Amino acid dipepetide frequency for Nocardia farcinica (strain IFM 10152)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.211AlaAla: 24.211 ± 0.215	0.982AlaCys: 0.982 ± 0.027	9.375AlaAsp: 9.375 ± 0.089	9.679AlaGlu: 9.679 ± 0.098	3.374AlaPhe: 3.374 ± 0.044	12.755AlaGly: 12.755 ± 0.104	2.942AlaHis: 2.942 ± 0.041	4.637AlaIle: 4.637 ± 0.058	2.596AlaLys: 2.596 ± 0.052	14.28AlaLeu: 14.28 ± 0.116	2.684AlaMet: 2.684 ± 0.044	2.158AlaAsn: 2.158 ± 0.035	7.5AlaPro: 7.5 ± 0.089	3.978AlaGln: 3.978 ± 0.05	10.7AlaArg: 10.7 ± 0.101	4.978AlaSer: 4.978 ± 0.057	7.832AlaThr: 7.832 ± 0.069	12.768AlaVal: 12.768 ± 0.105	1.779AlaTrp: 1.779 ± 0.032	2.399AlaTyr: 2.399 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.089CysAla: 1.089 ± 0.029	0.095CysCys: 0.095 ± 0.008	0.457CysAsp: 0.457 ± 0.017	0.372CysGlu: 0.372 ± 0.016	0.206CysPhe: 0.206 ± 0.013	0.892CysGly: 0.892 ± 0.024	0.193CysHis: 0.193 ± 0.01	0.169CysIle: 0.169 ± 0.012	0.106CysLys: 0.106 ± 0.008	0.653CysLeu: 0.653 ± 0.02	0.108CysMet: 0.108 ± 0.008	0.11CysAsn: 0.11 ± 0.008	0.54CysPro: 0.54 ± 0.017	0.161CysGln: 0.161 ± 0.01	0.602CysArg: 0.602 ± 0.021	0.413CysSer: 0.413 ± 0.018	0.469CysThr: 0.469 ± 0.017	0.589CysVal: 0.589 ± 0.019	0.118CysTrp: 0.118 ± 0.008	0.17CysTyr: 0.17 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.777AspAla: 7.777 ± 0.081	0.415AspCys: 0.415 ± 0.017	3.61AspAsp: 3.61 ± 0.052	3.916AspGlu: 3.916 ± 0.049	1.598AspPhe: 1.598 ± 0.032	5.653AspGly: 5.653 ± 0.063	1.437AspHis: 1.437 ± 0.025	2.249AspIle: 2.249 ± 0.038	1.1AspLys: 1.1 ± 0.031	6.554AspLeu: 6.554 ± 0.071	0.878AspMet: 0.878 ± 0.022	1.052AspAsn: 1.052 ± 0.022	4.955AspPro: 4.955 ± 0.06	1.666AspGln: 1.666 ± 0.032	5.485AspArg: 5.485 ± 0.068	2.516AspSer: 2.516 ± 0.041	3.425AspThr: 3.425 ± 0.051	4.521AspVal: 4.521 ± 0.059	0.959AspTrp: 0.959 ± 0.023	1.347AspTyr: 1.347 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.342GluAla: 6.342 ± 0.076	0.346GluCys: 0.346 ± 0.015	2.401GluAsp: 2.401 ± 0.037	2.586GluGlu: 2.586 ± 0.044	1.975GluPhe: 1.975 ± 0.035	3.399GluGly: 3.399 ± 0.049	1.789GluHis: 1.789 ± 0.037	2.655GluIle: 2.655 ± 0.035	1.128GluLys: 1.128 ± 0.031	7.26GluLeu: 7.26 ± 0.082	1.008GluMet: 1.008 ± 0.027	1.055GluAsn: 1.055 ± 0.025	3.551GluPro: 3.551 ± 0.059	2.571GluGln: 2.571 ± 0.042	5.43GluArg: 5.43 ± 0.066	2.646GluSer: 2.646 ± 0.043	2.807GluThr: 2.807 ± 0.039	4.698GluVal: 4.698 ± 0.048	0.808GluTrp: 0.808 ± 0.023	1.198GluTyr: 1.198 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.177PheAla: 4.177 ± 0.05	0.246PheCys: 0.246 ± 0.011	2.397PheAsp: 2.397 ± 0.045	1.543PheGlu: 1.543 ± 0.033	0.846PhePhe: 0.846 ± 0.022	3.261PheGly: 3.261 ± 0.049	0.605PheHis: 0.605 ± 0.016	0.722PheIle: 0.722 ± 0.024	0.413PheLys: 0.413 ± 0.017	2.585PheLeu: 2.585 ± 0.04	0.376PheMet: 0.376 ± 0.015	0.496PheAsn: 0.496 ± 0.017	1.375PhePro: 1.375 ± 0.03	0.661PheGln: 0.661 ± 0.022	1.788PheArg: 1.788 ± 0.03	1.259PheSer: 1.259 ± 0.029	1.982PheThr: 1.982 ± 0.034	2.515PheVal: 2.515 ± 0.04	0.388PheTrp: 0.388 ± 0.016	0.611PheTyr: 0.611 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.214GlyAla: 11.214 ± 0.096	0.783GlyCys: 0.783 ± 0.021	4.704GlyAsp: 4.704 ± 0.058	4.816GlyGlu: 4.816 ± 0.063	2.889GlyPhe: 2.889 ± 0.042	7.892GlyGly: 7.892 ± 0.089	2.065GlyHis: 2.065 ± 0.035	3.773GlyIle: 3.773 ± 0.063	2.16GlyLys: 2.16 ± 0.04	8.734GlyLeu: 8.734 ± 0.085	2.052GlyMet: 2.052 ± 0.034	1.678GlyAsn: 1.678 ± 0.031	4.949GlyPro: 4.949 ± 0.063	2.421GlyGln: 2.421 ± 0.046	7.163GlyArg: 7.163 ± 0.071	4.797GlySer: 4.797 ± 0.061	5.623GlyThr: 5.623 ± 0.06	7.551GlyVal: 7.551 ± 0.071	1.611GlyTrp: 1.611 ± 0.039	2.331GlyTyr: 2.331 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.712HisAla: 2.712 ± 0.051	0.218HisCys: 0.218 ± 0.009	1.331HisAsp: 1.331 ± 0.032	1.148HisGlu: 1.148 ± 0.026	0.626HisPhe: 0.626 ± 0.019	2.232HisGly: 2.232 ± 0.039	0.703HisHis: 0.703 ± 0.022	0.745HisIle: 0.745 ± 0.021	0.299HisLys: 0.299 ± 0.015	2.26HisLeu: 2.26 ± 0.042	0.329HisMet: 0.329 ± 0.013	0.413HisAsn: 0.413 ± 0.015	1.828HisPro: 1.828 ± 0.037	0.564HisGln: 0.564 ± 0.016	2.272HisArg: 2.272 ± 0.041	0.997HisSer: 0.997 ± 0.026	1.287HisThr: 1.287 ± 0.031	1.54HisVal: 1.54 ± 0.029	0.349HisTrp: 0.349 ± 0.015	0.516HisTyr: 0.516 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.931IleAla: 5.931 ± 0.064	0.278IleCys: 0.278 ± 0.013	3.093IleAsp: 3.093 ± 0.042	2.487IleGlu: 2.487 ± 0.035	0.838IlePhe: 0.838 ± 0.023	4.124IleGly: 4.124 ± 0.057	0.653IleHis: 0.653 ± 0.019	1.028IleIle: 1.028 ± 0.028	0.629IleLys: 0.629 ± 0.022	2.86IleLeu: 2.86 ± 0.046	0.515IleMet: 0.515 ± 0.019	0.755IleAsn: 0.755 ± 0.022	2.176IlePro: 2.176 ± 0.037	0.725IleGln: 0.725 ± 0.021	2.592IleArg: 2.592 ± 0.039	1.752IleSer: 1.752 ± 0.039	2.465IleThr: 2.465 ± 0.042	3.311IleVal: 3.311 ± 0.046	0.407IleTrp: 0.407 ± 0.016	0.689IleTyr: 0.689 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.33LysAla: 2.33 ± 0.043	0.097LysCys: 0.097 ± 0.008	0.868LysAsp: 0.868 ± 0.025	0.845LysGlu: 0.845 ± 0.027	0.548LysPhe: 0.548 ± 0.021	1.321LysGly: 1.321 ± 0.03	0.42LysHis: 0.42 ± 0.014	0.863LysIle: 0.863 ± 0.026	0.57LysLys: 0.57 ± 0.024	1.902LysLeu: 1.902 ± 0.038	0.362LysMet: 0.362 ± 0.015	0.442LysAsn: 0.442 ± 0.018	1.185LysPro: 1.185 ± 0.028	0.629LysGln: 0.629 ± 0.021	1.318LysArg: 1.318 ± 0.028	1.01LysSer: 1.01 ± 0.024	1.126LysThr: 1.126 ± 0.027	1.601LysVal: 1.601 ± 0.036	0.258LysTrp: 0.258 ± 0.013	0.44LysTyr: 0.44 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.956LeuAla: 15.956 ± 0.116	0.78LeuCys: 0.78 ± 0.02	7.201LeuAsp: 7.201 ± 0.097	4.592LeuGlu: 4.592 ± 0.055	2.693LeuPhe: 2.693 ± 0.053	9.183LeuGly: 9.183 ± 0.083	2.133LeuHis: 2.133 ± 0.037	3.647LeuIle: 3.647 ± 0.048	1.315LeuLys: 1.315 ± 0.036	10.313LeuLeu: 10.313 ± 0.108	1.487LeuMet: 1.487 ± 0.028	1.625LeuAsn: 1.625 ± 0.03	6.288LeuPro: 6.288 ± 0.068	1.959LeuGln: 1.959 ± 0.037	8.923LeuArg: 8.923 ± 0.077	4.891LeuSer: 4.891 ± 0.058	6.622LeuThr: 6.622 ± 0.066	8.972LeuVal: 8.972 ± 0.081	1.19LeuTrp: 1.19 ± 0.027	1.661LeuTyr: 1.661 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.226MetAla: 2.226 ± 0.042	0.146MetCys: 0.146 ± 0.01	0.813MetAsp: 0.813 ± 0.023	0.613MetGlu: 0.613 ± 0.021	0.577MetPhe: 0.577 ± 0.017	1.275MetGly: 1.275 ± 0.032	0.375MetHis: 0.375 ± 0.016	0.83MetIle: 0.83 ± 0.021	0.36MetLys: 0.36 ± 0.016	1.89MetLeu: 1.89 ± 0.035	0.361MetMet: 0.361 ± 0.017	0.472MetAsn: 0.472 ± 0.016	1.152MetPro: 1.152 ± 0.025	0.457MetGln: 0.457 ± 0.016	1.581MetArg: 1.581 ± 0.026	1.479MetSer: 1.479 ± 0.034	1.702MetThr: 1.702 ± 0.032	1.446MetVal: 1.446 ± 0.029	0.232MetTrp: 0.232 ± 0.012	0.325MetTyr: 0.325 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.252AsnAla: 2.252 ± 0.043	0.133AsnCys: 0.133 ± 0.008	0.9AsnAsp: 0.9 ± 0.025	0.815AsnGlu: 0.815 ± 0.022	0.505AsnPhe: 0.505 ± 0.018	1.722AsnGly: 1.722 ± 0.034	0.374AsnHis: 0.374 ± 0.017	0.753AsnIle: 0.753 ± 0.021	0.379AsnLys: 0.379 ± 0.017	1.719AsnLeu: 1.719 ± 0.03	0.346AsnMet: 0.346 ± 0.014	0.423AsnAsn: 0.423 ± 0.014	1.528AsnPro: 1.528 ± 0.033	0.539AsnGln: 0.539 ± 0.02	1.42AsnArg: 1.42 ± 0.031	0.908AsnSer: 0.908 ± 0.023	1.119AsnThr: 1.119 ± 0.028	1.343AsnVal: 1.343 ± 0.025	0.306AsnTrp: 0.306 ± 0.013	0.415AsnTyr: 0.415 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.203ProAla: 9.203 ± 0.101	0.33ProCys: 0.33 ± 0.017	4.705ProAsp: 4.705 ± 0.07	4.226ProGlu: 4.226 ± 0.056	1.562ProPhe: 1.562 ± 0.027	6.553ProGly: 6.553 ± 0.086	1.325ProHis: 1.325 ± 0.027	2.025ProIle: 2.025 ± 0.038	1.088ProLys: 1.088 ± 0.024	5.237ProLeu: 5.237 ± 0.065	1.114ProMet: 1.114 ± 0.028	1.052ProAsn: 1.052 ± 0.022	3.721ProPro: 3.721 ± 0.089	1.678ProGln: 1.678 ± 0.036	4.206ProArg: 4.206 ± 0.053	2.784ProSer: 2.784 ± 0.043	3.588ProThr: 3.588 ± 0.05	5.685ProVal: 5.685 ± 0.073	0.846ProTrp: 0.846 ± 0.022	1.102ProTyr: 1.102 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.516GlnAla: 3.516 ± 0.056	0.18GlnCys: 0.18 ± 0.008	1.086GlnAsp: 1.086 ± 0.028	1.128GlnGlu: 1.128 ± 0.028	0.803GlnPhe: 0.803 ± 0.019	1.782GlnGly: 1.782 ± 0.036	0.626GlnHis: 0.626 ± 0.019	1.28GlnIle: 1.28 ± 0.028	0.471GlnLys: 0.471 ± 0.016	3.22GlnLeu: 3.22 ± 0.044	0.545GlnMet: 0.545 ± 0.019	0.509GlnAsn: 0.509 ± 0.016	1.791GlnPro: 1.791 ± 0.041	1.223GlnGln: 1.223 ± 0.034	2.714GlnArg: 2.714 ± 0.045	1.145GlnSer: 1.145 ± 0.026	1.326GlnThr: 1.326 ± 0.024	2.584GlnVal: 2.584 ± 0.049	0.517GlnTrp: 0.517 ± 0.017	0.548GlnTyr: 0.548 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.935ArgAla: 10.935 ± 0.102	0.627ArgCys: 0.627 ± 0.023	4.377ArgAsp: 4.377 ± 0.056	4.686ArgGlu: 4.686 ± 0.053	2.501ArgPhe: 2.501 ± 0.04	5.841ArgGly: 5.841 ± 0.063	1.958ArgHis: 1.958 ± 0.033	3.707ArgIle: 3.707 ± 0.043	1.631ArgLys: 1.631 ± 0.038	8.267ArgLeu: 8.267 ± 0.083	2.058ArgMet: 2.058 ± 0.032	1.49ArgAsn: 1.49 ± 0.031	5.046ArgPro: 5.046 ± 0.072	2.164ArgGln: 2.164 ± 0.038	7.798ArgArg: 7.798 ± 0.091	3.994ArgSer: 3.994 ± 0.045	5.254ArgThr: 5.254 ± 0.068	6.338ArgVal: 6.338 ± 0.059	1.542ArgTrp: 1.542 ± 0.028	1.984ArgTyr: 1.984 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.583SerAla: 6.583 ± 0.072	0.364SerCys: 0.364 ± 0.014	2.5SerAsp: 2.5 ± 0.041	2.263SerGlu: 2.263 ± 0.039	1.414SerPhe: 1.414 ± 0.029	5.233SerGly: 5.233 ± 0.056	0.834SerHis: 0.834 ± 0.022	1.78SerIle: 1.78 ± 0.033	0.921SerLys: 0.921 ± 0.024	4.08SerLeu: 4.08 ± 0.046	1.168SerMet: 1.168 ± 0.025	0.827SerAsn: 0.827 ± 0.022	2.823SerPro: 2.823 ± 0.047	1.086SerGln: 1.086 ± 0.026	3.385SerArg: 3.385 ± 0.047	2.406SerSer: 2.406 ± 0.046	3.082SerThr: 3.082 ± 0.042	3.96SerVal: 3.96 ± 0.049	0.82SerTrp: 0.82 ± 0.022	1.087SerTyr: 1.087 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.997ThrAla: 8.997 ± 0.083	0.41ThrCys: 0.41 ± 0.015	3.771ThrAsp: 3.771 ± 0.052	3.531ThrGlu: 3.531 ± 0.043	1.618ThrPhe: 1.618 ± 0.03	6.324ThrGly: 6.324 ± 0.069	1.188ThrHis: 1.188 ± 0.022	2.112ThrIle: 2.112 ± 0.036	1.061ThrLys: 1.061 ± 0.029	5.7ThrLeu: 5.7 ± 0.054	1.048ThrMet: 1.048 ± 0.026	1.0ThrAsn: 1.0 ± 0.027	4.186ThrPro: 4.186 ± 0.059	1.293ThrGln: 1.293 ± 0.026	4.093ThrArg: 4.093 ± 0.05	2.742ThrSer: 2.742 ± 0.044	4.117ThrThr: 4.117 ± 0.062	6.261ThrVal: 6.261 ± 0.067	0.795ThrTrp: 0.795 ± 0.024	1.2ThrTyr: 1.2 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	12.126ValAla: 12.126 ± 0.108	0.716ValCys: 0.716 ± 0.019	5.481ValAsp: 5.481 ± 0.054	4.682ValGlu: 4.682 ± 0.047	2.513ValPhe: 2.513 ± 0.04	6.821ValGly: 6.821 ± 0.066	1.975ValHis: 1.975 ± 0.04	3.181ValIle: 3.181 ± 0.046	1.318ValLys: 1.318 ± 0.028	9.856ValLeu: 9.856 ± 0.088	1.275ValMet: 1.275 ± 0.025	1.607ValAsn: 1.607 ± 0.031	5.441ValPro: 5.441 ± 0.073	2.008ValGln: 2.008 ± 0.036	7.287ValArg: 7.287 ± 0.067	3.984ValSer: 3.984 ± 0.05	5.483ValThr: 5.483 ± 0.062	8.57ValVal: 8.57 ± 0.083	1.067ValTrp: 1.067 ± 0.023	1.529ValTyr: 1.529 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.583TrpAla: 1.583 ± 0.03	0.161TrpCys: 0.161 ± 0.01	0.745TrpAsp: 0.745 ± 0.021	0.689TrpGlu: 0.689 ± 0.02	0.51TrpPhe: 0.51 ± 0.02	0.956TrpGly: 0.956 ± 0.024	0.344TrpHis: 0.344 ± 0.014	0.583TrpIle: 0.583 ± 0.016	0.298TrpLys: 0.298 ± 0.013	1.714TrpLeu: 1.714 ± 0.03	0.321TrpMet: 0.321 ± 0.012	0.356TrpAsn: 0.356 ± 0.016	0.781TrpPro: 0.781 ± 0.025	0.609TrpGln: 0.609 ± 0.018	1.382TrpArg: 1.382 ± 0.031	0.938TrpSer: 0.938 ± 0.023	0.948TrpThr: 0.948 ± 0.023	1.107TrpVal: 1.107 ± 0.023	0.357TrpTrp: 0.357 ± 0.016	0.314TrpTyr: 0.314 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.446TyrAla: 2.446 ± 0.037	0.203TyrCys: 0.203 ± 0.01	1.298TyrAsp: 1.298 ± 0.03	1.037TyrGlu: 1.037 ± 0.024	0.649TyrPhe: 0.649 ± 0.023	1.988TyrGly: 1.988 ± 0.041	0.431TyrHis: 0.431 ± 0.017	0.572TyrIle: 0.572 ± 0.017	0.293TyrLys: 0.293 ± 0.013	2.347TyrLeu: 2.347 ± 0.03	0.277TyrMet: 0.277 ± 0.013	0.38TyrAsn: 0.38 ± 0.017	1.213TyrPro: 1.213 ± 0.027	0.603TyrGln: 0.603 ± 0.02	2.056TyrArg: 2.056 ± 0.036	0.976TyrSer: 0.976 ± 0.022	1.19TyrThr: 1.19 ± 0.029	1.559TyrVal: 1.559 ± 0.039	0.347TyrTrp: 0.347 ± 0.015	0.445TyrTyr: 0.445 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5941 proteins (1885749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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