Amino acid dipepetide frequency for Human betaherpesvirus 6A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.233AlaAla: 3.233 ± 0.332
1.102AlaCys: 1.102 ± 0.218
2.347AlaAsp: 2.347 ± 0.262
2.73AlaGlu: 2.73 ± 0.337
2.85AlaPhe: 2.85 ± 0.301
2.155AlaGly: 2.155 ± 0.294
1.341AlaHis: 1.341 ± 0.168
3.592AlaIle: 3.592 ± 0.262
2.706AlaLys: 2.706 ± 0.291
4.814AlaLeu: 4.814 ± 0.395
1.173AlaMet: 1.173 ± 0.163
2.419AlaAsn: 2.419 ± 0.267
1.82AlaPro: 1.82 ± 0.208
1.605AlaGln: 1.605 ± 0.163
3.161AlaArg: 3.161 ± 0.393
4.431AlaSer: 4.431 ± 1.025
3.305AlaThr: 3.305 ± 0.247
3.425AlaVal: 3.425 ± 0.315
0.383AlaTrp: 0.383 ± 0.093
1.509AlaTyr: 1.509 ± 0.162
0.0AlaXaa: 0.0 ± 0.0
Cys
1.389CysAla: 1.389 ± 0.276
0.479CysCys: 0.479 ± 0.105
1.485CysAsp: 1.485 ± 0.191
1.461CysGlu: 1.461 ± 0.2
1.245CysPhe: 1.245 ± 0.221
1.437CysGly: 1.437 ± 0.176
0.575CysHis: 0.575 ± 0.111
1.724CysIle: 1.724 ± 0.215
1.485CysLys: 1.485 ± 0.214
2.682CysLeu: 2.682 ± 0.313
0.862CysMet: 0.862 ± 0.15
1.245CysAsn: 1.245 ± 0.17
0.742CysPro: 0.742 ± 0.15
0.862CysGln: 0.862 ± 0.155
1.485CysArg: 1.485 ± 0.215
2.084CysSer: 2.084 ± 0.246
1.078CysThr: 1.078 ± 0.175
2.155CysVal: 2.155 ± 0.293
0.287CysTrp: 0.287 ± 0.079
0.91CysTyr: 0.91 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
2.251AspAla: 2.251 ± 0.252
1.317AspCys: 1.317 ± 0.191
2.73AspAsp: 2.73 ± 0.246
3.233AspGlu: 3.233 ± 0.327
3.041AspPhe: 3.041 ± 0.286
2.251AspGly: 2.251 ± 0.231
1.102AspHis: 1.102 ± 0.171
4.167AspIle: 4.167 ± 0.357
2.97AspLys: 2.97 ± 0.347
5.556AspLeu: 5.556 ± 0.451
1.437AspMet: 1.437 ± 0.207
2.61AspAsn: 2.61 ± 0.318
2.107AspPro: 2.107 ± 0.193
1.293AspGln: 1.293 ± 0.139
1.964AspArg: 1.964 ± 0.252
3.52AspSer: 3.52 ± 0.383
3.329AspThr: 3.329 ± 0.325
3.975AspVal: 3.975 ± 0.352
0.455AspTrp: 0.455 ± 0.097
1.988AspTyr: 1.988 ± 0.215
0.0AspXaa: 0.0 ± 0.0
Glu
2.371GluAla: 2.371 ± 0.198
1.197GluCys: 1.197 ± 0.188
2.898GluAsp: 2.898 ± 0.261
3.544GluGlu: 3.544 ± 0.305
2.419GluPhe: 2.419 ± 0.278
2.084GluGly: 2.084 ± 0.289
1.245GluHis: 1.245 ± 0.171
4.143GluIle: 4.143 ± 0.265
4.598GluLys: 4.598 ± 0.426
5.005GluLeu: 5.005 ± 0.375
1.748GluMet: 1.748 ± 0.199
4.215GluAsn: 4.215 ± 0.318
1.868GluPro: 1.868 ± 0.217
2.515GluGln: 2.515 ± 0.241
3.018GluArg: 3.018 ± 0.275
4.167GluSer: 4.167 ± 0.38
4.143GluThr: 4.143 ± 0.39
2.826GluVal: 2.826 ± 0.321
0.407GluTrp: 0.407 ± 0.1
1.796GluTyr: 1.796 ± 0.199
0.0GluXaa: 0.0 ± 0.0
Phe
2.658PheAla: 2.658 ± 0.267
1.748PheCys: 1.748 ± 0.229
2.658PheAsp: 2.658 ± 0.299
2.347PheGlu: 2.347 ± 0.218
3.544PhePhe: 3.544 ± 0.349
2.347PheGly: 2.347 ± 0.307
1.365PheHis: 1.365 ± 0.196
3.664PheIle: 3.664 ± 0.338
2.898PheLys: 2.898 ± 0.229
6.442PheLeu: 6.442 ± 0.475
1.269PheMet: 1.269 ± 0.158
3.281PheAsn: 3.281 ± 0.236
2.347PhePro: 2.347 ± 0.202
1.772PheGln: 1.772 ± 0.245
2.179PheArg: 2.179 ± 0.242
4.694PheSer: 4.694 ± 0.369
3.401PheThr: 3.401 ± 0.304
3.257PheVal: 3.257 ± 0.315
0.359PheTrp: 0.359 ± 0.089
2.227PheTyr: 2.227 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
2.06GlyAla: 2.06 ± 0.273
0.862GlyCys: 0.862 ± 0.171
2.658GlyAsp: 2.658 ± 0.29
2.419GlyGlu: 2.419 ± 0.294
1.988GlyPhe: 1.988 ± 0.227
2.107GlyGly: 2.107 ± 0.292
0.886GlyHis: 0.886 ± 0.13
2.275GlyIle: 2.275 ± 0.299
3.137GlyLys: 3.137 ± 0.273
4.431GlyLeu: 4.431 ± 0.343
1.126GlyMet: 1.126 ± 0.169
2.491GlyAsn: 2.491 ± 0.303
1.317GlyPro: 1.317 ± 0.198
1.605GlyGln: 1.605 ± 0.165
2.419GlyArg: 2.419 ± 0.323
2.706GlySer: 2.706 ± 0.273
2.563GlyThr: 2.563 ± 0.242
2.874GlyVal: 2.874 ± 0.361
0.479GlyTrp: 0.479 ± 0.103
1.605GlyTyr: 1.605 ± 0.234
0.0GlyXaa: 0.0 ± 0.0
His
1.221HisAla: 1.221 ± 0.157
0.695HisCys: 0.695 ± 0.144
1.485HisAsp: 1.485 ± 0.187
1.269HisGlu: 1.269 ± 0.188
1.509HisPhe: 1.509 ± 0.221
1.317HisGly: 1.317 ± 0.171
0.599HisHis: 0.599 ± 0.117
1.748HisIle: 1.748 ± 0.213
1.389HisLys: 1.389 ± 0.18
2.586HisLeu: 2.586 ± 0.242
0.742HisMet: 0.742 ± 0.108
1.269HisAsn: 1.269 ± 0.186
0.91HisPro: 0.91 ± 0.131
0.718HisGln: 0.718 ± 0.139
1.748HisArg: 1.748 ± 0.226
1.533HisSer: 1.533 ± 0.215
1.461HisThr: 1.461 ± 0.214
1.94HisVal: 1.94 ± 0.234
0.168HisTrp: 0.168 ± 0.066
0.766HisTyr: 0.766 ± 0.139
0.0HisXaa: 0.0 ± 0.0
Ile
3.377IleAla: 3.377 ± 0.331
1.724IleCys: 1.724 ± 0.206
3.473IleAsp: 3.473 ± 0.276
3.52IleGlu: 3.52 ± 0.368
3.281IlePhe: 3.281 ± 0.354
2.515IleGly: 2.515 ± 0.275
1.389IleHis: 1.389 ± 0.188
4.023IleIle: 4.023 ± 0.365
4.622IleLys: 4.622 ± 0.398
6.897IleLeu: 6.897 ± 0.526
1.724IleMet: 1.724 ± 0.202
3.688IleAsn: 3.688 ± 0.356
3.688IlePro: 3.688 ± 0.3
2.419IleGln: 2.419 ± 0.266
2.994IleArg: 2.994 ± 0.3
5.963IleSer: 5.963 ± 0.372
4.047IleThr: 4.047 ± 0.377
4.191IleVal: 4.191 ± 0.307
0.455IleTrp: 0.455 ± 0.093
3.305IleTyr: 3.305 ± 0.274
0.0IleXaa: 0.0 ± 0.0
Lys
2.994LysAla: 2.994 ± 0.393
1.485LysCys: 1.485 ± 0.196
3.449LysAsp: 3.449 ± 0.341
3.688LysGlu: 3.688 ± 0.31
3.041LysPhe: 3.041 ± 0.313
1.581LysGly: 1.581 ± 0.227
1.964LysHis: 1.964 ± 0.22
5.005LysIle: 5.005 ± 0.353
5.388LysLys: 5.388 ± 0.484
5.796LysLeu: 5.796 ± 0.42
1.461LysMet: 1.461 ± 0.177
4.311LysAsn: 4.311 ± 0.427
2.179LysPro: 2.179 ± 0.194
3.353LysGln: 3.353 ± 0.275
2.97LysArg: 2.97 ± 0.289
4.933LysSer: 4.933 ± 0.395
5.293LysThr: 5.293 ± 0.411
2.778LysVal: 2.778 ± 0.287
0.383LysTrp: 0.383 ± 0.099
2.036LysTyr: 2.036 ± 0.208
0.0LysXaa: 0.0 ± 0.0
Leu
4.454LeuAla: 4.454 ± 0.369
3.329LeuCys: 3.329 ± 0.315
4.502LeuAsp: 4.502 ± 0.417
4.67LeuGlu: 4.67 ± 0.427
5.82LeuPhe: 5.82 ± 0.436
4.526LeuGly: 4.526 ± 0.463
2.97LeuHis: 2.97 ± 0.353
5.843LeuIle: 5.843 ± 0.407
6.179LeuLys: 6.179 ± 0.37
10.561LeuLeu: 10.561 ± 0.855
2.395LeuMet: 2.395 ± 0.265
5.508LeuAsn: 5.508 ± 0.457
4.909LeuPro: 4.909 ± 0.381
4.119LeuGln: 4.119 ± 0.296
5.077LeuArg: 5.077 ± 0.399
9.124LeuSer: 9.124 ± 0.5
6.825LeuThr: 6.825 ± 0.439
4.215LeuVal: 4.215 ± 0.47
1.15LeuTrp: 1.15 ± 0.155
3.88LeuTyr: 3.88 ± 0.392
0.0LeuXaa: 0.0 ± 0.0
Met
1.724MetAla: 1.724 ± 0.256
0.647MetCys: 0.647 ± 0.134
1.341MetAsp: 1.341 ± 0.185
1.605MetGlu: 1.605 ± 0.198
1.485MetPhe: 1.485 ± 0.226
0.982MetGly: 0.982 ± 0.185
0.623MetHis: 0.623 ± 0.11
1.605MetIle: 1.605 ± 0.186
1.509MetLys: 1.509 ± 0.197
2.634MetLeu: 2.634 ± 0.294
0.623MetMet: 0.623 ± 0.15
1.317MetAsn: 1.317 ± 0.163
0.862MetPro: 0.862 ± 0.149
0.982MetGln: 0.982 ± 0.147
1.078MetArg: 1.078 ± 0.158
2.179MetSer: 2.179 ± 0.22
1.341MetThr: 1.341 ± 0.21
1.078MetVal: 1.078 ± 0.16
0.263MetTrp: 0.263 ± 0.08
1.078MetTyr: 1.078 ± 0.175
0.0MetXaa: 0.0 ± 0.0
Asn
2.682AsnAla: 2.682 ± 0.306
1.126AsnCys: 1.126 ± 0.163
3.137AsnAsp: 3.137 ± 0.253
2.922AsnGlu: 2.922 ± 0.254
2.826AsnPhe: 2.826 ± 0.261
2.539AsnGly: 2.539 ± 0.27
1.245AsnHis: 1.245 ± 0.193
4.167AsnIle: 4.167 ± 0.373
3.425AsnLys: 3.425 ± 0.384
6.011AsnLeu: 6.011 ± 0.425
1.437AsnMet: 1.437 ± 0.286
3.377AsnAsn: 3.377 ± 0.319
2.586AsnPro: 2.586 ± 0.371
1.413AsnGln: 1.413 ± 0.177
2.634AsnArg: 2.634 ± 0.276
5.005AsnSer: 5.005 ± 0.503
3.688AsnThr: 3.688 ± 0.443
4.023AsnVal: 4.023 ± 0.37
0.551AsnTrp: 0.551 ± 0.117
1.868AsnTyr: 1.868 ± 0.294
0.0AsnXaa: 0.0 ± 0.0
Pro
1.916ProAla: 1.916 ± 0.22
1.03ProCys: 1.03 ± 0.174
2.084ProAsp: 2.084 ± 0.235
2.539ProGlu: 2.539 ± 0.25
2.227ProPhe: 2.227 ± 0.242
1.94ProGly: 1.94 ± 0.208
0.862ProHis: 0.862 ± 0.13
3.281ProIle: 3.281 ± 0.29
2.994ProLys: 2.994 ± 0.267
4.023ProLeu: 4.023 ± 0.371
1.054ProMet: 1.054 ± 0.139
2.419ProAsn: 2.419 ± 0.257
2.419ProPro: 2.419 ± 0.372
1.317ProGln: 1.317 ± 0.199
2.155ProArg: 2.155 ± 0.246
3.544ProSer: 3.544 ± 0.461
2.563ProThr: 2.563 ± 0.299
2.922ProVal: 2.922 ± 0.351
0.407ProTrp: 0.407 ± 0.095
1.317ProTyr: 1.317 ± 0.193
0.0ProXaa: 0.0 ± 0.0
Gln
1.173GlnAla: 1.173 ± 0.166
0.814GlnCys: 0.814 ± 0.125
1.605GlnAsp: 1.605 ± 0.205
2.06GlnGlu: 2.06 ± 0.249
1.964GlnPhe: 1.964 ± 0.237
1.365GlnGly: 1.365 ± 0.212
0.886GlnHis: 0.886 ± 0.14
2.922GlnIle: 2.922 ± 0.292
2.586GlnLys: 2.586 ± 0.296
3.64GlnLeu: 3.64 ± 0.316
0.79GlnMet: 0.79 ± 0.174
2.874GlnAsn: 2.874 ± 0.329
1.173GlnPro: 1.173 ± 0.229
1.82GlnGln: 1.82 ± 0.298
1.892GlnArg: 1.892 ± 0.23
2.658GlnSer: 2.658 ± 0.244
2.563GlnThr: 2.563 ± 0.231
1.748GlnVal: 1.748 ± 0.236
0.359GlnTrp: 0.359 ± 0.097
1.389GlnTyr: 1.389 ± 0.211
0.0GlnXaa: 0.0 ± 0.0
Arg
3.353ArgAla: 3.353 ± 0.739
1.245ArgCys: 1.245 ± 0.171
2.826ArgAsp: 2.826 ± 0.369
2.826ArgGlu: 2.826 ± 0.286
2.491ArgPhe: 2.491 ± 0.297
2.515ArgGly: 2.515 ± 0.289
1.82ArgHis: 1.82 ± 0.24
2.826ArgIle: 2.826 ± 0.295
3.353ArgLys: 3.353 ± 0.262
4.814ArgLeu: 4.814 ± 0.416
1.317ArgMet: 1.317 ± 0.223
2.539ArgAsn: 2.539 ± 0.256
2.036ArgPro: 2.036 ± 0.249
2.227ArgGln: 2.227 ± 0.245
3.712ArgArg: 3.712 ± 0.491
3.449ArgSer: 3.449 ± 0.351
2.347ArgThr: 2.347 ± 0.273
3.281ArgVal: 3.281 ± 0.54
0.503ArgTrp: 0.503 ± 0.135
1.629ArgTyr: 1.629 ± 0.179
0.0ArgXaa: 0.0 ± 0.0
Ser
4.191SerAla: 4.191 ± 0.364
2.012SerCys: 2.012 ± 0.209
4.359SerAsp: 4.359 ± 0.359
5.245SerGlu: 5.245 ± 0.367
4.646SerPhe: 4.646 ± 0.369
3.425SerGly: 3.425 ± 0.336
2.012SerHis: 2.012 ± 0.243
5.221SerIle: 5.221 ± 0.396
5.245SerLys: 5.245 ± 0.536
7.903SerLeu: 7.903 ± 0.452
1.796SerMet: 1.796 ± 0.205
3.952SerAsn: 3.952 ± 0.505
4.071SerPro: 4.071 ± 0.373
2.227SerGln: 2.227 ± 0.246
4.383SerArg: 4.383 ± 1.062
8.478SerSer: 8.478 ± 1.641
4.694SerThr: 4.694 ± 0.407
5.173SerVal: 5.173 ± 0.409
0.814SerTrp: 0.814 ± 0.113
2.131SerTyr: 2.131 ± 0.238
0.0SerXaa: 0.0 ± 0.0
Thr
3.616ThrAla: 3.616 ± 0.345
1.868ThrCys: 1.868 ± 0.219
2.994ThrAsp: 2.994 ± 0.27
4.383ThrGlu: 4.383 ± 0.426
3.473ThrPhe: 3.473 ± 0.322
2.73ThrGly: 2.73 ± 0.237
1.988ThrHis: 1.988 ± 0.239
3.616ThrIle: 3.616 ± 0.338
3.329ThrLys: 3.329 ± 0.291
5.843ThrLeu: 5.843 ± 0.465
1.437ThrMet: 1.437 ± 0.189
3.329ThrAsn: 3.329 ± 0.371
3.281ThrPro: 3.281 ± 0.363
2.371ThrGln: 2.371 ± 0.257
2.467ThrArg: 2.467 ± 0.306
4.838ThrSer: 4.838 ± 0.444
4.55ThrThr: 4.55 ± 0.44
5.005ThrVal: 5.005 ± 0.387
0.383ThrTrp: 0.383 ± 0.102
2.036ThrTyr: 2.036 ± 0.226
0.0ThrXaa: 0.0 ± 0.0
Val
3.089ValAla: 3.089 ± 0.257
1.724ValCys: 1.724 ± 0.202
2.994ValAsp: 2.994 ± 0.331
2.994ValGlu: 2.994 ± 0.316
4.071ValPhe: 4.071 ± 0.342
2.012ValGly: 2.012 ± 0.217
1.485ValHis: 1.485 ± 0.188
3.928ValIle: 3.928 ± 0.301
3.353ValLys: 3.353 ± 0.374
6.322ValLeu: 6.322 ± 0.47
1.652ValMet: 1.652 ± 0.253
3.185ValAsn: 3.185 ± 0.323
2.826ValPro: 2.826 ± 0.238
2.179ValGln: 2.179 ± 0.229
3.568ValArg: 3.568 ± 0.476
5.173ValSer: 5.173 ± 0.312
4.071ValThr: 4.071 ± 0.328
3.856ValVal: 3.856 ± 0.429
0.479ValTrp: 0.479 ± 0.106
2.778ValTyr: 2.778 ± 0.301
0.0ValXaa: 0.0 ± 0.0
Trp
0.335TrpAla: 0.335 ± 0.074
0.263TrpCys: 0.263 ± 0.08
0.335TrpAsp: 0.335 ± 0.079
0.599TrpGlu: 0.599 ± 0.116
0.575TrpPhe: 0.575 ± 0.118
0.479TrpGly: 0.479 ± 0.126
0.072TrpHis: 0.072 ± 0.036
0.886TrpIle: 0.886 ± 0.141
0.383TrpLys: 0.383 ± 0.078
0.982TrpLeu: 0.982 ± 0.162
0.192TrpMet: 0.192 ± 0.067
0.359TrpAsn: 0.359 ± 0.084
0.551TrpPro: 0.551 ± 0.118
0.311TrpGln: 0.311 ± 0.071
0.383TrpArg: 0.383 ± 0.121
0.599TrpSer: 0.599 ± 0.126
0.647TrpThr: 0.647 ± 0.127
0.479TrpVal: 0.479 ± 0.119
0.096TrpTrp: 0.096 ± 0.052
0.311TrpTyr: 0.311 ± 0.076
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.012TyrAla: 2.012 ± 0.226
1.006TyrCys: 1.006 ± 0.147
1.94TyrAsp: 1.94 ± 0.164
2.155TyrGlu: 2.155 ± 0.224
1.964TyrPhe: 1.964 ± 0.185
1.7TyrGly: 1.7 ± 0.217
0.647TyrHis: 0.647 ± 0.116
2.658TyrIle: 2.658 ± 0.325
2.563TyrLys: 2.563 ± 0.229
3.113TyrLeu: 3.113 ± 0.324
0.695TyrMet: 0.695 ± 0.129
2.275TyrAsn: 2.275 ± 0.256
1.317TyrPro: 1.317 ± 0.169
1.173TyrGln: 1.173 ± 0.186
1.82TyrArg: 1.82 ± 0.19
2.898TyrSer: 2.898 ± 0.254
1.629TyrThr: 1.629 ± 0.196
2.539TyrVal: 2.539 ± 0.253
0.455TyrTrp: 0.455 ± 0.104
1.078TyrTyr: 1.078 ± 0.156
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 101 proteins (41757 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski