Amino acid dipepetide frequency for Agrococcus jejuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.469AlaAla: 22.469 ± 0.271
0.851AlaCys: 0.851 ± 0.036
9.347AlaAsp: 9.347 ± 0.111
8.154AlaGlu: 8.154 ± 0.112
4.191AlaPhe: 4.191 ± 0.064
12.597AlaGly: 12.597 ± 0.119
2.648AlaHis: 2.648 ± 0.059
7.302AlaIle: 7.302 ± 0.105
2.28AlaLys: 2.28 ± 0.062
15.023AlaLeu: 15.023 ± 0.189
3.299AlaMet: 3.299 ± 0.061
2.38AlaAsn: 2.38 ± 0.123
7.632AlaPro: 7.632 ± 0.149
4.035AlaGln: 4.035 ± 0.073
9.582AlaArg: 9.582 ± 0.133
8.577AlaSer: 8.577 ± 0.113
9.181AlaThr: 9.181 ± 0.162
12.565AlaVal: 12.565 ± 0.145
2.267AlaTrp: 2.267 ± 0.054
2.439AlaTyr: 2.439 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.73CysAla: 0.73 ± 0.031
0.044CysCys: 0.044 ± 0.006
0.348CysAsp: 0.348 ± 0.019
0.254CysGlu: 0.254 ± 0.016
0.153CysPhe: 0.153 ± 0.014
0.543CysGly: 0.543 ± 0.026
0.1CysHis: 0.1 ± 0.011
0.218CysIle: 0.218 ± 0.013
0.048CysLys: 0.048 ± 0.007
0.409CysLeu: 0.409 ± 0.021
0.097CysMet: 0.097 ± 0.009
0.08CysAsn: 0.08 ± 0.009
0.245CysPro: 0.245 ± 0.018
0.125CysGln: 0.125 ± 0.011
0.292CysArg: 0.292 ± 0.016
0.332CysSer: 0.332 ± 0.017
0.342CysThr: 0.342 ± 0.018
0.462CysVal: 0.462 ± 0.023
0.063CysTrp: 0.063 ± 0.007
0.089CysTyr: 0.089 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
12.418AspAla: 12.418 ± 0.169
0.24AspCys: 0.24 ± 0.014
5.348AspAsp: 5.348 ± 0.084
4.857AspGlu: 4.857 ± 0.073
1.465AspPhe: 1.465 ± 0.038
6.822AspGly: 6.822 ± 0.103
1.207AspHis: 1.207 ± 0.039
1.747AspIle: 1.747 ± 0.045
0.588AspLys: 0.588 ± 0.023
6.278AspLeu: 6.278 ± 0.095
0.858AspMet: 0.858 ± 0.03
0.558AspAsn: 0.558 ± 0.023
4.083AspPro: 4.083 ± 0.089
1.436AspGln: 1.436 ± 0.039
4.962AspArg: 4.962 ± 0.082
2.087AspSer: 2.087 ± 0.051
2.439AspThr: 2.439 ± 0.052
6.953AspVal: 6.953 ± 0.096
0.963AspTrp: 0.963 ± 0.033
1.015AspTyr: 1.015 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.875GluAla: 7.875 ± 0.112
0.224GluCys: 0.224 ± 0.014
2.511GluAsp: 2.511 ± 0.057
2.45GluGlu: 2.45 ± 0.056
1.164GluPhe: 1.164 ± 0.034
4.311GluGly: 4.311 ± 0.073
1.895GluHis: 1.895 ± 0.056
2.222GluIle: 2.222 ± 0.046
0.673GluLys: 0.673 ± 0.029
6.014GluLeu: 6.014 ± 0.084
0.744GluMet: 0.744 ± 0.027
0.639GluAsn: 0.639 ± 0.029
3.646GluPro: 3.646 ± 0.076
2.551GluGln: 2.551 ± 0.049
6.164GluArg: 6.164 ± 0.116
2.669GluSer: 2.669 ± 0.058
3.171GluThr: 3.171 ± 0.056
4.789GluVal: 4.789 ± 0.077
0.834GluTrp: 0.834 ± 0.03
0.853GluTyr: 0.853 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.104PheAla: 4.104 ± 0.076
0.145PheCys: 0.145 ± 0.013
2.262PheAsp: 2.262 ± 0.061
1.599PheGlu: 1.599 ± 0.041
0.783PhePhe: 0.783 ± 0.032
3.095PheGly: 3.095 ± 0.07
0.49PheHis: 0.49 ± 0.021
0.839PheIle: 0.839 ± 0.03
0.333PheLys: 0.333 ± 0.023
2.414PheLeu: 2.414 ± 0.055
0.385PheMet: 0.385 ± 0.021
0.433PheAsn: 0.433 ± 0.022
1.189PhePro: 1.189 ± 0.038
0.821PheGln: 0.821 ± 0.028
1.41PheArg: 1.41 ± 0.037
1.395PheSer: 1.395 ± 0.043
1.865PheThr: 1.865 ± 0.097
2.77PheVal: 2.77 ± 0.05
0.347PheTrp: 0.347 ± 0.018
0.464PheTyr: 0.464 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
11.719GlyAla: 11.719 ± 0.126
0.586GlyCys: 0.586 ± 0.027
5.889GlyAsp: 5.889 ± 0.104
4.993GlyGlu: 4.993 ± 0.071
3.213GlyPhe: 3.213 ± 0.05
7.958GlyGly: 7.958 ± 0.172
1.758GlyHis: 1.758 ± 0.049
4.921GlyIle: 4.921 ± 0.084
1.512GlyLys: 1.512 ± 0.045
8.646GlyLeu: 8.646 ± 0.107
2.109GlyMet: 2.109 ± 0.042
1.351GlyAsn: 1.351 ± 0.054
3.72GlyPro: 3.72 ± 0.063
2.635GlyGln: 2.635 ± 0.079
6.17GlyArg: 6.17 ± 0.098
5.322GlySer: 5.322 ± 0.101
6.179GlyThr: 6.179 ± 0.175
8.794GlyVal: 8.794 ± 0.107
1.686GlyTrp: 1.686 ± 0.046
1.881GlyTyr: 1.881 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
3.026HisAla: 3.026 ± 0.067
0.107HisCys: 0.107 ± 0.009
1.622HisAsp: 1.622 ± 0.043
1.282HisGlu: 1.282 ± 0.031
0.451HisPhe: 0.451 ± 0.021
2.16HisGly: 2.16 ± 0.049
0.572HisHis: 0.572 ± 0.027
0.542HisIle: 0.542 ± 0.026
0.193HisLys: 0.193 ± 0.014
2.049HisLeu: 2.049 ± 0.05
0.337HisMet: 0.337 ± 0.02
0.227HisAsn: 0.227 ± 0.016
1.563HisPro: 1.563 ± 0.043
0.469HisGln: 0.469 ± 0.02
1.637HisArg: 1.637 ± 0.047
0.768HisSer: 0.768 ± 0.029
0.79HisThr: 0.79 ± 0.032
2.236HisVal: 2.236 ± 0.057
0.288HisTrp: 0.288 ± 0.016
0.352HisTyr: 0.352 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.472IleAla: 7.472 ± 0.102
0.214IleCys: 0.214 ± 0.014
3.382IleAsp: 3.382 ± 0.063
2.588IleGlu: 2.588 ± 0.051
0.925IlePhe: 0.925 ± 0.038
4.472IleGly: 4.472 ± 0.076
0.747IleHis: 0.747 ± 0.027
1.134IleIle: 1.134 ± 0.04
0.474IleLys: 0.474 ± 0.026
3.396IleLeu: 3.396 ± 0.072
0.575IleMet: 0.575 ± 0.024
0.527IleAsn: 0.527 ± 0.026
2.181IlePro: 2.181 ± 0.044
0.998IleGln: 0.998 ± 0.033
2.587IleArg: 2.587 ± 0.054
1.632IleSer: 1.632 ± 0.041
2.381IleThr: 2.381 ± 0.06
5.314IleVal: 5.314 ± 0.077
0.456IleTrp: 0.456 ± 0.021
0.569IleTyr: 0.569 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.057LysAla: 2.057 ± 0.057
0.042LysCys: 0.042 ± 0.006
0.851LysAsp: 0.851 ± 0.033
0.691LysGlu: 0.691 ± 0.03
0.228LysPhe: 0.228 ± 0.014
1.247LysGly: 1.247 ± 0.043
0.395LysHis: 0.395 ± 0.022
0.517LysIle: 0.517 ± 0.026
0.379LysLys: 0.379 ± 0.024
0.924LysLeu: 0.924 ± 0.032
0.224LysMet: 0.224 ± 0.013
0.225LysAsn: 0.225 ± 0.014
0.932LysPro: 0.932 ± 0.031
0.531LysGln: 0.531 ± 0.025
1.202LysArg: 1.202 ± 0.043
0.716LysSer: 0.716 ± 0.031
0.855LysThr: 0.855 ± 0.028
1.296LysVal: 1.296 ± 0.039
0.127LysTrp: 0.127 ± 0.012
0.217LysTyr: 0.217 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
16.358LeuAla: 16.358 ± 0.189
0.485LeuCys: 0.485 ± 0.023
7.298LeuAsp: 7.298 ± 0.096
5.6LeuGlu: 5.6 ± 0.083
2.293LeuPhe: 2.293 ± 0.055
9.767LeuGly: 9.767 ± 0.138
1.965LeuHis: 1.965 ± 0.044
2.929LeuIle: 2.929 ± 0.066
1.175LeuLys: 1.175 ± 0.039
10.036LeuLeu: 10.036 ± 0.136
1.463LeuMet: 1.463 ± 0.042
1.222LeuAsn: 1.222 ± 0.042
5.413LeuPro: 5.413 ± 0.083
2.955LeuGln: 2.955 ± 0.057
7.249LeuArg: 7.249 ± 0.12
4.687LeuSer: 4.687 ± 0.079
5.487LeuThr: 5.487 ± 0.076
11.156LeuVal: 11.156 ± 0.139
1.17LeuTrp: 1.17 ± 0.031
1.292LeuTyr: 1.292 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.347MetAla: 2.347 ± 0.054
0.093MetCys: 0.093 ± 0.009
0.819MetAsp: 0.819 ± 0.027
0.636MetGlu: 0.636 ± 0.026
0.393MetPhe: 0.393 ± 0.019
1.401MetGly: 1.401 ± 0.044
0.475MetHis: 0.475 ± 0.024
0.596MetIle: 0.596 ± 0.025
0.238MetLys: 0.238 ± 0.015
2.333MetLeu: 2.333 ± 0.056
0.272MetMet: 0.272 ± 0.018
0.257MetAsn: 0.257 ± 0.013
1.324MetPro: 1.324 ± 0.039
0.731MetGln: 0.731 ± 0.027
1.803MetArg: 1.803 ± 0.038
1.241MetSer: 1.241 ± 0.038
1.723MetThr: 1.723 ± 0.038
1.385MetVal: 1.385 ± 0.041
0.198MetTrp: 0.198 ± 0.012
0.238MetTyr: 0.238 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.03AsnAla: 2.03 ± 0.048
0.08AsnCys: 0.08 ± 0.009
0.988AsnAsp: 0.988 ± 0.071
0.668AsnGlu: 0.668 ± 0.024
0.375AsnPhe: 0.375 ± 0.02
1.543AsnGly: 1.543 ± 0.077
0.28AsnHis: 0.28 ± 0.016
0.513AsnIle: 0.513 ± 0.026
0.193AsnLys: 0.193 ± 0.013
1.463AsnLeu: 1.463 ± 0.041
0.223AsnMet: 0.223 ± 0.016
0.261AsnAsn: 0.261 ± 0.016
1.272AsnPro: 1.272 ± 0.047
0.427AsnGln: 0.427 ± 0.023
0.922AsnArg: 0.922 ± 0.036
0.503AsnSer: 0.503 ± 0.023
0.668AsnThr: 0.668 ± 0.032
1.448AsnVal: 1.448 ± 0.044
0.2AsnTrp: 0.2 ± 0.014
0.26AsnTyr: 0.26 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
7.711ProAla: 7.711 ± 0.131
0.186ProCys: 0.186 ± 0.014
3.782ProAsp: 3.782 ± 0.067
3.837ProGlu: 3.837 ± 0.071
1.683ProPhe: 1.683 ± 0.045
4.962ProGly: 4.962 ± 0.085
1.119ProHis: 1.119 ± 0.034
2.461ProIle: 2.461 ± 0.05
0.824ProLys: 0.824 ± 0.032
4.887ProLeu: 4.887 ± 0.095
1.054ProMet: 1.054 ± 0.029
0.838ProAsn: 0.838 ± 0.032
2.358ProPro: 2.358 ± 0.075
1.579ProGln: 1.579 ± 0.047
3.241ProArg: 3.241 ± 0.059
3.233ProSer: 3.233 ± 0.068
4.034ProThr: 4.034 ± 0.09
5.18ProVal: 5.18 ± 0.115
0.907ProTrp: 0.907 ± 0.034
0.983ProTyr: 0.983 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.964GlnAla: 3.964 ± 0.072
0.132GlnCys: 0.132 ± 0.012
1.351GlnAsp: 1.351 ± 0.053
1.284GlnGlu: 1.284 ± 0.04
0.705GlnPhe: 0.705 ± 0.028
2.568GlnGly: 2.568 ± 0.093
0.759GlnHis: 0.759 ± 0.027
1.268GlnIle: 1.268 ± 0.039
0.387GlnLys: 0.387 ± 0.019
3.169GlnLeu: 3.169 ± 0.057
0.475GlnMet: 0.475 ± 0.023
0.414GlnAsn: 0.414 ± 0.023
2.028GlnPro: 2.028 ± 0.064
1.678GlnGln: 1.678 ± 0.06
2.815GlnArg: 2.815 ± 0.07
1.52GlnSer: 1.52 ± 0.038
1.606GlnThr: 1.606 ± 0.042
2.554GlnVal: 2.554 ± 0.053
0.44GlnTrp: 0.44 ± 0.019
0.551GlnTyr: 0.551 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
9.28ArgAla: 9.28 ± 0.142
0.338ArgCys: 0.338 ± 0.02
4.676ArgAsp: 4.676 ± 0.09
4.112ArgGlu: 4.112 ± 0.083
2.244ArgPhe: 2.244 ± 0.055
5.369ArgGly: 5.369 ± 0.078
1.57ArgHis: 1.57 ± 0.049
4.297ArgIle: 4.297 ± 0.064
1.128ArgLys: 1.128 ± 0.039
7.778ArgLeu: 7.778 ± 0.126
2.068ArgMet: 2.068 ± 0.051
0.987ArgAsn: 0.987 ± 0.03
3.382ArgPro: 3.382 ± 0.068
1.97ArgGln: 1.97 ± 0.058
6.779ArgArg: 6.779 ± 0.12
3.883ArgSer: 3.883 ± 0.071
4.393ArgThr: 4.393 ± 0.078
6.42ArgVal: 6.42 ± 0.099
1.32ArgTrp: 1.32 ± 0.041
1.392ArgTyr: 1.392 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.468SerAla: 6.468 ± 0.099
0.248SerCys: 0.248 ± 0.017
2.889SerAsp: 2.889 ± 0.055
2.345SerGlu: 2.345 ± 0.053
1.589SerPhe: 1.589 ± 0.041
5.248SerGly: 5.248 ± 0.094
0.915SerHis: 0.915 ± 0.029
2.643SerIle: 2.643 ± 0.05
0.885SerLys: 0.885 ± 0.034
4.993SerLeu: 4.993 ± 0.079
1.17SerMet: 1.17 ± 0.036
0.908SerAsn: 0.908 ± 0.03
2.889SerPro: 2.889 ± 0.061
1.339SerGln: 1.339 ± 0.033
3.367SerArg: 3.367 ± 0.062
3.088SerSer: 3.088 ± 0.068
3.783SerThr: 3.783 ± 0.09
4.369SerVal: 4.369 ± 0.069
0.858SerTrp: 0.858 ± 0.03
0.972SerTyr: 0.972 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.773ThrAla: 7.773 ± 0.131
0.321ThrCys: 0.321 ± 0.02
3.456ThrAsp: 3.456 ± 0.061
2.665ThrGlu: 2.665 ± 0.054
1.995ThrPhe: 1.995 ± 0.074
5.64ThrGly: 5.64 ± 0.108
1.192ThrHis: 1.192 ± 0.038
3.363ThrIle: 3.363 ± 0.093
0.895ThrLys: 0.895 ± 0.032
6.301ThrLeu: 6.301 ± 0.108
1.065ThrMet: 1.065 ± 0.031
1.086ThrAsn: 1.086 ± 0.039
4.192ThrPro: 4.192 ± 0.164
1.633ThrGln: 1.633 ± 0.047
3.672ThrArg: 3.672 ± 0.067
3.316ThrSer: 3.316 ± 0.069
4.446ThrThr: 4.446 ± 0.134
5.941ThrVal: 5.941 ± 0.121
0.999ThrTrp: 0.999 ± 0.046
1.239ThrTyr: 1.239 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
15.027ValAla: 15.027 ± 0.172
0.451ValCys: 0.451 ± 0.024
7.492ValAsp: 7.492 ± 0.096
5.841ValGlu: 5.841 ± 0.093
2.313ValPhe: 2.313 ± 0.053
8.535ValGly: 8.535 ± 0.115
1.968ValHis: 1.968 ± 0.046
3.354ValIle: 3.354 ± 0.066
1.051ValLys: 1.051 ± 0.034
10.293ValLeu: 10.293 ± 0.138
1.38ValMet: 1.38 ± 0.041
1.348ValAsn: 1.348 ± 0.039
5.268ValPro: 5.268 ± 0.096
2.684ValGln: 2.684 ± 0.055
6.775ValArg: 6.775 ± 0.095
4.263ValSer: 4.263 ± 0.072
5.984ValThr: 5.984 ± 0.142
11.117ValVal: 11.117 ± 0.146
1.129ValTrp: 1.129 ± 0.041
1.261ValTyr: 1.261 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.663TrpAla: 1.663 ± 0.046
0.103TrpCys: 0.103 ± 0.01
0.759TrpAsp: 0.759 ± 0.027
0.553TrpGlu: 0.553 ± 0.025
0.485TrpPhe: 0.485 ± 0.022
1.09TrpGly: 1.09 ± 0.037
0.358TrpHis: 0.358 ± 0.018
0.77TrpIle: 0.77 ± 0.031
0.182TrpLys: 0.182 ± 0.012
1.828TrpLeu: 1.828 ± 0.048
0.449TrpMet: 0.449 ± 0.021
0.319TrpAsn: 0.319 ± 0.016
0.713TrpPro: 0.713 ± 0.026
0.607TrpGln: 0.607 ± 0.024
1.291TrpArg: 1.291 ± 0.038
0.918TrpSer: 0.918 ± 0.034
0.988TrpThr: 0.988 ± 0.033
1.146TrpVal: 1.146 ± 0.039
0.374TrpTrp: 0.374 ± 0.02
0.266TrpTyr: 0.266 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.328TyrAla: 2.328 ± 0.052
0.085TyrCys: 0.085 ± 0.009
1.255TyrAsp: 1.255 ± 0.04
0.992TyrGlu: 0.992 ± 0.033
0.495TyrPhe: 0.495 ± 0.025
1.711TyrGly: 1.711 ± 0.046
0.256TyrHis: 0.256 ± 0.017
0.386TyrIle: 0.386 ± 0.02
0.22TyrLys: 0.22 ± 0.014
1.768TyrLeu: 1.768 ± 0.044
0.257TyrMet: 0.257 ± 0.018
0.259TyrAsn: 0.259 ± 0.017
0.826TyrPro: 0.826 ± 0.028
0.465TyrGln: 0.465 ± 0.026
1.467TyrArg: 1.467 ± 0.056
0.817TyrSer: 0.817 ± 0.032
0.874TyrThr: 0.874 ± 0.041
1.637TyrVal: 1.637 ± 0.044
0.237TyrTrp: 0.237 ± 0.014
0.332TyrTyr: 0.332 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3218 proteins (1039962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski