Amino acid dipepetide frequency for Vibrio phage vB_VorS-PVo5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.755AlaAla: 8.755 ± 1.723
0.758AlaCys: 0.758 ± 0.243
4.714AlaAsp: 4.714 ± 0.398
5.514AlaGlu: 5.514 ± 0.767
2.483AlaPhe: 2.483 ± 0.345
4.756AlaGly: 4.756 ± 0.485
1.137AlaHis: 1.137 ± 0.228
3.662AlaIle: 3.662 ± 0.443
7.577AlaLys: 7.577 ± 1.017
6.272AlaLeu: 6.272 ± 0.54
1.852AlaMet: 1.852 ± 0.322
3.746AlaAsn: 3.746 ± 0.603
2.694AlaPro: 2.694 ± 0.398
3.241AlaGln: 3.241 ± 0.38
2.736AlaArg: 2.736 ± 0.394
6.651AlaSer: 6.651 ± 1.431
5.514AlaThr: 5.514 ± 0.647
3.999AlaVal: 3.999 ± 0.447
1.137AlaTrp: 1.137 ± 0.185
3.031AlaTyr: 3.031 ± 0.357
0.168AlaXaa: 0.168 ± 0.078
Cys
0.631CysAla: 0.631 ± 0.15
0.084CysCys: 0.084 ± 0.063
0.547CysAsp: 0.547 ± 0.171
0.842CysGlu: 0.842 ± 0.177
0.253CysPhe: 0.253 ± 0.135
0.547CysGly: 0.547 ± 0.204
0.084CysHis: 0.084 ± 0.053
0.547CysIle: 0.547 ± 0.156
0.884CysLys: 0.884 ± 0.212
0.842CysLeu: 0.842 ± 0.204
0.21CysMet: 0.21 ± 0.084
0.463CysAsn: 0.463 ± 0.144
0.337CysPro: 0.337 ± 0.149
0.547CysGln: 0.547 ± 0.151
0.463CysArg: 0.463 ± 0.126
0.631CysSer: 0.631 ± 0.197
0.547CysThr: 0.547 ± 0.15
0.589CysVal: 0.589 ± 0.22
0.042CysTrp: 0.042 ± 0.048
0.379CysTyr: 0.379 ± 0.131
0.0CysXaa: 0.0 ± 0.0
Asp
5.388AspAla: 5.388 ± 0.739
0.379AspCys: 0.379 ± 0.126
2.946AspAsp: 2.946 ± 0.382
5.262AspGlu: 5.262 ± 0.615
2.526AspPhe: 2.526 ± 0.369
4.756AspGly: 4.756 ± 0.83
0.758AspHis: 0.758 ± 0.186
5.177AspIle: 5.177 ± 0.437
4.42AspLys: 4.42 ± 0.529
5.304AspLeu: 5.304 ± 0.5
1.473AspMet: 1.473 ± 0.267
3.367AspAsn: 3.367 ± 0.346
2.147AspPro: 2.147 ± 0.416
1.726AspGln: 1.726 ± 0.332
2.82AspArg: 2.82 ± 0.335
3.704AspSer: 3.704 ± 0.442
4.125AspThr: 4.125 ± 0.454
4.209AspVal: 4.209 ± 0.401
1.01AspTrp: 1.01 ± 0.177
2.526AspTyr: 2.526 ± 0.338
0.0AspXaa: 0.0 ± 0.0
Glu
6.061GluAla: 6.061 ± 0.747
0.8GluCys: 0.8 ± 0.22
3.788GluAsp: 3.788 ± 0.405
5.135GluGlu: 5.135 ± 0.527
2.694GluPhe: 2.694 ± 0.303
4.083GluGly: 4.083 ± 0.416
1.221GluHis: 1.221 ± 0.254
4.083GluIle: 4.083 ± 0.348
4.63GluLys: 4.63 ± 0.552
7.282GluLeu: 7.282 ± 0.806
1.389GluMet: 1.389 ± 0.294
3.199GluAsn: 3.199 ± 0.444
2.105GluPro: 2.105 ± 0.322
2.61GluGln: 2.61 ± 0.442
2.61GluArg: 2.61 ± 0.364
3.788GluSer: 3.788 ± 0.445
3.283GluThr: 3.283 ± 0.324
5.935GluVal: 5.935 ± 0.609
0.758GluTrp: 0.758 ± 0.213
3.283GluTyr: 3.283 ± 0.471
0.126GluXaa: 0.126 ± 0.083
Phe
2.231PheAla: 2.231 ± 0.291
0.505PheCys: 0.505 ± 0.17
3.746PheAsp: 3.746 ± 0.462
2.568PheGlu: 2.568 ± 0.383
1.263PhePhe: 1.263 ± 0.284
2.399PheGly: 2.399 ± 0.39
1.221PheHis: 1.221 ± 0.261
2.526PheIle: 2.526 ± 0.356
2.273PheLys: 2.273 ± 0.3
2.483PheLeu: 2.483 ± 0.319
0.589PheMet: 0.589 ± 0.173
2.231PheAsn: 2.231 ± 0.268
1.389PhePro: 1.389 ± 0.283
0.842PheGln: 0.842 ± 0.202
2.105PheArg: 2.105 ± 0.328
2.441PheSer: 2.441 ± 0.325
2.399PheThr: 2.399 ± 0.313
1.852PheVal: 1.852 ± 0.258
0.547PheTrp: 0.547 ± 0.145
1.473PheTyr: 1.473 ± 0.228
0.042PheXaa: 0.042 ± 0.038
Gly
4.293GlyAla: 4.293 ± 0.426
0.8GlyCys: 0.8 ± 0.202
4.546GlyAsp: 4.546 ± 0.602
5.009GlyGlu: 5.009 ± 0.498
3.031GlyPhe: 3.031 ± 0.328
3.662GlyGly: 3.662 ± 0.448
1.179GlyHis: 1.179 ± 0.223
4.588GlyIle: 4.588 ± 0.58
6.314GlyLys: 6.314 ± 0.699
4.756GlyLeu: 4.756 ± 0.483
1.515GlyMet: 1.515 ± 0.301
3.62GlyAsn: 3.62 ± 0.404
0.758GlyPro: 0.758 ± 0.173
2.063GlyGln: 2.063 ± 0.318
2.946GlyArg: 2.946 ± 0.398
4.841GlySer: 4.841 ± 0.578
4.42GlyThr: 4.42 ± 0.397
4.378GlyVal: 4.378 ± 0.396
1.179GlyTrp: 1.179 ± 0.235
2.441GlyTyr: 2.441 ± 0.395
0.042GlyXaa: 0.042 ± 0.038
His
0.884HisAla: 0.884 ± 0.178
0.21HisCys: 0.21 ± 0.097
1.221HisAsp: 1.221 ± 0.256
1.305HisGlu: 1.305 ± 0.244
0.631HisPhe: 0.631 ± 0.146
1.305HisGly: 1.305 ± 0.247
0.379HisHis: 0.379 ± 0.123
1.052HisIle: 1.052 ± 0.193
1.431HisLys: 1.431 ± 0.225
1.852HisLeu: 1.852 ± 0.318
0.631HisMet: 0.631 ± 0.19
0.968HisAsn: 0.968 ± 0.24
0.758HisPro: 0.758 ± 0.181
0.716HisGln: 0.716 ± 0.225
1.094HisArg: 1.094 ± 0.224
0.968HisSer: 0.968 ± 0.176
1.305HisThr: 1.305 ± 0.241
1.305HisVal: 1.305 ± 0.256
0.21HisTrp: 0.21 ± 0.075
0.673HisTyr: 0.673 ± 0.17
0.0HisXaa: 0.0 ± 0.0
Ile
4.462IleAla: 4.462 ± 0.5
0.421IleCys: 0.421 ± 0.163
4.546IleAsp: 4.546 ± 0.422
4.336IleGlu: 4.336 ± 0.51
1.473IlePhe: 1.473 ± 0.254
3.578IleGly: 3.578 ± 0.475
1.305IleHis: 1.305 ± 0.216
2.904IleIle: 2.904 ± 0.423
4.293IleLys: 4.293 ± 0.49
4.546IleLeu: 4.546 ± 0.519
1.557IleMet: 1.557 ± 0.277
3.367IleAsn: 3.367 ± 0.496
2.862IlePro: 2.862 ± 0.341
2.147IleGln: 2.147 ± 0.284
2.989IleArg: 2.989 ± 0.381
3.83IleSer: 3.83 ± 0.482
4.041IleThr: 4.041 ± 0.381
3.199IleVal: 3.199 ± 0.362
0.505IleTrp: 0.505 ± 0.153
2.273IleTyr: 2.273 ± 0.312
0.042IleXaa: 0.042 ± 0.045
Lys
7.114LysAla: 7.114 ± 0.882
0.421LysCys: 0.421 ± 0.127
4.083LysAsp: 4.083 ± 0.551
5.093LysGlu: 5.093 ± 0.479
2.904LysPhe: 2.904 ± 0.363
4.504LysGly: 4.504 ± 0.49
1.557LysHis: 1.557 ± 0.272
3.999LysIle: 3.999 ± 0.379
4.209LysLys: 4.209 ± 0.368
7.619LysLeu: 7.619 ± 0.699
1.768LysMet: 1.768 ± 0.339
2.862LysAsn: 2.862 ± 0.334
3.325LysPro: 3.325 ± 0.526
3.41LysGln: 3.41 ± 0.378
3.325LysArg: 3.325 ± 0.355
4.42LysSer: 4.42 ± 0.52
5.009LysThr: 5.009 ± 0.531
4.714LysVal: 4.714 ± 0.428
1.094LysTrp: 1.094 ± 0.2
3.199LysTyr: 3.199 ± 0.453
0.084LysXaa: 0.084 ± 0.06
Leu
5.935LeuAla: 5.935 ± 0.602
0.842LeuCys: 0.842 ± 0.19
6.651LeuAsp: 6.651 ± 0.525
6.735LeuGlu: 6.735 ± 0.694
2.357LeuPhe: 2.357 ± 0.341
5.851LeuGly: 5.851 ± 0.664
1.936LeuHis: 1.936 ± 0.314
4.714LeuIle: 4.714 ± 0.457
5.556LeuLys: 5.556 ± 0.542
6.103LeuLeu: 6.103 ± 0.622
1.894LeuMet: 1.894 ± 0.29
3.83LeuAsn: 3.83 ± 0.38
3.494LeuPro: 3.494 ± 0.423
3.241LeuGln: 3.241 ± 0.34
4.041LeuArg: 4.041 ± 0.486
5.64LeuSer: 5.64 ± 0.475
5.43LeuThr: 5.43 ± 0.57
5.556LeuVal: 5.556 ± 0.438
0.421LeuTrp: 0.421 ± 0.142
2.441LeuTyr: 2.441 ± 0.296
0.126LeuXaa: 0.126 ± 0.067
Met
2.357MetAla: 2.357 ± 0.415
0.21MetCys: 0.21 ± 0.101
1.557MetAsp: 1.557 ± 0.29
1.852MetGlu: 1.852 ± 0.281
0.631MetPhe: 0.631 ± 0.198
1.473MetGly: 1.473 ± 0.221
0.379MetHis: 0.379 ± 0.119
1.179MetIle: 1.179 ± 0.218
1.852MetLys: 1.852 ± 0.337
1.515MetLeu: 1.515 ± 0.324
0.463MetMet: 0.463 ± 0.15
0.926MetAsn: 0.926 ± 0.185
1.01MetPro: 1.01 ± 0.234
1.01MetGln: 1.01 ± 0.233
1.052MetArg: 1.052 ± 0.221
1.515MetSer: 1.515 ± 0.238
1.768MetThr: 1.768 ± 0.297
1.01MetVal: 1.01 ± 0.219
0.21MetTrp: 0.21 ± 0.087
1.052MetTyr: 1.052 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
4.251AsnAla: 4.251 ± 0.74
0.589AsnCys: 0.589 ± 0.232
2.063AsnAsp: 2.063 ± 0.318
2.652AsnGlu: 2.652 ± 0.386
1.557AsnPhe: 1.557 ± 0.267
3.367AsnGly: 3.367 ± 0.438
0.968AsnHis: 0.968 ± 0.252
3.704AsnIle: 3.704 ± 0.389
5.472AsnLys: 5.472 ± 0.362
4.209AsnLeu: 4.209 ± 0.447
1.221AsnMet: 1.221 ± 0.227
2.483AsnAsn: 2.483 ± 0.299
2.778AsnPro: 2.778 ± 0.401
1.263AsnGln: 1.263 ± 0.257
2.147AsnArg: 2.147 ± 0.3
3.704AsnSer: 3.704 ± 0.396
2.862AsnThr: 2.862 ± 0.443
2.989AsnVal: 2.989 ± 0.421
0.842AsnTrp: 0.842 ± 0.171
1.978AsnTyr: 1.978 ± 0.36
0.042AsnXaa: 0.042 ± 0.042
Pro
2.399ProAla: 2.399 ± 0.376
0.295ProCys: 0.295 ± 0.116
2.147ProAsp: 2.147 ± 0.253
2.652ProGlu: 2.652 ± 0.29
1.094ProPhe: 1.094 ± 0.248
2.568ProGly: 2.568 ± 0.675
0.842ProHis: 0.842 ± 0.161
2.526ProIle: 2.526 ± 0.305
2.273ProLys: 2.273 ± 0.329
2.778ProLeu: 2.778 ± 0.427
0.842ProMet: 0.842 ± 0.204
2.357ProAsn: 2.357 ± 0.378
0.758ProPro: 0.758 ± 0.204
1.179ProGln: 1.179 ± 0.256
1.726ProArg: 1.726 ± 0.321
3.031ProSer: 3.031 ± 0.465
2.61ProThr: 2.61 ± 0.49
2.526ProVal: 2.526 ± 0.268
0.337ProTrp: 0.337 ± 0.098
1.305ProTyr: 1.305 ± 0.282
0.042ProXaa: 0.042 ± 0.04
Gln
3.325GlnAla: 3.325 ± 0.41
0.631GlnCys: 0.631 ± 0.151
2.063GlnAsp: 2.063 ± 0.298
2.399GlnGlu: 2.399 ± 0.384
1.137GlnPhe: 1.137 ± 0.188
2.989GlnGly: 2.989 ± 0.501
0.505GlnHis: 0.505 ± 0.161
1.936GlnIle: 1.936 ± 0.227
2.568GlnLys: 2.568 ± 0.332
3.578GlnLeu: 3.578 ± 0.469
0.884GlnMet: 0.884 ± 0.237
1.6GlnAsn: 1.6 ± 0.194
1.179GlnPro: 1.179 ± 0.215
1.936GlnGln: 1.936 ± 0.31
1.515GlnArg: 1.515 ± 0.305
1.768GlnSer: 1.768 ± 0.334
2.315GlnThr: 2.315 ± 0.331
2.778GlnVal: 2.778 ± 0.375
0.379GlnTrp: 0.379 ± 0.144
1.221GlnTyr: 1.221 ± 0.254
0.0GlnXaa: 0.0 ± 0.0
Arg
3.283ArgAla: 3.283 ± 0.393
0.379ArgCys: 0.379 ± 0.138
3.62ArgAsp: 3.62 ± 0.395
2.652ArgGlu: 2.652 ± 0.351
2.526ArgPhe: 2.526 ± 0.309
3.283ArgGly: 3.283 ± 0.385
0.673ArgHis: 0.673 ± 0.197
2.736ArgIle: 2.736 ± 0.35
3.325ArgLys: 3.325 ± 0.352
3.241ArgLeu: 3.241 ± 0.388
1.557ArgMet: 1.557 ± 0.311
2.483ArgAsn: 2.483 ± 0.401
1.473ArgPro: 1.473 ± 0.226
1.936ArgGln: 1.936 ± 0.291
1.726ArgArg: 1.726 ± 0.251
2.483ArgSer: 2.483 ± 0.303
2.147ArgThr: 2.147 ± 0.38
2.989ArgVal: 2.989 ± 0.323
0.673ArgTrp: 0.673 ± 0.212
1.852ArgTyr: 1.852 ± 0.327
0.0ArgXaa: 0.0 ± 0.0
Ser
6.103SerAla: 6.103 ± 1.03
0.673SerCys: 0.673 ± 0.156
3.873SerAsp: 3.873 ± 0.427
4.125SerGlu: 4.125 ± 0.772
2.904SerPhe: 2.904 ± 0.284
5.051SerGly: 5.051 ± 0.56
0.8SerHis: 0.8 ± 0.143
3.41SerIle: 3.41 ± 0.448
5.304SerLys: 5.304 ± 0.49
5.514SerLeu: 5.514 ± 0.509
1.347SerMet: 1.347 ± 0.182
3.704SerAsn: 3.704 ± 0.568
2.61SerPro: 2.61 ± 0.341
2.02SerGln: 2.02 ± 0.392
2.736SerArg: 2.736 ± 0.348
4.293SerSer: 4.293 ± 0.642
4.251SerThr: 4.251 ± 0.539
3.915SerVal: 3.915 ± 0.444
1.052SerTrp: 1.052 ± 0.22
2.105SerTyr: 2.105 ± 0.288
0.21SerXaa: 0.21 ± 0.093
Thr
4.841ThrAla: 4.841 ± 0.527
0.253ThrCys: 0.253 ± 0.129
4.251ThrAsp: 4.251 ± 0.418
3.494ThrGlu: 3.494 ± 0.486
3.031ThrPhe: 3.031 ± 0.311
5.177ThrGly: 5.177 ± 0.6
1.431ThrHis: 1.431 ± 0.227
3.578ThrIle: 3.578 ± 0.343
4.756ThrLys: 4.756 ± 0.501
5.009ThrLeu: 5.009 ± 0.573
1.263ThrMet: 1.263 ± 0.266
3.536ThrAsn: 3.536 ± 0.483
2.568ThrPro: 2.568 ± 0.322
1.978ThrGln: 1.978 ± 0.294
2.778ThrArg: 2.778 ± 0.285
4.209ThrSer: 4.209 ± 0.679
4.083ThrThr: 4.083 ± 0.417
3.62ThrVal: 3.62 ± 0.403
1.389ThrTrp: 1.389 ± 0.341
2.736ThrTyr: 2.736 ± 0.37
0.084ThrXaa: 0.084 ± 0.062
Val
4.462ValAla: 4.462 ± 0.521
0.505ValCys: 0.505 ± 0.164
4.293ValAsp: 4.293 ± 0.381
4.167ValGlu: 4.167 ± 0.385
2.736ValPhe: 2.736 ± 0.367
3.536ValGly: 3.536 ± 0.352
1.431ValHis: 1.431 ± 0.325
2.862ValIle: 2.862 ± 0.405
4.125ValLys: 4.125 ± 0.469
4.841ValLeu: 4.841 ± 0.416
1.179ValMet: 1.179 ± 0.244
3.199ValAsn: 3.199 ± 0.309
2.357ValPro: 2.357 ± 0.302
2.231ValGln: 2.231 ± 0.33
3.746ValArg: 3.746 ± 0.524
4.714ValSer: 4.714 ± 0.32
4.083ValThr: 4.083 ± 0.49
4.336ValVal: 4.336 ± 0.54
0.884ValTrp: 0.884 ± 0.204
3.031ValTyr: 3.031 ± 0.368
0.084ValXaa: 0.084 ± 0.055
Trp
1.094TrpAla: 1.094 ± 0.227
0.253TrpCys: 0.253 ± 0.102
0.758TrpAsp: 0.758 ± 0.159
0.421TrpGlu: 0.421 ± 0.114
0.421TrpPhe: 0.421 ± 0.144
0.968TrpGly: 0.968 ± 0.22
0.295TrpHis: 0.295 ± 0.122
0.716TrpIle: 0.716 ± 0.306
0.926TrpLys: 0.926 ± 0.231
1.515TrpLeu: 1.515 ± 0.257
0.379TrpMet: 0.379 ± 0.173
0.842TrpAsn: 0.842 ± 0.158
0.253TrpPro: 0.253 ± 0.105
0.631TrpGln: 0.631 ± 0.147
0.673TrpArg: 0.673 ± 0.171
0.884TrpSer: 0.884 ± 0.332
0.673TrpThr: 0.673 ± 0.167
1.094TrpVal: 1.094 ± 0.226
0.126TrpTrp: 0.126 ± 0.065
0.379TrpTyr: 0.379 ± 0.142
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.399TyrAla: 2.399 ± 0.328
0.463TyrCys: 0.463 ± 0.156
2.526TyrAsp: 2.526 ± 0.341
2.568TyrGlu: 2.568 ± 0.374
1.389TyrPhe: 1.389 ± 0.21
2.483TyrGly: 2.483 ± 0.323
0.758TyrHis: 0.758 ± 0.176
2.736TyrIle: 2.736 ± 0.33
2.526TyrLys: 2.526 ± 0.407
3.494TyrLeu: 3.494 ± 0.441
0.968TyrMet: 0.968 ± 0.179
2.273TyrAsn: 2.273 ± 0.384
1.347TyrPro: 1.347 ± 0.188
1.894TyrGln: 1.894 ± 0.313
1.768TyrArg: 1.768 ± 0.262
2.357TyrSer: 2.357 ± 0.398
3.115TyrThr: 3.115 ± 0.482
1.768TyrVal: 1.768 ± 0.25
0.505TyrTrp: 0.505 ± 0.166
1.768TyrTyr: 1.768 ± 0.268
0.042TyrXaa: 0.042 ± 0.038
Xaa
0.126XaaAla: 0.126 ± 0.074
0.0XaaCys: 0.0 ± 0.0
0.084XaaAsp: 0.084 ± 0.051
0.084XaaGlu: 0.084 ± 0.059
0.084XaaPhe: 0.084 ± 0.065
0.042XaaGly: 0.042 ± 0.04
0.042XaaHis: 0.042 ± 0.038
0.084XaaIle: 0.084 ± 0.056
0.0XaaLys: 0.0 ± 0.0
0.042XaaLeu: 0.042 ± 0.042
0.0XaaMet: 0.0 ± 0.0
0.084XaaAsn: 0.084 ± 0.063
0.084XaaPro: 0.084 ± 0.057
0.084XaaGln: 0.084 ± 0.066
0.042XaaArg: 0.042 ± 0.042
0.126XaaSer: 0.126 ± 0.07
0.084XaaThr: 0.084 ± 0.055
0.042XaaVal: 0.042 ± 0.038
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 93 proteins (23758 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski