Amino acid dipepetide frequency for Knoellia remsis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.492AlaAla: 19.492 ± 0.2
0.839AlaCys: 0.839 ± 0.031
8.171AlaAsp: 8.171 ± 0.108
7.513AlaGlu: 7.513 ± 0.1
3.498AlaPhe: 3.498 ± 0.064
12.16AlaGly: 12.16 ± 0.116
2.46AlaHis: 2.46 ± 0.059
4.445AlaIle: 4.445 ± 0.074
3.099AlaLys: 3.099 ± 0.076
13.187AlaLeu: 13.187 ± 0.14
2.812AlaMet: 2.812 ± 0.054
2.228AlaAsn: 2.228 ± 0.055
6.309AlaPro: 6.309 ± 0.098
3.86AlaGln: 3.86 ± 0.059
9.442AlaArg: 9.442 ± 0.112
6.774AlaSer: 6.774 ± 0.086
8.219AlaThr: 8.219 ± 0.11
11.451AlaVal: 11.451 ± 0.13
2.007AlaTrp: 2.007 ± 0.053
2.794AlaTyr: 2.794 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.785CysAla: 0.785 ± 0.027
0.085CysCys: 0.085 ± 0.008
0.427CysAsp: 0.427 ± 0.022
0.31CysGlu: 0.31 ± 0.016
0.173CysPhe: 0.173 ± 0.011
0.719CysGly: 0.719 ± 0.026
0.139CysHis: 0.139 ± 0.011
0.198CysIle: 0.198 ± 0.014
0.093CysLys: 0.093 ± 0.009
0.536CysLeu: 0.536 ± 0.023
0.092CysMet: 0.092 ± 0.009
0.115CysAsn: 0.115 ± 0.011
0.403CysPro: 0.403 ± 0.022
0.152CysGln: 0.152 ± 0.013
0.464CysArg: 0.464 ± 0.019
0.365CysSer: 0.365 ± 0.019
0.435CysThr: 0.435 ± 0.024
0.509CysVal: 0.509 ± 0.022
0.086CysTrp: 0.086 ± 0.009
0.123CysTyr: 0.123 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.525AspAla: 8.525 ± 0.104
0.352AspCys: 0.352 ± 0.019
4.549AspAsp: 4.549 ± 0.074
4.715AspGlu: 4.715 ± 0.079
1.649AspPhe: 1.649 ± 0.037
6.676AspGly: 6.676 ± 0.083
1.409AspHis: 1.409 ± 0.04
2.227AspIle: 2.227 ± 0.043
1.251AspLys: 1.251 ± 0.042
6.891AspLeu: 6.891 ± 0.083
0.886AspMet: 0.886 ± 0.027
1.113AspAsn: 1.113 ± 0.038
4.484AspPro: 4.484 ± 0.069
1.539AspGln: 1.539 ± 0.038
4.75AspArg: 4.75 ± 0.076
2.721AspSer: 2.721 ± 0.054
3.379AspThr: 3.379 ± 0.056
6.169AspVal: 6.169 ± 0.077
0.916AspTrp: 0.916 ± 0.032
1.157AspTyr: 1.157 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.169GluAla: 7.169 ± 0.102
0.3GluCys: 0.3 ± 0.017
3.249GluAsp: 3.249 ± 0.059
3.159GluGlu: 3.159 ± 0.068
1.538GluPhe: 1.538 ± 0.041
4.466GluGly: 4.466 ± 0.063
1.452GluHis: 1.452 ± 0.041
2.231GluIle: 2.231 ± 0.051
1.514GluLys: 1.514 ± 0.041
6.324GluLeu: 6.324 ± 0.1
0.908GluMet: 0.908 ± 0.032
1.05GluAsn: 1.05 ± 0.032
3.16GluPro: 3.16 ± 0.068
2.297GluGln: 2.297 ± 0.051
5.468GluArg: 5.468 ± 0.091
3.027GluSer: 3.027 ± 0.051
3.032GluThr: 3.032 ± 0.051
5.489GluVal: 5.489 ± 0.085
0.87GluTrp: 0.87 ± 0.03
0.95GluTyr: 0.95 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.658PheAla: 3.658 ± 0.061
0.203PheCys: 0.203 ± 0.015
2.1PheAsp: 2.1 ± 0.05
1.48PheGlu: 1.48 ± 0.042
0.892PhePhe: 0.892 ± 0.035
3.124PheGly: 3.124 ± 0.062
0.549PheHis: 0.549 ± 0.02
0.912PheIle: 0.912 ± 0.031
0.504PheLys: 0.504 ± 0.021
2.421PheLeu: 2.421 ± 0.067
0.438PheMet: 0.438 ± 0.023
0.535PheAsn: 0.535 ± 0.023
1.313PhePro: 1.313 ± 0.033
0.56PheGln: 0.56 ± 0.025
1.649PheArg: 1.649 ± 0.042
1.387PheSer: 1.387 ± 0.035
1.969PheThr: 1.969 ± 0.047
2.676PheVal: 2.676 ± 0.055
0.446PheTrp: 0.446 ± 0.024
0.59PheTyr: 0.59 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.829GlyAla: 10.829 ± 0.121
0.657GlyCys: 0.657 ± 0.027
5.763GlyAsp: 5.763 ± 0.082
5.408GlyGlu: 5.408 ± 0.072
2.89GlyPhe: 2.89 ± 0.059
8.414GlyGly: 8.414 ± 0.128
1.954GlyHis: 1.954 ± 0.041
3.964GlyIle: 3.964 ± 0.068
2.344GlyLys: 2.344 ± 0.062
9.071GlyLeu: 9.071 ± 0.113
2.01GlyMet: 2.01 ± 0.044
1.697GlyAsn: 1.697 ± 0.045
4.53GlyPro: 4.53 ± 0.068
2.695GlyGln: 2.695 ± 0.049
7.222GlyArg: 7.222 ± 0.089
5.812GlySer: 5.812 ± 0.083
5.915GlyThr: 5.915 ± 0.088
8.177GlyVal: 8.177 ± 0.08
1.785GlyTrp: 1.785 ± 0.044
2.049GlyTyr: 2.049 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.279HisAla: 2.279 ± 0.05
0.156HisCys: 0.156 ± 0.011
1.546HisAsp: 1.546 ± 0.037
1.257HisGlu: 1.257 ± 0.039
0.495HisPhe: 0.495 ± 0.024
1.996HisGly: 1.996 ± 0.047
0.602HisHis: 0.602 ± 0.026
0.58HisIle: 0.58 ± 0.021
0.322HisLys: 0.322 ± 0.018
2.241HisLeu: 2.241 ± 0.053
0.291HisMet: 0.291 ± 0.016
0.35HisAsn: 0.35 ± 0.018
1.494HisPro: 1.494 ± 0.044
0.503HisGln: 0.503 ± 0.021
1.685HisArg: 1.685 ± 0.045
0.849HisSer: 0.849 ± 0.028
1.143HisThr: 1.143 ± 0.031
1.899HisVal: 1.899 ± 0.042
0.326HisTrp: 0.326 ± 0.019
0.382HisTyr: 0.382 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.293IleAla: 5.293 ± 0.077
0.261IleCys: 0.261 ± 0.016
2.709IleAsp: 2.709 ± 0.058
2.404IleGlu: 2.404 ± 0.055
0.903IlePhe: 0.903 ± 0.034
3.844IleGly: 3.844 ± 0.079
0.635IleHis: 0.635 ± 0.025
1.207IleIle: 1.207 ± 0.043
0.745IleLys: 0.745 ± 0.028
2.82IleLeu: 2.82 ± 0.062
0.49IleMet: 0.49 ± 0.024
0.802IleAsn: 0.802 ± 0.028
1.966IlePro: 1.966 ± 0.045
0.768IleGln: 0.768 ± 0.027
2.33IleArg: 2.33 ± 0.044
1.789IleSer: 1.789 ± 0.039
2.464IleThr: 2.464 ± 0.05
3.413IleVal: 3.413 ± 0.065
0.461IleTrp: 0.461 ± 0.024
0.614IleTyr: 0.614 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.048LysAla: 3.048 ± 0.066
0.087LysCys: 0.087 ± 0.009
1.387LysAsp: 1.387 ± 0.041
1.145LysGlu: 1.145 ± 0.04
0.499LysPhe: 0.499 ± 0.024
1.928LysGly: 1.928 ± 0.047
0.423LysHis: 0.423 ± 0.018
0.799LysIle: 0.799 ± 0.034
0.923LysLys: 0.923 ± 0.053
1.642LysLeu: 1.642 ± 0.05
0.368LysMet: 0.368 ± 0.021
0.543LysAsn: 0.543 ± 0.022
1.298LysPro: 1.298 ± 0.037
0.713LysGln: 0.713 ± 0.029
1.49LysArg: 1.49 ± 0.048
1.206LysSer: 1.206 ± 0.041
1.303LysThr: 1.303 ± 0.04
2.169LysVal: 2.169 ± 0.055
0.265LysTrp: 0.265 ± 0.015
0.45LysTyr: 0.45 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.128LeuAla: 14.128 ± 0.15
0.563LeuCys: 0.563 ± 0.024
7.103LeuAsp: 7.103 ± 0.092
5.058LeuGlu: 5.058 ± 0.081
2.355LeuPhe: 2.355 ± 0.062
9.431LeuGly: 9.431 ± 0.113
1.785LeuHis: 1.785 ± 0.045
3.144LeuIle: 3.144 ± 0.068
1.776LeuLys: 1.776 ± 0.043
9.64LeuLeu: 9.64 ± 0.135
1.637LeuMet: 1.637 ± 0.043
1.499LeuAsn: 1.499 ± 0.04
5.361LeuPro: 5.361 ± 0.076
2.075LeuGln: 2.075 ± 0.045
7.504LeuArg: 7.504 ± 0.099
5.215LeuSer: 5.215 ± 0.07
6.747LeuThr: 6.747 ± 0.079
9.875LeuVal: 9.875 ± 0.132
1.211LeuTrp: 1.211 ± 0.042
1.343LeuTyr: 1.343 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.292MetAla: 2.292 ± 0.047
0.121MetCys: 0.121 ± 0.01
0.899MetAsp: 0.899 ± 0.031
0.74MetGlu: 0.74 ± 0.025
0.479MetPhe: 0.479 ± 0.024
1.506MetGly: 1.506 ± 0.035
0.299MetHis: 0.299 ± 0.016
0.641MetIle: 0.641 ± 0.027
0.456MetLys: 0.456 ± 0.021
1.713MetLeu: 1.713 ± 0.044
0.314MetMet: 0.314 ± 0.019
0.438MetAsn: 0.438 ± 0.019
1.264MetPro: 1.264 ± 0.034
0.492MetGln: 0.492 ± 0.024
1.515MetArg: 1.515 ± 0.039
1.611MetSer: 1.611 ± 0.04
1.835MetThr: 1.835 ± 0.039
1.419MetVal: 1.419 ± 0.04
0.234MetTrp: 0.234 ± 0.015
0.269MetTyr: 0.269 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.296AsnAla: 2.296 ± 0.048
0.135AsnCys: 0.135 ± 0.011
1.038AsnAsp: 1.038 ± 0.035
0.911AsnGlu: 0.911 ± 0.031
0.509AsnPhe: 0.509 ± 0.024
1.724AsnGly: 1.724 ± 0.05
0.391AsnHis: 0.391 ± 0.019
0.713AsnIle: 0.713 ± 0.029
0.377AsnLys: 0.377 ± 0.019
1.834AsnLeu: 1.834 ± 0.046
0.284AsnMet: 0.284 ± 0.015
0.446AsnAsn: 0.446 ± 0.023
1.641AsnPro: 1.641 ± 0.042
0.54AsnGln: 0.54 ± 0.024
1.272AsnArg: 1.272 ± 0.041
0.901AsnSer: 0.901 ± 0.028
1.109AsnThr: 1.109 ± 0.033
1.527AsnVal: 1.527 ± 0.041
0.286AsnTrp: 0.286 ± 0.018
0.439AsnTyr: 0.439 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.009ProAla: 7.009 ± 0.098
0.246ProCys: 0.246 ± 0.019
4.285ProAsp: 4.285 ± 0.061
4.096ProGlu: 4.096 ± 0.068
1.553ProPhe: 1.553 ± 0.038
5.706ProGly: 5.706 ± 0.079
1.168ProHis: 1.168 ± 0.034
1.689ProIle: 1.689 ± 0.038
1.223ProLys: 1.223 ± 0.039
4.543ProLeu: 4.543 ± 0.067
1.112ProMet: 1.112 ± 0.033
1.016ProAsn: 1.016 ± 0.032
2.732ProPro: 2.732 ± 0.062
1.689ProGln: 1.689 ± 0.04
3.717ProArg: 3.717 ± 0.065
3.571ProSer: 3.571 ± 0.071
3.913ProThr: 3.913 ± 0.074
5.238ProVal: 5.238 ± 0.076
0.998ProTrp: 0.998 ± 0.034
1.033ProTyr: 1.033 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.325GlnAla: 3.325 ± 0.066
0.156GlnCys: 0.156 ± 0.012
1.35GlnAsp: 1.35 ± 0.038
1.263GlnGlu: 1.263 ± 0.036
0.751GlnPhe: 0.751 ± 0.025
2.194GlnGly: 2.194 ± 0.057
0.623GlnHis: 0.623 ± 0.023
1.078GlnIle: 1.078 ± 0.031
0.61GlnLys: 0.61 ± 0.029
2.947GlnLeu: 2.947 ± 0.065
0.52GlnMet: 0.52 ± 0.025
0.529GlnAsn: 0.529 ± 0.023
1.756GlnPro: 1.756 ± 0.046
1.232GlnGln: 1.232 ± 0.041
2.572GlnArg: 2.572 ± 0.052
1.46GlnSer: 1.46 ± 0.04
1.43GlnThr: 1.43 ± 0.04
2.618GlnVal: 2.618 ± 0.05
0.54GlnTrp: 0.54 ± 0.021
0.467GlnTyr: 0.467 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.9ArgAla: 8.9 ± 0.109
0.395ArgCys: 0.395 ± 0.018
4.971ArgAsp: 4.971 ± 0.069
4.875ArgGlu: 4.875 ± 0.079
2.178ArgPhe: 2.178 ± 0.046
5.98ArgGly: 5.98 ± 0.079
1.83ArgHis: 1.83 ± 0.049
3.109ArgIle: 3.109 ± 0.058
1.472ArgLys: 1.472 ± 0.043
7.724ArgLeu: 7.724 ± 0.096
1.746ArgMet: 1.746 ± 0.043
1.283ArgAsn: 1.283 ± 0.041
4.282ArgPro: 4.282 ± 0.075
2.101ArgGln: 2.101 ± 0.041
7.05ArgArg: 7.05 ± 0.101
4.216ArgSer: 4.216 ± 0.066
4.79ArgThr: 4.79 ± 0.066
6.276ArgVal: 6.276 ± 0.096
1.414ArgTrp: 1.414 ± 0.04
1.452ArgTyr: 1.452 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.909SerAla: 6.909 ± 0.082
0.326SerCys: 0.326 ± 0.019
3.227SerAsp: 3.227 ± 0.056
2.743SerGlu: 2.743 ± 0.054
1.571SerPhe: 1.571 ± 0.041
6.029SerGly: 6.029 ± 0.082
0.955SerHis: 0.955 ± 0.03
1.917SerIle: 1.917 ± 0.043
1.056SerLys: 1.056 ± 0.03
4.982SerLeu: 4.982 ± 0.071
1.308SerMet: 1.308 ± 0.036
1.018SerAsn: 1.018 ± 0.032
3.335SerPro: 3.335 ± 0.071
1.461SerGln: 1.461 ± 0.035
4.182SerArg: 4.182 ± 0.062
3.381SerSer: 3.381 ± 0.062
3.775SerThr: 3.775 ± 0.064
4.737SerVal: 4.737 ± 0.076
0.961SerTrp: 0.961 ± 0.027
1.082SerTyr: 1.082 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
8.064ThrAla: 8.064 ± 0.121
0.432ThrCys: 0.432 ± 0.02
4.021ThrAsp: 4.021 ± 0.066
3.276ThrGlu: 3.276 ± 0.065
1.934ThrPhe: 1.934 ± 0.045
6.332ThrGly: 6.332 ± 0.095
1.272ThrHis: 1.272 ± 0.034
2.451ThrIle: 2.451 ± 0.055
1.496ThrLys: 1.496 ± 0.044
5.724ThrLeu: 5.724 ± 0.072
1.203ThrMet: 1.203 ± 0.038
1.245ThrAsn: 1.245 ± 0.032
4.35ThrPro: 4.35 ± 0.074
1.636ThrGln: 1.636 ± 0.043
4.3ThrArg: 4.3 ± 0.069
3.901ThrSer: 3.901 ± 0.069
4.809ThrThr: 4.809 ± 0.084
6.042ThrVal: 6.042 ± 0.093
1.113ThrTrp: 1.113 ± 0.035
1.395ThrTyr: 1.395 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
12.264ValAla: 12.264 ± 0.124
0.637ValCys: 0.637 ± 0.024
6.278ValAsp: 6.278 ± 0.075
5.513ValGlu: 5.513 ± 0.083
2.329ValPhe: 2.329 ± 0.057
7.951ValGly: 7.951 ± 0.104
1.819ValHis: 1.819 ± 0.047
3.626ValIle: 3.626 ± 0.065
1.746ValLys: 1.746 ± 0.048
9.537ValLeu: 9.537 ± 0.122
1.595ValMet: 1.595 ± 0.04
1.708ValAsn: 1.708 ± 0.044
5.105ValPro: 5.105 ± 0.084
2.077ValGln: 2.077 ± 0.043
6.655ValArg: 6.655 ± 0.093
4.883ValSer: 4.883 ± 0.062
6.713ValThr: 6.713 ± 0.096
10.099ValVal: 10.099 ± 0.125
1.15ValTrp: 1.15 ± 0.039
1.228ValTyr: 1.228 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.691TrpAla: 1.691 ± 0.04
0.13TrpCys: 0.13 ± 0.011
0.862TrpAsp: 0.862 ± 0.028
0.705TrpGlu: 0.705 ± 0.025
0.612TrpPhe: 0.612 ± 0.028
1.197TrpGly: 1.197 ± 0.038
0.331TrpHis: 0.331 ± 0.019
0.496TrpIle: 0.496 ± 0.026
0.32TrpLys: 0.32 ± 0.019
1.811TrpLeu: 1.811 ± 0.049
0.315TrpMet: 0.315 ± 0.019
0.384TrpAsn: 0.384 ± 0.021
0.814TrpPro: 0.814 ± 0.03
0.546TrpGln: 0.546 ± 0.022
1.344TrpArg: 1.344 ± 0.046
1.018TrpSer: 1.018 ± 0.03
1.028TrpThr: 1.028 ± 0.033
1.445TrpVal: 1.445 ± 0.039
0.418TrpTrp: 0.418 ± 0.024
0.266TrpTyr: 0.266 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.804TyrAla: 2.804 ± 0.051
0.126TyrCys: 0.126 ± 0.012
1.422TyrAsp: 1.422 ± 0.039
1.078TyrGlu: 1.078 ± 0.034
0.6TyrPhe: 0.6 ± 0.023
1.812TyrGly: 1.812 ± 0.041
0.3TyrHis: 0.3 ± 0.016
0.491TyrIle: 0.491 ± 0.023
0.362TyrLys: 0.362 ± 0.018
1.864TyrLeu: 1.864 ± 0.045
0.207TyrMet: 0.207 ± 0.012
0.377TyrAsn: 0.377 ± 0.023
0.939TyrPro: 0.939 ± 0.032
0.483TyrGln: 0.483 ± 0.022
1.431TyrArg: 1.431 ± 0.042
0.87TyrSer: 0.87 ± 0.029
0.985TyrThr: 0.985 ± 0.038
1.683TyrVal: 1.683 ± 0.046
0.248TyrTrp: 0.248 ± 0.016
0.387TyrTyr: 0.387 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3374 proteins (1082194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski