Amino acid dipepetide frequency for Grapevine virus B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.583AlaAla: 1.583 ± 0.634
0.396AlaCys: 0.396 ± 0.216
2.77AlaAsp: 2.77 ± 0.875
4.749AlaGlu: 4.749 ± 1.105
2.77AlaPhe: 2.77 ± 0.992
3.957AlaGly: 3.957 ± 1.4
0.791AlaHis: 0.791 ± 0.432
3.166AlaIle: 3.166 ± 1.892
9.102AlaLys: 9.102 ± 2.079
6.727AlaLeu: 6.727 ± 1.26
0.791AlaMet: 0.791 ± 0.432
2.374AlaAsn: 2.374 ± 1.488
1.187AlaPro: 1.187 ± 0.571
3.166AlaGln: 3.166 ± 1.403
2.374AlaArg: 2.374 ± 1.545
2.374AlaSer: 2.374 ± 0.841
2.374AlaThr: 2.374 ± 1.593
2.77AlaVal: 2.77 ± 0.965
0.0AlaTrp: 0.0 ± 0.0
1.583AlaTyr: 1.583 ± 0.534
0.0AlaXaa: 0.0 ± 0.0
Cys
0.791CysAla: 0.791 ± 0.69
0.791CysCys: 0.791 ± 0.586
0.396CysAsp: 0.396 ± 0.216
1.583CysGlu: 1.583 ± 0.732
0.791CysPhe: 0.791 ± 0.432
1.979CysGly: 1.979 ± 0.756
0.396CysHis: 0.396 ± 0.216
0.791CysIle: 0.791 ± 0.586
1.979CysLys: 1.979 ± 0.596
3.957CysLeu: 3.957 ± 2.251
0.396CysMet: 0.396 ± 0.216
1.187CysAsn: 1.187 ± 0.571
0.791CysPro: 0.791 ± 0.432
0.0CysGln: 0.0 ± 0.0
1.187CysArg: 1.187 ± 0.744
2.77CysSer: 2.77 ± 1.005
0.791CysThr: 0.791 ± 0.432
3.166CysVal: 3.166 ± 2.098
0.0CysTrp: 0.0 ± 0.0
1.979CysTyr: 1.979 ± 0.756
0.0CysXaa: 0.0 ± 0.0
Asp
2.374AspAla: 2.374 ± 0.808
0.396AspCys: 0.396 ± 0.815
2.374AspAsp: 2.374 ± 1.295
5.936AspGlu: 5.936 ± 2.133
4.353AspPhe: 4.353 ± 0.881
5.54AspGly: 5.54 ± 1.835
1.979AspHis: 1.979 ± 1.079
1.187AspIle: 1.187 ± 0.617
3.562AspLys: 3.562 ± 0.785
4.353AspLeu: 4.353 ± 1.922
1.979AspMet: 1.979 ± 0.756
0.0AspAsn: 0.0 ± 0.0
3.562AspPro: 3.562 ± 1.943
1.583AspGln: 1.583 ± 0.534
3.166AspArg: 3.166 ± 1.022
2.77AspSer: 2.77 ± 0.965
0.791AspThr: 0.791 ± 0.518
4.353AspVal: 4.353 ± 1.243
1.187AspTrp: 1.187 ± 0.648
1.583AspTyr: 1.583 ± 0.764
0.0AspXaa: 0.0 ± 0.0
Glu
3.562GluAla: 3.562 ± 1.909
3.166GluCys: 3.166 ± 1.754
1.979GluAsp: 1.979 ± 0.975
9.893GluGlu: 9.893 ± 1.603
3.562GluPhe: 3.562 ± 0.999
4.749GluGly: 4.749 ± 1.806
0.791GluHis: 0.791 ± 0.432
3.166GluIle: 3.166 ± 0.612
3.957GluLys: 3.957 ± 1.649
5.54GluLeu: 5.54 ± 1.274
1.979GluMet: 1.979 ± 1.042
2.374GluAsn: 2.374 ± 1.593
3.957GluPro: 3.957 ± 1.094
2.77GluGln: 2.77 ± 1.197
5.144GluArg: 5.144 ± 1.526
6.727GluSer: 6.727 ± 1.862
3.957GluThr: 3.957 ± 0.958
5.54GluVal: 5.54 ± 1.695
1.187GluTrp: 1.187 ± 0.648
3.166GluTyr: 3.166 ± 0.833
0.0GluXaa: 0.0 ± 0.0
Phe
2.374PheAla: 2.374 ± 0.86
1.187PheCys: 1.187 ± 0.648
3.562PheAsp: 3.562 ± 1.284
2.77PheGlu: 2.77 ± 0.959
2.374PhePhe: 2.374 ± 1.295
2.77PheGly: 2.77 ± 0.931
1.187PheHis: 1.187 ± 0.48
1.583PheIle: 1.583 ± 0.863
1.979PheLys: 1.979 ± 0.684
3.957PheLeu: 3.957 ± 0.642
0.791PheMet: 0.791 ± 0.432
3.562PheAsn: 3.562 ± 0.892
1.979PhePro: 1.979 ± 2.393
1.979PheGln: 1.979 ± 1.079
3.166PheArg: 3.166 ± 1.682
2.374PheSer: 2.374 ± 0.643
3.166PheThr: 3.166 ± 0.834
2.77PheVal: 2.77 ± 1.269
0.0PheTrp: 0.0 ± 0.0
1.979PheTyr: 1.979 ± 0.756
0.0PheXaa: 0.0 ± 0.0
Gly
3.562GlyAla: 3.562 ± 1.033
2.374GlyCys: 2.374 ± 0.96
3.562GlyAsp: 3.562 ± 0.709
6.332GlyGlu: 6.332 ± 1.25
3.957GlyPhe: 3.957 ± 0.465
2.77GlyGly: 2.77 ± 0.817
0.791GlyHis: 0.791 ± 0.432
2.77GlyIle: 2.77 ± 0.83
3.166GlyLys: 3.166 ± 1.08
5.54GlyLeu: 5.54 ± 2.311
1.583GlyMet: 1.583 ± 1.389
0.791GlyAsn: 0.791 ± 0.432
1.583GlyPro: 1.583 ± 0.863
2.77GlyGln: 2.77 ± 0.725
3.562GlyArg: 3.562 ± 1.709
4.749GlySer: 4.749 ± 0.91
5.144GlyThr: 5.144 ± 1.345
5.144GlyVal: 5.144 ± 1.462
1.187GlyTrp: 1.187 ± 0.48
3.562GlyTyr: 3.562 ± 1.317
0.0GlyXaa: 0.0 ± 0.0
His
1.583HisAla: 1.583 ± 0.863
0.791HisCys: 0.791 ± 0.432
0.396HisAsp: 0.396 ± 0.216
0.396HisGlu: 0.396 ± 0.632
0.791HisPhe: 0.791 ± 0.518
1.583HisGly: 1.583 ± 1.036
0.791HisHis: 0.791 ± 0.518
1.979HisIle: 1.979 ± 1.079
0.791HisLys: 0.791 ± 0.432
4.353HisLeu: 4.353 ± 1.811
0.396HisMet: 0.396 ± 0.216
0.0HisAsn: 0.0 ± 0.0
1.187HisPro: 1.187 ± 0.648
1.187HisGln: 1.187 ± 0.48
0.791HisArg: 0.791 ± 0.432
1.979HisSer: 1.979 ± 1.079
1.583HisThr: 1.583 ± 0.785
0.396HisVal: 0.396 ± 0.216
0.0HisTrp: 0.0 ± 0.0
1.583HisTyr: 1.583 ± 0.615
0.0HisXaa: 0.0 ± 0.0
Ile
2.77IleAla: 2.77 ± 0.725
1.979IleCys: 1.979 ± 0.659
3.562IleAsp: 3.562 ± 0.785
4.353IleGlu: 4.353 ± 1.357
0.396IlePhe: 0.396 ± 0.216
3.166IleGly: 3.166 ± 0.942
0.396IleHis: 0.396 ± 0.216
1.583IleIle: 1.583 ± 0.732
1.979IleLys: 1.979 ± 0.841
4.749IleLeu: 4.749 ± 1.412
0.791IleMet: 0.791 ± 0.595
2.77IleAsn: 2.77 ± 0.725
1.583IlePro: 1.583 ± 1.763
1.187IleGln: 1.187 ± 0.899
4.353IleArg: 4.353 ± 1.242
4.353IleSer: 4.353 ± 2.307
1.979IleThr: 1.979 ± 0.659
2.374IleVal: 2.374 ± 1.295
0.791IleTrp: 0.791 ± 0.432
1.583IleTyr: 1.583 ± 0.863
0.0IleXaa: 0.0 ± 0.0
Lys
5.144LysAla: 5.144 ± 0.457
1.187LysCys: 1.187 ± 0.744
3.562LysAsp: 3.562 ± 1.4
5.936LysGlu: 5.936 ± 0.209
1.979LysPhe: 1.979 ± 1.079
7.123LysGly: 7.123 ± 1.248
1.979LysHis: 1.979 ± 1.079
3.166LysIle: 3.166 ± 0.612
5.54LysLys: 5.54 ± 1.274
6.727LysLeu: 6.727 ± 1.062
2.77LysMet: 2.77 ± 1.213
1.979LysAsn: 1.979 ± 0.685
1.979LysPro: 1.979 ± 0.664
2.77LysGln: 2.77 ± 1.486
3.957LysArg: 3.957 ± 1.678
5.144LysSer: 5.144 ± 1.709
1.979LysThr: 1.979 ± 0.659
4.749LysVal: 4.749 ± 0.452
0.396LysTrp: 0.396 ± 0.216
1.583LysTyr: 1.583 ± 0.736
0.0LysXaa: 0.0 ± 0.0
Leu
3.562LeuAla: 3.562 ± 1.383
3.166LeuCys: 3.166 ± 0.574
4.749LeuAsp: 4.749 ± 1.432
3.562LeuGlu: 3.562 ± 0.899
5.144LeuPhe: 5.144 ± 1.15
8.31LeuGly: 8.31 ± 0.993
0.791LeuHis: 0.791 ± 0.518
4.749LeuIle: 4.749 ± 2.02
9.893LeuLys: 9.893 ± 3.353
9.893LeuLeu: 9.893 ± 1.547
1.583LeuMet: 1.583 ± 1.763
4.749LeuAsn: 4.749 ± 1.557
4.353LeuPro: 4.353 ± 1.357
2.77LeuGln: 2.77 ± 1.005
5.936LeuArg: 5.936 ± 0.66
8.706LeuSer: 8.706 ± 2.509
5.936LeuThr: 5.936 ± 2.558
5.936LeuVal: 5.936 ± 1.423
0.396LeuTrp: 0.396 ± 0.216
3.957LeuTyr: 3.957 ± 2.158
0.0LeuXaa: 0.0 ± 0.0
Met
1.187MetAla: 1.187 ± 1.495
0.396MetCys: 0.396 ± 0.815
1.187MetAsp: 1.187 ± 0.48
2.77MetGlu: 2.77 ± 1.379
0.791MetPhe: 0.791 ± 0.69
3.562MetGly: 3.562 ± 1.328
0.0MetHis: 0.0 ± 0.0
1.583MetIle: 1.583 ± 0.863
1.187MetLys: 1.187 ± 0.648
1.187MetLeu: 1.187 ± 1.135
0.791MetMet: 0.791 ± 0.69
0.791MetAsn: 0.791 ± 0.432
0.791MetPro: 0.791 ± 0.432
0.0MetGln: 0.0 ± 0.0
1.979MetArg: 1.979 ± 0.756
3.166MetSer: 3.166 ± 1.792
0.396MetThr: 0.396 ± 0.216
1.583MetVal: 1.583 ± 0.534
0.0MetTrp: 0.0 ± 0.0
0.791MetTyr: 0.791 ± 0.69
0.0MetXaa: 0.0 ± 0.0
Asn
2.77AsnAla: 2.77 ± 1.187
0.791AsnCys: 0.791 ± 0.432
0.396AsnAsp: 0.396 ± 0.216
1.979AsnGlu: 1.979 ± 0.841
1.583AsnPhe: 1.583 ± 0.764
2.77AsnGly: 2.77 ± 1.09
1.187AsnHis: 1.187 ± 0.648
2.77AsnIle: 2.77 ± 1.976
3.166AsnLys: 3.166 ± 1.149
4.353AsnLeu: 4.353 ± 1.188
0.791AsnMet: 0.791 ± 0.46
0.791AsnAsn: 0.791 ± 0.785
2.374AsnPro: 2.374 ± 1.482
0.791AsnGln: 0.791 ± 0.432
1.583AsnArg: 1.583 ± 0.764
2.77AsnSer: 2.77 ± 1.197
0.791AsnThr: 0.791 ± 0.432
2.374AsnVal: 2.374 ± 1.234
0.396AsnTrp: 0.396 ± 0.673
3.166AsnTyr: 3.166 ± 1.528
0.0AsnXaa: 0.0 ± 0.0
Pro
1.979ProAla: 1.979 ± 1.376
1.187ProCys: 1.187 ± 0.48
4.353ProAsp: 4.353 ± 1.811
5.144ProGlu: 5.144 ± 1.756
0.396ProPhe: 0.396 ± 0.815
3.166ProGly: 3.166 ± 2.488
1.187ProHis: 1.187 ± 0.48
0.396ProIle: 0.396 ± 0.216
1.979ProLys: 1.979 ± 0.975
3.957ProLeu: 3.957 ± 1.604
1.583ProMet: 1.583 ± 0.732
0.791ProAsn: 0.791 ± 0.432
1.187ProPro: 1.187 ± 0.926
1.979ProGln: 1.979 ± 0.906
2.77ProArg: 2.77 ± 1.005
1.187ProSer: 1.187 ± 0.617
1.187ProThr: 1.187 ± 1.135
1.583ProVal: 1.583 ± 0.785
1.187ProTrp: 1.187 ± 1.653
2.374ProTyr: 2.374 ± 0.657
0.0ProXaa: 0.0 ± 0.0
Gln
1.583GlnAla: 1.583 ± 1.393
1.583GlnCys: 1.583 ± 0.534
2.374GlnAsp: 2.374 ± 0.657
1.979GlnGlu: 1.979 ± 0.684
1.187GlnPhe: 1.187 ± 1.878
1.187GlnGly: 1.187 ± 0.648
1.187GlnHis: 1.187 ± 0.899
2.77GlnIle: 2.77 ± 0.992
3.957GlnLys: 3.957 ± 0.924
1.979GlnLeu: 1.979 ± 0.659
0.791GlnMet: 0.791 ± 0.69
1.583GlnAsn: 1.583 ± 0.877
0.791GlnPro: 0.791 ± 0.432
3.562GlnGln: 3.562 ± 0.857
3.166GlnArg: 3.166 ± 0.764
3.562GlnSer: 3.562 ± 1.789
2.77GlnThr: 2.77 ± 1.703
2.374GlnVal: 2.374 ± 2.881
0.0GlnTrp: 0.0 ± 0.0
1.979GlnTyr: 1.979 ± 1.596
0.0GlnXaa: 0.0 ± 0.0
Arg
4.749ArgAla: 4.749 ± 0.943
1.187ArgCys: 1.187 ± 0.571
4.749ArgAsp: 4.749 ± 1.087
3.166ArgGlu: 3.166 ± 1.507
3.166ArgPhe: 3.166 ± 0.833
1.979ArgGly: 1.979 ± 0.596
0.396ArgHis: 0.396 ± 0.216
3.562ArgIle: 3.562 ± 2.23
3.957ArgLys: 3.957 ± 2.158
4.353ArgLeu: 4.353 ± 0.975
1.187ArgMet: 1.187 ± 0.899
3.166ArgAsn: 3.166 ± 1.332
1.583ArgPro: 1.583 ± 1.312
3.166ArgGln: 3.166 ± 1.707
4.353ArgArg: 4.353 ± 0.757
6.332ArgSer: 6.332 ± 2.082
2.374ArgThr: 2.374 ± 2.206
4.749ArgVal: 4.749 ± 0.721
0.396ArgTrp: 0.396 ± 0.216
2.374ArgTyr: 2.374 ± 1.226
0.0ArgXaa: 0.0 ± 0.0
Ser
7.123SerAla: 7.123 ± 1.813
1.583SerCys: 1.583 ± 0.764
3.957SerAsp: 3.957 ± 2.158
6.727SerGlu: 6.727 ± 1.258
3.957SerPhe: 3.957 ± 1.314
3.957SerGly: 3.957 ± 1.75
1.187SerHis: 1.187 ± 0.48
3.562SerIle: 3.562 ± 1.457
3.957SerLys: 3.957 ± 1.045
9.893SerLeu: 9.893 ± 2.536
1.979SerMet: 1.979 ± 1.079
2.77SerAsn: 2.77 ± 0.524
1.979SerPro: 1.979 ± 0.756
4.749SerGln: 4.749 ± 1.738
5.144SerArg: 5.144 ± 3.907
3.957SerSer: 3.957 ± 0.642
3.166SerThr: 3.166 ± 0.764
5.54SerVal: 5.54 ± 1.164
0.396SerTrp: 0.396 ± 0.216
2.374SerTyr: 2.374 ± 1.554
0.0SerXaa: 0.0 ± 0.0
Thr
2.374ThrAla: 2.374 ± 0.841
0.791ThrCys: 0.791 ± 0.432
3.957ThrAsp: 3.957 ± 1.186
4.353ThrGlu: 4.353 ± 1.2
3.166ThrPhe: 3.166 ± 1.141
1.979ThrGly: 1.979 ± 1.291
1.979ThrHis: 1.979 ± 0.684
2.374ThrIle: 2.374 ± 1.764
2.374ThrLys: 2.374 ± 0.822
5.54ThrLeu: 5.54 ± 2.277
1.187ThrMet: 1.187 ± 0.793
0.791ThrAsn: 0.791 ± 0.586
1.979ThrPro: 1.979 ± 1.327
2.374ThrGln: 2.374 ± 2.27
2.77ThrArg: 2.77 ± 1.585
3.166ThrSer: 3.166 ± 0.612
2.374ThrThr: 2.374 ± 0.657
2.374ThrVal: 2.374 ± 1.295
0.791ThrTrp: 0.791 ± 0.432
1.187ThrTyr: 1.187 ± 1.878
0.0ThrXaa: 0.0 ± 0.0
Val
3.166ValAla: 3.166 ± 0.883
1.979ValCys: 1.979 ± 0.906
2.77ValAsp: 2.77 ± 0.965
2.374ValGlu: 2.374 ± 2.27
2.77ValPhe: 2.77 ± 1.782
1.979ValGly: 1.979 ± 1.681
3.957ValHis: 3.957 ± 1.604
3.562ValIle: 3.562 ± 0.857
5.144ValLys: 5.144 ± 3.393
5.54ValLeu: 5.54 ± 3.022
2.374ValMet: 2.374 ± 0.808
4.749ValAsn: 4.749 ± 2.044
3.166ValPro: 3.166 ± 1.526
1.187ValGln: 1.187 ± 1.552
3.166ValArg: 3.166 ± 2.217
5.54ValSer: 5.54 ± 2.785
4.353ValThr: 4.353 ± 1.401
3.562ValVal: 3.562 ± 2.155
0.0ValTrp: 0.0 ± 0.0
2.77ValTyr: 2.77 ± 0.931
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.396TrpCys: 0.396 ± 0.216
0.0TrpAsp: 0.0 ± 0.0
0.396TrpGlu: 0.396 ± 0.216
0.0TrpPhe: 0.0 ± 0.0
0.396TrpGly: 0.396 ± 0.673
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.396TrpLys: 0.396 ± 0.216
1.187TrpLeu: 1.187 ± 0.48
0.0TrpMet: 0.0 ± 0.0
0.396TrpAsn: 0.396 ± 0.216
1.187TrpPro: 1.187 ± 0.648
0.0TrpGln: 0.0 ± 0.0
0.396TrpArg: 0.396 ± 0.216
1.979TrpSer: 1.979 ± 1.079
0.396TrpThr: 0.396 ± 0.216
0.791TrpVal: 0.791 ± 0.785
0.0TrpTrp: 0.0 ± 0.0
0.791TrpTyr: 0.791 ± 0.785
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.77TyrAla: 2.77 ± 0.992
0.396TyrCys: 0.396 ± 0.673
2.374TyrAsp: 2.374 ± 0.96
2.77TyrGlu: 2.77 ± 0.524
2.374TyrPhe: 2.374 ± 1.063
1.979TyrGly: 1.979 ± 0.801
1.583TyrHis: 1.583 ± 0.863
1.979TyrIle: 1.979 ± 0.596
1.583TyrLys: 1.583 ± 0.863
4.353TyrLeu: 4.353 ± 1.42
0.0TyrMet: 0.0 ± 0.594
1.979TyrAsn: 1.979 ± 0.756
2.374TyrPro: 2.374 ± 1.073
2.374TyrGln: 2.374 ± 1.735
1.979TyrArg: 1.979 ± 0.841
4.353TyrSer: 4.353 ± 1.258
2.374TyrThr: 2.374 ± 0.961
1.979TyrVal: 1.979 ± 0.801
0.396TyrTrp: 0.396 ± 0.216
0.396TyrTyr: 0.396 ± 0.879
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski