Amino acid dipepetide frequency for Anaerococcus vaginalis ATCC 51170

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.734AlaAla: 2.734 ± 0.088
0.724AlaCys: 0.724 ± 0.042
2.738AlaAsp: 2.738 ± 0.078
2.64AlaGlu: 2.64 ± 0.078
2.589AlaPhe: 2.589 ± 0.074
3.481AlaGly: 3.481 ± 0.098
0.722AlaHis: 0.722 ± 0.04
5.613AlaIle: 5.613 ± 0.128
5.469AlaLys: 5.469 ± 0.12
5.06AlaLeu: 5.06 ± 0.113
1.589AlaMet: 1.589 ± 0.064
3.138AlaAsn: 3.138 ± 0.078
1.168AlaPro: 1.168 ± 0.058
1.316AlaGln: 1.316 ± 0.051
1.963AlaArg: 1.963 ± 0.065
3.488AlaSer: 3.488 ± 0.077
2.295AlaThr: 2.295 ± 0.076
3.12AlaVal: 3.12 ± 0.089
0.245AlaTrp: 0.245 ± 0.021
2.247AlaTyr: 2.247 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.508CysAla: 0.508 ± 0.03
0.092CysCys: 0.092 ± 0.015
0.668CysAsp: 0.668 ± 0.037
0.64CysGlu: 0.64 ± 0.039
0.347CysPhe: 0.347 ± 0.027
0.921CysGly: 0.921 ± 0.049
0.19CysHis: 0.19 ± 0.019
0.718CysIle: 0.718 ± 0.045
0.805CysLys: 0.805 ± 0.042
0.802CysLeu: 0.802 ± 0.039
0.172CysMet: 0.172 ± 0.018
0.441CysAsn: 0.441 ± 0.034
0.423CysPro: 0.423 ± 0.031
0.268CysGln: 0.268 ± 0.023
0.244CysArg: 0.244 ± 0.021
0.459CysSer: 0.459 ± 0.031
0.35CysThr: 0.35 ± 0.03
0.48CysVal: 0.48 ± 0.034
0.046CysTrp: 0.046 ± 0.009
0.322CysTyr: 0.322 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.823AspAla: 2.823 ± 0.08
0.553AspCys: 0.553 ± 0.032
4.078AspAsp: 4.078 ± 0.098
5.926AspGlu: 5.926 ± 0.125
3.995AspPhe: 3.995 ± 0.099
4.009AspGly: 4.009 ± 0.133
0.777AspHis: 0.777 ± 0.039
6.319AspIle: 6.319 ± 0.114
7.204AspLys: 7.204 ± 0.145
6.792AspLeu: 6.792 ± 0.132
1.634AspMet: 1.634 ± 0.051
3.353AspAsn: 3.353 ± 0.092
1.659AspPro: 1.659 ± 0.066
1.495AspGln: 1.495 ± 0.048
2.117AspArg: 2.117 ± 0.063
3.556AspSer: 3.556 ± 0.087
2.482AspThr: 2.482 ± 0.078
3.282AspVal: 3.282 ± 0.096
0.393AspTrp: 0.393 ± 0.034
3.394AspTyr: 3.394 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
3.366GluAla: 3.366 ± 0.083
0.466GluCys: 0.466 ± 0.029
5.631GluAsp: 5.631 ± 0.128
6.841GluGlu: 6.841 ± 0.169
3.454GluPhe: 3.454 ± 0.084
3.563GluGly: 3.563 ± 0.096
0.716GluHis: 0.716 ± 0.049
8.383GluIle: 8.383 ± 0.153
10.936GluLys: 10.936 ± 0.202
5.659GluLeu: 5.659 ± 0.116
1.805GluMet: 1.805 ± 0.058
7.865GluAsn: 7.865 ± 0.145
1.065GluPro: 1.065 ± 0.047
1.408GluGln: 1.408 ± 0.059
2.221GluArg: 2.221 ± 0.078
3.744GluSer: 3.744 ± 0.097
2.494GluThr: 2.494 ± 0.081
4.347GluVal: 4.347 ± 0.088
0.322GluTrp: 0.322 ± 0.025
2.8GluTyr: 2.8 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.724PheAla: 2.724 ± 0.075
0.428PheCys: 0.428 ± 0.03
3.742PheAsp: 3.742 ± 0.09
3.634PheGlu: 3.634 ± 0.078
2.366PhePhe: 2.366 ± 0.084
2.871PheGly: 2.871 ± 0.079
0.528PheHis: 0.528 ± 0.033
4.596PheIle: 4.596 ± 0.117
4.0PheLys: 4.0 ± 0.105
4.528PheLeu: 4.528 ± 0.115
1.168PheMet: 1.168 ± 0.052
2.491PheAsn: 2.491 ± 0.07
1.198PhePro: 1.198 ± 0.046
1.005PheGln: 1.005 ± 0.045
1.325PheArg: 1.325 ± 0.056
3.694PheSer: 3.694 ± 0.09
2.384PheThr: 2.384 ± 0.073
3.186PheVal: 3.186 ± 0.086
0.309PheTrp: 0.309 ± 0.026
2.224PheTyr: 2.224 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
3.517GlyAla: 3.517 ± 0.109
0.651GlyCys: 0.651 ± 0.041
3.101GlyAsp: 3.101 ± 0.097
4.265GlyGlu: 4.265 ± 0.097
3.211GlyPhe: 3.211 ± 0.084
3.838GlyGly: 3.838 ± 0.121
0.912GlyHis: 0.912 ± 0.044
5.707GlyIle: 5.707 ± 0.112
5.919GlyLys: 5.919 ± 0.138
5.629GlyLeu: 5.629 ± 0.11
1.49GlyMet: 1.49 ± 0.064
3.069GlyAsn: 3.069 ± 0.091
1.159GlyPro: 1.159 ± 0.048
1.565GlyGln: 1.565 ± 0.055
2.03GlyArg: 2.03 ± 0.069
3.57GlySer: 3.57 ± 0.094
2.487GlyThr: 2.487 ± 0.082
3.837GlyVal: 3.837 ± 0.103
0.336GlyTrp: 0.336 ± 0.03
2.733GlyTyr: 2.733 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
0.64HisAla: 0.64 ± 0.033
0.142HisCys: 0.142 ± 0.015
0.729HisAsp: 0.729 ± 0.034
0.75HisGlu: 0.75 ± 0.04
0.613HisPhe: 0.613 ± 0.029
0.83HisGly: 0.83 ± 0.044
0.185HisHis: 0.185 ± 0.018
1.181HisIle: 1.181 ± 0.045
0.974HisLys: 0.974 ± 0.04
1.09HisLeu: 1.09 ± 0.049
0.284HisMet: 0.284 ± 0.023
0.594HisAsn: 0.594 ± 0.035
0.571HisPro: 0.571 ± 0.037
0.343HisGln: 0.343 ± 0.025
0.437HisArg: 0.437 ± 0.032
0.759HisSer: 0.759 ± 0.038
0.564HisThr: 0.564 ± 0.031
0.64HisVal: 0.64 ± 0.039
0.085HisTrp: 0.085 ± 0.014
0.501HisTyr: 0.501 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.321IleAla: 5.321 ± 0.103
0.969IleCys: 0.969 ± 0.049
6.904IleAsp: 6.904 ± 0.14
7.501IleGlu: 7.501 ± 0.132
5.119IlePhe: 5.119 ± 0.142
5.895IleGly: 5.895 ± 0.125
1.085IleHis: 1.085 ± 0.041
9.058IleIle: 9.058 ± 0.181
9.921IleLys: 9.921 ± 0.157
9.378IleLeu: 9.378 ± 0.173
2.165IleMet: 2.165 ± 0.063
6.296IleAsn: 6.296 ± 0.11
2.749IlePro: 2.749 ± 0.075
1.851IleGln: 1.851 ± 0.053
2.909IleArg: 2.909 ± 0.064
7.481IleSer: 7.481 ± 0.151
3.86IleThr: 3.86 ± 0.079
5.268IleVal: 5.268 ± 0.112
0.404IleTrp: 0.404 ± 0.026
3.981IleTyr: 3.981 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.615LysAla: 5.615 ± 0.12
0.583LysCys: 0.583 ± 0.04
8.017LysAsp: 8.017 ± 0.188
10.218LysGlu: 10.218 ± 0.186
3.934LysPhe: 3.934 ± 0.09
4.601LysGly: 4.601 ± 0.11
0.871LysHis: 0.871 ± 0.043
10.954LysIle: 10.954 ± 0.205
11.686LysLys: 11.686 ± 0.177
8.601LysLeu: 8.601 ± 0.134
2.541LysMet: 2.541 ± 0.064
9.483LysAsn: 9.483 ± 0.208
1.945LysPro: 1.945 ± 0.077
2.018LysGln: 2.018 ± 0.07
3.248LysArg: 3.248 ± 0.087
6.088LysSer: 6.088 ± 0.122
4.71LysThr: 4.71 ± 0.101
5.193LysVal: 5.193 ± 0.125
0.539LysTrp: 0.539 ± 0.032
4.5LysTyr: 4.5 ± 0.101
0.0LysXaa: 0.0 ± 0.0
Leu
5.286LeuAla: 5.286 ± 0.123
0.8LeuCys: 0.8 ± 0.039
6.472LeuAsp: 6.472 ± 0.1
7.161LeuGlu: 7.161 ± 0.152
4.048LeuPhe: 4.048 ± 0.109
5.629LeuGly: 5.629 ± 0.123
0.925LeuHis: 0.925 ± 0.037
8.705LeuIle: 8.705 ± 0.18
9.048LeuLys: 9.048 ± 0.144
7.773LeuLeu: 7.773 ± 0.16
2.244LeuMet: 2.244 ± 0.075
5.691LeuAsn: 5.691 ± 0.126
2.66LeuPro: 2.66 ± 0.074
1.883LeuGln: 1.883 ± 0.06
2.976LeuArg: 2.976 ± 0.07
7.088LeuSer: 7.088 ± 0.11
4.151LeuThr: 4.151 ± 0.093
5.327LeuVal: 5.327 ± 0.11
0.425LeuTrp: 0.425 ± 0.03
3.186LeuTyr: 3.186 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.851MetAla: 1.851 ± 0.059
0.181MetCys: 0.181 ± 0.018
1.732MetAsp: 1.732 ± 0.058
1.828MetGlu: 1.828 ± 0.051
0.848MetPhe: 0.848 ± 0.043
1.701MetGly: 1.701 ± 0.068
0.245MetHis: 0.245 ± 0.017
2.302MetIle: 2.302 ± 0.069
2.701MetLys: 2.701 ± 0.071
1.908MetLeu: 1.908 ± 0.069
0.628MetMet: 0.628 ± 0.034
1.413MetAsn: 1.413 ± 0.05
0.834MetPro: 0.834 ± 0.035
0.629MetGln: 0.629 ± 0.036
0.775MetArg: 0.775 ± 0.037
1.392MetSer: 1.392 ± 0.051
1.28MetThr: 1.28 ± 0.048
1.437MetVal: 1.437 ± 0.051
0.142MetTrp: 0.142 ± 0.016
0.807MetTyr: 0.807 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.782AsnAla: 2.782 ± 0.079
0.5AsnCys: 0.5 ± 0.031
3.643AsnAsp: 3.643 ± 0.085
5.039AsnGlu: 5.039 ± 0.1
3.382AsnPhe: 3.382 ± 0.095
3.367AsnGly: 3.367 ± 0.108
0.828AsnHis: 0.828 ± 0.047
7.008AsnIle: 7.008 ± 0.125
7.104AsnLys: 7.104 ± 0.162
7.03AsnLeu: 7.03 ± 0.162
1.538AsnMet: 1.538 ± 0.052
3.899AsnAsn: 3.899 ± 0.113
2.478AsnPro: 2.478 ± 0.08
1.789AsnGln: 1.789 ± 0.058
2.066AsnArg: 2.066 ± 0.072
4.105AsnSer: 4.105 ± 0.098
2.756AsnThr: 2.756 ± 0.069
3.126AsnVal: 3.126 ± 0.08
0.368AsnTrp: 0.368 ± 0.024
2.809AsnTyr: 2.809 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
1.25ProAla: 1.25 ± 0.061
0.26ProCys: 0.26 ± 0.025
1.549ProAsp: 1.549 ± 0.062
2.023ProGlu: 2.023 ± 0.066
1.282ProPhe: 1.282 ± 0.05
1.392ProGly: 1.392 ± 0.055
0.386ProHis: 0.386 ± 0.026
2.544ProIle: 2.544 ± 0.064
2.357ProLys: 2.357 ± 0.082
2.087ProLeu: 2.087 ± 0.065
0.596ProMet: 0.596 ± 0.034
1.559ProAsn: 1.559 ± 0.063
0.452ProPro: 0.452 ± 0.031
0.804ProGln: 0.804 ± 0.039
0.773ProArg: 0.773 ± 0.033
1.675ProSer: 1.675 ± 0.06
1.381ProThr: 1.381 ± 0.064
1.673ProVal: 1.673 ± 0.067
0.139ProTrp: 0.139 ± 0.016
1.154ProTyr: 1.154 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
1.611GlnAla: 1.611 ± 0.059
0.135GlnCys: 0.135 ± 0.017
1.275GlnAsp: 1.275 ± 0.053
1.803GlnGlu: 1.803 ± 0.069
0.834GlnPhe: 0.834 ± 0.042
1.387GlnGly: 1.387 ± 0.052
0.174GlnHis: 0.174 ± 0.016
2.452GlnIle: 2.452 ± 0.061
2.699GlnLys: 2.699 ± 0.078
1.689GlnLeu: 1.689 ± 0.06
0.734GlnMet: 0.734 ± 0.035
1.549GlnAsn: 1.549 ± 0.05
0.4GlnPro: 0.4 ± 0.027
0.471GlnGln: 0.471 ± 0.028
1.118GlnArg: 1.118 ± 0.061
1.229GlnSer: 1.229 ± 0.044
1.189GlnThr: 1.189 ± 0.053
1.575GlnVal: 1.575 ± 0.054
0.13GlnTrp: 0.13 ± 0.016
0.814GlnTyr: 0.814 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
1.796ArgAla: 1.796 ± 0.066
0.322ArgCys: 0.322 ± 0.026
1.968ArgAsp: 1.968 ± 0.07
2.67ArgGlu: 2.67 ± 0.089
1.421ArgPhe: 1.421 ± 0.052
1.764ArgGly: 1.764 ± 0.062
0.398ArgHis: 0.398 ± 0.03
2.955ArgIle: 2.955 ± 0.072
3.604ArgLys: 3.604 ± 0.08
3.003ArgLeu: 3.003 ± 0.067
0.859ArgMet: 0.859 ± 0.041
2.084ArgAsn: 2.084 ± 0.062
0.866ArgPro: 0.866 ± 0.043
0.949ArgGln: 0.949 ± 0.042
1.293ArgArg: 1.293 ± 0.056
1.689ArgSer: 1.689 ± 0.054
1.268ArgThr: 1.268 ± 0.04
1.796ArgVal: 1.796 ± 0.062
0.201ArgTrp: 0.201 ± 0.02
1.31ArgTyr: 1.31 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
2.907SerAla: 2.907 ± 0.084
0.667SerCys: 0.667 ± 0.036
3.687SerAsp: 3.687 ± 0.089
3.817SerGlu: 3.817 ± 0.082
3.563SerPhe: 3.563 ± 0.099
3.963SerGly: 3.963 ± 0.096
1.019SerHis: 1.019 ± 0.039
5.984SerIle: 5.984 ± 0.104
6.383SerLys: 6.383 ± 0.139
6.879SerLeu: 6.879 ± 0.129
1.682SerMet: 1.682 ± 0.053
3.872SerAsn: 3.872 ± 0.097
1.533SerPro: 1.533 ± 0.053
1.888SerGln: 1.888 ± 0.064
1.87SerArg: 1.87 ± 0.063
4.319SerSer: 4.319 ± 0.09
2.779SerThr: 2.779 ± 0.071
3.38SerVal: 3.38 ± 0.083
0.443SerTrp: 0.443 ± 0.033
3.302SerTyr: 3.302 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
2.407ThrAla: 2.407 ± 0.069
0.42ThrCys: 0.42 ± 0.029
2.416ThrAsp: 2.416 ± 0.071
2.535ThrGlu: 2.535 ± 0.078
1.995ThrPhe: 1.995 ± 0.071
3.104ThrGly: 3.104 ± 0.093
0.645ThrHis: 0.645 ± 0.03
4.502ThrIle: 4.502 ± 0.098
3.933ThrLys: 3.933 ± 0.092
3.87ThrLeu: 3.87 ± 0.086
1.026ThrMet: 1.026 ± 0.04
2.795ThrAsn: 2.795 ± 0.084
1.383ThrPro: 1.383 ± 0.068
1.029ThrGln: 1.029 ± 0.049
1.474ThrArg: 1.474 ± 0.05
2.88ThrSer: 2.88 ± 0.066
2.167ThrThr: 2.167 ± 0.071
2.498ThrVal: 2.498 ± 0.077
0.288ThrTrp: 0.288 ± 0.03
1.783ThrTyr: 1.783 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
2.934ValAla: 2.934 ± 0.08
0.594ValCys: 0.594 ± 0.038
4.096ValAsp: 4.096 ± 0.092
4.306ValGlu: 4.306 ± 0.096
2.877ValPhe: 2.877 ± 0.08
3.897ValGly: 3.897 ± 0.094
0.672ValHis: 0.672 ± 0.038
4.88ValIle: 4.88 ± 0.113
5.293ValLys: 5.293 ± 0.111
5.074ValLeu: 5.074 ± 0.109
1.355ValMet: 1.355 ± 0.053
3.35ValAsn: 3.35 ± 0.083
1.41ValPro: 1.41 ± 0.053
1.113ValGln: 1.113 ± 0.041
1.831ValArg: 1.831 ± 0.056
3.949ValSer: 3.949 ± 0.088
2.455ValThr: 2.455 ± 0.093
3.366ValVal: 3.366 ± 0.094
0.306ValTrp: 0.306 ± 0.028
2.137ValTyr: 2.137 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.325TrpAla: 0.325 ± 0.029
0.037TrpCys: 0.037 ± 0.009
0.416TrpAsp: 0.416 ± 0.028
0.348TrpGlu: 0.348 ± 0.025
0.19TrpPhe: 0.19 ± 0.022
0.361TrpGly: 0.361 ± 0.03
0.091TrpHis: 0.091 ± 0.016
0.576TrpIle: 0.576 ± 0.037
0.5TrpLys: 0.5 ± 0.037
0.471TrpLeu: 0.471 ± 0.036
0.178TrpMet: 0.178 ± 0.019
0.306TrpAsn: 0.306 ± 0.024
0.132TrpPro: 0.132 ± 0.015
0.226TrpGln: 0.226 ± 0.02
0.178TrpArg: 0.178 ± 0.018
0.281TrpSer: 0.281 ± 0.023
0.279TrpThr: 0.279 ± 0.028
0.283TrpVal: 0.283 ± 0.026
0.05TrpTrp: 0.05 ± 0.01
0.24TrpTyr: 0.24 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.943TyrAla: 1.943 ± 0.058
0.377TyrCys: 0.377 ± 0.028
2.98TyrAsp: 2.98 ± 0.078
3.14TyrGlu: 3.14 ± 0.074
2.336TyrPhe: 2.336 ± 0.072
2.448TyrGly: 2.448 ± 0.074
0.544TyrHis: 0.544 ± 0.032
3.677TyrIle: 3.677 ± 0.077
4.809TyrLys: 4.809 ± 0.113
4.153TyrLeu: 4.153 ± 0.092
0.946TyrMet: 0.946 ± 0.039
2.37TyrAsn: 2.37 ± 0.071
1.252TyrPro: 1.252 ± 0.044
1.218TyrGln: 1.218 ± 0.049
1.365TyrArg: 1.365 ± 0.051
2.489TyrSer: 2.489 ± 0.075
1.819TyrThr: 1.819 ± 0.067
2.082TyrVal: 2.082 ± 0.072
0.297TyrTrp: 0.297 ± 0.023
1.803TyrTyr: 1.803 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1764 proteins (562464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski