.0 ± 0.0
5.371PheAsp: 5.371 ± 1.87
3.222PheGlu: 3.222 ± 0.712
1.074PhePhe: 1.074 ± 0.654
2.148PheGly: 2.148 ± 0.544
1.074PheHis: 1.074 ± 0.654
3.222PheIle: 3.222 ± 2.592
6.445PheLys: 6.445 ± 1.425
3.222PheLeu: 3.222 ± 2.592
1.074PheMet: 1.074 ± 1.785
6.445PheAsn: 6.445 ± 0.768
1.074PhePro: 1.074 ± 0.654
1.074PheGln: 1.074 ± 0.97
2.148PheArg: 2.148 ± 1.308
3.222PheSer: 3.222 ± 0.712
4.296PheThr: 4.296 ± 1.089
5.371PheVal: 5.371 ± 1.086
1.074PheTrp: 1.074 ± 0.97
3.222PheTyr: 3.222 ± 1.43
0.0PheXaa: 0.0 ± 0.0
Gly
5.371GlyAla: 5.371 ± 1.333
0.0GlyCys: 0.0 ± 0.0
4.296GlyAsp: 4.296 ± 1.255
3.222GlyGlu: 3.222 ± 1.478
6.445GlyPhe: 6.445 ± 1.356
2.148GlyGly: 2.148 ± 0.544
1.074GlyHis: 1.074 ± 0.654
2.148GlyIle: 2.148 ± 1.308
2.148GlyLys: 2.148 ± 1.939
2.148GlyLeu: 2.148 ± 1.308
1.074GlyMet: 1.074 ± 0.97
3.222GlyAsn: 3.222 ± 0.712
3.222GlyPro: 3.222 ± 1.962
3.222GlyGln: 3.222 ± 1.962
2.148GlyArg: 2.148 ± 1.559
3.222GlySer: 3.222 ± 1.962
9.667GlyThr: 9.667 ± 1.469
3.222GlyVal: 3.222 ± 1.591
0.0GlyTrp: 0.0 ± 0.0
3.222GlyTyr: 3.222 ± 1.478
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.074HisPhe: 1.074 ± 0.654
1.074HisGly: 1.074 ± 0.654
2.148HisHis: 2.148 ± 0.544
2.148HisIle: 2.148 ± 1.308
1.074HisLys: 1.074 ± 0.654
3.222HisLeu: 3.222 ± 0.712
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
2.148HisVal: 2.148 ± 1.308
0.0HisTrp: 0.0 ± 0.0
1.074HisTyr: 1.074 ± 0.654
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
3.222IleCys: 3.222 ± 0.712
5.371IleAsp: 5.371 ± 3.459
2.148IleGlu: 2.148 ± 1.308
2.148IlePhe: 2.148 ± 1.939
4.296IleGly: 4.296 ± 2.382
1.074IleHis: 1.074 ± 0.654
6.445IleIle: 6.445 ± 4.31
2.148IleLys: 2.148 ± 1.939
2.148IleLeu: 2.148 ± 0.544
2.148IleMet: 2.148 ± 1.181
2.148IleAsn: 2.148 ± 2.003
3.222IlePro: 3.222 ± 1.591
1.074IleGln: 1.074 ± 0.654
2.148IleArg: 2.148 ± 1.308
5.371IleSer: 5.371 ± 4.53
3.222IleThr: 3.222 ± 0.712
6.445IleVal: 6.445 ± 1.425
1.074IleTrp: 1.074 ± 0.97
1.074IleTyr: 1.074 ± 0.654
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
0.0LysCys: 0.0 ± 0.0
2.148LysAsp: 2.148 ± 1.939
5.371LysGlu: 5.371 ± 1.048
2.148LysPhe: 2.148 ± 0.544
2.148LysGly: 2.148 ± 1.308
0.0LysHis: 0.0 ± 0.0
7.519LysIle: 7.519 ± 2.456
5.371LysLys: 5.371 ± 1.086
4.296LysLeu: 4.296 ± 2.382
3.222LysMet: 3.222 ± 1.962
4.296LysAsn: 4.296 ± 1.089
2.148LysPro: 2.148 ± 1.308
3.222LysGln: 3.222 ± 0.712
5.371LysArg: 5.371 ± 1.086
7.519LysSer: 7.519 ± 3.148
2.148LysThr: 2.148 ± 0.544
2.148LysVal: 2.148 ± 0.544
0.0LysTrp: 0.0 ± 0.0
3.222LysTyr: 3.222 ± 2.909
0.0LysXaa: 0.0 ± 0.0
Leu
3.222LeuAla: 3.222 ± 1.591
1.074LeuCys: 1.074 ± 0.97
3.222LeuAsp: 3.222 ± 1.478
8.593LeuGlu: 8.593 ± 5.274
5.371LeuPhe: 5.371 ± 1.333
5.371LeuGly: 5.371 ± 1.87
1.074LeuHis: 1.074 ± 0.654
4.296LeuIle: 4.296 ± 4.006
4.296LeuLys: 4.296 ± 2.382
6.445LeuLeu: 6.445 ± 2.505
1.074LeuMet: 1.074 ± 0.97
3.222LeuAsn: 3.222 ± 0.712
3.222LeuPro: 3.222 ± 1.43
2.148LeuGln: 2.148 ± 1.939
7.519LeuArg: 7.519 ± 3.148
4.296LeuSer: 4.296 ± 1.089
6.445LeuThr: 6.445 ± 0.768
2.148LeuVal: 2.148 ± 1.559
0.0LeuTrp: 0.0 ± 0.0
3.222LeuTyr: 3.222 ± 0.712
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
2.148MetAsp: 2.148 ± 1.939
2.148MetGlu: 2.148 ± 2.003
0.0MetPhe: 0.0 ± 0.0
1.074MetGly: 1.074 ± 0.654
0.0MetHis: 0.0 ± 0.0
1.074MetIle: 1.074 ± 0.654
0.0MetLys: 0.0 ± 0.0
3.222MetLeu: 3.222 ± 1.962
1.074MetMet: 1.074 ± 0.97
2.148MetAsn: 2.148 ± 3.57
2.148MetPro: 2.148 ± 0.544
2.148MetGln: 2.148 ± 0.544
3.222MetArg: 3.222 ± 1.43
4.296MetSer: 4.296 ± 1.102
1.074MetThr: 1.074 ± 0.654
0.0MetVal: 0.0 ± 0.0
1.074MetTrp: 1.074 ± 1.785
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
7.519AsnAla: 7.519 ± 1.853
0.0AsnCys: 0.0 ± 0.0
4.296AsnAsp: 4.296 ± 3.232
2.148AsnGlu: 2.148 ± 1.939
2.148AsnPhe: 2.148 ± 1.559
4.296AsnGly: 4.296 ± 1.102
1.074AsnHis: 1.074 ± 0.654
2.148AsnIle: 2.148 ± 1.308
6.445AsnLys: 6.445 ± 2.861
5.371AsnLeu: 5.371 ± 1.086
1.074AsnMet: 1.074 ± 1.785
4.296AsnAsn: 4.296 ± 1.255
1.074AsnPro: 1.074 ± 1.785
3.222AsnGln: 3.222 ± 1.962
5.371AsnArg: 5.371 ± 1.935
6.445AsnSer: 6.445 ± 2.505
3.222AsnThr: 3.222 ± 0.712
2.148AsnVal: 2.148 ± 1.308
1.074AsnTrp: 1.074 ± 0.654
1.074AsnTyr: 1.074 ± 0.97
0.0AsnXaa: 0.0 ± 0.0
Pro
4.296ProAla: 4.296 ± 2.616
0.0ProCys: 0.0 ± 0.0
3.222ProAsp: 3.222 ± 1.43
1.074ProGlu: 1.074 ± 1.785
4.296ProPhe: 4.296 ± 1.102
3.222ProGly: 3.222 ± 1.962
0.0ProHis: 0.0 ± 0.0
3.222ProIle: 3.222 ± 1.478
0.0ProLys: 0.0 ± 0.0
2.148ProLeu: 2.148 ± 2.003
1.074ProMet: 1.074 ± 1.632
3.222ProAsn: 3.222 ± 1.962
4.296ProPro: 4.296 ± 1.255
2.148ProGln: 2.148 ± 0.544
2.148ProArg: 2.148 ± 0.544
4.296ProSer: 4.296 ± 1.255
2.148ProThr: 2.148 ± 1.308
6.445ProVal: 6.445 ± 0.768
1.074ProTrp: 1.074 ± 0.97
1.074ProTyr: 1.074 ± 0.654
0.0ProXaa: 0.0 ± 0.0
Gln
2.148GlnAla: 2.148 ± 1.308
1.074GlnCys: 1.074 ± 0.654
2.148GlnAsp: 2.148 ± 1.308
2.148GlnGlu: 2.148 ± 0.544
0.0GlnPhe: 0.0 ± 0.0
3.222GlnGly: 3.222 ± 1.43
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
3.222GlnLys: 3.222 ± 1.43
5.371GlnLeu: 5.371 ± 1.333
0.0GlnMet: 0.0 ± 0.0
2.148GlnAsn: 2.148 ± 0.544
1.074GlnPro: 1.074 ± 0.97
0.0GlnGln: 0.0 ± 0.0
2.148GlnArg: 2.148 ± 1.308
4.296GlnSer: 4.296 ± 2.616
2.148GlnThr: 2.148 ± 1.308
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.074GlnTyr: 1.074 ± 0.654
0.0GlnXaa: 0.0 ± 0.0
Arg
3.222ArgAla: 3.222 ± 1.591
1.074ArgCys: 1.074 ± 0.654
3.222ArgAsp: 3.222 ± 0.712
1.074ArgGlu: 1.074 ± 0.97
5.371ArgPhe: 5.371 ± 1.333
2.148ArgGly: 2.148 ± 1.308
1.074ArgHis: 1.074 ± 0.97
3.222ArgIle: 3.222 ± 0.712
8.593ArgLys: 8.593 ± 3.794
3.222ArgLeu: 3.222 ± 1.478
4.296ArgMet: 4.296 ± 2.382
3.222ArgAsn: 3.222 ± 1.591
2.148ArgPro: 2.148 ± 1.308
3.222ArgGln: 3.222 ± 1.591
6.445ArgArg: 6.445 ± 3.924
1.074ArgSer: 1.074 ± 0.97
6.445ArgThr: 6.445 ± 1.356
2.148ArgVal: 2.148 ± 1.308
2.148ArgTrp: 2.148 ± 2.003
2.148ArgTyr: 2.148 ± 1.939
0.0ArgXaa: 0.0 ± 0.0
Ser
5.371SerAla: 5.371 ± 1.086
0.0SerCys: 0.0 ± 0.0
9.667SerAsp: 9.667 ± 2.245
2.148SerGlu: 2.148 ± 0.544
4.296SerPhe: 4.296 ± 1.255
4.296SerGly: 4.296 ± 1.255
2.148SerHis: 2.148 ± 1.308
6.445SerIle: 6.445 ± 0.768
3.222SerLys: 3.222 ± 0.712
6.445SerLeu: 6.445 ± 1.633
0.0SerMet: 0.0 ± 0.0
5.371SerAsn: 5.371 ± 1.935
4.296SerPro: 4.296 ± 1.867
3.222SerGln: 3.222 ± 0.712
2.148SerArg: 2.148 ± 1.559
5.371SerSer: 5.371 ± 1.87
2.148SerThr: 2.148 ± 0.544
4.296SerVal: 4.296 ± 1.255
0.0SerTrp: 0.0 ± 0.0
3.222SerTyr: 3.222 ± 1.962
0.0SerXaa: 0.0 ± 0.0
Thr
2.148ThrAla: 2.148 ± 0.544
0.0ThrCys: 0.0 ± 0.0
6.445ThrAsp: 6.445 ± 2.822
3.222ThrGlu: 3.222 ± 0.712
3.222ThrPhe: 3.222 ± 1.43
5.371ThrGly: 5.371 ± 3.27
0.0ThrHis: 0.0 ± 0.0
0.0ThrIle: 0.0 ± 0.0
4.296ThrLys: 4.296 ± 2.616
7.519ThrLeu: 7.519 ± 2.456
1.074ThrMet: 1.074 ± 0.97
5.371ThrAsn: 5.371 ± 1.086
1.074ThrPro: 1.074 ± 0.654
1.074ThrGln: 1.074 ± 0.654
5.371ThrArg: 5.371 ± 1.87
3.222ThrSer: 3.222 ± 1.962
6.445ThrThr: 6.445 ± 2.505
8.593ThrVal: 8.593 ± 4.65
2.148ThrTrp: 2.148 ± 1.939
3.222ThrTyr: 3.222 ± 1.962
0.0ThrXaa: 0.0 ± 0.0
Val
4.296ValAla: 4.296 ± 3.118
0.0ValCys: 0.0 ± 0.0
1.074ValAsp: 1.074 ± 0.97
5.371ValGlu: 5.371 ± 3.27
6.445ValPhe: 6.445 ± 2.861
4.296ValGly: 4.296 ± 1.255
2.148ValHis: 2.148 ± 1.308
3.222ValIle: 3.222 ± 1.43
4.296ValLys: 4.296 ± 2.382
4.296ValLeu: 4.296 ± 1.102
2.148ValMet: 2.148 ± 0.635
5.371ValAsn: 5.371 ± 2.302
3.222ValPro: 3.222 ± 1.962
0.0ValGln: 0.0 ± 0.0
4.296ValArg: 4.296 ± 1.255
8.593ValSer: 8.593 ± 2.203
2.148ValThr: 2.148 ± 1.308
2.148ValVal: 2.148 ± 1.939
0.0ValTrp: 0.0 ± 0.0
1.074ValTyr: 1.074 ± 0.97
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.074TrpIle: 1.074 ± 0.97
0.0TrpLys: 0.0 ± 0.0
2.148TrpLeu: 2.148 ± 2.003
0.0TrpMet: 0.0 ± 0.0
1.074TrpAsn: 1.074 ± 0.97
0.0TrpPro: 0.0 ± 0.0
1.074TrpGln: 1.074 ± 0.97
1.074TrpArg: 1.074 ± 1.785
0.0TrpSer: 0.0 ± 0.0
2.148TrpThr: 2.148 ± 0.544
1.074TrpVal: 1.074 ± 0.97
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.074TyrAla: 1.074 ± 0.654
2.148TyrCys: 2.148 ± 1.939
3.222TyrAsp: 3.222 ± 1.478
0.0TyrGlu: 0.0 ± 0.0
2.148TyrPhe: 2.148 ± 1.308
6.445TyrGly: 6.445 ± 2.956
0.0TyrHis: 0.0 ± 0.0
2.148TyrIle: 2.148 ± 0.544
1.074TyrLys: 1.074 ± 0.654
1.074TyrLeu: 1.074 ± 0.97
1.074TyrMet: 1.074 ± 0.654
1.074TyrAsn: 1.074 ± 0.654
2.148TyrPro: 2.148 ± 1.939
2.148TyrGln: 2.148 ± 0.544
2.148TyrArg: 2.148 ± 0.544
1.074TyrSer: 1.074 ± 0.654
2.148TyrThr: 2.148 ± 1.308
4.296TyrVal: 4.296 ± 1.089
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (932 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski