Amino acid dipepetide frequency for Sewage-associated circular DNA virus-7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.919AlaAla: 8.919 ± 3.437
0.0AlaCys: 0.0 ± 0.0
2.23AlaAsp: 2.23 ± 1.066
1.115AlaGlu: 1.115 ± 1.009
1.115AlaPhe: 1.115 ± 1.009
6.689AlaGly: 6.689 ± 2.518
1.115AlaHis: 1.115 ± 0.751
7.804AlaIle: 7.804 ± 2.448
4.459AlaLys: 4.459 ± 3.002
5.574AlaLeu: 5.574 ± 0.856
2.23AlaMet: 2.23 ± 0.839
1.115AlaAsn: 1.115 ± 0.751
3.344AlaPro: 3.344 ± 1.32
5.574AlaGln: 5.574 ± 2.656
3.344AlaArg: 3.344 ± 0.316
7.804AlaSer: 7.804 ± 1.575
4.459AlaThr: 4.459 ± 0.435
3.344AlaVal: 3.344 ± 1.697
3.344AlaTrp: 3.344 ± 3.026
2.23AlaTyr: 2.23 ± 0.839
0.0AlaXaa: 0.0 ± 0.0
Cys
1.115CysAla: 1.115 ± 1.009
1.115CysCys: 1.115 ± 1.009
0.0CysAsp: 0.0 ± 0.0
1.115CysGlu: 1.115 ± 1.009
1.115CysPhe: 1.115 ± 1.009
3.344CysGly: 3.344 ± 1.837
1.115CysHis: 1.115 ± 0.751
0.0CysIle: 0.0 ± 0.0
1.115CysLys: 1.115 ± 0.751
0.0CysLeu: 0.0 ± 0.0
1.115CysMet: 1.115 ± 0.904
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
2.23CysSer: 2.23 ± 0.88
0.0CysThr: 0.0 ± 0.0
1.115CysVal: 1.115 ± 0.751
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.344AspAla: 3.344 ± 1.697
0.0AspCys: 0.0 ± 0.0
2.23AspAsp: 2.23 ± 1.501
4.459AspGlu: 4.459 ± 2.663
0.0AspPhe: 0.0 ± 0.0
2.23AspGly: 2.23 ± 0.88
1.115AspHis: 1.115 ± 1.009
1.115AspIle: 1.115 ± 0.751
0.0AspLys: 0.0 ± 0.0
1.115AspLeu: 1.115 ± 0.751
2.23AspMet: 2.23 ± 1.501
1.115AspAsn: 1.115 ± 0.967
4.459AspPro: 4.459 ± 2.765
0.0AspGln: 0.0 ± 0.0
1.115AspArg: 1.115 ± 1.009
2.23AspSer: 2.23 ± 1.501
3.344AspThr: 3.344 ± 1.232
7.804AspVal: 7.804 ± 4.005
1.115AspTrp: 1.115 ± 1.009
1.115AspTyr: 1.115 ± 1.009
0.0AspXaa: 0.0 ± 0.0
Glu
2.23GluAla: 2.23 ± 1.066
0.0GluCys: 0.0 ± 0.0
1.115GluAsp: 1.115 ± 1.009
3.344GluGlu: 3.344 ± 1.768
2.23GluPhe: 2.23 ± 2.018
2.23GluGly: 2.23 ± 1.934
0.0GluHis: 0.0 ± 0.0
2.23GluIle: 2.23 ± 2.018
0.0GluLys: 0.0 ± 0.0
5.574GluLeu: 5.574 ± 2.203
2.23GluMet: 2.23 ± 0.839
0.0GluAsn: 0.0 ± 0.0
2.23GluPro: 2.23 ± 0.88
0.0GluGln: 0.0 ± 0.0
3.344GluArg: 3.344 ± 3.026
6.689GluSer: 6.689 ± 5.803
3.344GluThr: 3.344 ± 1.768
1.115GluVal: 1.115 ± 0.751
2.23GluTrp: 2.23 ± 0.88
1.115GluTyr: 1.115 ± 0.751
0.0GluXaa: 0.0 ± 0.0
Phe
2.23PheAla: 2.23 ± 0.88
0.0PheCys: 0.0 ± 0.0
1.115PheAsp: 1.115 ± 0.751
1.115PheGlu: 1.115 ± 1.009
0.0PhePhe: 0.0 ± 0.0
5.574PheGly: 5.574 ± 3.566
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
2.23PheLys: 2.23 ± 0.839
2.23PheLeu: 2.23 ± 2.018
1.115PheMet: 1.115 ± 0.751
0.0PheAsn: 0.0 ± 0.0
0.0PhePro: 0.0 ± 0.0
1.115PheGln: 1.115 ± 0.751
4.459PheArg: 4.459 ± 1.208
1.115PheSer: 1.115 ± 0.751
1.115PheThr: 1.115 ± 1.009
2.23PheVal: 2.23 ± 0.839
2.23PheTrp: 2.23 ± 2.018
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.459GlyAla: 4.459 ± 1.86
1.115GlyCys: 1.115 ± 0.967
0.0GlyAsp: 0.0 ± 0.0
1.115GlyGlu: 1.115 ± 1.009
3.344GlyPhe: 3.344 ± 1.69
2.23GlyGly: 2.23 ± 0.839
0.0GlyHis: 0.0 ± 0.0
6.689GlyIle: 6.689 ± 2.464
5.574GlyLys: 5.574 ± 0.856
4.459GlyLeu: 4.459 ± 1.761
3.344GlyMet: 3.344 ± 0.316
2.23GlyAsn: 2.23 ± 0.839
2.23GlyPro: 2.23 ± 1.934
4.459GlyGln: 4.459 ± 1.679
6.689GlyArg: 6.689 ± 0.632
8.919GlySer: 8.919 ± 0.871
10.033GlyThr: 10.033 ± 0.947
5.574GlyVal: 5.574 ± 0.856
0.0GlyTrp: 0.0 ± 0.0
5.574GlyTyr: 5.574 ± 1.97
0.0GlyXaa: 0.0 ± 0.0
His
1.115HisAla: 1.115 ± 1.009
1.115HisCys: 1.115 ± 0.751
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
3.344HisPhe: 3.344 ± 1.697
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.115HisLys: 1.115 ± 0.751
2.23HisLeu: 2.23 ± 0.88
0.0HisMet: 0.0 ± 0.0
1.115HisAsn: 1.115 ± 0.751
2.23HisPro: 2.23 ± 0.88
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
4.459HisSer: 4.459 ± 1.208
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
1.115HisTrp: 1.115 ± 1.009
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.115IleAla: 1.115 ± 0.751
1.115IleCys: 1.115 ± 1.009
2.23IleAsp: 2.23 ± 2.018
2.23IleGlu: 2.23 ± 1.501
3.344IlePhe: 3.344 ± 1.232
3.344IleGly: 3.344 ± 1.69
1.115IleHis: 1.115 ± 0.751
1.115IleIle: 1.115 ± 0.751
4.459IleLys: 4.459 ± 1.86
1.115IleLeu: 1.115 ± 0.967
2.23IleMet: 2.23 ± 0.835
5.574IleAsn: 5.574 ± 3.753
4.459IlePro: 4.459 ± 2.132
2.23IleGln: 2.23 ± 1.934
2.23IleArg: 2.23 ± 1.066
4.459IleSer: 4.459 ± 0.435
5.574IleThr: 5.574 ± 1.97
0.0IleVal: 0.0 ± 0.0
1.115IleTrp: 1.115 ± 1.009
2.23IleTyr: 2.23 ± 0.839
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
1.115LysCys: 1.115 ± 0.751
2.23LysAsp: 2.23 ± 0.839
4.459LysGlu: 4.459 ± 1.169
1.115LysPhe: 1.115 ± 1.009
6.689LysGly: 6.689 ± 2.464
1.115LysHis: 1.115 ± 0.751
1.115LysIle: 1.115 ± 0.967
7.804LysLys: 7.804 ± 4.108
2.23LysLeu: 2.23 ± 0.88
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
3.344LysPro: 3.344 ± 0.316
2.23LysGln: 2.23 ± 1.934
3.344LysArg: 3.344 ± 1.232
3.344LysSer: 3.344 ± 0.316
4.459LysThr: 4.459 ± 3.002
2.23LysVal: 2.23 ± 1.501
2.23LysTrp: 2.23 ± 0.88
1.115LysTyr: 1.115 ± 0.967
0.0LysXaa: 0.0 ± 0.0
Leu
6.689LeuAla: 6.689 ± 0.632
3.344LeuCys: 3.344 ± 1.837
5.574LeuAsp: 5.574 ± 2.48
6.689LeuGlu: 6.689 ± 4.508
0.0LeuPhe: 0.0 ± 0.0
6.689LeuGly: 6.689 ± 0.632
1.115LeuHis: 1.115 ± 1.009
2.23LeuIle: 2.23 ± 1.501
1.115LeuLys: 1.115 ± 0.967
4.459LeuLeu: 4.459 ± 2.132
1.115LeuMet: 1.115 ± 0.76
4.459LeuAsn: 4.459 ± 1.208
4.459LeuPro: 4.459 ± 2.643
0.0LeuGln: 0.0 ± 0.0
5.574LeuArg: 5.574 ± 2.203
4.459LeuSer: 4.459 ± 1.761
8.919LeuThr: 8.919 ± 1.952
3.344LeuVal: 3.344 ± 1.32
1.115LeuTrp: 1.115 ± 0.967
2.23LeuTyr: 2.23 ± 0.88
0.0LeuXaa: 0.0 ± 0.0
Met
2.23MetAla: 2.23 ± 2.018
1.115MetCys: 1.115 ± 0.751
0.0MetAsp: 0.0 ± 0.0
1.115MetGlu: 1.115 ± 1.009
0.0MetPhe: 0.0 ± 0.0
1.115MetGly: 1.115 ± 0.751
1.115MetHis: 1.115 ± 1.009
3.344MetIle: 3.344 ± 2.252
1.115MetLys: 1.115 ± 0.751
2.23MetLeu: 2.23 ± 1.501
0.0MetMet: 0.0 ± 0.0
3.344MetAsn: 3.344 ± 1.32
2.23MetPro: 2.23 ± 1.934
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.115MetSer: 1.115 ± 0.967
3.344MetThr: 3.344 ± 1.69
1.115MetVal: 1.115 ± 0.967
0.0MetTrp: 0.0 ± 0.0
1.115MetTyr: 1.115 ± 0.751
0.0MetXaa: 0.0 ± 0.0
Asn
4.459AsnAla: 4.459 ± 0.435
1.115AsnCys: 1.115 ± 0.751
3.344AsnAsp: 3.344 ± 1.232
1.115AsnGlu: 1.115 ± 0.751
1.115AsnPhe: 1.115 ± 0.967
1.115AsnGly: 1.115 ± 1.009
0.0AsnHis: 0.0 ± 0.0
1.115AsnIle: 1.115 ± 1.009
1.115AsnLys: 1.115 ± 0.751
4.459AsnLeu: 4.459 ± 1.208
1.115AsnMet: 1.115 ± 0.967
2.23AsnAsn: 2.23 ± 1.501
1.115AsnPro: 1.115 ± 0.751
1.115AsnGln: 1.115 ± 0.751
1.115AsnArg: 1.115 ± 0.751
3.344AsnSer: 3.344 ± 1.69
4.459AsnThr: 4.459 ± 1.86
5.574AsnVal: 5.574 ± 0.82
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.23ProAla: 2.23 ± 1.066
1.115ProCys: 1.115 ± 0.967
1.115ProAsp: 1.115 ± 0.967
2.23ProGlu: 2.23 ± 1.934
1.115ProPhe: 1.115 ± 1.009
1.115ProGly: 1.115 ± 0.967
2.23ProHis: 2.23 ± 1.066
3.344ProIle: 3.344 ± 1.32
2.23ProLys: 2.23 ± 1.934
6.689ProLeu: 6.689 ± 1.773
1.115ProMet: 1.115 ± 0.751
1.115ProAsn: 1.115 ± 1.009
5.574ProPro: 5.574 ± 2.755
0.0ProGln: 0.0 ± 0.0
4.459ProArg: 4.459 ± 2.132
8.919ProSer: 8.919 ± 6.429
3.344ProThr: 3.344 ± 1.32
6.689ProVal: 6.689 ± 2.118
0.0ProTrp: 0.0 ± 0.0
2.23ProTyr: 2.23 ± 0.839
0.0ProXaa: 0.0 ± 0.0
Gln
5.574GlnAla: 5.574 ± 0.82
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.115GlnGlu: 1.115 ± 0.967
1.115GlnPhe: 1.115 ± 1.009
4.459GlnGly: 4.459 ± 1.86
0.0GlnHis: 0.0 ± 0.0
1.115GlnIle: 1.115 ± 0.751
0.0GlnLys: 0.0 ± 0.0
5.574GlnLeu: 5.574 ± 1.186
0.0GlnMet: 0.0 ± 0.0
1.115GlnAsn: 1.115 ± 0.967
1.115GlnPro: 1.115 ± 0.967
5.574GlnGln: 5.574 ± 3.753
3.344GlnArg: 3.344 ± 1.232
4.459GlnSer: 4.459 ± 1.169
3.344GlnThr: 3.344 ± 1.32
2.23GlnVal: 2.23 ± 1.501
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.344ArgAla: 3.344 ± 3.026
0.0ArgCys: 0.0 ± 0.0
1.115ArgAsp: 1.115 ± 1.009
1.115ArgGlu: 1.115 ± 0.967
2.23ArgPhe: 2.23 ± 1.501
5.574ArgGly: 5.574 ± 1.97
0.0ArgHis: 0.0 ± 0.0
2.23ArgIle: 2.23 ± 1.066
2.23ArgLys: 2.23 ± 0.88
4.459ArgLeu: 4.459 ± 1.169
0.0ArgMet: 0.0 ± 0.0
3.344ArgAsn: 3.344 ± 1.697
2.23ArgPro: 2.23 ± 1.066
2.23ArgGln: 2.23 ± 0.839
6.689ArgArg: 6.689 ± 2.118
8.919ArgSer: 8.919 ± 2.337
7.804ArgThr: 7.804 ± 1.629
8.919ArgVal: 8.919 ± 0.917
1.115ArgTrp: 1.115 ± 1.009
1.115ArgTyr: 1.115 ± 1.009
0.0ArgXaa: 0.0 ± 0.0
Ser
7.804SerAla: 7.804 ± 1.707
0.0SerCys: 0.0 ± 0.0
5.574SerAsp: 5.574 ± 1.186
5.574SerGlu: 5.574 ± 1.382
1.115SerPhe: 1.115 ± 0.751
8.919SerGly: 8.919 ± 1.952
2.23SerHis: 2.23 ± 1.066
2.23SerIle: 2.23 ± 0.88
4.459SerLys: 4.459 ± 2.765
4.459SerLeu: 4.459 ± 1.169
2.23SerMet: 2.23 ± 1.934
6.689SerAsn: 6.689 ± 1.107
8.919SerPro: 8.919 ± 5.219
3.344SerGln: 3.344 ± 1.32
5.574SerArg: 5.574 ± 1.382
11.148SerSer: 11.148 ± 4.244
6.689SerThr: 6.689 ± 1.773
4.459SerVal: 4.459 ± 2.643
2.23SerTrp: 2.23 ± 0.88
3.344SerTyr: 3.344 ± 0.316
0.0SerXaa: 0.0 ± 0.0
Thr
8.919ThrAla: 8.919 ± 3.437
1.115ThrCys: 1.115 ± 1.009
2.23ThrAsp: 2.23 ± 1.501
0.0ThrGlu: 0.0 ± 0.0
2.23ThrPhe: 2.23 ± 0.88
6.689ThrGly: 6.689 ± 0.632
4.459ThrHis: 4.459 ± 0.435
7.804ThrIle: 7.804 ± 1.687
6.689ThrLys: 6.689 ± 1.936
5.574ThrLeu: 5.574 ± 2.755
2.23ThrMet: 2.23 ± 0.88
0.0ThrAsn: 0.0 ± 0.0
2.23ThrPro: 2.23 ± 2.018
5.574ThrGln: 5.574 ± 1.186
5.574ThrArg: 5.574 ± 1.186
4.459ThrSer: 4.459 ± 1.169
4.459ThrThr: 4.459 ± 1.958
4.459ThrVal: 4.459 ± 1.86
2.23ThrTrp: 2.23 ± 1.934
3.344ThrTyr: 3.344 ± 1.32
0.0ThrXaa: 0.0 ± 0.0
Val
7.804ValAla: 7.804 ± 3.064
1.115ValCys: 1.115 ± 0.751
7.804ValAsp: 7.804 ± 4.005
2.23ValGlu: 2.23 ± 1.066
3.344ValPhe: 3.344 ± 1.768
7.804ValGly: 7.804 ± 2.687
1.115ValHis: 1.115 ± 0.751
4.459ValIle: 4.459 ± 0.435
1.115ValLys: 1.115 ± 0.751
4.459ValLeu: 4.459 ± 2.643
1.115ValMet: 1.115 ± 0.751
3.344ValAsn: 3.344 ± 0.316
2.23ValPro: 2.23 ± 1.501
2.23ValGln: 2.23 ± 2.018
4.459ValArg: 4.459 ± 0.435
3.344ValSer: 3.344 ± 1.697
2.23ValThr: 2.23 ± 0.88
7.804ValVal: 7.804 ± 1.687
3.344ValTrp: 3.344 ± 1.837
1.115ValTyr: 1.115 ± 0.751
0.0ValXaa: 0.0 ± 0.0
Trp
1.115TrpAla: 1.115 ± 0.751
1.115TrpCys: 1.115 ± 1.009
2.23TrpAsp: 2.23 ± 2.018
1.115TrpGlu: 1.115 ± 1.009
0.0TrpPhe: 0.0 ± 0.0
1.115TrpGly: 1.115 ± 1.009
0.0TrpHis: 0.0 ± 0.0
3.344TrpIle: 3.344 ± 1.697
2.23TrpLys: 2.23 ± 1.066
2.23TrpLeu: 2.23 ± 2.018
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
2.23TrpPro: 2.23 ± 1.934
2.23TrpGln: 2.23 ± 1.066
1.115TrpArg: 1.115 ± 0.967
2.23TrpSer: 2.23 ± 0.88
1.115TrpThr: 1.115 ± 0.967
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.115TrpTyr: 1.115 ± 1.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.115TyrAla: 1.115 ± 0.751
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
0.0TyrPhe: 0.0 ± 0.0
1.115TyrGly: 1.115 ± 0.751
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
1.115TyrLys: 1.115 ± 0.967
4.459TyrLeu: 4.459 ± 1.208
1.115TyrMet: 1.115 ± 0.751
2.23TyrAsn: 2.23 ± 0.839
2.23TyrPro: 2.23 ± 1.066
2.23TyrGln: 2.23 ± 1.501
2.23TyrArg: 2.23 ± 0.839
3.344TyrSer: 3.344 ± 1.837
2.23TyrThr: 2.23 ± 1.501
4.459TyrVal: 4.459 ± 1.86
1.115TyrTrp: 1.115 ± 1.009
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski