Amino acid dipepetide frequency for Panagrellus redivivus (Microworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.299AlaAla: 7.299 ± 0.054	1.218AlaCys: 1.218 ± 0.012	4.022AlaAsp: 4.022 ± 0.029	4.737AlaGlu: 4.737 ± 0.054	3.273AlaPhe: 3.273 ± 0.022	3.86AlaGly: 3.86 ± 0.03	1.516AlaHis: 1.516 ± 0.014	4.248AlaIle: 4.248 ± 0.023	4.311AlaLys: 4.311 ± 0.038	6.25AlaLeu: 6.25 ± 0.032	1.808AlaMet: 1.808 ± 0.014	3.315AlaAsn: 3.315 ± 0.023	4.662AlaPro: 4.662 ± 0.043	2.626AlaGln: 2.626 ± 0.021	3.416AlaArg: 3.416 ± 0.023	6.195AlaSer: 6.195 ± 0.04	4.954AlaThr: 4.954 ± 0.043	5.342AlaVal: 5.342 ± 0.027	0.662AlaTrp: 0.662 ± 0.008	2.065AlaTyr: 2.065 ± 0.016	0.033AlaXaa: 0.033 ± 0.002
Cys	1.306CysAla: 1.306 ± 0.016	0.59CysCys: 0.59 ± 0.014	1.096CysAsp: 1.096 ± 0.013	1.0CysGlu: 1.0 ± 0.013	0.995CysPhe: 0.995 ± 0.01	1.224CysGly: 1.224 ± 0.015	0.535CysHis: 0.535 ± 0.009	1.103CysIle: 1.103 ± 0.012	0.959CysLys: 0.959 ± 0.011	1.703CysLeu: 1.703 ± 0.015	0.423CysMet: 0.423 ± 0.007	0.919CysAsn: 0.919 ± 0.012	1.196CysPro: 1.196 ± 0.019	0.788CysGln: 0.788 ± 0.013	1.169CysArg: 1.169 ± 0.013	1.352CysSer: 1.352 ± 0.015	1.042CysThr: 1.042 ± 0.012	1.293CysVal: 1.293 ± 0.013	0.208CysTrp: 0.208 ± 0.004	0.678CysTyr: 0.678 ± 0.011	0.007CysXaa: 0.007 ± 0.001
Asp	4.364AspAla: 4.364 ± 0.035	0.999AspCys: 0.999 ± 0.012	4.44AspAsp: 4.44 ± 0.036	4.247AspGlu: 4.247 ± 0.029	2.653AspPhe: 2.653 ± 0.019	3.526AspGly: 3.526 ± 0.026	1.223AspHis: 1.223 ± 0.013	2.989AspIle: 2.989 ± 0.018	2.854AspLys: 2.854 ± 0.027	4.48AspLeu: 4.48 ± 0.025	1.158AspMet: 1.158 ± 0.011	2.461AspAsn: 2.461 ± 0.017	2.785AspPro: 2.785 ± 0.019	1.663AspGln: 1.663 ± 0.014	2.699AspArg: 2.699 ± 0.022	4.002AspSer: 4.002 ± 0.026	2.788AspThr: 2.788 ± 0.018	3.918AspVal: 3.918 ± 0.021	0.607AspTrp: 0.607 ± 0.008	1.967AspTyr: 1.967 ± 0.013	0.013AspXaa: 0.013 ± 0.001
Glu	4.919GluAla: 4.919 ± 0.05	1.037GluCys: 1.037 ± 0.013	3.41GluAsp: 3.41 ± 0.026	4.354GluGlu: 4.354 ± 0.048	2.333GluPhe: 2.333 ± 0.016	2.635GluGly: 2.635 ± 0.02	1.404GluHis: 1.404 ± 0.016	3.218GluIle: 3.218 ± 0.021	4.084GluLys: 4.084 ± 0.038	5.102GluLeu: 5.102 ± 0.036	1.394GluMet: 1.394 ± 0.013	2.895GluAsn: 2.895 ± 0.019	2.861GluPro: 2.861 ± 0.027	2.147GluGln: 2.147 ± 0.019	3.29GluArg: 3.29 ± 0.026	4.238GluSer: 4.238 ± 0.036	3.542GluThr: 3.542 ± 0.029	3.776GluVal: 3.776 ± 0.028	0.583GluTrp: 0.583 ± 0.008	1.787GluTyr: 1.787 ± 0.015	0.012GluXaa: 0.012 ± 0.001
Phe	3.249PheAla: 3.249 ± 0.021	1.029PheCys: 1.029 ± 0.011	2.954PheAsp: 2.954 ± 0.02	2.706PheGlu: 2.706 ± 0.018	2.155PhePhe: 2.155 ± 0.02	2.926PheGly: 2.926 ± 0.02	1.079PheHis: 1.079 ± 0.01	2.561PheIle: 2.561 ± 0.02	2.282PheLys: 2.282 ± 0.019	3.844PheLeu: 3.844 ± 0.028	1.017PheMet: 1.017 ± 0.011	2.176PheAsn: 2.176 ± 0.016	1.939PhePro: 1.939 ± 0.016	1.433PheGln: 1.433 ± 0.013	2.191PheArg: 2.191 ± 0.015	2.977PheSer: 2.977 ± 0.02	2.594PheThr: 2.594 ± 0.016	3.294PheVal: 3.294 ± 0.022	0.539PheTrp: 0.539 ± 0.009	1.57PheTyr: 1.57 ± 0.018	0.013PheXaa: 0.013 ± 0.001
Gly	3.633GlyAla: 3.633 ± 0.029	1.093GlyCys: 1.093 ± 0.014	2.897GlyAsp: 2.897 ± 0.021	2.703GlyGlu: 2.703 ± 0.023	2.764GlyPhe: 2.764 ± 0.022	4.045GlyGly: 4.045 ± 0.051	1.39GlyHis: 1.39 ± 0.015	3.158GlyIle: 3.158 ± 0.024	2.918GlyLys: 2.918 ± 0.02	4.26GlyLeu: 4.26 ± 0.03	1.221GlyMet: 1.221 ± 0.013	2.643GlyAsn: 2.643 ± 0.023	2.604GlyPro: 2.604 ± 0.033	2.034GlyGln: 2.034 ± 0.022	2.94GlyArg: 2.94 ± 0.021	4.409GlySer: 4.409 ± 0.033	3.337GlyThr: 3.337 ± 0.026	3.351GlyVal: 3.351 ± 0.02	0.612GlyTrp: 0.612 ± 0.008	2.053GlyTyr: 2.053 ± 0.018	0.016GlyXaa: 0.016 ± 0.001
His	1.565HisAla: 1.565 ± 0.014	0.6HisCys: 0.6 ± 0.009	1.271HisAsp: 1.271 ± 0.012	1.312HisGlu: 1.312 ± 0.011	1.215HisPhe: 1.215 ± 0.014	1.497HisGly: 1.497 ± 0.017	0.899HisHis: 0.899 ± 0.019	1.244HisIle: 1.244 ± 0.013	1.11HisLys: 1.11 ± 0.012	2.163HisLeu: 2.163 ± 0.017	0.521HisMet: 0.521 ± 0.008	1.024HisAsn: 1.024 ± 0.01	1.406HisPro: 1.406 ± 0.012	0.964HisGln: 0.964 ± 0.011	1.611HisArg: 1.611 ± 0.016	1.688HisSer: 1.688 ± 0.014	1.15HisThr: 1.15 ± 0.011	1.606HisVal: 1.606 ± 0.015	0.294HisTrp: 0.294 ± 0.006	0.841HisTyr: 0.841 ± 0.01	0.006HisXaa: 0.006 ± 0.001
Ile	4.265IleAla: 4.265 ± 0.023	1.236IleCys: 1.236 ± 0.013	3.519IleAsp: 3.519 ± 0.022	3.377IleGlu: 3.377 ± 0.021	2.403IlePhe: 2.403 ± 0.022	3.068IleGly: 3.068 ± 0.019	1.339IleHis: 1.339 ± 0.014	3.106IleIle: 3.106 ± 0.021	2.807IleLys: 2.807 ± 0.021	4.586IleLeu: 4.586 ± 0.028	1.193IleMet: 1.193 ± 0.011	2.513IleAsn: 2.513 ± 0.017	2.931IlePro: 2.931 ± 0.019	2.018IleGln: 2.018 ± 0.016	2.979IleArg: 2.979 ± 0.022	3.915IleSer: 3.915 ± 0.021	3.297IleThr: 3.297 ± 0.023	4.126IleVal: 4.126 ± 0.023	0.572IleTrp: 0.572 ± 0.008	1.684IleTyr: 1.684 ± 0.016	0.012IleXaa: 0.012 ± 0.001
Lys	4.214LysAla: 4.214 ± 0.039	1.135LysCys: 1.135 ± 0.015	2.913LysAsp: 2.913 ± 0.025	3.37LysGlu: 3.37 ± 0.03	2.229LysPhe: 2.229 ± 0.015	2.318LysGly: 2.318 ± 0.021	1.441LysHis: 1.441 ± 0.014	2.846LysIle: 2.846 ± 0.018	4.642LysLys: 4.642 ± 0.063	5.227LysLeu: 5.227 ± 0.03	1.37LysMet: 1.37 ± 0.013	2.598LysAsn: 2.598 ± 0.019	3.433LysPro: 3.433 ± 0.035	2.227LysGln: 2.227 ± 0.016	3.513LysArg: 3.513 ± 0.023	4.103LysSer: 4.103 ± 0.028	3.709LysThr: 3.709 ± 0.024	3.402LysVal: 3.402 ± 0.021	0.595LysTrp: 0.595 ± 0.008	1.824LysTyr: 1.824 ± 0.016	0.016LysXaa: 0.016 ± 0.001
Leu	6.277LeuAla: 6.277 ± 0.031	1.713LeuCys: 1.713 ± 0.016	4.374LeuAsp: 4.374 ± 0.024	4.785LeuGlu: 4.785 ± 0.034	3.898LeuPhe: 3.898 ± 0.025	3.974LeuGly: 3.974 ± 0.022	2.15LeuHis: 2.15 ± 0.018	4.854LeuIle: 4.854 ± 0.027	5.203LeuLys: 5.203 ± 0.028	7.859LeuLeu: 7.859 ± 0.043	1.99LeuMet: 1.99 ± 0.017	4.076LeuAsn: 4.076 ± 0.023	5.074LeuPro: 5.074 ± 0.028	3.487LeuGln: 3.487 ± 0.022	5.026LeuArg: 5.026 ± 0.028	6.318LeuSer: 6.318 ± 0.032	5.186LeuThr: 5.186 ± 0.025	5.054LeuVal: 5.054 ± 0.03	0.847LeuTrp: 0.847 ± 0.009	2.546LeuTyr: 2.546 ± 0.019	0.03LeuXaa: 0.03 ± 0.002
Met	1.916MetAla: 1.916 ± 0.014	0.402MetCys: 0.402 ± 0.007	1.208MetAsp: 1.208 ± 0.012	1.29MetGlu: 1.29 ± 0.014	1.053MetPhe: 1.053 ± 0.011	1.037MetGly: 1.037 ± 0.011	0.559MetHis: 0.559 ± 0.008	1.203MetIle: 1.203 ± 0.012	1.306MetLys: 1.306 ± 0.013	2.084MetLeu: 2.084 ± 0.016	0.672MetMet: 0.672 ± 0.01	1.103MetAsn: 1.103 ± 0.012	1.552MetPro: 1.552 ± 0.015	0.874MetGln: 0.874 ± 0.011	1.251MetArg: 1.251 ± 0.012	1.931MetSer: 1.931 ± 0.013	1.503MetThr: 1.503 ± 0.013	1.329MetVal: 1.329 ± 0.012	0.206MetTrp: 0.206 ± 0.005	0.68MetTyr: 0.68 ± 0.009	0.005MetXaa: 0.005 ± 0.001
Asn	3.664AsnAla: 3.664 ± 0.021	0.942AsnCys: 0.942 ± 0.01	2.718AsnAsp: 2.718 ± 0.018	2.711AsnGlu: 2.711 ± 0.018	2.146AsnPhe: 2.146 ± 0.016	3.416AsnGly: 3.416 ± 0.028	1.079AsnHis: 1.079 ± 0.012	2.463AsnIle: 2.463 ± 0.019	2.207AsnLys: 2.207 ± 0.016	3.891AsnLeu: 3.891 ± 0.021	1.059AsnMet: 1.059 ± 0.012	2.447AsnAsn: 2.447 ± 0.02	2.563AsnPro: 2.563 ± 0.021	1.662AsnGln: 1.662 ± 0.017	2.437AsnArg: 2.437 ± 0.017	3.289AsnSer: 3.289 ± 0.021	2.533AsnThr: 2.533 ± 0.017	3.419AsnVal: 3.419 ± 0.021	0.491AsnTrp: 0.491 ± 0.007	1.535AsnTyr: 1.535 ± 0.015	0.01AsnXaa: 0.01 ± 0.001
Pro	4.577ProAla: 4.577 ± 0.036	0.794ProCys: 0.794 ± 0.012	2.748ProAsp: 2.748 ± 0.02	3.687ProGlu: 3.687 ± 0.028	2.156ProPhe: 2.156 ± 0.016	3.04ProGly: 3.04 ± 0.066	1.151ProHis: 1.151 ± 0.013	2.929ProIle: 2.929 ± 0.019	3.393ProLys: 3.393 ± 0.024	4.229ProLeu: 4.229 ± 0.024	1.331ProMet: 1.331 ± 0.015	2.503ProAsn: 2.503 ± 0.019	5.209ProPro: 5.209 ± 0.058	2.297ProGln: 2.297 ± 0.027	2.853ProArg: 2.853 ± 0.021	5.292ProSer: 5.292 ± 0.032	4.075ProThr: 4.075 ± 0.029	3.853ProVal: 3.853 ± 0.025	0.493ProTrp: 0.493 ± 0.008	1.631ProTyr: 1.631 ± 0.013	0.027ProXaa: 0.027 ± 0.002
Gln	2.57GlnAla: 2.57 ± 0.022	0.818GlnCys: 0.818 ± 0.014	1.326GlnAsp: 1.326 ± 0.012	1.703GlnGlu: 1.703 ± 0.018	1.617GlnPhe: 1.617 ± 0.013	1.56GlnGly: 1.56 ± 0.018	1.041GlnHis: 1.041 ± 0.013	2.079GlnIle: 2.079 ± 0.015	2.31GlnLys: 2.31 ± 0.02	3.661GlnLeu: 3.661 ± 0.025	1.055GlnMet: 1.055 ± 0.014	1.913GlnAsn: 1.913 ± 0.016	2.449GlnPro: 2.449 ± 0.029	2.556GlnGln: 2.556 ± 0.051	2.377GlnArg: 2.377 ± 0.018	2.706GlnSer: 2.706 ± 0.019	2.195GlnThr: 2.195 ± 0.016	2.093GlnVal: 2.093 ± 0.016	0.443GlnTrp: 0.443 ± 0.008	1.242GlnTyr: 1.242 ± 0.012	0.011GlnXaa: 0.011 ± 0.001
Arg	3.418ArgAla: 3.418 ± 0.02	1.143ArgCys: 1.143 ± 0.011	2.642ArgAsp: 2.642 ± 0.02	2.983ArgGlu: 2.983 ± 0.027	2.485ArgPhe: 2.485 ± 0.018	2.616ArgGly: 2.616 ± 0.024	1.6ArgHis: 1.6 ± 0.013	3.05ArgIle: 3.05 ± 0.018	3.441ArgLys: 3.441 ± 0.023	4.918ArgLeu: 4.918 ± 0.027	1.259ArgMet: 1.259 ± 0.013	2.602ArgAsn: 2.602 ± 0.019	2.938ArgPro: 2.938 ± 0.022	2.473ArgGln: 2.473 ± 0.019	4.691ArgArg: 4.691 ± 0.033	4.088ArgSer: 4.088 ± 0.028	2.82ArgThr: 2.82 ± 0.02	3.14ArgVal: 3.14 ± 0.024	0.577ArgTrp: 0.577 ± 0.008	1.775ArgTyr: 1.775 ± 0.014	0.024ArgXaa: 0.024 ± 0.002
Ser	5.733SerAla: 5.733 ± 0.035	1.32SerCys: 1.32 ± 0.013	4.427SerAsp: 4.427 ± 0.034	4.283SerGlu: 4.283 ± 0.035	3.158SerPhe: 3.158 ± 0.022	4.384SerGly: 4.384 ± 0.027	1.623SerHis: 1.623 ± 0.013	4.138SerIle: 4.138 ± 0.025	4.247SerLys: 4.247 ± 0.034	6.027SerLeu: 6.027 ± 0.031	1.786SerMet: 1.786 ± 0.015	3.689SerAsn: 3.689 ± 0.021	4.546SerPro: 4.546 ± 0.034	2.601SerGln: 2.601 ± 0.021	3.964SerArg: 3.964 ± 0.025	7.793SerSer: 7.793 ± 0.06	5.837SerThr: 5.837 ± 0.046	5.03SerVal: 5.03 ± 0.028	0.711SerTrp: 0.711 ± 0.01	2.009SerTyr: 2.009 ± 0.013	0.031SerXaa: 0.031 ± 0.002
Thr	4.926ThrAla: 4.926 ± 0.032	1.206ThrCys: 1.206 ± 0.017	3.366ThrAsp: 3.366 ± 0.022	3.426ThrGlu: 3.426 ± 0.032	2.688ThrPhe: 2.688 ± 0.018	3.189ThrGly: 3.189 ± 0.027	1.25ThrHis: 1.25 ± 0.012	3.457ThrIle: 3.457 ± 0.019	3.138ThrLys: 3.138 ± 0.02	5.081ThrLeu: 5.081 ± 0.021	1.366ThrMet: 1.366 ± 0.012	2.625ThrAsn: 2.625 ± 0.016	4.238ThrPro: 4.238 ± 0.034	1.919ThrGln: 1.919 ± 0.017	2.697ThrArg: 2.697 ± 0.021	5.305ThrSer: 5.305 ± 0.035	5.549ThrThr: 5.549 ± 0.093	4.802ThrVal: 4.802 ± 0.028	0.616ThrTrp: 0.616 ± 0.007	1.697ThrTyr: 1.697 ± 0.016	0.025ThrXaa: 0.025 ± 0.002
Val	5.094ValAla: 5.094 ± 0.027	1.327ValCys: 1.327 ± 0.015	4.012ValAsp: 4.012 ± 0.021	4.102ValGlu: 4.102 ± 0.029	3.229ValPhe: 3.229 ± 0.023	3.212ValGly: 3.212 ± 0.019	1.578ValHis: 1.578 ± 0.014	3.944ValIle: 3.944 ± 0.023	3.739ValLys: 3.739 ± 0.02	5.613ValLeu: 5.613 ± 0.028	1.493ValMet: 1.493 ± 0.013	3.1ValAsn: 3.1 ± 0.017	3.813ValPro: 3.813 ± 0.023	2.353ValGln: 2.353 ± 0.016	3.139ValArg: 3.139 ± 0.022	4.865ValSer: 4.865 ± 0.029	4.081ValThr: 4.081 ± 0.025	5.006ValVal: 5.006 ± 0.027	0.616ValTrp: 0.616 ± 0.009	2.119ValTyr: 2.119 ± 0.016	0.025ValXaa: 0.025 ± 0.002
Trp	0.629TrpAla: 0.629 ± 0.008	0.195TrpCys: 0.195 ± 0.004	0.503TrpAsp: 0.503 ± 0.009	0.474TrpGlu: 0.474 ± 0.006	0.474TrpPhe: 0.474 ± 0.008	0.457TrpGly: 0.457 ± 0.008	0.306TrpHis: 0.306 ± 0.006	0.648TrpIle: 0.648 ± 0.009	0.639TrpLys: 0.639 ± 0.009	1.012TrpLeu: 1.012 ± 0.012	0.326TrpMet: 0.326 ± 0.006	0.533TrpAsn: 0.533 ± 0.008	0.49TrpPro: 0.49 ± 0.007	0.443TrpGln: 0.443 ± 0.008	0.641TrpArg: 0.641 ± 0.009	0.735TrpSer: 0.735 ± 0.01	0.651TrpThr: 0.651 ± 0.008	0.545TrpVal: 0.545 ± 0.008	0.152TrpTrp: 0.152 ± 0.004	0.344TrpTyr: 0.344 ± 0.007	0.003TrpXaa: 0.003 ± 0.001
Tyr	2.171TyrAla: 2.171 ± 0.016	0.777TyrCys: 0.777 ± 0.011	1.974TyrAsp: 1.974 ± 0.014	1.758TyrGlu: 1.758 ± 0.015	1.589TyrPhe: 1.589 ± 0.015	2.08TyrGly: 2.08 ± 0.019	0.814TyrHis: 0.814 ± 0.009	1.692TyrIle: 1.692 ± 0.015	1.522TyrLys: 1.522 ± 0.015	2.702TyrLeu: 2.702 ± 0.019	0.713TyrMet: 0.713 ± 0.008	1.531TyrAsn: 1.531 ± 0.013	1.558TyrPro: 1.558 ± 0.016	1.151TyrGln: 1.151 ± 0.012	1.774TyrArg: 1.774 ± 0.015	2.106TyrSer: 2.106 ± 0.017	1.704TyrThr: 1.704 ± 0.014	2.063TyrVal: 2.063 ± 0.016	0.372TyrTrp: 0.372 ± 0.007	1.324TyrTyr: 1.324 ± 0.013	0.007TyrXaa: 0.007 ± 0.001
Xaa	0.021XaaAla: 0.021 ± 0.002	0.009XaaCys: 0.009 ± 0.001	0.014XaaAsp: 0.014 ± 0.001	0.014XaaGlu: 0.014 ± 0.001	0.015XaaPhe: 0.015 ± 0.001	0.019XaaGly: 0.019 ± 0.001	0.01XaaHis: 0.01 ± 0.001	0.016XaaIle: 0.016 ± 0.001	0.015XaaLys: 0.015 ± 0.001	0.028XaaLeu: 0.028 ± 0.002	0.011XaaMet: 0.011 ± 0.001	0.014XaaAsn: 0.014 ± 0.001	0.022XaaPro: 0.022 ± 0.002	0.01XaaGln: 0.01 ± 0.001	0.027XaaArg: 0.027 ± 0.002	0.028XaaSer: 0.028 ± 0.002	0.02XaaThr: 0.02 ± 0.001	0.018XaaVal: 0.018 ± 0.001	0.003XaaTrp: 0.003 ± 0.001	0.009XaaTyr: 0.009 ± 0.001	1.571XaaXaa: 1.571 ± 0.074

Statistics based on 26326 proteins (10071718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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