Amino acid dipepetide frequency for Campylobacter sp. RM16192

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.689AlaAla: 4.689 ± 0.123
0.918AlaCys: 0.918 ± 0.054
3.306AlaAsp: 3.306 ± 0.079
3.327AlaGlu: 3.327 ± 0.089
3.493AlaPhe: 3.493 ± 0.093
4.45AlaGly: 4.45 ± 0.107
1.22AlaHis: 1.22 ± 0.05
6.461AlaIle: 6.461 ± 0.142
7.549AlaLys: 7.549 ± 0.128
7.416AlaLeu: 7.416 ± 0.141
2.127AlaMet: 2.127 ± 0.069
4.36AlaAsn: 4.36 ± 0.099
1.798AlaPro: 1.798 ± 0.067
2.1AlaGln: 2.1 ± 0.064
2.866AlaArg: 2.866 ± 0.082
4.463AlaSer: 4.463 ± 0.114
3.299AlaThr: 3.299 ± 0.081
4.371AlaVal: 4.371 ± 0.096
0.455AlaTrp: 0.455 ± 0.031
2.564AlaTyr: 2.564 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.764CysAla: 0.764 ± 0.042
0.147CysCys: 0.147 ± 0.018
0.765CysAsp: 0.765 ± 0.035
1.114CysGlu: 1.114 ± 0.054
0.548CysPhe: 0.548 ± 0.031
0.929CysGly: 0.929 ± 0.044
0.244CysHis: 0.244 ± 0.031
0.737CysIle: 0.737 ± 0.038
0.879CysLys: 0.879 ± 0.051
0.798CysLeu: 0.798 ± 0.04
0.284CysMet: 0.284 ± 0.023
0.41CysAsn: 0.41 ± 0.027
0.367CysPro: 0.367 ± 0.031
0.25CysGln: 0.25 ± 0.023
0.269CysArg: 0.269 ± 0.024
0.668CysSer: 0.668 ± 0.033
0.35CysThr: 0.35 ± 0.027
0.794CysVal: 0.794 ± 0.045
0.068CysTrp: 0.068 ± 0.011
0.341CysTyr: 0.341 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.692AspAla: 3.692 ± 0.101
0.492AspCys: 0.492 ± 0.031
3.202AspAsp: 3.202 ± 0.099
5.805AspGlu: 5.805 ± 0.113
3.254AspPhe: 3.254 ± 0.075
3.741AspGly: 3.741 ± 0.145
0.762AspHis: 0.762 ± 0.041
5.735AspIle: 5.735 ± 0.12
5.275AspLys: 5.275 ± 0.113
4.624AspLeu: 4.624 ± 0.105
1.574AspMet: 1.574 ± 0.058
2.499AspAsn: 2.499 ± 0.082
1.412AspPro: 1.412 ± 0.052
1.019AspGln: 1.019 ± 0.045
2.093AspArg: 2.093 ± 0.075
3.345AspSer: 3.345 ± 0.092
2.652AspThr: 2.652 ± 0.118
3.336AspVal: 3.336 ± 0.079
0.363AspTrp: 0.363 ± 0.039
2.027AspTyr: 2.027 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.117GluAla: 5.117 ± 0.109
0.769GluCys: 0.769 ± 0.045
3.299GluAsp: 3.299 ± 0.096
4.204GluGlu: 4.204 ± 0.115
4.378GluPhe: 4.378 ± 0.098
3.18GluGly: 3.18 ± 0.105
1.078GluHis: 1.078 ± 0.04
7.876GluIle: 7.876 ± 0.152
5.976GluLys: 5.976 ± 0.11
7.461GluLeu: 7.461 ± 0.145
1.592GluMet: 1.592 ± 0.059
4.651GluAsn: 4.651 ± 0.089
1.741GluPro: 1.741 ± 0.067
2.334GluGln: 2.334 ± 0.07
2.772GluArg: 2.772 ± 0.067
3.527GluSer: 3.527 ± 0.088
2.251GluThr: 2.251 ± 0.073
4.085GluVal: 4.085 ± 0.094
0.494GluTrp: 0.494 ± 0.033
2.56GluTyr: 2.56 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.922PheAla: 3.922 ± 0.104
0.706PheCys: 0.706 ± 0.034
3.769PheAsp: 3.769 ± 0.093
3.978PheGlu: 3.978 ± 0.084
2.905PhePhe: 2.905 ± 0.084
3.935PheGly: 3.935 ± 0.099
0.681PheHis: 0.681 ± 0.036
4.714PheIle: 4.714 ± 0.114
4.626PheLys: 4.626 ± 0.106
5.35PheLeu: 5.35 ± 0.125
1.303PheMet: 1.303 ± 0.049
2.828PheAsn: 2.828 ± 0.072
1.121PhePro: 1.121 ± 0.049
0.974PheGln: 0.974 ± 0.038
1.615PheArg: 1.615 ± 0.055
4.082PheSer: 4.082 ± 0.1
2.24PheThr: 2.24 ± 0.073
3.401PheVal: 3.401 ± 0.094
0.429PheTrp: 0.429 ± 0.03
2.314PheTyr: 2.314 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
4.714GlyAla: 4.714 ± 0.124
0.828GlyCys: 0.828 ± 0.048
3.335GlyAsp: 3.335 ± 0.109
4.129GlyGlu: 4.129 ± 0.09
3.89GlyPhe: 3.89 ± 0.087
4.448GlyGly: 4.448 ± 0.15
1.064GlyHis: 1.064 ± 0.049
5.417GlyIle: 5.417 ± 0.109
5.025GlyLys: 5.025 ± 0.109
5.456GlyLeu: 5.456 ± 0.117
1.615GlyMet: 1.615 ± 0.054
2.675GlyAsn: 2.675 ± 0.15
0.835GlyPro: 0.835 ± 0.041
1.423GlyGln: 1.423 ± 0.058
2.23GlyArg: 2.23 ± 0.066
3.877GlySer: 3.877 ± 0.111
2.519GlyThr: 2.519 ± 0.071
5.061GlyVal: 5.061 ± 0.1
0.514GlyTrp: 0.514 ± 0.029
2.65GlyTyr: 2.65 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.006HisAla: 1.006 ± 0.047
0.192HisCys: 0.192 ± 0.019
0.753HisAsp: 0.753 ± 0.04
0.968HisGlu: 0.968 ± 0.043
0.866HisPhe: 0.866 ± 0.038
1.073HisGly: 1.073 ± 0.042
0.347HisHis: 0.347 ± 0.03
1.405HisIle: 1.405 ± 0.058
1.288HisLys: 1.288 ± 0.044
1.444HisLeu: 1.444 ± 0.058
0.399HisMet: 0.399 ± 0.029
0.751HisAsn: 0.751 ± 0.034
0.695HisPro: 0.695 ± 0.035
0.514HisGln: 0.514 ± 0.034
0.51HisArg: 0.51 ± 0.032
1.01HisSer: 1.01 ± 0.042
0.828HisThr: 0.828 ± 0.036
0.726HisVal: 0.726 ± 0.035
0.117HisTrp: 0.117 ± 0.015
0.598HisTyr: 0.598 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.658IleAla: 6.658 ± 0.128
1.225IleCys: 1.225 ± 0.055
5.462IleAsp: 5.462 ± 0.102
5.848IleGlu: 5.848 ± 0.106
4.729IlePhe: 4.729 ± 0.135
5.26IleGly: 5.26 ± 0.118
1.055IleHis: 1.055 ± 0.05
6.673IleIle: 6.673 ± 0.123
8.243IleLys: 8.243 ± 0.128
8.733IleLeu: 8.733 ± 0.175
1.854IleMet: 1.854 ± 0.065
5.467IleAsn: 5.467 ± 0.111
2.424IlePro: 2.424 ± 0.066
1.786IleGln: 1.786 ± 0.06
2.891IleArg: 2.891 ± 0.082
6.845IleSer: 6.845 ± 0.123
3.942IleThr: 3.942 ± 0.106
5.388IleVal: 5.388 ± 0.123
0.586IleTrp: 0.586 ± 0.038
3.557IleTyr: 3.557 ± 0.1
0.0IleXaa: 0.0 ± 0.0
Lys
5.902LysAla: 5.902 ± 0.106
0.659LysCys: 0.659 ± 0.037
6.268LysAsp: 6.268 ± 0.146
7.623LysGlu: 7.623 ± 0.128
6.168LysPhe: 6.168 ± 0.123
4.184LysGly: 4.184 ± 0.114
1.288LysHis: 1.288 ± 0.053
8.708LysIle: 8.708 ± 0.139
7.612LysLys: 7.612 ± 0.135
6.597LysLeu: 6.597 ± 0.124
2.26LysMet: 2.26 ± 0.069
6.57LysAsn: 6.57 ± 0.127
2.474LysPro: 2.474 ± 0.074
2.479LysGln: 2.479 ± 0.078
3.518LysArg: 3.518 ± 0.082
5.769LysSer: 5.769 ± 0.112
4.369LysThr: 4.369 ± 0.088
4.314LysVal: 4.314 ± 0.117
0.508LysTrp: 0.508 ± 0.034
2.609LysTyr: 2.609 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
7.271LeuAla: 7.271 ± 0.135
0.974LeuCys: 0.974 ± 0.04
5.23LeuAsp: 5.23 ± 0.108
6.297LeuGlu: 6.297 ± 0.122
4.624LeuPhe: 4.624 ± 0.112
6.049LeuGly: 6.049 ± 0.143
1.382LeuHis: 1.382 ± 0.053
7.336LeuIle: 7.336 ± 0.135
9.928LeuLys: 9.928 ± 0.145
7.725LeuLeu: 7.725 ± 0.146
2.282LeuMet: 2.282 ± 0.065
6.403LeuAsn: 6.403 ± 0.138
3.047LeuPro: 3.047 ± 0.076
2.481LeuGln: 2.481 ± 0.071
3.538LeuArg: 3.538 ± 0.084
7.145LeuSer: 7.145 ± 0.104
4.087LeuThr: 4.087 ± 0.079
5.223LeuVal: 5.223 ± 0.121
0.561LeuTrp: 0.561 ± 0.034
2.988LeuTyr: 2.988 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.908MetAla: 1.908 ± 0.062
0.21MetCys: 0.21 ± 0.02
1.229MetAsp: 1.229 ± 0.049
1.143MetGlu: 1.143 ± 0.045
1.058MetPhe: 1.058 ± 0.045
1.581MetGly: 1.581 ± 0.062
0.41MetHis: 0.41 ± 0.027
2.219MetIle: 2.219 ± 0.064
2.158MetLys: 2.158 ± 0.061
2.537MetLeu: 2.537 ± 0.072
0.708MetMet: 0.708 ± 0.043
1.292MetAsn: 1.292 ± 0.047
1.126MetPro: 1.126 ± 0.049
1.094MetGln: 1.094 ± 0.046
1.13MetArg: 1.13 ± 0.046
1.982MetSer: 1.982 ± 0.066
0.945MetThr: 0.945 ± 0.041
1.355MetVal: 1.355 ± 0.054
0.158MetTrp: 0.158 ± 0.016
0.543MetTyr: 0.543 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.922AsnAla: 3.922 ± 0.093
0.474AsnCys: 0.474 ± 0.034
3.171AsnAsp: 3.171 ± 0.142
4.641AsnGlu: 4.641 ± 0.107
3.41AsnPhe: 3.41 ± 0.085
3.442AsnGly: 3.442 ± 0.114
0.821AsnHis: 0.821 ± 0.037
5.039AsnIle: 5.039 ± 0.104
4.263AsnLys: 4.263 ± 0.096
7.614AsnLeu: 7.614 ± 0.139
1.215AsnMet: 1.215 ± 0.052
2.524AsnAsn: 2.524 ± 0.082
2.037AsnPro: 2.037 ± 0.072
1.595AsnGln: 1.595 ± 0.053
1.973AsnArg: 1.973 ± 0.064
4.24AsnSer: 4.24 ± 0.107
2.478AsnThr: 2.478 ± 0.08
2.866AsnVal: 2.866 ± 0.076
0.289AsnTrp: 0.289 ± 0.024
1.827AsnTyr: 1.827 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.682ProAla: 1.682 ± 0.055
0.298ProCys: 0.298 ± 0.024
1.477ProAsp: 1.477 ± 0.052
1.811ProGlu: 1.811 ± 0.06
1.606ProPhe: 1.606 ± 0.056
1.297ProGly: 1.297 ± 0.051
0.568ProHis: 0.568 ± 0.035
2.504ProIle: 2.504 ± 0.074
2.634ProLys: 2.634 ± 0.075
2.497ProLeu: 2.497 ± 0.067
0.679ProMet: 0.679 ± 0.038
1.852ProAsn: 1.852 ± 0.071
0.738ProPro: 0.738 ± 0.037
0.859ProGln: 0.859 ± 0.039
0.938ProArg: 0.938 ± 0.04
1.899ProSer: 1.899 ± 0.059
1.475ProThr: 1.475 ± 0.061
1.764ProVal: 1.764 ± 0.06
0.198ProTrp: 0.198 ± 0.018
1.202ProTyr: 1.202 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.795GlnAla: 1.795 ± 0.066
0.199GlnCys: 0.199 ± 0.02
1.597GlnAsp: 1.597 ± 0.075
1.692GlnGlu: 1.692 ± 0.057
1.015GlnPhe: 1.015 ± 0.044
1.418GlnGly: 1.418 ± 0.057
0.327GlnHis: 0.327 ± 0.027
3.236GlnIle: 3.236 ± 0.073
2.912GlnLys: 2.912 ± 0.079
1.656GlnLeu: 1.656 ± 0.062
0.702GlnMet: 0.702 ± 0.033
2.548GlnAsn: 2.548 ± 0.08
0.553GlnPro: 0.553 ± 0.031
0.568GlnGln: 0.568 ± 0.038
1.055GlnArg: 1.055 ± 0.041
1.692GlnSer: 1.692 ± 0.057
1.419GlnThr: 1.419 ± 0.054
1.321GlnVal: 1.321 ± 0.052
0.151GlnTrp: 0.151 ± 0.018
0.72GlnTyr: 0.72 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.799ArgAla: 2.799 ± 0.069
0.327ArgCys: 0.327 ± 0.026
2.16ArgAsp: 2.16 ± 0.065
2.821ArgGlu: 2.821 ± 0.077
1.951ArgPhe: 1.951 ± 0.058
2.136ArgGly: 2.136 ± 0.065
0.667ArgHis: 0.667 ± 0.038
2.981ArgIle: 2.981 ± 0.076
2.499ArgLys: 2.499 ± 0.071
3.776ArgLeu: 3.776 ± 0.071
0.931ArgMet: 0.931 ± 0.044
1.877ArgAsn: 1.877 ± 0.054
0.931ArgPro: 0.931 ± 0.041
1.071ArgGln: 1.071 ± 0.044
1.52ArgArg: 1.52 ± 0.05
2.125ArgSer: 2.125 ± 0.063
1.344ArgThr: 1.344 ± 0.05
2.808ArgVal: 2.808 ± 0.076
0.295ArgTrp: 0.295 ± 0.026
1.461ArgTyr: 1.461 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.583SerAla: 4.583 ± 0.103
0.685SerCys: 0.685 ± 0.04
3.699SerAsp: 3.699 ± 0.092
4.842SerGlu: 4.842 ± 0.109
3.674SerPhe: 3.674 ± 0.095
4.766SerGly: 4.766 ± 0.108
1.058SerHis: 1.058 ± 0.049
5.359SerIle: 5.359 ± 0.102
6.108SerLys: 6.108 ± 0.135
6.599SerLeu: 6.599 ± 0.117
1.59SerMet: 1.59 ± 0.054
3.502SerAsn: 3.502 ± 0.1
1.755SerPro: 1.755 ± 0.064
1.917SerGln: 1.917 ± 0.066
2.382SerArg: 2.382 ± 0.068
4.79SerSer: 4.79 ± 0.119
2.706SerThr: 2.706 ± 0.069
4.457SerVal: 4.457 ± 0.089
0.478SerTrp: 0.478 ± 0.031
2.361SerTyr: 2.361 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
3.07ThrAla: 3.07 ± 0.071
0.363ThrCys: 0.363 ± 0.026
2.21ThrAsp: 2.21 ± 0.068
1.949ThrGlu: 1.949 ± 0.077
1.885ThrPhe: 1.885 ± 0.063
2.902ThrGly: 2.902 ± 0.093
0.918ThrHis: 0.918 ± 0.05
3.911ThrIle: 3.911 ± 0.106
4.064ThrLys: 4.064 ± 0.101
4.648ThrLeu: 4.648 ± 0.11
0.994ThrMet: 0.994 ± 0.035
2.53ThrAsn: 2.53 ± 0.09
2.048ThrPro: 2.048 ± 0.062
1.509ThrGln: 1.509 ± 0.056
1.579ThrArg: 1.579 ± 0.062
2.954ThrSer: 2.954 ± 0.075
2.42ThrThr: 2.42 ± 0.073
2.107ThrVal: 2.107 ± 0.064
0.275ThrTrp: 0.275 ± 0.021
1.392ThrTyr: 1.392 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.748ValAla: 4.748 ± 0.105
0.812ValCys: 0.812 ± 0.042
3.374ValAsp: 3.374 ± 0.085
3.839ValGlu: 3.839 ± 0.088
3.074ValPhe: 3.074 ± 0.081
4.138ValGly: 4.138 ± 0.112
0.798ValHis: 0.798 ± 0.044
4.919ValIle: 4.919 ± 0.102
5.323ValLys: 5.323 ± 0.104
5.686ValLeu: 5.686 ± 0.113
1.665ValMet: 1.665 ± 0.06
3.04ValAsn: 3.04 ± 0.077
1.665ValPro: 1.665 ± 0.064
1.279ValGln: 1.279 ± 0.055
2.098ValArg: 2.098 ± 0.062
4.289ValSer: 4.289 ± 0.076
2.515ValThr: 2.515 ± 0.075
4.644ValVal: 4.644 ± 0.117
0.392ValTrp: 0.392 ± 0.03
1.858ValTyr: 1.858 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.041
0.093TrpCys: 0.093 ± 0.014
0.393TrpAsp: 0.393 ± 0.029
0.323TrpGlu: 0.323 ± 0.025
0.361TrpPhe: 0.361 ± 0.03
0.503TrpGly: 0.503 ± 0.039
0.155TrpHis: 0.155 ± 0.016
0.622TrpIle: 0.622 ± 0.035
0.358TrpLys: 0.358 ± 0.025
0.785TrpLeu: 0.785 ± 0.036
0.217TrpMet: 0.217 ± 0.022
0.261TrpAsn: 0.261 ± 0.023
0.099TrpPro: 0.099 ± 0.014
0.331TrpGln: 0.331 ± 0.024
0.244TrpArg: 0.244 ± 0.021
0.433TrpSer: 0.433 ± 0.028
0.235TrpThr: 0.235 ± 0.02
0.402TrpVal: 0.402 ± 0.029
0.09TrpTrp: 0.09 ± 0.014
0.232TrpTyr: 0.232 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.447TyrAla: 2.447 ± 0.066
0.352TyrCys: 0.352 ± 0.024
2.203TyrAsp: 2.203 ± 0.068
2.991TyrGlu: 2.991 ± 0.078
2.005TyrPhe: 2.005 ± 0.062
2.273TyrGly: 2.273 ± 0.092
0.65TyrHis: 0.65 ± 0.035
2.774TyrIle: 2.774 ± 0.071
3.16TyrLys: 3.16 ± 0.09
3.166TyrLeu: 3.166 ± 0.084
0.792TyrMet: 0.792 ± 0.037
1.802TyrAsn: 1.802 ± 0.055
1.11TyrPro: 1.11 ± 0.047
0.995TyrGln: 0.995 ± 0.046
1.258TyrArg: 1.258 ± 0.052
2.177TyrSer: 2.177 ± 0.061
1.653TyrThr: 1.653 ± 0.057
1.734TyrVal: 1.734 ± 0.053
0.261TyrTrp: 0.261 ± 0.023
1.292TyrTyr: 1.292 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1867 proteins (556605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski