Amino acid dipepetide frequency for Mycobacterium virus Astro

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.51AlaAla: 10.51 ± 1.072
0.855AlaCys: 0.855 ± 0.211
6.171AlaAsp: 6.171 ± 0.693
7.943AlaGlu: 7.943 ± 0.831
3.544AlaPhe: 3.544 ± 0.512
7.332AlaGly: 7.332 ± 0.81
1.466AlaHis: 1.466 ± 0.233
3.788AlaIle: 3.788 ± 0.491
4.888AlaLys: 4.888 ± 0.889
8.615AlaLeu: 8.615 ± 0.871
2.566AlaMet: 2.566 ± 0.479
3.3AlaAsn: 3.3 ± 0.469
3.788AlaPro: 3.788 ± 0.511
2.994AlaGln: 2.994 ± 0.586
5.194AlaArg: 5.194 ± 0.567
4.949AlaSer: 4.949 ± 0.579
5.988AlaThr: 5.988 ± 0.543
5.316AlaVal: 5.316 ± 0.67
1.711AlaTrp: 1.711 ± 0.277
2.383AlaTyr: 2.383 ± 0.399
0.0AlaXaa: 0.0 ± 0.0
Cys
0.611CysAla: 0.611 ± 0.173
0.244CysCys: 0.244 ± 0.134
0.672CysAsp: 0.672 ± 0.21
0.306CysGlu: 0.306 ± 0.144
0.244CysPhe: 0.244 ± 0.115
1.161CysGly: 1.161 ± 0.306
0.367CysHis: 0.367 ± 0.155
0.367CysIle: 0.367 ± 0.2
0.244CysLys: 0.244 ± 0.119
0.611CysLeu: 0.611 ± 0.205
0.183CysMet: 0.183 ± 0.097
0.489CysAsn: 0.489 ± 0.158
0.489CysPro: 0.489 ± 0.162
0.367CysGln: 0.367 ± 0.144
0.489CysArg: 0.489 ± 0.169
0.489CysSer: 0.489 ± 0.157
0.55CysThr: 0.55 ± 0.211
0.794CysVal: 0.794 ± 0.226
0.244CysTrp: 0.244 ± 0.112
0.428CysTyr: 0.428 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
5.805AspAla: 5.805 ± 0.682
1.1AspCys: 1.1 ± 0.309
4.277AspAsp: 4.277 ± 0.621
5.683AspGlu: 5.683 ± 0.551
2.444AspPhe: 2.444 ± 0.384
5.927AspGly: 5.927 ± 0.515
1.955AspHis: 1.955 ± 0.363
3.483AspIle: 3.483 ± 0.463
3.422AspLys: 3.422 ± 0.459
6.782AspLeu: 6.782 ± 0.78
1.833AspMet: 1.833 ± 0.344
1.711AspAsn: 1.711 ± 0.288
4.644AspPro: 4.644 ± 0.656
2.139AspGln: 2.139 ± 0.303
3.238AspArg: 3.238 ± 0.519
3.605AspSer: 3.605 ± 0.465
2.994AspThr: 2.994 ± 0.369
3.972AspVal: 3.972 ± 0.405
1.528AspTrp: 1.528 ± 0.362
3.3AspTyr: 3.3 ± 0.463
0.0AspXaa: 0.0 ± 0.0
Glu
7.577GluAla: 7.577 ± 0.836
0.794GluCys: 0.794 ± 0.198
5.805GluAsp: 5.805 ± 0.703
5.316GluGlu: 5.316 ± 0.682
2.383GluPhe: 2.383 ± 0.372
5.683GluGly: 5.683 ± 0.671
1.039GluHis: 1.039 ± 0.242
4.888GluIle: 4.888 ± 0.572
2.75GluLys: 2.75 ± 0.537
7.149GluLeu: 7.149 ± 0.624
1.833GluMet: 1.833 ± 0.424
1.711GluAsn: 1.711 ± 0.316
3.361GluPro: 3.361 ± 0.412
2.994GluGln: 2.994 ± 0.395
4.583GluArg: 4.583 ± 0.535
3.116GluSer: 3.116 ± 0.399
4.033GluThr: 4.033 ± 0.471
4.949GluVal: 4.949 ± 0.476
1.405GluTrp: 1.405 ± 0.299
2.016GluTyr: 2.016 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
3.116PheAla: 3.116 ± 0.384
0.183PheCys: 0.183 ± 0.09
3.055PheAsp: 3.055 ± 0.5
2.322PheGlu: 2.322 ± 0.349
0.733PhePhe: 0.733 ± 0.194
2.75PheGly: 2.75 ± 0.376
0.611PheHis: 0.611 ± 0.17
1.528PheIle: 1.528 ± 0.292
1.65PheLys: 1.65 ± 0.271
2.933PheLeu: 2.933 ± 0.605
0.672PheMet: 0.672 ± 0.168
1.466PheAsn: 1.466 ± 0.299
1.466PhePro: 1.466 ± 0.312
1.283PheGln: 1.283 ± 0.273
1.528PheArg: 1.528 ± 0.328
1.589PheSer: 1.589 ± 0.255
2.077PheThr: 2.077 ± 0.361
2.75PheVal: 2.75 ± 0.41
1.039PheTrp: 1.039 ± 0.264
1.039PheTyr: 1.039 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
6.294GlyAla: 6.294 ± 0.882
0.917GlyCys: 0.917 ± 0.252
5.988GlyAsp: 5.988 ± 0.638
5.866GlyGlu: 5.866 ± 0.801
2.933GlyPhe: 2.933 ± 0.452
7.699GlyGly: 7.699 ± 1.09
1.711GlyHis: 1.711 ± 0.305
4.277GlyIle: 4.277 ± 0.428
3.727GlyLys: 3.727 ± 0.636
7.516GlyLeu: 7.516 ± 0.961
1.772GlyMet: 1.772 ± 0.254
2.872GlyAsn: 2.872 ± 0.381
3.727GlyPro: 3.727 ± 0.439
2.566GlyGln: 2.566 ± 0.317
4.155GlyArg: 4.155 ± 0.511
4.094GlySer: 4.094 ± 0.529
5.01GlyThr: 5.01 ± 0.679
5.438GlyVal: 5.438 ± 0.604
2.627GlyTrp: 2.627 ± 0.355
2.627GlyTyr: 2.627 ± 0.405
0.0GlyXaa: 0.0 ± 0.0
His
1.1HisAla: 1.1 ± 0.244
0.306HisCys: 0.306 ± 0.138
1.161HisAsp: 1.161 ± 0.25
1.344HisGlu: 1.344 ± 0.245
1.039HisPhe: 1.039 ± 0.254
1.65HisGly: 1.65 ± 0.355
0.489HisHis: 0.489 ± 0.181
1.344HisIle: 1.344 ± 0.296
0.367HisLys: 0.367 ± 0.183
1.833HisLeu: 1.833 ± 0.339
0.244HisMet: 0.244 ± 0.131
0.672HisAsn: 0.672 ± 0.205
1.1HisPro: 1.1 ± 0.222
0.611HisGln: 0.611 ± 0.202
1.222HisArg: 1.222 ± 0.286
0.794HisSer: 0.794 ± 0.206
1.344HisThr: 1.344 ± 0.33
1.222HisVal: 1.222 ± 0.265
0.489HisTrp: 0.489 ± 0.162
0.794HisTyr: 0.794 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
5.071IleAla: 5.071 ± 0.636
0.306IleCys: 0.306 ± 0.145
3.422IleAsp: 3.422 ± 0.431
3.727IleGlu: 3.727 ± 0.471
1.039IlePhe: 1.039 ± 0.231
4.216IleGly: 4.216 ± 0.65
0.978IleHis: 0.978 ± 0.215
1.711IleIle: 1.711 ± 0.354
2.016IleLys: 2.016 ± 0.33
3.911IleLeu: 3.911 ± 0.453
1.039IleMet: 1.039 ± 0.215
2.016IleAsn: 2.016 ± 0.321
3.544IlePro: 3.544 ± 0.433
1.344IleGln: 1.344 ± 0.269
3.727IleArg: 3.727 ± 0.489
2.933IleSer: 2.933 ± 0.391
3.666IleThr: 3.666 ± 0.547
2.872IleVal: 2.872 ± 0.422
0.672IleTrp: 0.672 ± 0.182
1.344IleTyr: 1.344 ± 0.242
0.0IleXaa: 0.0 ± 0.0
Lys
5.56LysAla: 5.56 ± 0.807
0.183LysCys: 0.183 ± 0.09
2.383LysAsp: 2.383 ± 0.41
2.811LysGlu: 2.811 ± 0.504
1.772LysPhe: 1.772 ± 0.347
2.933LysGly: 2.933 ± 0.41
0.917LysHis: 0.917 ± 0.248
1.711LysIle: 1.711 ± 0.331
2.994LysLys: 2.994 ± 0.382
3.849LysLeu: 3.849 ± 0.476
1.344LysMet: 1.344 ± 0.44
1.405LysAsn: 1.405 ± 0.281
3.3LysPro: 3.3 ± 0.395
1.955LysGln: 1.955 ± 0.436
2.627LysArg: 2.627 ± 0.415
2.077LysSer: 2.077 ± 0.342
2.811LysThr: 2.811 ± 0.423
3.849LysVal: 3.849 ± 0.624
0.917LysTrp: 0.917 ± 0.257
1.222LysTyr: 1.222 ± 0.308
0.0LysXaa: 0.0 ± 0.0
Leu
8.066LeuAla: 8.066 ± 0.784
0.611LeuCys: 0.611 ± 0.183
6.11LeuAsp: 6.11 ± 0.529
6.538LeuGlu: 6.538 ± 0.656
1.772LeuPhe: 1.772 ± 0.374
6.599LeuGly: 6.599 ± 0.645
1.283LeuHis: 1.283 ± 0.328
3.666LeuIle: 3.666 ± 0.489
4.46LeuLys: 4.46 ± 0.504
6.477LeuLeu: 6.477 ± 0.476
2.505LeuMet: 2.505 ± 0.416
3.727LeuAsn: 3.727 ± 0.528
3.605LeuPro: 3.605 ± 0.62
2.2LeuGln: 2.2 ± 0.433
5.499LeuArg: 5.499 ± 0.545
5.621LeuSer: 5.621 ± 0.574
5.499LeuThr: 5.499 ± 0.631
5.133LeuVal: 5.133 ± 0.536
1.589LeuTrp: 1.589 ± 0.347
3.116LeuTyr: 3.116 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
2.444MetAla: 2.444 ± 0.365
0.183MetCys: 0.183 ± 0.111
1.344MetAsp: 1.344 ± 0.336
1.894MetGlu: 1.894 ± 0.342
0.55MetPhe: 0.55 ± 0.203
1.1MetGly: 1.1 ± 0.215
0.672MetHis: 0.672 ± 0.228
0.733MetIle: 0.733 ± 0.203
1.405MetLys: 1.405 ± 0.353
1.955MetLeu: 1.955 ± 0.364
0.733MetMet: 0.733 ± 0.162
0.917MetAsn: 0.917 ± 0.225
0.733MetPro: 0.733 ± 0.186
0.855MetGln: 0.855 ± 0.315
1.528MetArg: 1.528 ± 0.366
2.872MetSer: 2.872 ± 0.364
2.811MetThr: 2.811 ± 0.378
1.344MetVal: 1.344 ± 0.295
0.489MetTrp: 0.489 ± 0.167
0.794MetTyr: 0.794 ± 0.224
0.0MetXaa: 0.0 ± 0.0
Asn
2.689AsnAla: 2.689 ± 0.41
0.367AsnCys: 0.367 ± 0.127
2.261AsnAsp: 2.261 ± 0.425
1.955AsnGlu: 1.955 ± 0.332
1.344AsnPhe: 1.344 ± 0.349
3.422AsnGly: 3.422 ± 0.435
0.855AsnHis: 0.855 ± 0.259
2.016AsnIle: 2.016 ± 0.328
1.589AsnLys: 1.589 ± 0.295
1.772AsnLeu: 1.772 ± 0.324
0.611AsnMet: 0.611 ± 0.174
0.794AsnAsn: 0.794 ± 0.232
2.75AsnPro: 2.75 ± 0.399
1.528AsnGln: 1.528 ± 0.358
2.016AsnArg: 2.016 ± 0.331
1.405AsnSer: 1.405 ± 0.352
2.2AsnThr: 2.2 ± 0.377
2.2AsnVal: 2.2 ± 0.344
0.733AsnTrp: 0.733 ± 0.218
1.161AsnTyr: 1.161 ± 0.246
0.0AsnXaa: 0.0 ± 0.0
Pro
4.338ProAla: 4.338 ± 0.565
0.428ProCys: 0.428 ± 0.217
3.666ProAsp: 3.666 ± 0.441
4.094ProGlu: 4.094 ± 0.548
1.466ProPhe: 1.466 ± 0.359
4.399ProGly: 4.399 ± 0.668
0.611ProHis: 0.611 ± 0.193
2.872ProIle: 2.872 ± 0.4
2.261ProLys: 2.261 ± 0.415
3.116ProLeu: 3.116 ± 0.483
1.466ProMet: 1.466 ± 0.258
1.65ProAsn: 1.65 ± 0.347
3.422ProPro: 3.422 ± 0.695
1.955ProGln: 1.955 ± 0.302
1.955ProArg: 1.955 ± 0.379
2.322ProSer: 2.322 ± 0.406
3.666ProThr: 3.666 ± 0.427
4.644ProVal: 4.644 ± 0.508
1.528ProTrp: 1.528 ± 0.486
1.65ProTyr: 1.65 ± 0.373
0.0ProXaa: 0.0 ± 0.0
Gln
4.46GlnAla: 4.46 ± 0.867
0.244GlnCys: 0.244 ± 0.118
1.528GlnAsp: 1.528 ± 0.298
1.772GlnGlu: 1.772 ± 0.383
1.283GlnPhe: 1.283 ± 0.241
2.811GlnGly: 2.811 ± 0.616
0.733GlnHis: 0.733 ± 0.187
1.833GlnIle: 1.833 ± 0.334
1.833GlnLys: 1.833 ± 0.447
3.788GlnLeu: 3.788 ± 0.435
0.733GlnMet: 0.733 ± 0.205
0.917GlnAsn: 0.917 ± 0.277
1.528GlnPro: 1.528 ± 0.381
1.466GlnGln: 1.466 ± 0.331
1.344GlnArg: 1.344 ± 0.287
0.794GlnSer: 0.794 ± 0.245
1.894GlnThr: 1.894 ± 0.378
3.177GlnVal: 3.177 ± 0.401
0.55GlnTrp: 0.55 ± 0.159
1.161GlnTyr: 1.161 ± 0.234
0.0GlnXaa: 0.0 ± 0.0
Arg
4.46ArgAla: 4.46 ± 0.492
0.855ArgCys: 0.855 ± 0.239
4.094ArgAsp: 4.094 ± 0.465
4.155ArgGlu: 4.155 ± 0.706
2.2ArgPhe: 2.2 ± 0.396
4.827ArgGly: 4.827 ± 0.618
1.161ArgHis: 1.161 ± 0.278
3.3ArgIle: 3.3 ± 0.392
2.566ArgLys: 2.566 ± 0.41
4.277ArgLeu: 4.277 ± 0.503
1.955ArgMet: 1.955 ± 0.361
1.833ArgAsn: 1.833 ± 0.346
2.2ArgPro: 2.2 ± 0.439
2.077ArgGln: 2.077 ± 0.341
4.766ArgArg: 4.766 ± 0.778
2.994ArgSer: 2.994 ± 0.418
3.177ArgThr: 3.177 ± 0.46
3.972ArgVal: 3.972 ± 0.428
1.1ArgTrp: 1.1 ± 0.225
1.833ArgTyr: 1.833 ± 0.383
0.0ArgXaa: 0.0 ± 0.0
Ser
4.155SerAla: 4.155 ± 0.402
0.306SerCys: 0.306 ± 0.123
4.399SerAsp: 4.399 ± 0.53
3.788SerGlu: 3.788 ± 0.436
2.261SerPhe: 2.261 ± 0.32
4.766SerGly: 4.766 ± 0.621
0.917SerHis: 0.917 ± 0.231
2.077SerIle: 2.077 ± 0.354
2.872SerLys: 2.872 ± 0.468
4.949SerLeu: 4.949 ± 0.648
1.711SerMet: 1.711 ± 0.344
1.772SerAsn: 1.772 ± 0.344
1.955SerPro: 1.955 ± 0.381
1.772SerGln: 1.772 ± 0.395
3.055SerArg: 3.055 ± 0.495
2.689SerSer: 2.689 ± 0.369
2.566SerThr: 2.566 ± 0.406
3.544SerVal: 3.544 ± 0.465
1.65SerTrp: 1.65 ± 0.288
1.405SerTyr: 1.405 ± 0.305
0.0SerXaa: 0.0 ± 0.0
Thr
5.988ThrAla: 5.988 ± 0.776
0.367ThrCys: 0.367 ± 0.163
4.216ThrAsp: 4.216 ± 0.564
4.827ThrGlu: 4.827 ± 0.535
2.627ThrPhe: 2.627 ± 0.477
5.683ThrGly: 5.683 ± 0.726
0.672ThrHis: 0.672 ± 0.33
2.566ThrIle: 2.566 ± 0.423
2.505ThrLys: 2.505 ± 0.379
5.01ThrLeu: 5.01 ± 0.552
1.466ThrMet: 1.466 ± 0.327
2.077ThrAsn: 2.077 ± 0.371
3.849ThrPro: 3.849 ± 0.526
2.444ThrGln: 2.444 ± 0.413
3.177ThrArg: 3.177 ± 0.488
2.994ThrSer: 2.994 ± 0.485
3.422ThrThr: 3.422 ± 0.555
4.277ThrVal: 4.277 ± 0.556
1.589ThrTrp: 1.589 ± 0.274
1.955ThrTyr: 1.955 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
6.355ValAla: 6.355 ± 0.605
0.733ValCys: 0.733 ± 0.203
4.705ValAsp: 4.705 ± 0.622
5.133ValGlu: 5.133 ± 0.573
2.505ValPhe: 2.505 ± 0.424
4.338ValGly: 4.338 ± 0.509
1.589ValHis: 1.589 ± 0.322
4.277ValIle: 4.277 ± 0.479
3.544ValLys: 3.544 ± 0.431
4.46ValLeu: 4.46 ± 0.542
1.466ValMet: 1.466 ± 0.306
2.077ValAsn: 2.077 ± 0.411
3.727ValPro: 3.727 ± 0.432
1.833ValGln: 1.833 ± 0.335
4.277ValArg: 4.277 ± 0.538
4.46ValSer: 4.46 ± 0.542
4.949ValThr: 4.949 ± 0.476
4.766ValVal: 4.766 ± 0.626
1.65ValTrp: 1.65 ± 0.287
1.833ValTyr: 1.833 ± 0.436
0.0ValXaa: 0.0 ± 0.0
Trp
2.689TrpAla: 2.689 ± 0.513
0.244TrpCys: 0.244 ± 0.129
1.344TrpAsp: 1.344 ± 0.285
1.283TrpGlu: 1.283 ± 0.229
0.733TrpPhe: 0.733 ± 0.181
1.711TrpGly: 1.711 ± 0.391
0.672TrpHis: 0.672 ± 0.253
1.528TrpIle: 1.528 ± 0.318
0.733TrpLys: 0.733 ± 0.198
1.772TrpLeu: 1.772 ± 0.354
0.733TrpMet: 0.733 ± 0.186
0.917TrpAsn: 0.917 ± 0.23
0.733TrpPro: 0.733 ± 0.211
0.855TrpGln: 0.855 ± 0.176
0.978TrpArg: 0.978 ± 0.236
1.65TrpSer: 1.65 ± 0.347
1.222TrpThr: 1.222 ± 0.321
1.955TrpVal: 1.955 ± 0.361
0.367TrpTrp: 0.367 ± 0.147
0.489TrpTyr: 0.489 ± 0.175
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.016TyrAla: 2.016 ± 0.297
0.122TyrCys: 0.122 ± 0.089
3.238TyrAsp: 3.238 ± 0.571
2.689TyrGlu: 2.689 ± 0.397
0.917TyrPhe: 0.917 ± 0.249
2.811TyrGly: 2.811 ± 0.389
0.428TyrHis: 0.428 ± 0.191
1.589TyrIle: 1.589 ± 0.319
0.794TyrLys: 0.794 ± 0.244
3.3TyrLeu: 3.3 ± 0.417
0.428TyrMet: 0.428 ± 0.203
1.344TyrAsn: 1.344 ± 0.343
1.589TyrPro: 1.589 ± 0.278
0.611TyrGln: 0.611 ± 0.165
2.444TyrArg: 2.444 ± 0.398
1.161TyrSer: 1.161 ± 0.312
1.833TyrThr: 1.833 ± 0.284
2.505TyrVal: 2.505 ± 0.488
0.733TyrTrp: 0.733 ± 0.22
0.794TyrTyr: 0.794 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 99 proteins (16367 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski