Amino acid dipepetide frequency for Vibrio phage Ceto

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.799AlaAla: 6.799 ± 0.888
0.888AlaCys: 0.888 ± 0.175
4.495AlaAsp: 4.495 ± 0.341
5.411AlaGlu: 5.411 ± 0.482
2.858AlaPhe: 2.858 ± 0.272
4.495AlaGly: 4.495 ± 0.358
1.138AlaHis: 1.138 ± 0.165
4.246AlaIle: 4.246 ± 0.321
6.91AlaLys: 6.91 ± 0.645
6.743AlaLeu: 6.743 ± 0.53
1.915AlaMet: 1.915 ± 0.23
4.135AlaAsn: 4.135 ± 0.374
2.886AlaPro: 2.886 ± 0.354
2.914AlaGln: 2.914 ± 0.304
3.524AlaArg: 3.524 ± 0.37
5.3AlaSer: 5.3 ± 0.697
4.579AlaThr: 4.579 ± 0.39
3.94AlaVal: 3.94 ± 0.291
0.86AlaTrp: 0.86 ± 0.191
2.747AlaTyr: 2.747 ± 0.299
0.0AlaXaa: 0.0 ± 0.0
Cys
0.721CysAla: 0.721 ± 0.132
0.139CysCys: 0.139 ± 0.06
0.777CysAsp: 0.777 ± 0.158
0.832CysGlu: 0.832 ± 0.138
0.305CysPhe: 0.305 ± 0.11
0.694CysGly: 0.694 ± 0.164
0.25CysHis: 0.25 ± 0.087
0.749CysIle: 0.749 ± 0.141
1.027CysLys: 1.027 ± 0.161
1.027CysLeu: 1.027 ± 0.169
0.388CysMet: 0.388 ± 0.107
0.749CysAsn: 0.749 ± 0.157
0.416CysPro: 0.416 ± 0.108
0.721CysGln: 0.721 ± 0.137
0.61CysArg: 0.61 ± 0.136
0.583CysSer: 0.583 ± 0.139
1.027CysThr: 1.027 ± 0.168
0.916CysVal: 0.916 ± 0.193
0.083CysTrp: 0.083 ± 0.046
0.444CysTyr: 0.444 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
4.468AspAla: 4.468 ± 0.351
0.749AspCys: 0.749 ± 0.143
3.469AspAsp: 3.469 ± 0.271
4.357AspGlu: 4.357 ± 0.416
3.052AspPhe: 3.052 ± 0.251
4.246AspGly: 4.246 ± 0.42
0.86AspHis: 0.86 ± 0.154
4.745AspIle: 4.745 ± 0.336
4.912AspLys: 4.912 ± 0.384
5.05AspLeu: 5.05 ± 0.358
1.942AspMet: 1.942 ± 0.226
3.025AspAsn: 3.025 ± 0.341
2.47AspPro: 2.47 ± 0.268
1.332AspGln: 1.332 ± 0.164
2.414AspArg: 2.414 ± 0.249
3.746AspSer: 3.746 ± 0.343
4.135AspThr: 4.135 ± 0.422
4.551AspVal: 4.551 ± 0.367
1.165AspTrp: 1.165 ± 0.175
2.303AspTyr: 2.303 ± 0.251
0.0AspXaa: 0.0 ± 0.0
Glu
5.467GluAla: 5.467 ± 0.515
1.054GluCys: 1.054 ± 0.193
3.691GluAsp: 3.691 ± 0.34
4.967GluGlu: 4.967 ± 0.497
2.886GluPhe: 2.886 ± 0.316
4.079GluGly: 4.079 ± 0.356
1.609GluHis: 1.609 ± 0.193
4.412GluIle: 4.412 ± 0.305
5.245GluLys: 5.245 ± 0.522
6.577GluLeu: 6.577 ± 0.481
1.859GluMet: 1.859 ± 0.248
3.358GluAsn: 3.358 ± 0.33
1.942GluPro: 1.942 ± 0.248
2.858GluGln: 2.858 ± 0.332
3.247GluArg: 3.247 ± 0.27
3.108GluSer: 3.108 ± 0.319
3.358GluThr: 3.358 ± 0.326
5.272GluVal: 5.272 ± 0.473
1.082GluTrp: 1.082 ± 0.151
3.136GluTyr: 3.136 ± 0.356
0.0GluXaa: 0.0 ± 0.0
Phe
3.052PheAla: 3.052 ± 0.385
0.721PheCys: 0.721 ± 0.125
3.33PheAsp: 3.33 ± 0.309
3.385PheGlu: 3.385 ± 0.314
1.582PhePhe: 1.582 ± 0.212
3.052PheGly: 3.052 ± 0.29
1.276PheHis: 1.276 ± 0.171
2.608PheIle: 2.608 ± 0.267
2.83PheLys: 2.83 ± 0.297
2.692PheLeu: 2.692 ± 0.31
0.832PheMet: 0.832 ± 0.149
2.22PheAsn: 2.22 ± 0.215
1.498PhePro: 1.498 ± 0.179
0.721PheGln: 0.721 ± 0.137
1.693PheArg: 1.693 ± 0.202
2.497PheSer: 2.497 ± 0.291
2.803PheThr: 2.803 ± 0.359
1.804PheVal: 1.804 ± 0.247
0.61PheTrp: 0.61 ± 0.127
1.609PheTyr: 1.609 ± 0.234
0.0PheXaa: 0.0 ± 0.0
Gly
4.301GlyAla: 4.301 ± 0.468
0.832GlyCys: 0.832 ± 0.164
4.162GlyAsp: 4.162 ± 0.378
4.273GlyGlu: 4.273 ± 0.344
3.136GlyPhe: 3.136 ± 0.265
3.496GlyGly: 3.496 ± 0.387
1.082GlyHis: 1.082 ± 0.164
4.246GlyIle: 4.246 ± 0.36
5.689GlyLys: 5.689 ± 0.481
5.411GlyLeu: 5.411 ± 0.407
1.776GlyMet: 1.776 ± 0.182
3.358GlyAsn: 3.358 ± 0.315
0.527GlyPro: 0.527 ± 0.113
1.748GlyGln: 1.748 ± 0.236
2.719GlyArg: 2.719 ± 0.299
3.996GlySer: 3.996 ± 0.394
4.495GlyThr: 4.495 ± 0.438
4.412GlyVal: 4.412 ± 0.287
1.36GlyTrp: 1.36 ± 0.2
2.941GlyTyr: 2.941 ± 0.326
0.0GlyXaa: 0.0 ± 0.0
His
0.943HisAla: 0.943 ± 0.164
0.416HisCys: 0.416 ± 0.133
1.11HisAsp: 1.11 ± 0.193
1.415HisGlu: 1.415 ± 0.184
0.888HisPhe: 0.888 ± 0.148
1.387HisGly: 1.387 ± 0.195
0.499HisHis: 0.499 ± 0.11
1.582HisIle: 1.582 ± 0.193
1.471HisLys: 1.471 ± 0.221
1.887HisLeu: 1.887 ± 0.232
0.805HisMet: 0.805 ± 0.147
1.054HisAsn: 1.054 ± 0.163
0.943HisPro: 0.943 ± 0.175
0.749HisGln: 0.749 ± 0.163
1.193HisArg: 1.193 ± 0.193
0.943HisSer: 0.943 ± 0.195
1.11HisThr: 1.11 ± 0.208
1.027HisVal: 1.027 ± 0.163
0.333HisTrp: 0.333 ± 0.089
0.721HisTyr: 0.721 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
4.273IleAla: 4.273 ± 0.418
0.638IleCys: 0.638 ± 0.146
4.301IleAsp: 4.301 ± 0.406
5.411IleGlu: 5.411 ± 0.468
1.998IlePhe: 1.998 ± 0.231
3.691IleGly: 3.691 ± 0.329
1.554IleHis: 1.554 ± 0.239
3.552IleIle: 3.552 ± 0.335
4.745IleLys: 4.745 ± 0.35
4.745IleLeu: 4.745 ± 0.383
1.36IleMet: 1.36 ± 0.169
3.746IleAsn: 3.746 ± 0.388
2.692IlePro: 2.692 ± 0.303
2.331IleGln: 2.331 ± 0.268
2.969IleArg: 2.969 ± 0.291
4.19IleSer: 4.19 ± 0.332
3.968IleThr: 3.968 ± 0.438
3.58IleVal: 3.58 ± 0.37
0.583IleTrp: 0.583 ± 0.129
2.275IleTyr: 2.275 ± 0.243
0.0IleXaa: 0.0 ± 0.0
Lys
7.048LysAla: 7.048 ± 0.701
0.749LysCys: 0.749 ± 0.15
4.468LysAsp: 4.468 ± 0.38
5.134LysGlu: 5.134 ± 0.425
3.08LysPhe: 3.08 ± 0.315
4.19LysGly: 4.19 ± 0.318
1.859LysHis: 1.859 ± 0.244
4.162LysIle: 4.162 ± 0.386
4.523LysLys: 4.523 ± 0.365
7.992LysLeu: 7.992 ± 0.542
2.248LysMet: 2.248 ± 0.275
2.914LysAsn: 2.914 ± 0.275
2.886LysPro: 2.886 ± 0.371
3.08LysGln: 3.08 ± 0.311
3.052LysArg: 3.052 ± 0.343
3.552LysSer: 3.552 ± 0.293
4.329LysThr: 4.329 ± 0.283
4.828LysVal: 4.828 ± 0.37
0.832LysTrp: 0.832 ± 0.159
3.441LysTyr: 3.441 ± 0.339
0.0LysXaa: 0.0 ± 0.0
Leu
7.215LeuAla: 7.215 ± 0.506
0.888LeuCys: 0.888 ± 0.179
6.521LeuAsp: 6.521 ± 0.418
6.604LeuGlu: 6.604 ± 0.497
2.664LeuPhe: 2.664 ± 0.315
5.744LeuGly: 5.744 ± 0.409
1.831LeuHis: 1.831 ± 0.23
5.078LeuIle: 5.078 ± 0.337
4.939LeuLys: 4.939 ± 0.425
6.771LeuLeu: 6.771 ± 0.47
2.275LeuMet: 2.275 ± 0.232
3.885LeuAsn: 3.885 ± 0.345
3.524LeuPro: 3.524 ± 0.398
3.358LeuGln: 3.358 ± 0.27
4.135LeuArg: 4.135 ± 0.324
5.522LeuSer: 5.522 ± 0.393
5.189LeuThr: 5.189 ± 0.388
6.133LeuVal: 6.133 ± 0.41
0.805LeuTrp: 0.805 ± 0.17
2.775LeuTyr: 2.775 ± 0.292
0.0LeuXaa: 0.0 ± 0.0
Met
2.275MetAla: 2.275 ± 0.301
0.277MetCys: 0.277 ± 0.073
1.498MetAsp: 1.498 ± 0.224
1.915MetGlu: 1.915 ± 0.241
1.027MetPhe: 1.027 ± 0.173
1.443MetGly: 1.443 ± 0.181
0.388MetHis: 0.388 ± 0.093
1.526MetIle: 1.526 ± 0.212
2.303MetLys: 2.303 ± 0.302
2.164MetLeu: 2.164 ± 0.239
0.638MetMet: 0.638 ± 0.123
1.054MetAsn: 1.054 ± 0.189
1.138MetPro: 1.138 ± 0.199
1.11MetGln: 1.11 ± 0.189
1.249MetArg: 1.249 ± 0.169
1.693MetSer: 1.693 ± 0.2
1.498MetThr: 1.498 ± 0.217
1.304MetVal: 1.304 ± 0.194
0.388MetTrp: 0.388 ± 0.091
1.054MetTyr: 1.054 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
3.913AsnAla: 3.913 ± 0.383
0.583AsnCys: 0.583 ± 0.15
2.137AsnAsp: 2.137 ± 0.268
2.636AsnGlu: 2.636 ± 0.284
1.693AsnPhe: 1.693 ± 0.259
3.802AsnGly: 3.802 ± 0.308
1.11AsnHis: 1.11 ± 0.199
4.024AsnIle: 4.024 ± 0.334
4.579AsnLys: 4.579 ± 0.385
4.329AsnLeu: 4.329 ± 0.352
1.138AsnMet: 1.138 ± 0.197
2.442AsnAsn: 2.442 ± 0.286
2.497AsnPro: 2.497 ± 0.29
1.498AsnGln: 1.498 ± 0.253
2.081AsnArg: 2.081 ± 0.246
3.413AsnSer: 3.413 ± 0.333
2.997AsnThr: 2.997 ± 0.361
2.914AsnVal: 2.914 ± 0.314
0.583AsnTrp: 0.583 ± 0.124
1.859AsnTyr: 1.859 ± 0.234
0.0AsnXaa: 0.0 ± 0.0
Pro
2.331ProAla: 2.331 ± 0.273
0.25ProCys: 0.25 ± 0.085
2.608ProAsp: 2.608 ± 0.308
3.052ProGlu: 3.052 ± 0.271
1.637ProPhe: 1.637 ± 0.203
1.97ProGly: 1.97 ± 0.287
0.999ProHis: 0.999 ± 0.143
2.525ProIle: 2.525 ± 0.338
2.053ProLys: 2.053 ± 0.243
2.553ProLeu: 2.553 ± 0.308
0.86ProMet: 0.86 ± 0.168
1.998ProAsn: 1.998 ± 0.286
0.916ProPro: 0.916 ± 0.226
1.138ProGln: 1.138 ± 0.169
1.471ProArg: 1.471 ± 0.198
2.525ProSer: 2.525 ± 0.357
2.303ProThr: 2.303 ± 0.266
2.497ProVal: 2.497 ± 0.225
0.416ProTrp: 0.416 ± 0.098
1.249ProTyr: 1.249 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
3.385GlnAla: 3.385 ± 0.362
0.555GlnCys: 0.555 ± 0.096
1.887GlnAsp: 1.887 ± 0.225
2.275GlnGlu: 2.275 ± 0.255
1.276GlnPhe: 1.276 ± 0.179
2.137GlnGly: 2.137 ± 0.209
0.472GlnHis: 0.472 ± 0.13
2.414GlnIle: 2.414 ± 0.215
2.636GlnLys: 2.636 ± 0.271
3.524GlnLeu: 3.524 ± 0.378
1.027GlnMet: 1.027 ± 0.159
1.443GlnAsn: 1.443 ± 0.194
1.082GlnPro: 1.082 ± 0.183
1.471GlnGln: 1.471 ± 0.257
2.026GlnArg: 2.026 ± 0.238
2.053GlnSer: 2.053 ± 0.332
1.776GlnThr: 1.776 ± 0.212
2.553GlnVal: 2.553 ± 0.299
0.666GlnTrp: 0.666 ± 0.14
1.387GlnTyr: 1.387 ± 0.188
0.0GlnXaa: 0.0 ± 0.0
Arg
3.718ArgAla: 3.718 ± 0.344
0.555ArgCys: 0.555 ± 0.112
3.33ArgAsp: 3.33 ± 0.321
2.914ArgGlu: 2.914 ± 0.314
1.915ArgPhe: 1.915 ± 0.264
3.219ArgGly: 3.219 ± 0.339
0.971ArgHis: 0.971 ± 0.22
2.636ArgIle: 2.636 ± 0.26
3.191ArgLys: 3.191 ± 0.319
4.218ArgLeu: 4.218 ± 0.398
1.221ArgMet: 1.221 ± 0.195
2.581ArgAsn: 2.581 ± 0.28
1.027ArgPro: 1.027 ± 0.191
1.804ArgGln: 1.804 ± 0.224
1.998ArgArg: 1.998 ± 0.309
2.053ArgSer: 2.053 ± 0.273
2.414ArgThr: 2.414 ± 0.279
2.719ArgVal: 2.719 ± 0.276
0.666ArgTrp: 0.666 ± 0.118
1.97ArgTyr: 1.97 ± 0.208
0.0ArgXaa: 0.0 ± 0.0
Ser
4.717SerAla: 4.717 ± 0.538
0.638SerCys: 0.638 ± 0.128
3.191SerAsp: 3.191 ± 0.284
3.33SerGlu: 3.33 ± 0.355
2.692SerPhe: 2.692 ± 0.281
4.745SerGly: 4.745 ± 0.502
0.888SerHis: 0.888 ± 0.188
4.079SerIle: 4.079 ± 0.354
4.69SerLys: 4.69 ± 0.332
5.328SerLeu: 5.328 ± 0.41
1.776SerMet: 1.776 ± 0.214
3.108SerAsn: 3.108 ± 0.291
2.026SerPro: 2.026 ± 0.268
2.442SerGln: 2.442 ± 0.273
2.303SerArg: 2.303 ± 0.241
3.385SerSer: 3.385 ± 0.385
3.802SerThr: 3.802 ± 0.344
3.94SerVal: 3.94 ± 0.369
0.943SerTrp: 0.943 ± 0.194
2.053SerTyr: 2.053 ± 0.242
0.0SerXaa: 0.0 ± 0.0
Thr
4.246ThrAla: 4.246 ± 0.358
0.666ThrCys: 0.666 ± 0.157
3.524ThrAsp: 3.524 ± 0.349
3.58ThrGlu: 3.58 ± 0.356
3.191ThrPhe: 3.191 ± 0.349
4.329ThrGly: 4.329 ± 0.407
1.304ThrHis: 1.304 ± 0.207
3.94ThrIle: 3.94 ± 0.372
4.551ThrLys: 4.551 ± 0.369
5.161ThrLeu: 5.161 ± 0.419
1.138ThrMet: 1.138 ± 0.19
2.969ThrAsn: 2.969 ± 0.291
2.719ThrPro: 2.719 ± 0.303
1.998ThrGln: 1.998 ± 0.264
2.359ThrArg: 2.359 ± 0.232
4.19ThrSer: 4.19 ± 0.394
3.94ThrThr: 3.94 ± 0.449
3.413ThrVal: 3.413 ± 0.379
1.082ThrTrp: 1.082 ± 0.185
2.664ThrTyr: 2.664 ± 0.242
0.0ThrXaa: 0.0 ± 0.0
Val
4.773ValAla: 4.773 ± 0.373
0.832ValCys: 0.832 ± 0.157
4.329ValAsp: 4.329 ± 0.334
4.44ValGlu: 4.44 ± 0.369
2.747ValPhe: 2.747 ± 0.283
3.885ValGly: 3.885 ± 0.317
1.054ValHis: 1.054 ± 0.144
2.803ValIle: 2.803 ± 0.276
4.579ValLys: 4.579 ± 0.342
4.662ValLeu: 4.662 ± 0.332
1.332ValMet: 1.332 ± 0.205
3.358ValAsn: 3.358 ± 0.308
2.497ValPro: 2.497 ± 0.328
2.192ValGln: 2.192 ± 0.236
3.441ValArg: 3.441 ± 0.339
4.273ValSer: 4.273 ± 0.384
4.024ValThr: 4.024 ± 0.455
4.412ValVal: 4.412 ± 0.393
0.971ValTrp: 0.971 ± 0.159
2.525ValTyr: 2.525 ± 0.37
0.0ValXaa: 0.0 ± 0.0
Trp
1.027TrpAla: 1.027 ± 0.175
0.222TrpCys: 0.222 ± 0.088
1.304TrpAsp: 1.304 ± 0.192
0.721TrpGlu: 0.721 ± 0.136
0.555TrpPhe: 0.555 ± 0.117
0.999TrpGly: 0.999 ± 0.166
0.388TrpHis: 0.388 ± 0.117
0.749TrpIle: 0.749 ± 0.169
0.916TrpLys: 0.916 ± 0.147
1.304TrpLeu: 1.304 ± 0.201
0.388TrpMet: 0.388 ± 0.106
0.721TrpAsn: 0.721 ± 0.148
0.222TrpPro: 0.222 ± 0.083
0.555TrpGln: 0.555 ± 0.12
0.943TrpArg: 0.943 ± 0.157
0.805TrpSer: 0.805 ± 0.199
0.721TrpThr: 0.721 ± 0.158
0.943TrpVal: 0.943 ± 0.162
0.194TrpTrp: 0.194 ± 0.072
0.555TrpTyr: 0.555 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.109TyrAla: 2.109 ± 0.273
0.805TyrCys: 0.805 ± 0.164
2.858TyrAsp: 2.858 ± 0.356
2.553TyrGlu: 2.553 ± 0.242
1.637TyrPhe: 1.637 ± 0.189
2.359TyrGly: 2.359 ± 0.245
0.943TyrHis: 0.943 ± 0.158
2.525TyrIle: 2.525 ± 0.293
2.581TyrLys: 2.581 ± 0.266
3.718TyrLeu: 3.718 ± 0.342
0.999TyrMet: 0.999 ± 0.164
2.137TyrAsn: 2.137 ± 0.246
1.443TyrPro: 1.443 ± 0.172
2.026TyrGln: 2.026 ± 0.276
1.693TyrArg: 1.693 ± 0.248
2.248TyrSer: 2.248 ± 0.268
2.497TyrThr: 2.497 ± 0.243
1.97TyrVal: 1.97 ± 0.219
0.61TyrTrp: 0.61 ± 0.133
1.665TyrTyr: 1.665 ± 0.308
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 181 proteins (36038 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski