Amino acid dipepetide frequency for Rodentibacter heylii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.045AlaAla: 6.045 ± 0.119
0.922AlaCys: 0.922 ± 0.045
3.752AlaAsp: 3.752 ± 0.075
5.416AlaGlu: 5.416 ± 0.11
3.331AlaPhe: 3.331 ± 0.087
5.158AlaGly: 5.158 ± 0.105
1.353AlaHis: 1.353 ± 0.042
6.008AlaIle: 6.008 ± 0.118
5.305AlaLys: 5.305 ± 0.092
9.301AlaLeu: 9.301 ± 0.142
2.112AlaMet: 2.112 ± 0.059
3.562AlaAsn: 3.562 ± 0.11
2.221AlaPro: 2.221 ± 0.063
3.599AlaGln: 3.599 ± 0.083
3.29AlaArg: 3.29 ± 0.08
3.774AlaSer: 3.774 ± 0.079
3.796AlaThr: 3.796 ± 0.081
5.509AlaVal: 5.509 ± 0.111
0.775AlaTrp: 0.775 ± 0.033
2.357AlaTyr: 2.357 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.772CysAla: 0.772 ± 0.04
0.179CysCys: 0.179 ± 0.017
0.514CysAsp: 0.514 ± 0.027
0.604CysGlu: 0.604 ± 0.03
0.53CysPhe: 0.53 ± 0.028
0.958CysGly: 0.958 ± 0.041
0.283CysHis: 0.283 ± 0.025
0.678CysIle: 0.678 ± 0.037
0.453CysLys: 0.453 ± 0.031
1.176CysLeu: 1.176 ± 0.044
0.188CysMet: 0.188 ± 0.019
0.38CysAsn: 0.38 ± 0.026
0.473CysPro: 0.473 ± 0.029
0.556CysGln: 0.556 ± 0.03
0.514CysArg: 0.514 ± 0.033
0.711CysSer: 0.711 ± 0.036
0.45CysThr: 0.45 ± 0.026
0.644CysVal: 0.644 ± 0.031
0.127CysTrp: 0.127 ± 0.014
0.423CysTyr: 0.423 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.912AspAla: 2.912 ± 0.072
0.568AspCys: 0.568 ± 0.028
2.138AspAsp: 2.138 ± 0.066
3.436AspGlu: 3.436 ± 0.074
2.504AspPhe: 2.504 ± 0.058
2.7AspGly: 2.7 ± 0.069
0.825AspHis: 0.825 ± 0.036
4.157AspIle: 4.157 ± 0.086
3.247AspLys: 3.247 ± 0.079
4.895AspLeu: 4.895 ± 0.093
1.057AspMet: 1.057 ± 0.041
2.418AspAsn: 2.418 ± 0.061
1.912AspPro: 1.912 ± 0.052
1.641AspGln: 1.641 ± 0.048
2.068AspArg: 2.068 ± 0.059
2.663AspSer: 2.663 ± 0.062
2.11AspThr: 2.11 ± 0.057
2.992AspVal: 2.992 ± 0.071
0.76AspTrp: 0.76 ± 0.037
2.212AspTyr: 2.212 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.003GluAla: 4.003 ± 0.09
0.508GluCys: 0.508 ± 0.028
2.385GluAsp: 2.385 ± 0.07
3.811GluGlu: 3.811 ± 0.086
2.504GluPhe: 2.504 ± 0.071
3.403GluGly: 3.403 ± 0.081
1.378GluHis: 1.378 ± 0.047
5.138GluIle: 5.138 ± 0.107
5.35GluLys: 5.35 ± 0.103
6.538GluLeu: 6.538 ± 0.114
1.67GluMet: 1.67 ± 0.042
3.862GluAsn: 3.862 ± 0.074
1.766GluPro: 1.766 ± 0.052
4.2GluGln: 4.2 ± 0.078
3.236GluArg: 3.236 ± 0.077
3.19GluSer: 3.19 ± 0.07
3.026GluThr: 3.026 ± 0.069
3.454GluVal: 3.454 ± 0.086
0.712GluTrp: 0.712 ± 0.035
1.851GluTyr: 1.851 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.352PheAla: 3.352 ± 0.089
0.576PheCys: 0.576 ± 0.027
2.663PheAsp: 2.663 ± 0.061
2.555PheGlu: 2.555 ± 0.063
2.277PhePhe: 2.277 ± 0.072
3.49PheGly: 3.49 ± 0.097
0.819PheHis: 0.819 ± 0.034
3.76PheIle: 3.76 ± 0.094
2.141PheLys: 2.141 ± 0.06
4.302PheLeu: 4.302 ± 0.094
1.063PheMet: 1.063 ± 0.044
2.501PheAsn: 2.501 ± 0.063
1.582PhePro: 1.582 ± 0.052
1.528PheGln: 1.528 ± 0.058
1.613PheArg: 1.613 ± 0.054
3.757PheSer: 3.757 ± 0.091
2.305PheThr: 2.305 ± 0.067
2.781PheVal: 2.781 ± 0.067
0.584PheTrp: 0.584 ± 0.034
1.661PheTyr: 1.661 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
4.957GlyAla: 4.957 ± 0.1
0.786GlyCys: 0.786 ± 0.034
2.895GlyAsp: 2.895 ± 0.077
4.165GlyGlu: 4.165 ± 0.082
3.212GlyPhe: 3.212 ± 0.085
4.664GlyGly: 4.664 ± 0.12
1.205GlyHis: 1.205 ± 0.045
5.901GlyIle: 5.901 ± 0.115
4.931GlyLys: 4.931 ± 0.092
6.941GlyLeu: 6.941 ± 0.13
1.838GlyMet: 1.838 ± 0.054
2.952GlyAsn: 2.952 ± 0.086
1.194GlyPro: 1.194 ± 0.046
2.552GlyGln: 2.552 ± 0.063
2.921GlyArg: 2.921 ± 0.07
3.725GlySer: 3.725 ± 0.084
3.287GlyThr: 3.287 ± 0.071
4.585GlyVal: 4.585 ± 0.093
0.877GlyTrp: 0.877 ± 0.04
2.535GlyTyr: 2.535 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.061HisAla: 1.061 ± 0.044
0.399HisCys: 0.399 ± 0.026
0.732HisAsp: 0.732 ± 0.035
0.723HisGlu: 0.723 ± 0.034
1.23HisPhe: 1.23 ± 0.046
1.177HisGly: 1.177 ± 0.042
0.728HisHis: 0.728 ± 0.037
1.82HisIle: 1.82 ± 0.057
1.058HisLys: 1.058 ± 0.042
2.373HisLeu: 2.373 ± 0.065
0.327HisMet: 0.327 ± 0.023
1.072HisAsn: 1.072 ± 0.044
0.955HisPro: 0.955 ± 0.045
1.219HisGln: 1.219 ± 0.052
1.055HisArg: 1.055 ± 0.038
1.458HisSer: 1.458 ± 0.044
1.012HisThr: 1.012 ± 0.051
0.687HisVal: 0.687 ± 0.034
0.315HisTrp: 0.315 ± 0.025
0.921HisTyr: 0.921 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
7.032IleAla: 7.032 ± 0.117
0.941IleCys: 0.941 ± 0.035
4.242IleAsp: 4.242 ± 0.081
5.167IleGlu: 5.167 ± 0.1
3.349IlePhe: 3.349 ± 0.09
5.839IleGly: 5.839 ± 0.114
1.427IleHis: 1.427 ± 0.05
5.515IleIle: 5.515 ± 0.115
4.267IleLys: 4.267 ± 0.082
7.665IleLeu: 7.665 ± 0.13
1.48IleMet: 1.48 ± 0.05
3.911IleAsn: 3.911 ± 0.08
3.156IlePro: 3.156 ± 0.07
3.093IleGln: 3.093 ± 0.074
3.4IleArg: 3.4 ± 0.084
5.299IleSer: 5.299 ± 0.093
4.08IleThr: 4.08 ± 0.086
4.659IleVal: 4.659 ± 0.074
0.768IleTrp: 0.768 ± 0.034
2.396IleTyr: 2.396 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.812LysAla: 4.812 ± 0.081
0.412LysCys: 0.412 ± 0.027
2.68LysAsp: 2.68 ± 0.069
3.779LysGlu: 3.779 ± 0.094
2.082LysPhe: 2.082 ± 0.062
3.876LysGly: 3.876 ± 0.092
1.205LysHis: 1.205 ± 0.044
4.761LysIle: 4.761 ± 0.082
4.023LysLys: 4.023 ± 0.088
6.331LysLeu: 6.331 ± 0.106
1.781LysMet: 1.781 ± 0.052
3.533LysAsn: 3.533 ± 0.071
2.364LysPro: 2.364 ± 0.065
3.44LysGln: 3.44 ± 0.088
2.842LysArg: 2.842 ± 0.072
3.561LysSer: 3.561 ± 0.071
3.575LysThr: 3.575 ± 0.075
3.907LysVal: 3.907 ± 0.083
0.66LysTrp: 0.66 ± 0.032
1.88LysTyr: 1.88 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
9.054LeuAla: 9.054 ± 0.128
1.182LeuCys: 1.182 ± 0.048
5.234LeuAsp: 5.234 ± 0.099
6.039LeuGlu: 6.039 ± 0.102
4.968LeuPhe: 4.968 ± 0.115
7.081LeuGly: 7.081 ± 0.117
1.968LeuHis: 1.968 ± 0.059
7.658LeuIle: 7.658 ± 0.129
6.07LeuLys: 6.07 ± 0.11
11.116LeuLeu: 11.116 ± 0.196
2.442LeuMet: 2.442 ± 0.061
5.615LeuAsn: 5.615 ± 0.116
4.855LeuPro: 4.855 ± 0.094
4.746LeuGln: 4.746 ± 0.097
4.551LeuArg: 4.551 ± 0.097
7.946LeuSer: 7.946 ± 0.13
6.165LeuThr: 6.165 ± 0.096
6.31LeuVal: 6.31 ± 0.109
1.095LeuTrp: 1.095 ± 0.049
2.883LeuTyr: 2.883 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.175MetAla: 2.175 ± 0.049
0.192MetCys: 0.192 ± 0.017
0.876MetAsp: 0.876 ± 0.034
1.106MetGlu: 1.106 ± 0.046
0.839MetPhe: 0.839 ± 0.036
1.463MetGly: 1.463 ± 0.049
0.378MetHis: 0.378 ± 0.025
1.624MetIle: 1.624 ± 0.053
1.627MetLys: 1.627 ± 0.05
2.66MetLeu: 2.66 ± 0.064
0.672MetMet: 0.672 ± 0.034
1.23MetAsn: 1.23 ± 0.038
1.057MetPro: 1.057 ± 0.037
1.234MetGln: 1.234 ± 0.05
1.016MetArg: 1.016 ± 0.038
1.525MetSer: 1.525 ± 0.05
1.497MetThr: 1.497 ± 0.045
1.429MetVal: 1.429 ± 0.052
0.239MetTrp: 0.239 ± 0.019
0.49MetTyr: 0.49 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.809AsnAla: 3.809 ± 0.089
0.425AsnCys: 0.425 ± 0.023
2.189AsnAsp: 2.189 ± 0.059
3.08AsnGlu: 3.08 ± 0.072
2.005AsnPhe: 2.005 ± 0.052
3.429AsnGly: 3.429 ± 0.097
1.033AsnHis: 1.033 ± 0.044
4.307AsnIle: 4.307 ± 0.081
2.968AsnLys: 2.968 ± 0.088
5.26AsnLeu: 5.26 ± 0.096
1.083AsnMet: 1.083 ± 0.039
2.51AsnAsn: 2.51 ± 0.077
2.305AsnPro: 2.305 ± 0.052
2.635AsnGln: 2.635 ± 0.078
2.379AsnArg: 2.379 ± 0.059
2.748AsnSer: 2.748 ± 0.074
2.572AsnThr: 2.572 ± 0.08
3.002AsnVal: 3.002 ± 0.092
0.684AsnTrp: 0.684 ± 0.034
1.778AsnTyr: 1.778 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.405ProAla: 2.405 ± 0.068
0.346ProCys: 0.346 ± 0.023
1.861ProAsp: 1.861 ± 0.057
2.836ProGlu: 2.836 ± 0.077
1.827ProPhe: 1.827 ± 0.062
1.505ProGly: 1.505 ± 0.052
0.95ProHis: 0.95 ± 0.045
3.108ProIle: 3.108 ± 0.071
2.257ProLys: 2.257 ± 0.067
3.922ProLeu: 3.922 ± 0.085
0.915ProMet: 0.915 ± 0.036
2.262ProAsn: 2.262 ± 0.057
1.106ProPro: 1.106 ± 0.046
1.82ProGln: 1.82 ± 0.052
1.327ProArg: 1.327 ± 0.047
2.152ProSer: 2.152 ± 0.059
2.286ProThr: 2.286 ± 0.062
2.359ProVal: 2.359 ± 0.069
0.374ProTrp: 0.374 ± 0.024
1.406ProTyr: 1.406 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.043GlnAla: 4.043 ± 0.083
0.405GlnCys: 0.405 ± 0.028
2.109GlnAsp: 2.109 ± 0.056
2.815GlnGlu: 2.815 ± 0.077
2.16GlnPhe: 2.16 ± 0.066
3.153GlnGly: 3.153 ± 0.081
1.168GlnHis: 1.168 ± 0.043
3.729GlnIle: 3.729 ± 0.079
3.053GlnLys: 3.053 ± 0.073
4.916GlnLeu: 4.916 ± 0.098
0.976GlnMet: 0.976 ± 0.038
2.58GlnAsn: 2.58 ± 0.065
1.77GlnPro: 1.77 ± 0.064
3.403GlnGln: 3.403 ± 0.097
2.404GlnArg: 2.404 ± 0.072
2.958GlnSer: 2.958 ± 0.066
2.49GlnThr: 2.49 ± 0.066
2.79GlnVal: 2.79 ± 0.066
0.641GlnTrp: 0.641 ± 0.037
1.637GlnTyr: 1.637 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.963ArgAla: 2.963 ± 0.074
0.422ArgCys: 0.422 ± 0.024
2.031ArgAsp: 2.031 ± 0.06
2.915ArgGlu: 2.915 ± 0.081
2.377ArgPhe: 2.377 ± 0.066
2.549ArgGly: 2.549 ± 0.069
1.066ArgHis: 1.066 ± 0.043
3.516ArgIle: 3.516 ± 0.074
2.623ArgLys: 2.623 ± 0.067
5.135ArgLeu: 5.135 ± 0.108
0.976ArgMet: 0.976 ± 0.041
2.147ArgAsn: 2.147 ± 0.057
1.582ArgPro: 1.582 ± 0.054
2.605ArgGln: 2.605 ± 0.072
2.294ArgArg: 2.294 ± 0.073
2.421ArgSer: 2.421 ± 0.066
2.195ArgThr: 2.195 ± 0.06
2.606ArgVal: 2.606 ± 0.065
0.522ArgTrp: 0.522 ± 0.03
1.956ArgTyr: 1.956 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.184SerAla: 5.184 ± 0.091
0.604SerCys: 0.604 ± 0.034
2.988SerAsp: 2.988 ± 0.075
3.664SerGlu: 3.664 ± 0.088
2.784SerPhe: 2.784 ± 0.074
4.778SerGly: 4.778 ± 0.092
1.225SerHis: 1.225 ± 0.039
4.591SerIle: 4.591 ± 0.103
3.117SerLys: 3.117 ± 0.072
6.539SerLeu: 6.539 ± 0.115
1.298SerMet: 1.298 ± 0.049
2.635SerAsn: 2.635 ± 0.068
2.388SerPro: 2.388 ± 0.064
2.961SerGln: 2.961 ± 0.07
2.745SerArg: 2.745 ± 0.072
3.831SerSer: 3.831 ± 0.09
3.144SerThr: 3.144 ± 0.079
4.168SerVal: 4.168 ± 0.087
0.709SerTrp: 0.709 ± 0.031
1.942SerTyr: 1.942 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.727ThrAla: 4.727 ± 0.103
0.45ThrCys: 0.45 ± 0.025
2.676ThrAsp: 2.676 ± 0.068
3.49ThrGlu: 3.49 ± 0.069
2.285ThrPhe: 2.285 ± 0.065
3.593ThrGly: 3.593 ± 0.083
1.125ThrHis: 1.125 ± 0.041
3.585ThrIle: 3.585 ± 0.088
2.79ThrLys: 2.79 ± 0.076
6.136ThrLeu: 6.136 ± 0.092
1.069ThrMet: 1.069 ± 0.037
2.126ThrAsn: 2.126 ± 0.057
2.39ThrPro: 2.39 ± 0.061
2.498ThrGln: 2.498 ± 0.071
1.99ThrArg: 1.99 ± 0.061
2.708ThrSer: 2.708 ± 0.064
2.821ThrThr: 2.821 ± 0.07
3.44ThrVal: 3.44 ± 0.075
0.467ThrTrp: 0.467 ± 0.03
1.519ThrTyr: 1.519 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.036ValAla: 5.036 ± 0.107
0.684ValCys: 0.684 ± 0.032
3.168ValAsp: 3.168 ± 0.075
4.199ValGlu: 4.199 ± 0.089
2.605ValPhe: 2.605 ± 0.056
4.336ValGly: 4.336 ± 0.091
1.009ValHis: 1.009 ± 0.042
4.899ValIle: 4.899 ± 0.095
4.029ValLys: 4.029 ± 0.081
6.329ValLeu: 6.329 ± 0.114
1.546ValMet: 1.546 ± 0.05
3.054ValAsn: 3.054 ± 0.081
2.248ValPro: 2.248 ± 0.063
2.325ValGln: 2.325 ± 0.061
2.785ValArg: 2.785 ± 0.076
4.176ValSer: 4.176 ± 0.09
3.048ValThr: 3.048 ± 0.074
4.171ValVal: 4.171 ± 0.092
0.613ValTrp: 0.613 ± 0.034
1.77ValTyr: 1.77 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.766TrpAla: 0.766 ± 0.039
0.125TrpCys: 0.125 ± 0.013
0.487TrpAsp: 0.487 ± 0.028
0.567TrpGlu: 0.567 ± 0.028
0.599TrpPhe: 0.599 ± 0.028
0.751TrpGly: 0.751 ± 0.033
0.314TrpHis: 0.314 ± 0.021
0.828TrpIle: 0.828 ± 0.04
0.666TrpLys: 0.666 ± 0.032
1.651TrpLeu: 1.651 ± 0.057
0.204TrpMet: 0.204 ± 0.017
0.559TrpAsn: 0.559 ± 0.027
0.165TrpPro: 0.165 ± 0.014
0.986TrpGln: 0.986 ± 0.046
0.647TrpArg: 0.647 ± 0.029
0.542TrpSer: 0.542 ± 0.029
0.476TrpThr: 0.476 ± 0.028
0.715TrpVal: 0.715 ± 0.035
0.167TrpTrp: 0.167 ± 0.017
0.374TrpTyr: 0.374 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.478TyrAla: 2.478 ± 0.06
0.487TyrCys: 0.487 ± 0.03
1.597TyrAsp: 1.597 ± 0.055
1.619TyrGlu: 1.619 ± 0.047
1.841TyrPhe: 1.841 ± 0.054
2.22TyrGly: 2.22 ± 0.063
0.864TyrHis: 0.864 ± 0.04
2.104TyrIle: 2.104 ± 0.056
1.531TyrLys: 1.531 ± 0.056
3.792TyrLeu: 3.792 ± 0.069
0.629TyrMet: 0.629 ± 0.032
1.293TyrAsn: 1.293 ± 0.051
1.536TyrPro: 1.536 ± 0.049
2.158TyrGln: 2.158 ± 0.062
1.821TyrArg: 1.821 ± 0.055
2.152TyrSer: 2.152 ± 0.06
1.548TyrThr: 1.548 ± 0.05
1.821TyrVal: 1.821 ± 0.056
0.499TyrTrp: 0.499 ± 0.026
1.236TyrTyr: 1.236 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1998 proteins (647336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski