Amino acid dipepetide frequency for Chelativorans sp. (strain BNC1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.018AlaAla: 16.018 ± 0.154	1.01AlaCys: 1.01 ± 0.032	6.254AlaAsp: 6.254 ± 0.07	8.26AlaGlu: 8.26 ± 0.106	4.512AlaPhe: 4.512 ± 0.064	10.464AlaGly: 10.464 ± 0.115	2.153AlaHis: 2.153 ± 0.038	6.644AlaIle: 6.644 ± 0.073	3.705AlaLys: 3.705 ± 0.059	12.622AlaLeu: 12.622 ± 0.111	3.351AlaMet: 3.351 ± 0.053	2.883AlaAsn: 2.883 ± 0.051	5.05AlaPro: 5.05 ± 0.078	3.687AlaGln: 3.687 ± 0.057	8.602AlaArg: 8.602 ± 0.097	6.321AlaSer: 6.321 ± 0.071	5.412AlaThr: 5.412 ± 0.072	8.621AlaVal: 8.621 ± 0.095	1.431AlaTrp: 1.431 ± 0.03	2.523AlaTyr: 2.523 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.026	0.125CysCys: 0.125 ± 0.009	0.506CysAsp: 0.506 ± 0.02	0.444CysGlu: 0.444 ± 0.016	0.326CysPhe: 0.326 ± 0.014	0.866CysGly: 0.866 ± 0.027	0.232CysHis: 0.232 ± 0.013	0.409CysIle: 0.409 ± 0.017	0.186CysLys: 0.186 ± 0.012	0.826CysLeu: 0.826 ± 0.027	0.157CysMet: 0.157 ± 0.011	0.202CysAsn: 0.202 ± 0.013	0.431CysPro: 0.431 ± 0.017	0.24CysGln: 0.24 ± 0.013	0.674CysArg: 0.674 ± 0.024	0.511CysSer: 0.511 ± 0.022	0.421CysThr: 0.421 ± 0.018	0.592CysVal: 0.592 ± 0.022	0.104CysTrp: 0.104 ± 0.009	0.193CysTyr: 0.193 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.071AspAla: 6.071 ± 0.076	0.464AspCys: 0.464 ± 0.018	2.764AspAsp: 2.764 ± 0.059	3.714AspGlu: 3.714 ± 0.057	2.179AspPhe: 2.179 ± 0.039	4.807AspGly: 4.807 ± 0.077	1.159AspHis: 1.159 ± 0.033	3.118AspIle: 3.118 ± 0.049	1.465AspLys: 1.465 ± 0.032	5.623AspLeu: 5.623 ± 0.063	1.27AspMet: 1.27 ± 0.028	1.229AspAsn: 1.229 ± 0.032	3.384AspPro: 3.384 ± 0.052	1.627AspGln: 1.627 ± 0.037	4.269AspArg: 4.269 ± 0.057	2.076AspSer: 2.076 ± 0.045	2.347AspThr: 2.347 ± 0.043	3.886AspVal: 3.886 ± 0.055	0.903AspTrp: 0.903 ± 0.024	1.43AspTyr: 1.43 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	8.153GluAla: 8.153 ± 0.104	0.402GluCys: 0.402 ± 0.018	3.044GluAsp: 3.044 ± 0.054	4.335GluGlu: 4.335 ± 0.079	1.977GluPhe: 1.977 ± 0.036	4.723GluGly: 4.723 ± 0.063	1.285GluHis: 1.285 ± 0.035	4.042GluIle: 4.042 ± 0.056	2.755GluLys: 2.755 ± 0.046	5.767GluLeu: 5.767 ± 0.072	1.744GluMet: 1.744 ± 0.032	2.006GluAsn: 2.006 ± 0.038	2.951GluPro: 2.951 ± 0.056	2.242GluGln: 2.242 ± 0.046	5.633GluArg: 5.633 ± 0.08	2.725GluSer: 2.725 ± 0.043	3.66GluThr: 3.66 ± 0.049	4.125GluVal: 4.125 ± 0.059	0.766GluTrp: 0.766 ± 0.024	1.107GluTyr: 1.107 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.435PheAla: 4.435 ± 0.062	0.392PheCys: 0.392 ± 0.018	2.478PheAsp: 2.478 ± 0.042	2.263PheGlu: 2.263 ± 0.037	1.542PhePhe: 1.542 ± 0.04	3.601PheGly: 3.601 ± 0.057	0.769PheHis: 0.769 ± 0.022	1.846PheIle: 1.846 ± 0.039	0.963PheLys: 0.963 ± 0.027	3.647PheLeu: 3.647 ± 0.055	0.827PheMet: 0.827 ± 0.028	1.06PheAsn: 1.06 ± 0.029	1.749PhePro: 1.749 ± 0.037	1.076PheGln: 1.076 ± 0.024	2.534PheArg: 2.534 ± 0.038	2.517PheSer: 2.517 ± 0.042	2.044PheThr: 2.044 ± 0.041	2.823PheVal: 2.823 ± 0.052	0.549PheTrp: 0.549 ± 0.022	0.962PheTyr: 0.962 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.79GlyAla: 8.79 ± 0.1	0.815GlyCys: 0.815 ± 0.027	4.122GlyAsp: 4.122 ± 0.071	5.286GlyGlu: 5.286 ± 0.067	3.618GlyPhe: 3.618 ± 0.048	7.448GlyGly: 7.448 ± 0.13	1.839GlyHis: 1.839 ± 0.04	4.983GlyIle: 4.983 ± 0.072	3.215GlyLys: 3.215 ± 0.048	8.482GlyLeu: 8.482 ± 0.097	2.292GlyMet: 2.292 ± 0.039	2.38GlyAsn: 2.38 ± 0.054	3.475GlyPro: 3.475 ± 0.046	2.837GlyGln: 2.837 ± 0.049	6.373GlyArg: 6.373 ± 0.08	4.896GlySer: 4.896 ± 0.066	4.682GlyThr: 4.682 ± 0.135	5.766GlyVal: 5.766 ± 0.066	1.291GlyTrp: 1.291 ± 0.029	2.36GlyTyr: 2.36 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.133HisAla: 2.133 ± 0.036	0.231HisCys: 0.231 ± 0.013	1.13HisAsp: 1.13 ± 0.032	1.153HisGlu: 1.153 ± 0.031	0.865HisPhe: 0.865 ± 0.026	1.779HisGly: 1.779 ± 0.038	0.557HisHis: 0.557 ± 0.025	1.025HisIle: 1.025 ± 0.026	0.48HisLys: 0.48 ± 0.019	2.049HisLeu: 2.049 ± 0.038	0.524HisMet: 0.524 ± 0.021	0.478HisAsn: 0.478 ± 0.017	1.339HisPro: 1.339 ± 0.032	0.61HisGln: 0.61 ± 0.019	1.466HisArg: 1.466 ± 0.035	1.018HisSer: 1.018 ± 0.026	0.849HisThr: 0.849 ± 0.025	1.481HisVal: 1.481 ± 0.036	0.308HisTrp: 0.308 ± 0.014	0.524HisTyr: 0.524 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.612IleAla: 7.612 ± 0.084	0.54IleCys: 0.54 ± 0.021	3.496IleAsp: 3.496 ± 0.044	3.909IleGlu: 3.909 ± 0.049	1.948IlePhe: 1.948 ± 0.038	5.073IleGly: 5.073 ± 0.064	0.961IleHis: 0.961 ± 0.025	2.623IleIle: 2.623 ± 0.051	1.393IleLys: 1.393 ± 0.036	4.863IleLeu: 4.863 ± 0.061	1.095IleMet: 1.095 ± 0.029	1.482IleAsn: 1.482 ± 0.035	2.526IlePro: 2.526 ± 0.044	1.285IleGln: 1.285 ± 0.031	3.631IleArg: 3.631 ± 0.048	3.364IleSer: 3.364 ± 0.054	2.774IleThr: 2.774 ± 0.047	4.463IleVal: 4.463 ± 0.055	0.651IleTrp: 0.651 ± 0.023	1.317IleTyr: 1.317 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.156LysAla: 4.156 ± 0.061	0.166LysCys: 0.166 ± 0.011	1.552LysAsp: 1.552 ± 0.037	1.897LysGlu: 1.897 ± 0.045	0.858LysPhe: 0.858 ± 0.029	2.537LysGly: 2.537 ± 0.044	0.65LysHis: 0.65 ± 0.021	1.769LysIle: 1.769 ± 0.034	1.276LysLys: 1.276 ± 0.032	3.337LysLeu: 3.337 ± 0.05	0.78LysMet: 0.78 ± 0.022	0.918LysAsn: 0.918 ± 0.025	2.005LysPro: 2.005 ± 0.037	1.003LysGln: 1.003 ± 0.025	2.469LysArg: 2.469 ± 0.048	1.878LysSer: 1.878 ± 0.037	1.857LysThr: 1.857 ± 0.034	2.275LysVal: 2.275 ± 0.046	0.361LysTrp: 0.361 ± 0.015	0.594LysTyr: 0.594 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.719LeuAla: 12.719 ± 0.111	0.842LeuCys: 0.842 ± 0.028	5.685LeuAsp: 5.685 ± 0.077	5.732LeuGlu: 5.732 ± 0.071	3.673LeuPhe: 3.673 ± 0.057	8.168LeuGly: 8.168 ± 0.094	1.782LeuHis: 1.782 ± 0.037	5.214LeuIle: 5.214 ± 0.077	3.636LeuLys: 3.636 ± 0.056	9.601LeuLeu: 9.601 ± 0.11	2.295LeuMet: 2.295 ± 0.04	2.64LeuAsn: 2.64 ± 0.044	5.531LeuPro: 5.531 ± 0.077	2.949LeuGln: 2.949 ± 0.045	6.953LeuArg: 6.953 ± 0.083	6.856LeuSer: 6.856 ± 0.069	5.374LeuThr: 5.374 ± 0.074	7.348LeuVal: 7.348 ± 0.083	1.113LeuTrp: 1.113 ± 0.03	2.12LeuTyr: 2.12 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.027MetAla: 3.027 ± 0.05	0.159MetCys: 0.159 ± 0.01	1.103MetAsp: 1.103 ± 0.03	1.304MetGlu: 1.304 ± 0.029	0.696MetPhe: 0.696 ± 0.026	1.846MetGly: 1.846 ± 0.037	0.443MetHis: 0.443 ± 0.018	1.388MetIle: 1.388 ± 0.032	1.022MetLys: 1.022 ± 0.027	2.578MetLeu: 2.578 ± 0.044	0.675MetMet: 0.675 ± 0.025	0.789MetAsn: 0.789 ± 0.021	1.545MetPro: 1.545 ± 0.033	0.829MetGln: 0.829 ± 0.023	2.041MetArg: 2.041 ± 0.043	1.586MetSer: 1.586 ± 0.032	1.661MetThr: 1.661 ± 0.034	1.718MetVal: 1.718 ± 0.037	0.198MetTrp: 0.198 ± 0.011	0.303MetTyr: 0.303 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.222AsnAla: 3.222 ± 0.05	0.245AsnCys: 0.245 ± 0.011	1.378AsnAsp: 1.378 ± 0.039	1.477AsnGlu: 1.477 ± 0.033	1.014AsnPhe: 1.014 ± 0.029	2.523AsnGly: 2.523 ± 0.058	0.502AsnHis: 0.502 ± 0.02	1.466AsnIle: 1.466 ± 0.034	0.679AsnLys: 0.679 ± 0.022	2.764AsnLeu: 2.764 ± 0.05	0.653AsnMet: 0.653 ± 0.018	0.744AsnAsn: 0.744 ± 0.023	1.919AsnPro: 1.919 ± 0.041	0.811AsnGln: 0.811 ± 0.028	1.879AsnArg: 1.879 ± 0.036	1.394AsnSer: 1.394 ± 0.036	1.327AsnThr: 1.327 ± 0.038	1.997AsnVal: 1.997 ± 0.036	0.43AsnTrp: 0.43 ± 0.016	0.676AsnTyr: 0.676 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.054ProAla: 6.054 ± 0.077	0.328ProCys: 0.328 ± 0.016	3.486ProAsp: 3.486 ± 0.052	4.087ProGlu: 4.087 ± 0.065	2.001ProPhe: 2.001 ± 0.04	4.523ProGly: 4.523 ± 0.056	1.06ProHis: 1.06 ± 0.025	2.489ProIle: 2.489 ± 0.045	1.589ProLys: 1.589 ± 0.038	4.777ProLeu: 4.777 ± 0.07	1.14ProMet: 1.14 ± 0.032	1.394ProAsn: 1.394 ± 0.034	2.501ProPro: 2.501 ± 0.052	1.612ProGln: 1.612 ± 0.039	2.954ProArg: 2.954 ± 0.047	2.96ProSer: 2.96 ± 0.048	2.332ProThr: 2.332 ± 0.041	4.147ProVal: 4.147 ± 0.051	0.696ProTrp: 0.696 ± 0.025	1.234ProTyr: 1.234 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.874GlnAla: 3.874 ± 0.053	0.189GlnCys: 0.189 ± 0.011	1.432GlnAsp: 1.432 ± 0.034	1.828GlnGlu: 1.828 ± 0.039	1.06GlnPhe: 1.06 ± 0.028	2.284GlnGly: 2.284 ± 0.041	0.626GlnHis: 0.626 ± 0.021	1.94GlnIle: 1.94 ± 0.038	1.138GlnLys: 1.138 ± 0.028	2.838GlnLeu: 2.838 ± 0.049	0.906GlnMet: 0.906 ± 0.027	0.95GlnAsn: 0.95 ± 0.029	1.785GlnPro: 1.785 ± 0.038	1.299GlnGln: 1.299 ± 0.045	2.438GlnArg: 2.438 ± 0.043	1.723GlnSer: 1.723 ± 0.029	1.643GlnThr: 1.643 ± 0.034	2.283GlnVal: 2.283 ± 0.042	0.368GlnTrp: 0.368 ± 0.016	0.608GlnTyr: 0.608 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.762ArgAla: 7.762 ± 0.086	0.556ArgCys: 0.556 ± 0.023	3.963ArgAsp: 3.963 ± 0.051	4.826ArgGlu: 4.826 ± 0.062	3.109ArgPhe: 3.109 ± 0.044	4.929ArgGly: 4.929 ± 0.055	1.724ArgHis: 1.724 ± 0.034	4.269ArgIle: 4.269 ± 0.05	2.583ArgLys: 2.583 ± 0.048	8.142ArgLeu: 8.142 ± 0.09	1.95ArgMet: 1.95 ± 0.039	2.105ArgAsn: 2.105 ± 0.04	3.644ArgPro: 3.644 ± 0.059	2.842ArgGln: 2.842 ± 0.055	6.229ArgArg: 6.229 ± 0.076	4.083ArgSer: 4.083 ± 0.057	3.349ArgThr: 3.349 ± 0.05	4.766ArgVal: 4.766 ± 0.056	0.946ArgTrp: 0.946 ± 0.026	1.786ArgTyr: 1.786 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.451SerAla: 6.451 ± 0.077	0.453SerCys: 0.453 ± 0.018	2.892SerAsp: 2.892 ± 0.048	3.17SerGlu: 3.17 ± 0.046	2.507SerPhe: 2.507 ± 0.048	5.798SerGly: 5.798 ± 0.079	1.135SerHis: 1.135 ± 0.029	3.037SerIle: 3.037 ± 0.051	1.587SerLys: 1.587 ± 0.034	5.554SerLeu: 5.554 ± 0.064	1.412SerMet: 1.412 ± 0.032	1.474SerAsn: 1.474 ± 0.034	2.995SerPro: 2.995 ± 0.044	1.687SerGln: 1.687 ± 0.035	4.063SerArg: 4.063 ± 0.059	3.23SerSer: 3.23 ± 0.058	2.774SerThr: 2.774 ± 0.045	4.078SerVal: 4.078 ± 0.057	0.79SerTrp: 0.79 ± 0.023	1.389SerTyr: 1.389 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.002ThrAla: 6.002 ± 0.062	0.404ThrCys: 0.404 ± 0.017	2.545ThrAsp: 2.545 ± 0.044	2.803ThrGlu: 2.803 ± 0.047	1.962ThrPhe: 1.962 ± 0.036	5.166ThrGly: 5.166 ± 0.089	0.972ThrHis: 0.972 ± 0.031	3.009ThrIle: 3.009 ± 0.053	1.349ThrLys: 1.349 ± 0.037	5.421ThrLeu: 5.421 ± 0.096	1.186ThrMet: 1.186 ± 0.025	1.347ThrAsn: 1.347 ± 0.041	2.958ThrPro: 2.958 ± 0.046	1.312ThrGln: 1.312 ± 0.029	3.316ThrArg: 3.316 ± 0.054	2.755ThrSer: 2.755 ± 0.048	2.644ThrThr: 2.644 ± 0.054	4.28ThrVal: 4.28 ± 0.059	0.591ThrTrp: 0.591 ± 0.023	1.208ThrTyr: 1.208 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.59ValAla: 8.59 ± 0.094	0.628ValCys: 0.628 ± 0.023	3.924ValAsp: 3.924 ± 0.06	4.952ValGlu: 4.952 ± 0.064	2.797ValPhe: 2.797 ± 0.046	5.399ValGly: 5.399 ± 0.077	1.34ValHis: 1.34 ± 0.034	4.056ValIle: 4.056 ± 0.056	2.239ValLys: 2.239 ± 0.039	7.46ValLeu: 7.46 ± 0.086	1.874ValMet: 1.874 ± 0.042	1.999ValAsn: 1.999 ± 0.037	3.77ValPro: 3.77 ± 0.052	2.003ValGln: 2.003 ± 0.038	4.98ValArg: 4.98 ± 0.057	4.505ValSer: 4.505 ± 0.05	4.236ValThr: 4.236 ± 0.054	5.825ValVal: 5.825 ± 0.078	0.845ValTrp: 0.845 ± 0.026	1.465ValTyr: 1.465 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.155TrpAla: 1.155 ± 0.031	0.128TrpCys: 0.128 ± 0.01	0.596TrpAsp: 0.596 ± 0.02	0.622TrpGlu: 0.622 ± 0.021	0.518TrpPhe: 0.518 ± 0.017	0.875TrpGly: 0.875 ± 0.026	0.333TrpHis: 0.333 ± 0.013	0.663TrpIle: 0.663 ± 0.019	0.505TrpLys: 0.505 ± 0.019	1.578TrpLeu: 1.578 ± 0.037	0.344TrpMet: 0.344 ± 0.015	0.447TrpAsn: 0.447 ± 0.016	0.681TrpPro: 0.681 ± 0.02	0.524TrpGln: 0.524 ± 0.02	1.148TrpArg: 1.148 ± 0.028	0.816TrpSer: 0.816 ± 0.026	0.708TrpThr: 0.708 ± 0.021	0.765TrpVal: 0.765 ± 0.028	0.22TrpTrp: 0.22 ± 0.013	0.269TrpTyr: 0.269 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.407TyrAla: 2.407 ± 0.039	0.26TyrCys: 0.26 ± 0.014	1.436TyrAsp: 1.436 ± 0.033	1.378TyrGlu: 1.378 ± 0.034	0.915TyrPhe: 0.915 ± 0.025	2.142TyrGly: 2.142 ± 0.039	0.476TyrHis: 0.476 ± 0.018	1.018TyrIle: 1.018 ± 0.025	0.571TyrLys: 0.571 ± 0.017	2.304TyrLeu: 2.304 ± 0.04	0.436TyrMet: 0.436 ± 0.019	0.576TyrAsn: 0.576 ± 0.021	1.123TyrPro: 1.123 ± 0.027	0.74TyrGln: 0.74 ± 0.024	1.912TyrArg: 1.912 ± 0.035	1.261TyrSer: 1.261 ± 0.033	1.135TyrThr: 1.135 ± 0.032	1.647TyrVal: 1.647 ± 0.034	0.333TyrTrp: 0.333 ± 0.015	0.601TyrTyr: 0.601 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4530 proteins (1453148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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