Amino acid dipepetide frequency for Halomonas sp. 204

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.674AlaAla: 12.674 ± 0.161	1.249AlaCys: 1.249 ± 0.035	5.897AlaAsp: 5.897 ± 0.086	8.153AlaGlu: 8.153 ± 0.1	3.9AlaPhe: 3.9 ± 0.054	9.556AlaGly: 9.556 ± 0.117	2.25AlaHis: 2.25 ± 0.052	5.427AlaIle: 5.427 ± 0.084	2.508AlaLys: 2.508 ± 0.059	14.034AlaLeu: 14.034 ± 0.16	3.4AlaMet: 3.4 ± 0.059	2.578AlaAsn: 2.578 ± 0.057	4.9AlaPro: 4.9 ± 0.08	3.684AlaGln: 3.684 ± 0.067	8.616AlaArg: 8.616 ± 0.12	6.345AlaSer: 6.345 ± 0.078	5.451AlaThr: 5.451 ± 0.073	7.444AlaVal: 7.444 ± 0.092	2.0AlaTrp: 2.0 ± 0.052	2.334AlaTyr: 2.334 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.911CysAla: 0.911 ± 0.028	0.123CysCys: 0.123 ± 0.011	0.548CysAsp: 0.548 ± 0.023	0.52CysGlu: 0.52 ± 0.023	0.318CysPhe: 0.318 ± 0.018	0.922CysGly: 0.922 ± 0.035	0.343CysHis: 0.343 ± 0.019	0.377CysIle: 0.377 ± 0.02	0.21CysLys: 0.21 ± 0.015	1.041CysLeu: 1.041 ± 0.03	0.171CysMet: 0.171 ± 0.012	0.2CysAsn: 0.2 ± 0.013	0.514CysPro: 0.514 ± 0.022	0.327CysGln: 0.327 ± 0.018	0.817CysArg: 0.817 ± 0.028	0.457CysSer: 0.457 ± 0.021	0.383CysThr: 0.383 ± 0.02	0.646CysVal: 0.646 ± 0.029	0.131CysTrp: 0.131 ± 0.012	0.235CysTyr: 0.235 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.621AspAla: 6.621 ± 0.099	0.462AspCys: 0.462 ± 0.023	3.583AspAsp: 3.583 ± 0.073	4.072AspGlu: 4.072 ± 0.067	2.094AspPhe: 2.094 ± 0.041	4.704AspGly: 4.704 ± 0.089	1.441AspHis: 1.441 ± 0.04	2.722AspIle: 2.722 ± 0.051	1.483AspLys: 1.483 ± 0.044	5.603AspLeu: 5.603 ± 0.077	1.227AspMet: 1.227 ± 0.037	1.54AspAsn: 1.54 ± 0.038	3.098AspPro: 3.098 ± 0.059	1.844AspGln: 1.844 ± 0.045	3.598AspArg: 3.598 ± 0.068	2.727AspSer: 2.727 ± 0.051	2.935AspThr: 2.935 ± 0.064	3.586AspVal: 3.586 ± 0.082	0.959AspTrp: 0.959 ± 0.036	1.658AspTyr: 1.658 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	9.003GluAla: 9.003 ± 0.115	0.497GluCys: 0.497 ± 0.021	2.795GluAsp: 2.795 ± 0.061	4.751GluGlu: 4.751 ± 0.074	1.675GluPhe: 1.675 ± 0.045	5.413GluGly: 5.413 ± 0.075	1.8GluHis: 1.8 ± 0.041	3.112GluIle: 3.112 ± 0.057	2.027GluLys: 2.027 ± 0.058	7.383GluLeu: 7.383 ± 0.108	1.575GluMet: 1.575 ± 0.038	1.478GluAsn: 1.478 ± 0.042	2.948GluPro: 2.948 ± 0.068	3.153GluGln: 3.153 ± 0.068	6.523GluArg: 6.523 ± 0.103	3.383GluSer: 3.383 ± 0.057	3.423GluThr: 3.423 ± 0.059	5.212GluVal: 5.212 ± 0.077	0.948GluTrp: 0.948 ± 0.03	1.227GluTyr: 1.227 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.563PheAla: 3.563 ± 0.062	0.359PheCys: 0.359 ± 0.017	2.361PheAsp: 2.361 ± 0.05	2.13PheGlu: 2.13 ± 0.048	1.334PhePhe: 1.334 ± 0.038	3.215PheGly: 3.215 ± 0.068	0.847PheHis: 0.847 ± 0.026	1.675PheIle: 1.675 ± 0.047	0.896PheLys: 0.896 ± 0.034	3.173PheLeu: 3.173 ± 0.07	0.862PheMet: 0.862 ± 0.034	1.022PheAsn: 1.022 ± 0.031	1.476PhePro: 1.476 ± 0.039	1.084PheGln: 1.084 ± 0.036	2.047PheArg: 2.047 ± 0.043	2.125PheSer: 2.125 ± 0.048	1.984PheThr: 1.984 ± 0.043	2.396PheVal: 2.396 ± 0.049	0.467PheTrp: 0.467 ± 0.021	0.916PheTyr: 0.916 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.77GlyAla: 7.77 ± 0.093	0.915GlyCys: 0.915 ± 0.033	4.652GlyAsp: 4.652 ± 0.089	6.329GlyGlu: 6.329 ± 0.086	3.134GlyPhe: 3.134 ± 0.061	6.983GlyGly: 6.983 ± 0.12	2.1GlyHis: 2.1 ± 0.047	4.372GlyIle: 4.372 ± 0.078	2.77GlyLys: 2.77 ± 0.056	9.587GlyLeu: 9.587 ± 0.117	2.494GlyMet: 2.494 ± 0.046	2.126GlyAsn: 2.126 ± 0.06	2.932GlyPro: 2.932 ± 0.056	3.04GlyGln: 3.04 ± 0.062	5.973GlyArg: 5.973 ± 0.09	4.482GlySer: 4.482 ± 0.085	3.808GlyThr: 3.808 ± 0.075	6.638GlyVal: 6.638 ± 0.082	1.472GlyTrp: 1.472 ± 0.044	2.337GlyTyr: 2.337 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.571HisAla: 2.571 ± 0.051	0.295HisCys: 0.295 ± 0.016	1.541HisAsp: 1.541 ± 0.047	1.409HisGlu: 1.409 ± 0.038	1.0HisPhe: 1.0 ± 0.032	2.228HisGly: 2.228 ± 0.045	0.835HisHis: 0.835 ± 0.031	0.89HisIle: 0.89 ± 0.03	0.53HisLys: 0.53 ± 0.022	2.807HisLeu: 2.807 ± 0.053	0.425HisMet: 0.425 ± 0.02	0.56HisAsn: 0.56 ± 0.025	1.655HisPro: 1.655 ± 0.037	0.943HisGln: 0.943 ± 0.033	1.941HisArg: 1.941 ± 0.046	1.126HisSer: 1.126 ± 0.032	1.005HisThr: 1.005 ± 0.032	1.373HisVal: 1.373 ± 0.04	0.442HisTrp: 0.442 ± 0.023	0.776HisTyr: 0.776 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.461IleAla: 5.461 ± 0.079	0.427IleCys: 0.427 ± 0.022	3.386IleAsp: 3.386 ± 0.057	3.502IleGlu: 3.502 ± 0.068	1.507IlePhe: 1.507 ± 0.047	4.184IleGly: 4.184 ± 0.07	1.028IleHis: 1.028 ± 0.032	2.062IleIle: 2.062 ± 0.049	1.374IleLys: 1.374 ± 0.044	4.078IleLeu: 4.078 ± 0.082	0.926IleMet: 0.926 ± 0.034	1.513IleAsn: 1.513 ± 0.047	2.14IlePro: 2.14 ± 0.048	1.46IleGln: 1.46 ± 0.037	2.942IleArg: 2.942 ± 0.06	2.668IleSer: 2.668 ± 0.053	2.65IleThr: 2.65 ± 0.057	3.13IleVal: 3.13 ± 0.062	0.481IleTrp: 0.481 ± 0.024	1.027IleTyr: 1.027 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.068LysAla: 3.068 ± 0.066	0.174LysCys: 0.174 ± 0.013	1.177LysAsp: 1.177 ± 0.038	1.657LysGlu: 1.657 ± 0.058	0.633LysPhe: 0.633 ± 0.027	2.237LysGly: 2.237 ± 0.049	0.567LysHis: 0.567 ± 0.027	1.176LysIle: 1.176 ± 0.039	1.069LysLys: 1.069 ± 0.043	2.805LysLeu: 2.805 ± 0.061	0.598LysMet: 0.598 ± 0.026	0.701LysAsn: 0.701 ± 0.034	1.509LysPro: 1.509 ± 0.041	1.096LysGln: 1.096 ± 0.037	2.253LysArg: 2.253 ± 0.05	1.468LysSer: 1.468 ± 0.039	1.38LysThr: 1.38 ± 0.036	2.056LysVal: 2.056 ± 0.055	0.258LysTrp: 0.258 ± 0.016	0.527LysTyr: 0.527 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.344LeuAla: 15.344 ± 0.171	1.12LeuCys: 1.12 ± 0.036	7.126LeuAsp: 7.126 ± 0.108	8.26LeuGlu: 8.26 ± 0.131	3.84LeuPhe: 3.84 ± 0.085	9.704LeuGly: 9.704 ± 0.112	2.484LeuHis: 2.484 ± 0.052	5.14LeuIle: 5.14 ± 0.071	3.293LeuLys: 3.293 ± 0.066	12.806LeuLeu: 12.806 ± 0.188	2.934LeuMet: 2.934 ± 0.062	2.769LeuAsn: 2.769 ± 0.05	6.513LeuPro: 6.513 ± 0.091	3.136LeuGln: 3.136 ± 0.057	7.213LeuArg: 7.213 ± 0.108	6.536LeuSer: 6.536 ± 0.082	6.169LeuThr: 6.169 ± 0.083	8.683LeuVal: 8.683 ± 0.099	1.498LeuTrp: 1.498 ± 0.046	2.363LeuTyr: 2.363 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.218MetAla: 3.218 ± 0.059	0.168MetCys: 0.168 ± 0.013	1.036MetAsp: 1.036 ± 0.03	1.277MetGlu: 1.277 ± 0.034	0.632MetPhe: 0.632 ± 0.029	1.972MetGly: 1.972 ± 0.047	0.491MetHis: 0.491 ± 0.021	1.247MetIle: 1.247 ± 0.031	0.779MetLys: 0.779 ± 0.028	2.858MetLeu: 2.858 ± 0.064	0.604MetMet: 0.604 ± 0.027	0.767MetAsn: 0.767 ± 0.027	1.385MetPro: 1.385 ± 0.039	0.907MetGln: 0.907 ± 0.032	1.635MetArg: 1.635 ± 0.043	1.73MetSer: 1.73 ± 0.042	1.707MetThr: 1.707 ± 0.036	1.772MetVal: 1.772 ± 0.044	0.191MetTrp: 0.191 ± 0.015	0.32MetTyr: 0.32 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.773AsnAla: 2.773 ± 0.052	0.21AsnCys: 0.21 ± 0.013	1.442AsnAsp: 1.442 ± 0.04	1.427AsnGlu: 1.427 ± 0.036	0.822AsnPhe: 0.822 ± 0.032	2.062AsnGly: 2.062 ± 0.069	0.596AsnHis: 0.596 ± 0.022	1.295AsnIle: 1.295 ± 0.045	0.633AsnLys: 0.633 ± 0.031	2.745AsnLeu: 2.745 ± 0.05	0.51AsnMet: 0.51 ± 0.024	0.695AsnAsn: 0.695 ± 0.029	1.632AsnPro: 1.632 ± 0.042	0.906AsnGln: 0.906 ± 0.028	1.843AsnArg: 1.843 ± 0.041	1.143AsnSer: 1.143 ± 0.041	1.28AsnThr: 1.28 ± 0.042	1.76AsnVal: 1.76 ± 0.063	0.333AsnTrp: 0.333 ± 0.017	0.623AsnTyr: 0.623 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.4ProAla: 5.4 ± 0.086	0.355ProCys: 0.355 ± 0.017	3.219ProAsp: 3.219 ± 0.053	4.342ProGlu: 4.342 ± 0.07	1.742ProPhe: 1.742 ± 0.041	4.58ProGly: 4.58 ± 0.075	1.168ProHis: 1.168 ± 0.032	1.951ProIle: 1.951 ± 0.044	1.067ProLys: 1.067 ± 0.035	5.937ProLeu: 5.937 ± 0.086	1.246ProMet: 1.246 ± 0.035	1.164ProAsn: 1.164 ± 0.034	2.338ProPro: 2.338 ± 0.058	1.633ProGln: 1.633 ± 0.04	3.327ProArg: 3.327 ± 0.059	2.6ProSer: 2.6 ± 0.052	2.224ProThr: 2.224 ± 0.049	3.801ProVal: 3.801 ± 0.07	0.857ProTrp: 0.857 ± 0.031	1.04ProTyr: 1.04 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.087GlnAla: 5.087 ± 0.088	0.274GlnCys: 0.274 ± 0.015	1.542GlnAsp: 1.542 ± 0.037	2.135GlnGlu: 2.135 ± 0.051	1.001GlnPhe: 1.001 ± 0.03	3.204GlnGly: 3.204 ± 0.054	0.896GlnHis: 0.896 ± 0.028	1.379GlnIle: 1.379 ± 0.039	0.906GlnLys: 0.906 ± 0.031	3.987GlnLeu: 3.987 ± 0.072	0.781GlnMet: 0.781 ± 0.029	0.697GlnAsn: 0.697 ± 0.033	1.807GlnPro: 1.807 ± 0.043	1.859GlnGln: 1.859 ± 0.056	3.296GlnArg: 3.296 ± 0.066	1.677GlnSer: 1.677 ± 0.044	1.517GlnThr: 1.517 ± 0.037	2.717GlnVal: 2.717 ± 0.053	0.497GlnTrp: 0.497 ± 0.022	0.651GlnTyr: 0.651 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.579ArgAla: 6.579 ± 0.103	0.657ArgCys: 0.657 ± 0.026	4.394ArgAsp: 4.394 ± 0.081	5.663ArgGlu: 5.663 ± 0.092	2.882ArgPhe: 2.882 ± 0.055	4.993ArgGly: 4.993 ± 0.068	2.43ArgHis: 2.43 ± 0.051	3.336ArgIle: 3.336 ± 0.072	1.815ArgLys: 1.815 ± 0.049	10.941ArgLeu: 10.941 ± 0.179	1.685ArgMet: 1.685 ± 0.036	1.61ArgAsn: 1.61 ± 0.04	3.278ArgPro: 3.278 ± 0.067	3.441ArgGln: 3.441 ± 0.071	6.637ArgArg: 6.637 ± 0.129	3.21ArgSer: 3.21 ± 0.055	2.803ArgThr: 2.803 ± 0.052	5.358ArgVal: 5.358 ± 0.082	1.145ArgTrp: 1.145 ± 0.037	2.05ArgTyr: 2.05 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.338SerAla: 5.338 ± 0.073	0.395SerCys: 0.395 ± 0.019	2.876SerAsp: 2.876 ± 0.056	3.148SerGlu: 3.148 ± 0.058	1.854SerPhe: 1.854 ± 0.044	5.13SerGly: 5.13 ± 0.084	1.36SerHis: 1.36 ± 0.038	2.297SerIle: 2.297 ± 0.05	1.166SerLys: 1.166 ± 0.038	6.735SerLeu: 6.735 ± 0.083	1.335SerMet: 1.335 ± 0.034	1.281SerAsn: 1.281 ± 0.035	2.955SerPro: 2.955 ± 0.052	1.926SerGln: 1.926 ± 0.044	4.381SerArg: 4.381 ± 0.078	2.927SerSer: 2.927 ± 0.065	2.4SerThr: 2.4 ± 0.046	3.831SerVal: 3.831 ± 0.078	0.705SerTrp: 0.705 ± 0.023	1.166SerTyr: 1.166 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.058ThrAla: 5.058 ± 0.076	0.438ThrCys: 0.438 ± 0.022	2.423ThrAsp: 2.423 ± 0.062	2.556ThrGlu: 2.556 ± 0.056	1.763ThrPhe: 1.763 ± 0.041	4.396ThrGly: 4.396 ± 0.076	1.142ThrHis: 1.142 ± 0.033	2.113ThrIle: 2.113 ± 0.049	0.924ThrLys: 0.924 ± 0.035	7.464ThrLeu: 7.464 ± 0.094	0.974ThrMet: 0.974 ± 0.036	1.15ThrAsn: 1.15 ± 0.043	3.464ThrPro: 3.464 ± 0.058	1.619ThrGln: 1.619 ± 0.041	3.804ThrArg: 3.804 ± 0.067	2.546ThrSer: 2.546 ± 0.055	2.671ThrThr: 2.671 ± 0.059	3.458ThrVal: 3.458 ± 0.071	0.631ThrTrp: 0.631 ± 0.028	1.048ThrTyr: 1.048 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.478ValAla: 8.478 ± 0.098	0.643ValCys: 0.643 ± 0.023	4.11ValAsp: 4.11 ± 0.075	5.184ValGlu: 5.184 ± 0.08	2.422ValPhe: 2.422 ± 0.048	5.583ValGly: 5.583 ± 0.079	1.465ValHis: 1.465 ± 0.037	3.945ValIle: 3.945 ± 0.064	2.064ValLys: 2.064 ± 0.052	7.69ValLeu: 7.69 ± 0.094	2.133ValMet: 2.133 ± 0.05	1.962ValAsn: 1.962 ± 0.051	3.494ValPro: 3.494 ± 0.06	2.023ValGln: 2.023 ± 0.047	4.451ValArg: 4.451 ± 0.068	4.106ValSer: 4.106 ± 0.069	4.19ValThr: 4.19 ± 0.077	6.015ValVal: 6.015 ± 0.08	0.862ValTrp: 0.862 ± 0.029	1.47ValTyr: 1.47 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.151TrpAla: 1.151 ± 0.037	0.179TrpCys: 0.179 ± 0.013	0.578TrpAsp: 0.578 ± 0.024	0.7TrpGlu: 0.7 ± 0.03	0.502TrpPhe: 0.502 ± 0.022	0.944TrpGly: 0.944 ± 0.03	0.45TrpHis: 0.45 ± 0.025	0.599TrpIle: 0.599 ± 0.027	0.381TrpLys: 0.381 ± 0.016	2.425TrpLeu: 2.425 ± 0.066	0.358TrpMet: 0.358 ± 0.02	0.329TrpAsn: 0.329 ± 0.02	0.723TrpPro: 0.723 ± 0.03	0.91TrpGln: 0.91 ± 0.029	1.365TrpArg: 1.365 ± 0.039	0.78TrpSer: 0.78 ± 0.03	0.558TrpThr: 0.558 ± 0.023	0.955TrpVal: 0.955 ± 0.029	0.293TrpTrp: 0.293 ± 0.019	0.335TrpTyr: 0.335 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.335TyrAla: 2.335 ± 0.051	0.253TyrCys: 0.253 ± 0.016	1.273TyrAsp: 1.273 ± 0.036	1.111TyrGlu: 1.111 ± 0.033	0.876TyrPhe: 0.876 ± 0.03	1.905TyrGly: 1.905 ± 0.046	0.658TyrHis: 0.658 ± 0.024	0.834TyrIle: 0.834 ± 0.027	0.512TyrLys: 0.512 ± 0.025	2.831TyrLeu: 2.831 ± 0.049	0.457TyrMet: 0.457 ± 0.024	0.585TyrAsn: 0.585 ± 0.026	1.23TyrPro: 1.23 ± 0.034	0.923TyrGln: 0.923 ± 0.03	2.246TyrArg: 2.246 ± 0.048	1.169TyrSer: 1.169 ± 0.034	1.102TyrThr: 1.102 ± 0.038	1.456TyrVal: 1.456 ± 0.035	0.344TyrTrp: 0.344 ± 0.017	0.654TyrTyr: 0.654 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3670 proteins (1072441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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