Amino acid dipepetide frequency for Actinomyces graevenitzii C83

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.668AlaAla: 16.668 ± 0.28
1.088AlaCys: 1.088 ± 0.045
6.639AlaAsp: 6.639 ± 0.113
5.709AlaGlu: 5.709 ± 0.128
3.082AlaPhe: 3.082 ± 0.067
10.37AlaGly: 10.37 ± 0.171
2.393AlaHis: 2.393 ± 0.067
5.298AlaIle: 5.298 ± 0.104
5.163AlaLys: 5.163 ± 0.105
13.466AlaLeu: 13.466 ± 0.198
2.699AlaMet: 2.699 ± 0.073
3.712AlaAsn: 3.712 ± 0.085
6.08AlaPro: 6.08 ± 0.151
6.315AlaGln: 6.315 ± 0.156
7.13AlaArg: 7.13 ± 0.143
8.17AlaSer: 8.17 ± 0.148
7.201AlaThr: 7.201 ± 0.136
9.46AlaVal: 9.46 ± 0.14
1.809AlaTrp: 1.809 ± 0.057
2.764AlaTyr: 2.764 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.078CysAla: 1.078 ± 0.043
0.11CysCys: 0.11 ± 0.014
0.419CysAsp: 0.419 ± 0.025
0.422CysGlu: 0.422 ± 0.027
0.272CysPhe: 0.272 ± 0.022
0.838CysGly: 0.838 ± 0.041
0.202CysHis: 0.202 ± 0.017
0.374CysIle: 0.374 ± 0.025
0.236CysLys: 0.236 ± 0.018
0.891CysLeu: 0.891 ± 0.043
0.179CysMet: 0.179 ± 0.016
0.183CysAsn: 0.183 ± 0.017
0.47CysPro: 0.47 ± 0.032
0.323CysGln: 0.323 ± 0.025
0.405CysArg: 0.405 ± 0.026
0.54CysSer: 0.54 ± 0.026
0.469CysThr: 0.469 ± 0.027
0.604CysVal: 0.604 ± 0.029
0.11CysTrp: 0.11 ± 0.015
0.186CysTyr: 0.186 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.516AspAla: 6.516 ± 0.116
0.384AspCys: 0.384 ± 0.027
3.329AspAsp: 3.329 ± 0.08
3.511AspGlu: 3.511 ± 0.077
1.756AspPhe: 1.756 ± 0.055
4.795AspGly: 4.795 ± 0.099
1.056AspHis: 1.056 ± 0.043
2.39AspIle: 2.39 ± 0.065
1.916AspLys: 1.916 ± 0.055
5.391AspLeu: 5.391 ± 0.103
1.009AspMet: 1.009 ± 0.035
1.511AspAsn: 1.511 ± 0.051
3.281AspPro: 3.281 ± 0.083
1.933AspGln: 1.933 ± 0.062
2.827AspArg: 2.827 ± 0.079
3.16AspSer: 3.16 ± 0.074
2.801AspThr: 2.801 ± 0.065
4.327AspVal: 4.327 ± 0.095
0.854AspTrp: 0.854 ± 0.038
1.694AspTyr: 1.694 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.725GluAla: 6.725 ± 0.125
0.335GluCys: 0.335 ± 0.028
2.59GluAsp: 2.59 ± 0.071
2.93GluGlu: 2.93 ± 0.084
1.475GluPhe: 1.475 ± 0.052
3.807GluGly: 3.807 ± 0.086
1.324GluHis: 1.324 ± 0.051
2.829GluIle: 2.829 ± 0.079
1.882GluLys: 1.882 ± 0.058
6.217GluLeu: 6.217 ± 0.118
1.046GluMet: 1.046 ± 0.041
1.731GluAsn: 1.731 ± 0.045
2.518GluPro: 2.518 ± 0.077
2.93GluGln: 2.93 ± 0.088
4.102GluArg: 4.102 ± 0.103
2.548GluSer: 2.548 ± 0.072
2.577GluThr: 2.577 ± 0.072
4.543GluVal: 4.543 ± 0.095
0.455GluTrp: 0.455 ± 0.026
1.255GluTyr: 1.255 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.219PheAla: 3.219 ± 0.087
0.27PheCys: 0.27 ± 0.02
1.846PheAsp: 1.846 ± 0.06
1.599PheGlu: 1.599 ± 0.049
0.998PhePhe: 0.998 ± 0.043
2.703PheGly: 2.703 ± 0.079
0.486PheHis: 0.486 ± 0.029
1.5PheIle: 1.5 ± 0.056
1.157PheLys: 1.157 ± 0.049
2.41PheLeu: 2.41 ± 0.073
0.672PheMet: 0.672 ± 0.038
1.062PheAsn: 1.062 ± 0.044
1.199PhePro: 1.199 ± 0.045
0.711PheGln: 0.711 ± 0.03
1.177PheArg: 1.177 ± 0.039
2.098PheSer: 2.098 ± 0.068
2.095PheThr: 2.095 ± 0.065
2.217PheVal: 2.217 ± 0.061
0.424PheTrp: 0.424 ± 0.025
0.731PheTyr: 0.731 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
9.92GlyAla: 9.92 ± 0.161
0.748GlyCys: 0.748 ± 0.036
4.063GlyAsp: 4.063 ± 0.084
4.099GlyGlu: 4.099 ± 0.089
2.567GlyPhe: 2.567 ± 0.068
6.544GlyGly: 6.544 ± 0.139
1.759GlyHis: 1.759 ± 0.059
3.821GlyIle: 3.821 ± 0.075
3.467GlyLys: 3.467 ± 0.082
7.891GlyLeu: 7.891 ± 0.126
1.817GlyMet: 1.817 ± 0.053
2.295GlyAsn: 2.295 ± 0.079
3.212GlyPro: 3.212 ± 0.094
3.993GlyGln: 3.993 ± 0.094
4.931GlyArg: 4.931 ± 0.103
5.363GlySer: 5.363 ± 0.121
4.911GlyThr: 4.911 ± 0.111
6.915GlyVal: 6.915 ± 0.124
1.43GlyTrp: 1.43 ± 0.052
2.436GlyTyr: 2.436 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
2.143HisAla: 2.143 ± 0.069
0.21HisCys: 0.21 ± 0.016
1.054HisAsp: 1.054 ± 0.046
1.151HisGlu: 1.151 ± 0.045
0.542HisPhe: 0.542 ± 0.032
1.723HisGly: 1.723 ± 0.053
0.494HisHis: 0.494 ± 0.03
0.832HisIle: 0.832 ± 0.037
0.55HisLys: 0.55 ± 0.027
2.018HisLeu: 2.018 ± 0.062
0.474HisMet: 0.474 ± 0.028
0.574HisAsn: 0.574 ± 0.034
1.315HisPro: 1.315 ± 0.048
0.714HisGln: 0.714 ± 0.033
1.245HisArg: 1.245 ± 0.05
1.244HisSer: 1.244 ± 0.049
1.14HisThr: 1.14 ± 0.044
1.494HisVal: 1.494 ± 0.049
0.335HisTrp: 0.335 ± 0.024
0.54HisTyr: 0.54 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.687IleAla: 5.687 ± 0.11
0.474IleCys: 0.474 ± 0.03
3.237IleAsp: 3.237 ± 0.079
2.962IleGlu: 2.962 ± 0.075
1.404IlePhe: 1.404 ± 0.05
3.784IleGly: 3.784 ± 0.087
0.776IleHis: 0.776 ± 0.037
2.192IleIle: 2.192 ± 0.073
1.691IleLys: 1.691 ± 0.052
3.509IleLeu: 3.509 ± 0.088
0.967IleMet: 0.967 ± 0.037
1.678IleAsn: 1.678 ± 0.058
2.205IlePro: 2.205 ± 0.066
0.95IleGln: 0.95 ± 0.04
2.068IleArg: 2.068 ± 0.06
3.29IleSer: 3.29 ± 0.078
3.115IleThr: 3.115 ± 0.068
3.729IleVal: 3.729 ± 0.076
0.582IleTrp: 0.582 ± 0.034
1.141IleTyr: 1.141 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.587LysAla: 4.587 ± 0.1
0.175LysCys: 0.175 ± 0.018
1.914LysAsp: 1.914 ± 0.059
1.843LysGlu: 1.843 ± 0.06
0.891LysPhe: 0.891 ± 0.037
2.453LysGly: 2.453 ± 0.062
0.722LysHis: 0.722 ± 0.033
1.562LysIle: 1.562 ± 0.059
1.377LysLys: 1.377 ± 0.064
3.548LysLeu: 3.548 ± 0.075
0.755LysMet: 0.755 ± 0.036
1.146LysAsn: 1.146 ± 0.042
1.931LysPro: 1.931 ± 0.061
1.635LysGln: 1.635 ± 0.056
2.542LysArg: 2.542 ± 0.075
1.928LysSer: 1.928 ± 0.063
2.119LysThr: 2.119 ± 0.063
2.948LysVal: 2.948 ± 0.072
0.411LysTrp: 0.411 ± 0.027
0.879LysTyr: 0.879 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
13.89LeuAla: 13.89 ± 0.175
0.804LeuCys: 0.804 ± 0.039
5.745LeuAsp: 5.745 ± 0.117
5.895LeuGlu: 5.895 ± 0.129
2.621LeuPhe: 2.621 ± 0.092
8.26LeuGly: 8.26 ± 0.118
1.869LeuHis: 1.869 ± 0.063
4.605LeuIle: 4.605 ± 0.1
3.157LeuLys: 3.157 ± 0.086
9.504LeuLeu: 9.504 ± 0.171
1.877LeuMet: 1.877 ± 0.058
2.877LeuAsn: 2.877 ± 0.073
5.158LeuPro: 5.158 ± 0.1
2.762LeuGln: 2.762 ± 0.073
6.454LeuArg: 6.454 ± 0.114
6.605LeuSer: 6.605 ± 0.109
6.195LeuThr: 6.195 ± 0.099
8.509LeuVal: 8.509 ± 0.135
1.118LeuTrp: 1.118 ± 0.043
1.925LeuTyr: 1.925 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.386MetAla: 2.386 ± 0.066
0.158MetCys: 0.158 ± 0.016
1.046MetAsp: 1.046 ± 0.045
0.918MetGlu: 0.918 ± 0.038
0.612MetPhe: 0.612 ± 0.033
1.699MetGly: 1.699 ± 0.056
0.411MetHis: 0.411 ± 0.025
0.904MetIle: 0.904 ± 0.035
0.564MetLys: 0.564 ± 0.028
2.076MetLeu: 2.076 ± 0.064
0.382MetMet: 0.382 ± 0.027
0.561MetAsn: 0.561 ± 0.03
1.202MetPro: 1.202 ± 0.04
0.655MetGln: 0.655 ± 0.032
1.644MetArg: 1.644 ± 0.057
1.742MetSer: 1.742 ± 0.058
1.247MetThr: 1.247 ± 0.045
1.65MetVal: 1.65 ± 0.05
0.225MetTrp: 0.225 ± 0.02
0.388MetTyr: 0.388 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.077
0.295AsnCys: 0.295 ± 0.023
1.472AsnAsp: 1.472 ± 0.05
1.498AsnGlu: 1.498 ± 0.047
0.88AsnPhe: 0.88 ± 0.041
2.647AsnGly: 2.647 ± 0.087
0.568AsnHis: 0.568 ± 0.027
1.312AsnIle: 1.312 ± 0.047
0.983AsnLys: 0.983 ± 0.045
3.004AsnLeu: 3.004 ± 0.074
0.632AsnMet: 0.632 ± 0.028
0.981AsnAsn: 0.981 ± 0.054
2.088AsnPro: 2.088 ± 0.066
1.34AsnGln: 1.34 ± 0.047
1.621AsnArg: 1.621 ± 0.055
2.004AsnSer: 2.004 ± 0.065
1.717AsnThr: 1.717 ± 0.056
2.163AsnVal: 2.163 ± 0.061
0.565AsnTrp: 0.565 ± 0.028
0.95AsnTyr: 0.95 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
6.636ProAla: 6.636 ± 0.142
0.275ProCys: 0.275 ± 0.022
2.745ProAsp: 2.745 ± 0.074
3.084ProGlu: 3.084 ± 0.07
1.366ProPhe: 1.366 ± 0.046
4.529ProGly: 4.529 ± 0.112
1.012ProHis: 1.012 ± 0.039
1.916ProIle: 1.916 ± 0.054
1.764ProLys: 1.764 ± 0.048
4.479ProLeu: 4.479 ± 0.089
0.866ProMet: 0.866 ± 0.037
1.54ProAsn: 1.54 ± 0.058
1.742ProPro: 1.742 ± 0.066
2.453ProGln: 2.453 ± 0.072
2.581ProArg: 2.581 ± 0.073
3.487ProSer: 3.487 ± 0.103
3.655ProThr: 3.655 ± 0.14
4.25ProVal: 4.25 ± 0.097
0.71ProTrp: 0.71 ± 0.032
1.267ProTyr: 1.267 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
6.214GlnAla: 6.214 ± 0.139
0.315GlnCys: 0.315 ± 0.025
1.612GlnAsp: 1.612 ± 0.052
1.868GlnGlu: 1.868 ± 0.063
0.873GlnPhe: 0.873 ± 0.033
3.132GlnGly: 3.132 ± 0.089
0.637GlnHis: 0.637 ± 0.031
2.077GlnIle: 2.077 ± 0.056
1.011GlnLys: 1.011 ± 0.041
5.159GlnLeu: 5.159 ± 0.108
0.905GlnMet: 0.905 ± 0.04
1.045GlnAsn: 1.045 ± 0.042
2.056GlnPro: 2.056 ± 0.083
1.593GlnGln: 1.593 ± 0.071
2.841GlnArg: 2.841 ± 0.074
2.079GlnSer: 2.079 ± 0.066
1.767GlnThr: 1.767 ± 0.061
4.324GlnVal: 4.324 ± 0.089
0.571GlnTrp: 0.571 ± 0.029
0.807GlnTyr: 0.807 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
6.784ArgAla: 6.784 ± 0.138
0.494ArgCys: 0.494 ± 0.03
3.009ArgAsp: 3.009 ± 0.081
3.902ArgGlu: 3.902 ± 0.101
1.812ArgPhe: 1.812 ± 0.053
4.108ArgGly: 4.108 ± 0.082
1.269ArgHis: 1.269 ± 0.05
2.826ArgIle: 2.826 ± 0.076
2.2ArgLys: 2.2 ± 0.066
6.291ArgLeu: 6.291 ± 0.113
1.414ArgMet: 1.414 ± 0.05
1.731ArgAsn: 1.731 ± 0.058
2.879ArgPro: 2.879 ± 0.08
2.82ArgGln: 2.82 ± 0.073
4.992ArgArg: 4.992 ± 0.126
3.945ArgSer: 3.945 ± 0.082
3.132ArgThr: 3.132 ± 0.078
4.52ArgVal: 4.52 ± 0.082
0.955ArgTrp: 0.955 ± 0.04
1.699ArgTyr: 1.699 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
8.544SerAla: 8.544 ± 0.169
0.488SerCys: 0.488 ± 0.026
3.361SerAsp: 3.361 ± 0.073
3.361SerGlu: 3.361 ± 0.077
2.042SerPhe: 2.042 ± 0.059
6.228SerGly: 6.228 ± 0.124
1.303SerHis: 1.303 ± 0.054
2.535SerIle: 2.535 ± 0.064
2.177SerLys: 2.177 ± 0.071
6.071SerLeu: 6.071 ± 0.111
1.298SerMet: 1.298 ± 0.041
1.728SerAsn: 1.728 ± 0.051
3.324SerPro: 3.324 ± 0.09
3.192SerGln: 3.192 ± 0.091
3.639SerArg: 3.639 ± 0.075
4.632SerSer: 4.632 ± 0.146
3.731SerThr: 3.731 ± 0.081
4.678SerVal: 4.678 ± 0.096
0.953SerTrp: 0.953 ± 0.037
1.754SerTyr: 1.754 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
6.509ThrAla: 6.509 ± 0.131
0.547ThrCys: 0.547 ± 0.033
3.082ThrAsp: 3.082 ± 0.074
2.487ThrGlu: 2.487 ± 0.073
1.789ThrPhe: 1.789 ± 0.055
5.006ThrGly: 5.006 ± 0.101
1.248ThrHis: 1.248 ± 0.05
2.751ThrIle: 2.751 ± 0.07
2.093ThrLys: 2.093 ± 0.058
5.604ThrLeu: 5.604 ± 0.102
1.082ThrMet: 1.082 ± 0.045
1.969ThrAsn: 1.969 ± 0.068
3.773ThrPro: 3.773 ± 0.098
2.369ThrGln: 2.369 ± 0.078
3.088ThrArg: 3.088 ± 0.076
4.031ThrSer: 4.031 ± 0.084
3.743ThrThr: 3.743 ± 0.09
4.694ThrVal: 4.694 ± 0.091
0.986ThrTrp: 0.986 ± 0.041
1.604ThrTyr: 1.604 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
10.206ValAla: 10.206 ± 0.154
0.711ValCys: 0.711 ± 0.034
4.976ValAsp: 4.976 ± 0.104
4.596ValGlu: 4.596 ± 0.096
2.329ValPhe: 2.329 ± 0.068
6.411ValGly: 6.411 ± 0.116
1.486ValHis: 1.486 ± 0.041
4.063ValIle: 4.063 ± 0.091
2.765ValLys: 2.765 ± 0.072
7.926ValLeu: 7.926 ± 0.121
1.59ValMet: 1.59 ± 0.058
2.495ValAsn: 2.495 ± 0.064
4.026ValPro: 4.026 ± 0.084
2.399ValGln: 2.399 ± 0.059
4.885ValArg: 4.885 ± 0.095
5.68ValSer: 5.68 ± 0.089
4.857ValThr: 4.857 ± 0.1
7.875ValVal: 7.875 ± 0.143
0.994ValTrp: 0.994 ± 0.035
1.675ValTyr: 1.675 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
1.413TrpAla: 1.413 ± 0.053
0.193TrpCys: 0.193 ± 0.016
0.817TrpAsp: 0.817 ± 0.038
0.629TrpGlu: 0.629 ± 0.029
0.443TrpPhe: 0.443 ± 0.029
0.969TrpGly: 0.969 ± 0.035
0.36TrpHis: 0.36 ± 0.025
0.679TrpIle: 0.679 ± 0.037
0.388TrpLys: 0.388 ± 0.027
1.764TrpLeu: 1.764 ± 0.057
0.312TrpMet: 0.312 ± 0.027
0.5TrpAsn: 0.5 ± 0.03
0.612TrpPro: 0.612 ± 0.03
0.818TrpGln: 0.818 ± 0.039
1.039TrpArg: 1.039 ± 0.039
0.842TrpSer: 0.842 ± 0.037
0.598TrpThr: 0.598 ± 0.031
1.175TrpVal: 1.175 ± 0.048
0.295TrpTrp: 0.295 ± 0.022
0.356TrpTyr: 0.356 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.703TyrAla: 2.703 ± 0.068
0.239TyrCys: 0.239 ± 0.023
1.481TyrAsp: 1.481 ± 0.055
1.355TyrGlu: 1.355 ± 0.05
0.821TyrPhe: 0.821 ± 0.039
2.177TyrGly: 2.177 ± 0.066
0.416TyrHis: 0.416 ± 0.029
0.977TyrIle: 0.977 ± 0.042
0.829TyrLys: 0.829 ± 0.036
2.612TyrLeu: 2.612 ± 0.076
0.492TyrMet: 0.492 ± 0.028
0.792TyrAsn: 0.792 ± 0.042
1.287TyrPro: 1.287 ± 0.056
0.98TyrGln: 0.98 ± 0.043
1.568TyrArg: 1.568 ± 0.056
1.654TyrSer: 1.654 ± 0.048
1.385TyrThr: 1.385 ± 0.057
1.868TyrVal: 1.868 ± 0.052
0.416TyrTrp: 0.416 ± 0.026
0.73TyrTyr: 0.73 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1852 proteins (644062 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski