Amino acid dipepetide frequency for Paracoccus sp. JM45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.791AlaAla: 15.791 ± 0.18	1.044AlaCys: 1.044 ± 0.035	7.409AlaAsp: 7.409 ± 0.085	6.988AlaGlu: 6.988 ± 0.087	4.175AlaPhe: 4.175 ± 0.069	10.456AlaGly: 10.456 ± 0.107	2.256AlaHis: 2.256 ± 0.046	6.482AlaIle: 6.482 ± 0.093	3.718AlaLys: 3.718 ± 0.077	13.04AlaLeu: 13.04 ± 0.13	4.107AlaMet: 4.107 ± 0.068	2.74AlaAsn: 2.74 ± 0.052	5.319AlaPro: 5.319 ± 0.081	4.881AlaGln: 4.881 ± 0.07	8.35AlaArg: 8.35 ± 0.106	5.772AlaSer: 5.772 ± 0.075	6.324AlaThr: 6.324 ± 0.087	8.205AlaVal: 8.205 ± 0.093	1.526AlaTrp: 1.526 ± 0.036	2.361AlaTyr: 2.361 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.005CysAla: 1.005 ± 0.033	0.115CysCys: 0.115 ± 0.01	0.637CysAsp: 0.637 ± 0.026	0.356CysGlu: 0.356 ± 0.019	0.32CysPhe: 0.32 ± 0.019	0.899CysGly: 0.899 ± 0.03	0.303CysHis: 0.303 ± 0.017	0.441CysIle: 0.441 ± 0.023	0.209CysLys: 0.209 ± 0.014	0.86CysLeu: 0.86 ± 0.032	0.182CysMet: 0.182 ± 0.014	0.212CysAsn: 0.212 ± 0.014	0.501CysPro: 0.501 ± 0.023	0.277CysGln: 0.277 ± 0.015	0.532CysArg: 0.532 ± 0.023	0.467CysSer: 0.467 ± 0.022	0.438CysThr: 0.438 ± 0.022	0.607CysVal: 0.607 ± 0.024	0.125CysTrp: 0.125 ± 0.011	0.188CysTyr: 0.188 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.638AspAla: 7.638 ± 0.099	0.518AspCys: 0.518 ± 0.026	4.124AspAsp: 4.124 ± 0.076	3.284AspGlu: 3.284 ± 0.064	2.331AspPhe: 2.331 ± 0.05	5.566AspGly: 5.566 ± 0.092	1.596AspHis: 1.596 ± 0.04	3.396AspIle: 3.396 ± 0.057	1.808AspLys: 1.808 ± 0.049	6.986AspLeu: 6.986 ± 0.097	1.947AspMet: 1.947 ± 0.045	1.474AspAsn: 1.474 ± 0.037	3.876AspPro: 3.876 ± 0.063	2.485AspGln: 2.485 ± 0.049	4.855AspArg: 4.855 ± 0.077	2.549AspSer: 2.549 ± 0.051	2.983AspThr: 2.983 ± 0.055	4.156AspVal: 4.156 ± 0.07	1.245AspTrp: 1.245 ± 0.037	1.599AspTyr: 1.599 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.343GluAla: 6.343 ± 0.1	0.382GluCys: 0.382 ± 0.022	2.948GluAsp: 2.948 ± 0.058	2.605GluGlu: 2.605 ± 0.072	1.759GluPhe: 1.759 ± 0.042	4.283GluGly: 4.283 ± 0.07	1.03GluHis: 1.03 ± 0.034	2.892GluIle: 2.892 ± 0.059	1.78GluLys: 1.78 ± 0.05	4.638GluLeu: 4.638 ± 0.072	1.564GluMet: 1.564 ± 0.043	1.65GluAsn: 1.65 ± 0.04	2.245GluPro: 2.245 ± 0.052	1.976GluGln: 1.976 ± 0.047	3.66GluArg: 3.66 ± 0.068	2.086GluSer: 2.086 ± 0.049	3.161GluThr: 3.161 ± 0.058	3.409GluVal: 3.409 ± 0.063	0.748GluTrp: 0.748 ± 0.028	1.062GluTyr: 1.062 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.289PheAla: 4.289 ± 0.074	0.428PheCys: 0.428 ± 0.019	2.877PheAsp: 2.877 ± 0.056	1.791PheGlu: 1.791 ± 0.042	1.39PhePhe: 1.39 ± 0.046	3.689PheGly: 3.689 ± 0.061	0.769PheHis: 0.769 ± 0.026	1.826PheIle: 1.826 ± 0.05	0.923PheLys: 0.923 ± 0.033	3.441PheLeu: 3.441 ± 0.071	0.903PheMet: 0.903 ± 0.031	1.027PheAsn: 1.027 ± 0.03	1.569PhePro: 1.569 ± 0.043	1.122PheGln: 1.122 ± 0.038	2.124PheArg: 2.124 ± 0.049	2.132PheSer: 2.132 ± 0.046	2.111PheThr: 2.111 ± 0.051	2.592PheVal: 2.592 ± 0.055	0.613PheTrp: 0.613 ± 0.03	0.821PheTyr: 0.821 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.198GlyAla: 9.198 ± 0.11	0.877GlyCys: 0.877 ± 0.027	4.922GlyAsp: 4.922 ± 0.072	3.74GlyGlu: 3.74 ± 0.071	3.776GlyPhe: 3.776 ± 0.062	6.917GlyGly: 6.917 ± 0.106	2.024GlyHis: 2.024 ± 0.052	4.841GlyIle: 4.841 ± 0.076	3.025GlyLys: 3.025 ± 0.055	9.262GlyLeu: 9.262 ± 0.108	2.838GlyMet: 2.838 ± 0.054	2.343GlyAsn: 2.343 ± 0.062	3.719GlyPro: 3.719 ± 0.062	3.79GlyGln: 3.79 ± 0.073	5.709GlyArg: 5.709 ± 0.085	4.271GlySer: 4.271 ± 0.072	4.514GlyThr: 4.514 ± 0.065	6.1GlyVal: 6.1 ± 0.081	1.494GlyTrp: 1.494 ± 0.041	2.155GlyTyr: 2.155 ± 0.047	0.001GlyXaa: 0.001 ± 0.001
His	2.398HisAla: 2.398 ± 0.051	0.224HisCys: 0.224 ± 0.015	1.541HisAsp: 1.541 ± 0.044	0.968HisGlu: 0.968 ± 0.031	0.787HisPhe: 0.787 ± 0.026	1.963HisGly: 1.963 ± 0.047	0.605HisHis: 0.605 ± 0.024	1.076HisIle: 1.076 ± 0.031	0.519HisLys: 0.519 ± 0.021	2.276HisLeu: 2.276 ± 0.051	0.633HisMet: 0.633 ± 0.023	0.479HisAsn: 0.479 ± 0.02	1.442HisPro: 1.442 ± 0.037	0.712HisGln: 0.712 ± 0.027	1.397HisArg: 1.397 ± 0.038	1.013HisSer: 1.013 ± 0.034	0.766HisThr: 0.766 ± 0.03	1.478HisVal: 1.478 ± 0.037	0.31HisTrp: 0.31 ± 0.017	0.519HisTyr: 0.519 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.437IleAla: 7.437 ± 0.09	0.667IleCys: 0.667 ± 0.032	3.694IleAsp: 3.694 ± 0.061	3.073IleGlu: 3.073 ± 0.059	1.956IlePhe: 1.956 ± 0.048	5.148IleGly: 5.148 ± 0.077	0.998IleHis: 0.998 ± 0.032	2.79IleIle: 2.79 ± 0.059	1.413IleLys: 1.413 ± 0.041	5.025IleLeu: 5.025 ± 0.067	1.37IleMet: 1.37 ± 0.033	1.514IleAsn: 1.514 ± 0.038	2.561IlePro: 2.561 ± 0.05	1.402IleGln: 1.402 ± 0.036	3.605IleArg: 3.605 ± 0.064	3.228IleSer: 3.228 ± 0.057	3.299IleThr: 3.299 ± 0.063	3.846IleVal: 3.846 ± 0.074	0.83IleTrp: 0.83 ± 0.031	1.203IleTyr: 1.203 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.69LysAla: 3.69 ± 0.069	0.165LysCys: 0.165 ± 0.012	1.657LysAsp: 1.657 ± 0.047	1.309LysGlu: 1.309 ± 0.037	0.831LysPhe: 0.831 ± 0.03	2.641LysGly: 2.641 ± 0.055	0.589LysHis: 0.589 ± 0.024	1.7LysIle: 1.7 ± 0.043	0.988LysLys: 0.988 ± 0.039	2.889LysLeu: 2.889 ± 0.05	0.906LysMet: 0.906 ± 0.028	0.86LysAsn: 0.86 ± 0.038	1.742LysPro: 1.742 ± 0.045	0.874LysGln: 0.874 ± 0.031	1.992LysArg: 1.992 ± 0.046	1.8LysSer: 1.8 ± 0.044	1.876LysThr: 1.876 ± 0.041	2.19LysVal: 2.19 ± 0.058	0.381LysTrp: 0.381 ± 0.019	0.585LysTyr: 0.585 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.784LeuAla: 12.784 ± 0.128	0.898LeuCys: 0.898 ± 0.03	6.374LeuAsp: 6.374 ± 0.088	4.552LeuGlu: 4.552 ± 0.074	3.33LeuPhe: 3.33 ± 0.065	8.398LeuGly: 8.398 ± 0.104	1.984LeuHis: 1.984 ± 0.047	5.568LeuIle: 5.568 ± 0.074	2.82LeuLys: 2.82 ± 0.053	8.942LeuLeu: 8.942 ± 0.125	2.926LeuMet: 2.926 ± 0.056	2.75LeuAsn: 2.75 ± 0.054	5.926LeuPro: 5.926 ± 0.083	3.123LeuGln: 3.123 ± 0.055	7.137LeuArg: 7.137 ± 0.091	6.807LeuSer: 6.807 ± 0.08	6.52LeuThr: 6.52 ± 0.08	6.94LeuVal: 6.94 ± 0.094	1.321LeuTrp: 1.321 ± 0.041	1.878LeuTyr: 1.878 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.813MetAla: 3.813 ± 0.059	0.182MetCys: 0.182 ± 0.012	1.584MetAsp: 1.584 ± 0.037	1.153MetGlu: 1.153 ± 0.032	0.901MetPhe: 0.901 ± 0.029	2.498MetGly: 2.498 ± 0.048	0.481MetHis: 0.481 ± 0.022	1.807MetIle: 1.807 ± 0.045	1.012MetLys: 1.012 ± 0.036	3.015MetLeu: 3.015 ± 0.054	0.915MetMet: 0.915 ± 0.031	0.933MetAsn: 0.933 ± 0.032	1.777MetPro: 1.777 ± 0.046	1.231MetGln: 1.231 ± 0.034	2.002MetArg: 2.002 ± 0.043	1.896MetSer: 1.896 ± 0.045	2.432MetThr: 2.432 ± 0.044	2.03MetVal: 2.03 ± 0.048	0.291MetTrp: 0.291 ± 0.017	0.362MetTyr: 0.362 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.194AsnAla: 3.194 ± 0.056	0.282AsnCys: 0.282 ± 0.019	1.638AsnAsp: 1.638 ± 0.05	1.184AsnGlu: 1.184 ± 0.036	0.973AsnPhe: 0.973 ± 0.03	2.437AsnGly: 2.437 ± 0.051	0.55AsnHis: 0.55 ± 0.024	1.529AsnIle: 1.529 ± 0.042	0.662AsnLys: 0.662 ± 0.031	2.785AsnLeu: 2.785 ± 0.049	0.739AsnMet: 0.739 ± 0.029	0.727AsnAsn: 0.727 ± 0.029	1.878AsnPro: 1.878 ± 0.046	0.802AsnGln: 0.802 ± 0.029	1.858AsnArg: 1.858 ± 0.043	1.315AsnSer: 1.315 ± 0.04	1.355AsnThr: 1.355 ± 0.034	1.838AsnVal: 1.838 ± 0.042	0.502AsnTrp: 0.502 ± 0.023	0.655AsnTyr: 0.655 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.185ProAla: 6.185 ± 0.102	0.337ProCys: 0.337 ± 0.02	4.508ProAsp: 4.508 ± 0.071	3.698ProGlu: 3.698 ± 0.067	1.946ProPhe: 1.946 ± 0.037	3.604ProGly: 3.604 ± 0.067	1.119ProHis: 1.119 ± 0.033	2.221ProIle: 2.221 ± 0.05	1.593ProLys: 1.593 ± 0.038	4.737ProLeu: 4.737 ± 0.075	1.428ProMet: 1.428 ± 0.041	1.282ProAsn: 1.282 ± 0.033	2.135ProPro: 2.135 ± 0.052	2.037ProGln: 2.037 ± 0.044	2.996ProArg: 2.996 ± 0.06	2.577ProSer: 2.577 ± 0.052	2.552ProThr: 2.552 ± 0.051	4.459ProVal: 4.459 ± 0.067	0.735ProTrp: 0.735 ± 0.025	1.112ProTyr: 1.112 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.786GlnAla: 4.786 ± 0.08	0.213GlnCys: 0.213 ± 0.015	2.246GlnAsp: 2.246 ± 0.049	1.404GlnGlu: 1.404 ± 0.036	1.111GlnPhe: 1.111 ± 0.035	3.244GlnGly: 3.244 ± 0.059	0.678GlnHis: 0.678 ± 0.028	2.489GlnIle: 2.489 ± 0.049	1.061GlnLys: 1.061 ± 0.035	3.291GlnLeu: 3.291 ± 0.055	1.397GlnMet: 1.397 ± 0.034	1.119GlnAsn: 1.119 ± 0.032	1.92GlnPro: 1.92 ± 0.046	1.391GlnGln: 1.391 ± 0.043	2.309GlnArg: 2.309 ± 0.054	1.954GlnSer: 1.954 ± 0.043	2.13GlnThr: 2.13 ± 0.046	2.868GlnVal: 2.868 ± 0.049	0.438GlnTrp: 0.438 ± 0.023	0.597GlnTyr: 0.597 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.642ArgAla: 7.642 ± 0.1	0.493ArgCys: 0.493 ± 0.022	4.783ArgAsp: 4.783 ± 0.083	3.188ArgGlu: 3.188 ± 0.062	2.594ArgPhe: 2.594 ± 0.051	4.469ArgGly: 4.469 ± 0.073	1.743ArgHis: 1.743 ± 0.041	4.155ArgIle: 4.155 ± 0.07	2.239ArgLys: 2.239 ± 0.05	7.468ArgLeu: 7.468 ± 0.104	2.199ArgMet: 2.199 ± 0.046	1.989ArgAsn: 1.989 ± 0.044	3.431ArgPro: 3.431 ± 0.064	2.788ArgGln: 2.788 ± 0.056	4.842ArgArg: 4.842 ± 0.09	3.254ArgSer: 3.254 ± 0.066	2.991ArgThr: 2.991 ± 0.06	4.491ArgVal: 4.491 ± 0.072	0.926ArgTrp: 0.926 ± 0.034	1.405ArgTyr: 1.405 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.789SerAla: 5.789 ± 0.083	0.432SerCys: 0.432 ± 0.019	3.488SerAsp: 3.488 ± 0.069	2.66SerGlu: 2.66 ± 0.055	2.272SerPhe: 2.272 ± 0.053	5.561SerGly: 5.561 ± 0.074	1.117SerHis: 1.117 ± 0.031	2.629SerIle: 2.629 ± 0.052	1.486SerLys: 1.486 ± 0.042	5.261SerLeu: 5.261 ± 0.074	1.481SerMet: 1.481 ± 0.04	1.376SerAsn: 1.376 ± 0.036	2.556SerPro: 2.556 ± 0.05	1.863SerGln: 1.863 ± 0.042	3.439SerArg: 3.439 ± 0.054	2.681SerSer: 2.681 ± 0.058	2.639SerThr: 2.639 ± 0.055	3.796SerVal: 3.796 ± 0.068	0.725SerTrp: 0.725 ± 0.029	1.29SerTyr: 1.29 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.517ThrAla: 6.517 ± 0.095	0.462ThrCys: 0.462 ± 0.023	3.513ThrAsp: 3.513 ± 0.061	2.826ThrGlu: 2.826 ± 0.059	1.782ThrPhe: 1.782 ± 0.046	5.579ThrGly: 5.579 ± 0.079	1.152ThrHis: 1.152 ± 0.034	3.002ThrIle: 3.002 ± 0.054	1.437ThrLys: 1.437 ± 0.039	5.861ThrLeu: 5.861 ± 0.087	1.428ThrMet: 1.428 ± 0.039	1.35ThrAsn: 1.35 ± 0.037	3.513ThrPro: 3.513 ± 0.059	1.898ThrGln: 1.898 ± 0.046	3.768ThrArg: 3.768 ± 0.059	2.83ThrSer: 2.83 ± 0.06	3.042ThrThr: 3.042 ± 0.053	4.145ThrVal: 4.145 ± 0.072	0.655ThrTrp: 0.655 ± 0.029	1.175ThrTyr: 1.175 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.715ValAla: 8.715 ± 0.109	0.566ValCys: 0.566 ± 0.026	3.989ValAsp: 3.989 ± 0.062	3.83ValGlu: 3.83 ± 0.07	2.722ValPhe: 2.722 ± 0.061	5.163ValGly: 5.163 ± 0.08	1.249ValHis: 1.249 ± 0.037	4.569ValIle: 4.569 ± 0.074	1.964ValLys: 1.964 ± 0.05	7.25ValLeu: 7.25 ± 0.093	2.412ValMet: 2.412 ± 0.049	1.971ValAsn: 1.971 ± 0.043	3.407ValPro: 3.407 ± 0.057	2.483ValGln: 2.483 ± 0.049	3.872ValArg: 3.872 ± 0.057	4.005ValSer: 4.005 ± 0.068	4.973ValThr: 4.973 ± 0.066	5.312ValVal: 5.312 ± 0.089	0.974ValTrp: 0.974 ± 0.035	1.339ValTyr: 1.339 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.367TrpAla: 1.367 ± 0.038	0.134TrpCys: 0.134 ± 0.01	0.808TrpAsp: 0.808 ± 0.027	0.561TrpGlu: 0.561 ± 0.024	0.602TrpPhe: 0.602 ± 0.023	1.036TrpGly: 1.036 ± 0.03	0.342TrpHis: 0.342 ± 0.019	0.738TrpIle: 0.738 ± 0.024	0.454TrpLys: 0.454 ± 0.021	1.726TrpLeu: 1.726 ± 0.049	0.456TrpMet: 0.456 ± 0.021	0.488TrpAsn: 0.488 ± 0.026	0.723TrpPro: 0.723 ± 0.03	0.77TrpGln: 0.77 ± 0.026	1.177TrpArg: 1.177 ± 0.043	0.812TrpSer: 0.812 ± 0.028	0.782TrpThr: 0.782 ± 0.03	0.919TrpVal: 0.919 ± 0.033	0.249TrpTrp: 0.249 ± 0.015	0.276TrpTyr: 0.276 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.36TyrAla: 2.36 ± 0.048	0.255TyrCys: 0.255 ± 0.015	1.677TyrAsp: 1.677 ± 0.042	1.051TyrGlu: 1.051 ± 0.034	0.879TyrPhe: 0.879 ± 0.031	1.966TyrGly: 1.966 ± 0.051	0.521TyrHis: 0.521 ± 0.022	0.908TyrIle: 0.908 ± 0.032	0.557TyrLys: 0.557 ± 0.024	2.223TyrLeu: 2.223 ± 0.052	0.484TyrMet: 0.484 ± 0.023	0.618TyrAsn: 0.618 ± 0.026	1.02TyrPro: 1.02 ± 0.03	0.738TyrGln: 0.738 ± 0.026	1.463TyrArg: 1.463 ± 0.033	1.094TyrSer: 1.094 ± 0.032	1.049TyrThr: 1.049 ± 0.031	1.382TyrVal: 1.382 ± 0.039	0.334TyrTrp: 0.334 ± 0.02	0.53TyrTyr: 0.53 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3379 proteins (1057785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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