Amino acid dipepetide frequency for Streptococcus satellite phage Javan302

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.149AlaAla: 1.149 ± 0.561
1.149AlaCys: 1.149 ± 0.783
3.063AlaAsp: 3.063 ± 0.811
6.508AlaGlu: 6.508 ± 1.826
2.68AlaPhe: 2.68 ± 1.383
3.828AlaGly: 3.828 ± 0.897
0.383AlaHis: 0.383 ± 0.414
3.446AlaIle: 3.446 ± 0.948
6.508AlaLys: 6.508 ± 1.152
4.977AlaLeu: 4.977 ± 0.956
3.446AlaMet: 3.446 ± 1.839
2.68AlaAsn: 2.68 ± 0.984
2.68AlaPro: 2.68 ± 0.78
2.297AlaGln: 2.297 ± 0.962
2.297AlaArg: 2.297 ± 0.93
1.531AlaSer: 1.531 ± 0.814
3.446AlaThr: 3.446 ± 0.837
2.68AlaVal: 2.68 ± 0.905
0.766AlaTrp: 0.766 ± 0.432
0.766AlaTyr: 0.766 ± 0.482
0.0AlaXaa: 0.0 ± 0.0
Cys
0.383CysAla: 0.383 ± 0.386
0.0CysCys: 0.0 ± 0.0
0.766CysAsp: 0.766 ± 0.494
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.766CysGly: 0.766 ± 0.667
0.0CysHis: 0.0 ± 0.0
0.383CysIle: 0.383 ± 0.384
1.149CysLys: 1.149 ± 0.575
0.383CysLeu: 0.383 ± 0.386
0.0CysMet: 0.0 ± 0.0
0.766CysAsn: 0.766 ± 0.661
0.766CysPro: 0.766 ± 0.667
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.383CysTyr: 0.383 ± 0.388
0.0CysXaa: 0.0 ± 0.0
Asp
0.766AspAla: 0.766 ± 0.493
0.0AspCys: 0.0 ± 0.0
2.297AspAsp: 2.297 ± 0.526
6.126AspGlu: 6.126 ± 1.626
3.828AspPhe: 3.828 ± 0.801
1.149AspGly: 1.149 ± 0.778
0.0AspHis: 0.0 ± 0.0
3.063AspIle: 3.063 ± 0.992
4.594AspLys: 4.594 ± 1.591
6.126AspLeu: 6.126 ± 0.921
1.914AspMet: 1.914 ± 0.554
3.063AspAsn: 3.063 ± 1.213
0.766AspPro: 0.766 ± 0.531
1.149AspGln: 1.149 ± 1.001
3.063AspArg: 3.063 ± 1.53
3.063AspSer: 3.063 ± 1.263
4.211AspThr: 4.211 ± 0.95
4.594AspVal: 4.594 ± 1.259
0.766AspTrp: 0.766 ± 0.388
3.063AspTyr: 3.063 ± 1.185
0.0AspXaa: 0.0 ± 0.0
Glu
5.36GluAla: 5.36 ± 1.782
0.766GluCys: 0.766 ± 0.517
5.36GluAsp: 5.36 ± 0.936
4.977GluGlu: 4.977 ± 1.575
2.297GluPhe: 2.297 ± 1.06
3.446GluGly: 3.446 ± 1.011
2.68GluHis: 2.68 ± 0.855
5.743GluIle: 5.743 ± 1.729
8.806GluLys: 8.806 ± 1.614
12.634GluLeu: 12.634 ± 2.557
1.914GluMet: 1.914 ± 0.816
5.36GluAsn: 5.36 ± 1.363
1.914GluPro: 1.914 ± 0.974
3.063GluGln: 3.063 ± 0.712
4.594GluArg: 4.594 ± 1.468
4.594GluSer: 4.594 ± 1.162
3.446GluThr: 3.446 ± 1.291
4.211GluVal: 4.211 ± 1.085
1.149GluTrp: 1.149 ± 0.699
4.977GluTyr: 4.977 ± 0.86
0.0GluXaa: 0.0 ± 0.0
Phe
1.914PheAla: 1.914 ± 0.631
0.766PheCys: 0.766 ± 0.667
4.211PheAsp: 4.211 ± 0.904
5.36PheGlu: 5.36 ± 1.338
1.914PhePhe: 1.914 ± 1.201
2.297PheGly: 2.297 ± 1.106
0.766PheHis: 0.766 ± 0.52
3.446PheIle: 3.446 ± 1.004
4.211PheLys: 4.211 ± 0.946
2.68PheLeu: 2.68 ± 1.121
1.149PheMet: 1.149 ± 0.73
2.297PheAsn: 2.297 ± 1.303
0.766PhePro: 0.766 ± 0.616
1.531PheGln: 1.531 ± 0.821
2.297PheArg: 2.297 ± 1.021
1.914PheSer: 1.914 ± 0.785
2.68PheThr: 2.68 ± 1.03
0.766PheVal: 0.766 ± 0.548
1.149PheTrp: 1.149 ± 0.664
1.149PheTyr: 1.149 ± 0.602
0.0PheXaa: 0.0 ± 0.0
Gly
2.68GlyAla: 2.68 ± 1.245
0.766GlyCys: 0.766 ± 0.493
3.063GlyAsp: 3.063 ± 1.229
3.063GlyGlu: 3.063 ± 1.074
1.914GlyPhe: 1.914 ± 1.133
3.446GlyGly: 3.446 ± 1.135
1.149GlyHis: 1.149 ± 0.613
4.977GlyIle: 4.977 ± 1.093
2.68GlyLys: 2.68 ± 1.215
6.891GlyLeu: 6.891 ± 1.6
0.766GlyMet: 0.766 ± 0.656
2.297GlyAsn: 2.297 ± 0.982
0.383GlyPro: 0.383 ± 0.334
1.531GlyGln: 1.531 ± 0.591
2.297GlyArg: 2.297 ± 1.133
1.531GlySer: 1.531 ± 0.686
3.828GlyThr: 3.828 ± 1.036
3.828GlyVal: 3.828 ± 1.17
1.149GlyTrp: 1.149 ± 0.795
4.594GlyTyr: 4.594 ± 1.659
0.0GlyXaa: 0.0 ± 0.0
His
1.914HisAla: 1.914 ± 0.763
0.0HisCys: 0.0 ± 0.0
0.383HisAsp: 0.383 ± 0.386
1.531HisGlu: 1.531 ± 0.663
2.68HisPhe: 2.68 ± 0.798
1.914HisGly: 1.914 ± 0.761
0.383HisHis: 0.383 ± 0.388
0.766HisIle: 0.766 ± 0.776
1.149HisLys: 1.149 ± 0.759
1.149HisLeu: 1.149 ± 0.516
0.383HisMet: 0.383 ± 0.39
1.914HisAsn: 1.914 ± 1.04
0.766HisPro: 0.766 ± 0.522
0.766HisGln: 0.766 ± 0.517
1.149HisArg: 1.149 ± 0.604
1.149HisSer: 1.149 ± 0.526
1.149HisThr: 1.149 ± 0.677
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.149HisTyr: 1.149 ± 0.596
0.0HisXaa: 0.0 ± 0.0
Ile
3.446IleAla: 3.446 ± 1.12
0.383IleCys: 0.383 ± 0.352
2.297IleAsp: 2.297 ± 1.081
4.977IleGlu: 4.977 ± 1.98
3.063IlePhe: 3.063 ± 1.22
4.594IleGly: 4.594 ± 1.087
1.914IleHis: 1.914 ± 0.846
4.211IleIle: 4.211 ± 1.441
8.04IleLys: 8.04 ± 1.36
4.211IleLeu: 4.211 ± 1.047
0.766IleMet: 0.766 ± 0.388
3.063IleAsn: 3.063 ± 1.372
3.828IlePro: 3.828 ± 1.348
1.531IleGln: 1.531 ± 0.59
3.063IleArg: 3.063 ± 1.056
6.126IleSer: 6.126 ± 1.087
3.828IleThr: 3.828 ± 1.102
3.828IleVal: 3.828 ± 0.914
0.383IleTrp: 0.383 ± 0.414
2.297IleTyr: 2.297 ± 0.903
0.0IleXaa: 0.0 ± 0.0
Lys
6.891LysAla: 6.891 ± 1.116
0.0LysCys: 0.0 ± 0.0
3.446LysAsp: 3.446 ± 1.554
11.103LysGlu: 11.103 ± 2.0
4.211LysPhe: 4.211 ± 1.622
5.743LysGly: 5.743 ± 1.218
4.977LysHis: 4.977 ± 1.178
6.126LysIle: 6.126 ± 1.287
6.508LysLys: 6.508 ± 2.085
6.126LysLeu: 6.126 ± 1.33
2.297LysMet: 2.297 ± 0.856
5.743LysAsn: 5.743 ± 1.2
4.594LysPro: 4.594 ± 1.61
3.828LysGln: 3.828 ± 1.435
7.274LysArg: 7.274 ± 1.303
3.446LysSer: 3.446 ± 0.792
5.36LysThr: 5.36 ± 1.143
4.594LysVal: 4.594 ± 1.013
0.766LysTrp: 0.766 ± 0.55
2.297LysTyr: 2.297 ± 1.278
0.0LysXaa: 0.0 ± 0.0
Leu
5.743LeuAla: 5.743 ± 1.081
0.383LeuCys: 0.383 ± 0.331
7.274LeuAsp: 7.274 ± 1.624
9.188LeuGlu: 9.188 ± 1.986
3.063LeuPhe: 3.063 ± 1.05
3.828LeuGly: 3.828 ± 1.494
0.0LeuHis: 0.0 ± 0.0
7.274LeuIle: 7.274 ± 1.682
9.954LeuLys: 9.954 ± 1.813
9.571LeuLeu: 9.571 ± 2.45
1.914LeuMet: 1.914 ± 0.819
6.508LeuAsn: 6.508 ± 1.858
2.68LeuPro: 2.68 ± 1.165
4.211LeuGln: 4.211 ± 1.354
3.063LeuArg: 3.063 ± 0.979
6.508LeuSer: 6.508 ± 1.547
4.977LeuThr: 4.977 ± 1.514
5.743LeuVal: 5.743 ± 1.38
0.766LeuTrp: 0.766 ± 0.493
2.68LeuTyr: 2.68 ± 0.95
0.0LeuXaa: 0.0 ± 0.0
Met
1.149MetAla: 1.149 ± 0.809
0.0MetCys: 0.0 ± 0.0
1.531MetAsp: 1.531 ± 0.724
2.68MetGlu: 2.68 ± 0.772
1.149MetPhe: 1.149 ± 0.786
1.914MetGly: 1.914 ± 0.933
0.0MetHis: 0.0 ± 0.0
1.531MetIle: 1.531 ± 0.606
3.063MetLys: 3.063 ± 0.946
0.383MetLeu: 0.383 ± 0.366
0.383MetMet: 0.383 ± 0.367
1.914MetAsn: 1.914 ± 0.907
0.766MetPro: 0.766 ± 0.459
1.914MetGln: 1.914 ± 0.833
1.914MetArg: 1.914 ± 0.809
1.149MetSer: 1.149 ± 0.509
4.211MetThr: 4.211 ± 1.607
1.531MetVal: 1.531 ± 0.739
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.063AsnAla: 3.063 ± 0.848
0.383AsnCys: 0.383 ± 0.334
3.446AsnAsp: 3.446 ± 1.239
3.446AsnGlu: 3.446 ± 1.084
1.149AsnPhe: 1.149 ± 1.164
5.36AsnGly: 5.36 ± 1.659
1.531AsnHis: 1.531 ± 0.643
3.446AsnIle: 3.446 ± 1.405
5.36AsnLys: 5.36 ± 1.118
6.891AsnLeu: 6.891 ± 1.376
1.149AsnMet: 1.149 ± 0.739
2.297AsnAsn: 2.297 ± 0.643
2.297AsnPro: 2.297 ± 1.138
2.297AsnGln: 2.297 ± 0.9
0.766AsnArg: 0.766 ± 0.661
3.446AsnSer: 3.446 ± 1.139
4.211AsnThr: 4.211 ± 1.107
1.531AsnVal: 1.531 ± 0.728
0.0AsnTrp: 0.0 ± 0.0
0.766AsnTyr: 0.766 ± 0.403
0.0AsnXaa: 0.0 ± 0.0
Pro
1.914ProAla: 1.914 ± 0.871
0.0ProCys: 0.0 ± 0.0
1.149ProAsp: 1.149 ± 0.566
3.446ProGlu: 3.446 ± 0.887
2.68ProPhe: 2.68 ± 1.435
0.383ProGly: 0.383 ± 0.386
0.0ProHis: 0.0 ± 0.0
1.149ProIle: 1.149 ± 0.621
2.297ProLys: 2.297 ± 1.669
2.297ProLeu: 2.297 ± 0.99
1.149ProMet: 1.149 ± 0.634
3.063ProAsn: 3.063 ± 1.436
1.149ProPro: 1.149 ± 0.769
1.531ProGln: 1.531 ± 0.641
3.446ProArg: 3.446 ± 0.987
3.063ProSer: 3.063 ± 1.014
1.149ProThr: 1.149 ± 0.545
3.446ProVal: 3.446 ± 1.164
0.383ProTrp: 0.383 ± 0.331
1.914ProTyr: 1.914 ± 1.076
0.0ProXaa: 0.0 ± 0.0
Gln
3.828GlnAla: 3.828 ± 1.391
0.0GlnCys: 0.0 ± 0.0
1.914GlnAsp: 1.914 ± 0.692
4.594GlnGlu: 4.594 ± 1.46
1.531GlnPhe: 1.531 ± 0.54
0.766GlnGly: 0.766 ± 0.769
0.766GlnHis: 0.766 ± 0.432
2.297GlnIle: 2.297 ± 0.852
5.36GlnLys: 5.36 ± 1.58
2.68GlnLeu: 2.68 ± 0.66
0.383GlnMet: 0.383 ± 0.382
1.149GlnAsn: 1.149 ± 0.545
0.766GlnPro: 0.766 ± 0.464
2.297GlnGln: 2.297 ± 0.938
1.914GlnArg: 1.914 ± 0.723
1.531GlnSer: 1.531 ± 0.707
3.063GlnThr: 3.063 ± 0.971
1.149GlnVal: 1.149 ± 0.694
0.0GlnTrp: 0.0 ± 0.0
1.914GlnTyr: 1.914 ± 0.749
0.0GlnXaa: 0.0 ± 0.0
Arg
2.297ArgAla: 2.297 ± 0.751
0.0ArgCys: 0.0 ± 0.0
3.063ArgAsp: 3.063 ± 1.515
5.36ArgGlu: 5.36 ± 0.875
1.914ArgPhe: 1.914 ± 0.9
1.149ArgGly: 1.149 ± 0.738
1.149ArgHis: 1.149 ± 0.699
4.211ArgIle: 4.211 ± 1.173
4.977ArgLys: 4.977 ± 1.306
4.977ArgLeu: 4.977 ± 1.434
1.531ArgMet: 1.531 ± 0.778
3.828ArgAsn: 3.828 ± 1.555
2.68ArgPro: 2.68 ± 0.967
2.297ArgGln: 2.297 ± 0.898
2.68ArgArg: 2.68 ± 0.807
1.914ArgSer: 1.914 ± 0.94
3.063ArgThr: 3.063 ± 0.955
2.297ArgVal: 2.297 ± 0.969
0.0ArgTrp: 0.0 ± 0.0
3.446ArgTyr: 3.446 ± 1.347
0.0ArgXaa: 0.0 ± 0.0
Ser
3.828SerAla: 3.828 ± 0.887
0.383SerCys: 0.383 ± 0.499
2.297SerAsp: 2.297 ± 1.07
3.828SerGlu: 3.828 ± 0.933
1.531SerPhe: 1.531 ± 0.779
3.446SerGly: 3.446 ± 0.833
0.766SerHis: 0.766 ± 0.531
4.594SerIle: 4.594 ± 1.067
4.211SerLys: 4.211 ± 1.681
7.657SerLeu: 7.657 ± 1.302
1.531SerMet: 1.531 ± 0.699
3.063SerAsn: 3.063 ± 0.845
0.383SerPro: 0.383 ± 0.331
0.766SerGln: 0.766 ± 0.519
3.446SerArg: 3.446 ± 1.146
1.531SerSer: 1.531 ± 0.805
2.297SerThr: 2.297 ± 0.805
3.063SerVal: 3.063 ± 1.182
0.383SerTrp: 0.383 ± 0.331
2.68SerTyr: 2.68 ± 1.374
0.0SerXaa: 0.0 ± 0.0
Thr
3.828ThrAla: 3.828 ± 0.739
0.0ThrCys: 0.0 ± 0.0
3.063ThrAsp: 3.063 ± 0.945
3.828ThrGlu: 3.828 ± 0.749
5.36ThrPhe: 5.36 ± 2.303
3.063ThrGly: 3.063 ± 0.923
2.297ThrHis: 2.297 ± 0.778
2.68ThrIle: 2.68 ± 0.732
4.211ThrLys: 4.211 ± 1.342
6.508ThrLeu: 6.508 ± 1.1
2.68ThrMet: 2.68 ± 1.102
0.383ThrAsn: 0.383 ± 0.423
3.446ThrPro: 3.446 ± 0.841
3.063ThrGln: 3.063 ± 0.965
4.211ThrArg: 4.211 ± 1.122
3.828ThrSer: 3.828 ± 0.944
4.977ThrThr: 4.977 ± 1.594
2.297ThrVal: 2.297 ± 0.762
0.383ThrTrp: 0.383 ± 0.384
3.063ThrTyr: 3.063 ± 0.957
0.0ThrXaa: 0.0 ± 0.0
Val
3.446ValAla: 3.446 ± 1.332
0.383ValCys: 0.383 ± 0.331
2.68ValAsp: 2.68 ± 0.812
3.828ValGlu: 3.828 ± 1.218
1.531ValPhe: 1.531 ± 0.697
3.063ValGly: 3.063 ± 1.322
0.0ValHis: 0.0 ± 0.0
3.063ValIle: 3.063 ± 0.974
5.743ValLys: 5.743 ± 1.394
3.446ValLeu: 3.446 ± 0.825
1.531ValMet: 1.531 ± 0.702
2.297ValAsn: 2.297 ± 0.735
3.828ValPro: 3.828 ± 1.576
1.531ValGln: 1.531 ± 0.615
2.297ValArg: 2.297 ± 1.004
1.914ValSer: 1.914 ± 0.884
4.211ValThr: 4.211 ± 1.429
5.743ValVal: 5.743 ± 1.828
0.0ValTrp: 0.0 ± 0.0
2.297ValTyr: 2.297 ± 1.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.383TrpAla: 0.383 ± 0.331
0.0TrpCys: 0.0 ± 0.0
0.383TrpAsp: 0.383 ± 0.331
0.766TrpGlu: 0.766 ± 0.528
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.383TrpHis: 0.383 ± 0.331
1.149TrpIle: 1.149 ± 0.591
1.149TrpLys: 1.149 ± 0.688
0.766TrpLeu: 0.766 ± 0.579
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.383TrpGln: 0.383 ± 0.331
0.766TrpArg: 0.766 ± 0.459
0.383TrpSer: 0.383 ± 0.384
0.0TrpThr: 0.0 ± 0.0
0.383TrpVal: 0.383 ± 0.331
0.0TrpTrp: 0.0 ± 0.0
1.149TrpTyr: 1.149 ± 0.4
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.297TyrAla: 2.297 ± 1.01
0.383TyrCys: 0.383 ± 0.384
1.914TyrAsp: 1.914 ± 0.56
2.68TyrGlu: 2.68 ± 1.247
0.766TyrPhe: 0.766 ± 0.553
2.68TyrGly: 2.68 ± 1.257
1.149TyrHis: 1.149 ± 0.754
2.297TyrIle: 2.297 ± 0.956
5.743TyrLys: 5.743 ± 1.63
4.977TyrLeu: 4.977 ± 1.12
1.914TyrMet: 1.914 ± 0.796
1.149TyrAsn: 1.149 ± 0.758
1.149TyrPro: 1.149 ± 1.153
1.914TyrGln: 1.914 ± 1.159
2.297TyrArg: 2.297 ± 0.833
3.063TyrSer: 3.063 ± 0.997
3.063TyrThr: 3.063 ± 0.918
1.149TyrVal: 1.149 ± 0.55
0.0TyrTrp: 0.0 ± 0.0
1.531TyrTyr: 1.531 ± 1.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski