Amino acid dipepetide frequency for Paenirhodobacter enshiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.098AlaAla: 19.098 ± 0.222	1.088AlaCys: 1.088 ± 0.033	6.952AlaAsp: 6.952 ± 0.095	9.205AlaGlu: 9.205 ± 0.12	4.392AlaPhe: 4.392 ± 0.077	12.123AlaGly: 12.123 ± 0.139	2.396AlaHis: 2.396 ± 0.054	6.142AlaIle: 6.142 ± 0.097	3.682AlaLys: 3.682 ± 0.08	15.544AlaLeu: 15.544 ± 0.184	4.053AlaMet: 4.053 ± 0.067	2.428AlaAsn: 2.428 ± 0.061	6.83AlaPro: 6.83 ± 0.115	4.199AlaGln: 4.199 ± 0.08	10.554AlaArg: 10.554 ± 0.127	5.632AlaSer: 5.632 ± 0.093	6.34AlaThr: 6.34 ± 0.083	8.839AlaVal: 8.839 ± 0.126	1.393AlaTrp: 1.393 ± 0.049	2.311AlaTyr: 2.311 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.091CysAla: 1.091 ± 0.038	0.112CysCys: 0.112 ± 0.014	0.572CysAsp: 0.572 ± 0.028	0.43CysGlu: 0.43 ± 0.02	0.313CysPhe: 0.313 ± 0.019	0.88CysGly: 0.88 ± 0.034	0.259CysHis: 0.259 ± 0.019	0.375CysIle: 0.375 ± 0.022	0.181CysLys: 0.181 ± 0.016	0.821CysLeu: 0.821 ± 0.029	0.141CysMet: 0.141 ± 0.012	0.18CysAsn: 0.18 ± 0.014	0.516CysPro: 0.516 ± 0.026	0.195CysGln: 0.195 ± 0.015	0.591CysArg: 0.591 ± 0.024	0.434CysSer: 0.434 ± 0.02	0.479CysThr: 0.479 ± 0.027	0.56CysVal: 0.56 ± 0.024	0.128CysTrp: 0.128 ± 0.013	0.206CysTyr: 0.206 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.019AspAla: 7.019 ± 0.087	0.464AspCys: 0.464 ± 0.024	2.927AspAsp: 2.927 ± 0.065	3.269AspGlu: 3.269 ± 0.061	2.159AspPhe: 2.159 ± 0.049	5.027AspGly: 5.027 ± 0.08	1.169AspHis: 1.169 ± 0.038	2.827AspIle: 2.827 ± 0.058	1.65AspLys: 1.65 ± 0.051	6.312AspLeu: 6.312 ± 0.102	1.54AspMet: 1.54 ± 0.043	1.051AspAsn: 1.051 ± 0.033	3.903AspPro: 3.903 ± 0.065	1.547AspGln: 1.547 ± 0.04	4.156AspArg: 4.156 ± 0.087	2.107AspSer: 2.107 ± 0.052	2.953AspThr: 2.953 ± 0.066	3.729AspVal: 3.729 ± 0.068	1.23AspTrp: 1.23 ± 0.035	1.577AspTyr: 1.577 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.843GluAla: 8.843 ± 0.116	0.302GluCys: 0.302 ± 0.018	2.983GluAsp: 2.983 ± 0.064	3.102GluGlu: 3.102 ± 0.076	1.715GluPhe: 1.715 ± 0.047	5.067GluGly: 5.067 ± 0.077	1.059GluHis: 1.059 ± 0.036	3.672GluIle: 3.672 ± 0.064	2.048GluLys: 2.048 ± 0.06	4.944GluLeu: 4.944 ± 0.079	1.723GluMet: 1.723 ± 0.047	1.416GluAsn: 1.416 ± 0.044	2.604GluPro: 2.604 ± 0.068	1.672GluGln: 1.672 ± 0.047	4.667GluArg: 4.667 ± 0.082	1.949GluSer: 1.949 ± 0.048	3.892GluThr: 3.892 ± 0.073	4.314GluVal: 4.314 ± 0.078	0.636GluTrp: 0.636 ± 0.026	0.97GluTyr: 0.97 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.418PheAla: 4.418 ± 0.076	0.384PheCys: 0.384 ± 0.021	2.653PheAsp: 2.653 ± 0.049	2.08PheGlu: 2.08 ± 0.062	1.242PhePhe: 1.242 ± 0.047	3.828PheGly: 3.828 ± 0.072	0.726PheHis: 0.726 ± 0.027	1.52PheIle: 1.52 ± 0.044	0.761PheLys: 0.761 ± 0.033	3.283PheLeu: 3.283 ± 0.064	0.829PheMet: 0.829 ± 0.029	0.882PheAsn: 0.882 ± 0.036	1.594PhePro: 1.594 ± 0.044	0.92PheGln: 0.92 ± 0.034	2.465PheArg: 2.465 ± 0.057	2.014PheSer: 2.014 ± 0.043	2.039PheThr: 2.039 ± 0.044	2.683PheVal: 2.683 ± 0.06	0.527PheTrp: 0.527 ± 0.029	0.839PheTyr: 0.839 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	11.04GlyAla: 11.04 ± 0.128	0.925GlyCys: 0.925 ± 0.035	4.293GlyAsp: 4.293 ± 0.074	4.764GlyGlu: 4.764 ± 0.077	3.737GlyPhe: 3.737 ± 0.071	7.488GlyGly: 7.488 ± 0.122	2.042GlyHis: 2.042 ± 0.051	4.546GlyIle: 4.546 ± 0.07	3.293GlyLys: 3.293 ± 0.058	9.874GlyLeu: 9.874 ± 0.108	2.574GlyMet: 2.574 ± 0.059	1.839GlyAsn: 1.839 ± 0.045	4.041GlyPro: 4.041 ± 0.073	3.004GlyGln: 3.004 ± 0.063	6.758GlyArg: 6.758 ± 0.099	4.174GlySer: 4.174 ± 0.072	5.001GlyThr: 5.001 ± 0.085	6.345GlyVal: 6.345 ± 0.093	1.642GlyTrp: 1.642 ± 0.043	2.32GlyTyr: 2.32 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.361HisAla: 2.361 ± 0.055	0.213HisCys: 0.213 ± 0.017	1.304HisAsp: 1.304 ± 0.04	1.049HisGlu: 1.049 ± 0.042	0.765HisPhe: 0.765 ± 0.031	1.816HisGly: 1.816 ± 0.049	0.477HisHis: 0.477 ± 0.026	0.822HisIle: 0.822 ± 0.028	0.469HisLys: 0.469 ± 0.026	2.006HisLeu: 2.006 ± 0.059	0.556HisMet: 0.556 ± 0.024	0.431HisAsn: 0.431 ± 0.022	1.435HisPro: 1.435 ± 0.04	0.494HisGln: 0.494 ± 0.025	1.499HisArg: 1.499 ± 0.052	0.812HisSer: 0.812 ± 0.028	0.737HisThr: 0.737 ± 0.028	1.559HisVal: 1.559 ± 0.037	0.345HisTrp: 0.345 ± 0.02	0.55HisTyr: 0.55 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.74IleAla: 7.74 ± 0.108	0.574IleCys: 0.574 ± 0.029	3.254IleAsp: 3.254 ± 0.061	3.657IleGlu: 3.657 ± 0.069	1.599IlePhe: 1.599 ± 0.049	5.097IleGly: 5.097 ± 0.086	0.88IleHis: 0.88 ± 0.034	1.645IleIle: 1.645 ± 0.053	1.084IleLys: 1.084 ± 0.037	4.501IleLeu: 4.501 ± 0.075	0.925IleMet: 0.925 ± 0.033	1.11IleAsn: 1.11 ± 0.033	2.304IlePro: 2.304 ± 0.059	1.033IleGln: 1.033 ± 0.036	3.567IleArg: 3.567 ± 0.067	2.752IleSer: 2.752 ± 0.053	2.33IleThr: 2.33 ± 0.053	4.21IleVal: 4.21 ± 0.069	0.669IleTrp: 0.669 ± 0.028	1.022IleTyr: 1.022 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.959LysAla: 3.959 ± 0.079	0.155LysCys: 0.155 ± 0.012	1.571LysAsp: 1.571 ± 0.057	1.36LysGlu: 1.36 ± 0.05	0.862LysPhe: 0.862 ± 0.033	2.638LysGly: 2.638 ± 0.055	0.459LysHis: 0.459 ± 0.024	1.675LysIle: 1.675 ± 0.043	1.101LysLys: 1.101 ± 0.039	2.797LysLeu: 2.797 ± 0.064	0.962LysMet: 0.962 ± 0.037	0.717LysAsn: 0.717 ± 0.029	1.754LysPro: 1.754 ± 0.05	0.755LysGln: 0.755 ± 0.032	1.94LysArg: 1.94 ± 0.057	1.568LysSer: 1.568 ± 0.052	1.961LysThr: 1.961 ± 0.053	2.489LysVal: 2.489 ± 0.061	0.357LysTrp: 0.357 ± 0.017	0.635LysTyr: 0.635 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	14.061LeuAla: 14.061 ± 0.169	1.001LeuCys: 1.001 ± 0.034	6.32LeuAsp: 6.32 ± 0.095	4.756LeuGlu: 4.756 ± 0.082	3.415LeuPhe: 3.415 ± 0.068	9.076LeuGly: 9.076 ± 0.112	1.966LeuHis: 1.966 ± 0.055	5.347LeuIle: 5.347 ± 0.085	3.214LeuLys: 3.214 ± 0.07	8.726LeuLeu: 8.726 ± 0.126	2.8LeuMet: 2.8 ± 0.062	2.52LeuAsn: 2.52 ± 0.05	6.048LeuPro: 6.048 ± 0.097	2.244LeuGln: 2.244 ± 0.05	7.929LeuArg: 7.929 ± 0.116	7.1LeuSer: 7.1 ± 0.091	5.82LeuThr: 5.82 ± 0.08	6.957LeuVal: 6.957 ± 0.109	1.369LeuTrp: 1.369 ± 0.039	1.904LeuTyr: 1.904 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.636MetAla: 3.636 ± 0.063	0.175MetCys: 0.175 ± 0.014	1.293MetAsp: 1.293 ± 0.039	1.222MetGlu: 1.222 ± 0.037	0.796MetPhe: 0.796 ± 0.033	2.205MetGly: 2.205 ± 0.057	0.437MetHis: 0.437 ± 0.025	1.528MetIle: 1.528 ± 0.038	1.051MetLys: 1.051 ± 0.034	2.719MetLeu: 2.719 ± 0.056	0.727MetMet: 0.727 ± 0.031	0.779MetAsn: 0.779 ± 0.027	1.581MetPro: 1.581 ± 0.041	0.928MetGln: 0.928 ± 0.038	2.053MetArg: 2.053 ± 0.05	1.752MetSer: 1.752 ± 0.046	2.168MetThr: 2.168 ± 0.05	1.825MetVal: 1.825 ± 0.05	0.175MetTrp: 0.175 ± 0.014	0.315MetTyr: 0.315 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.816AsnAla: 2.816 ± 0.064	0.229AsnCys: 0.229 ± 0.016	1.207AsnAsp: 1.207 ± 0.039	0.964AsnGlu: 0.964 ± 0.029	0.827AsnPhe: 0.827 ± 0.035	2.164AsnGly: 2.164 ± 0.056	0.418AsnHis: 0.418 ± 0.021	1.109AsnIle: 1.109 ± 0.034	0.602AsnLys: 0.602 ± 0.028	2.271AsnLeu: 2.271 ± 0.056	0.607AsnMet: 0.607 ± 0.026	0.448AsnAsn: 0.448 ± 0.025	1.708AsnPro: 1.708 ± 0.05	0.577AsnGln: 0.577 ± 0.026	1.628AsnArg: 1.628 ± 0.041	0.887AsnSer: 0.887 ± 0.034	1.159AsnThr: 1.159 ± 0.046	1.626AsnVal: 1.626 ± 0.041	0.401AsnTrp: 0.401 ± 0.021	0.592AsnTyr: 0.592 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.378ProAla: 7.378 ± 0.119	0.376ProCys: 0.376 ± 0.023	3.79ProAsp: 3.79 ± 0.069	4.685ProGlu: 4.685 ± 0.084	2.07ProPhe: 2.07 ± 0.049	5.346ProGly: 5.346 ± 0.077	1.014ProHis: 1.014 ± 0.036	2.011ProIle: 2.011 ± 0.05	1.651ProLys: 1.651 ± 0.048	4.813ProLeu: 4.813 ± 0.082	1.342ProMet: 1.342 ± 0.04	1.178ProAsn: 1.178 ± 0.041	2.393ProPro: 2.393 ± 0.07	1.456ProGln: 1.456 ± 0.04	3.173ProArg: 3.173 ± 0.075	2.384ProSer: 2.384 ± 0.058	2.358ProThr: 2.358 ± 0.052	4.917ProVal: 4.917 ± 0.077	0.699ProTrp: 0.699 ± 0.03	1.08ProTyr: 1.08 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.832GlnAla: 3.832 ± 0.06	0.177GlnCys: 0.177 ± 0.014	1.39GlnAsp: 1.39 ± 0.039	1.16GlnGlu: 1.16 ± 0.037	0.891GlnPhe: 0.891 ± 0.031	2.473GlnGly: 2.473 ± 0.062	0.48GlnHis: 0.48 ± 0.023	1.977GlnIle: 1.977 ± 0.049	0.956GlnLys: 0.956 ± 0.03	2.548GlnLeu: 2.548 ± 0.057	1.005GlnMet: 1.005 ± 0.033	0.744GlnAsn: 0.744 ± 0.033	1.509GlnPro: 1.509 ± 0.045	0.95GlnGln: 0.95 ± 0.039	1.998GlnArg: 1.998 ± 0.05	1.61GlnSer: 1.61 ± 0.044	1.605GlnThr: 1.605 ± 0.039	2.209GlnVal: 2.209 ± 0.052	0.332GlnTrp: 0.332 ± 0.019	0.514GlnTyr: 0.514 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.694ArgAla: 9.694 ± 0.125	0.457ArgCys: 0.457 ± 0.026	4.281ArgAsp: 4.281 ± 0.066	4.121ArgGlu: 4.121 ± 0.073	2.831ArgPhe: 2.831 ± 0.059	5.158ArgGly: 5.158 ± 0.078	1.716ArgHis: 1.716 ± 0.051	4.373ArgIle: 4.373 ± 0.074	2.244ArgLys: 2.244 ± 0.059	8.365ArgLeu: 8.365 ± 0.109	2.188ArgMet: 2.188 ± 0.05	1.693ArgAsn: 1.693 ± 0.043	3.945ArgPro: 3.945 ± 0.065	2.304ArgGln: 2.304 ± 0.05	5.889ArgArg: 5.889 ± 0.107	3.265ArgSer: 3.265 ± 0.06	3.302ArgThr: 3.302 ± 0.06	4.871ArgVal: 4.871 ± 0.084	0.891ArgTrp: 0.891 ± 0.033	1.627ArgTyr: 1.627 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.152SerAla: 6.152 ± 0.084	0.424SerCys: 0.424 ± 0.023	2.934SerAsp: 2.934 ± 0.062	2.583SerGlu: 2.583 ± 0.055	2.116SerPhe: 2.116 ± 0.053	5.522SerGly: 5.522 ± 0.091	1.05SerHis: 1.05 ± 0.037	2.149SerIle: 2.149 ± 0.047	1.347SerLys: 1.347 ± 0.042	4.797SerLeu: 4.797 ± 0.071	1.207SerMet: 1.207 ± 0.036	1.11SerAsn: 1.11 ± 0.036	2.573SerPro: 2.573 ± 0.05	1.415SerGln: 1.415 ± 0.044	3.278SerArg: 3.278 ± 0.061	2.468SerSer: 2.468 ± 0.067	2.412SerThr: 2.412 ± 0.056	3.917SerVal: 3.917 ± 0.077	0.765SerTrp: 0.765 ± 0.03	1.268SerTyr: 1.268 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.51ThrAla: 6.51 ± 0.095	0.437ThrCys: 0.437 ± 0.021	2.976ThrAsp: 2.976 ± 0.048	3.243ThrGlu: 3.243 ± 0.063	1.854ThrPhe: 1.854 ± 0.047	5.443ThrGly: 5.443 ± 0.077	1.029ThrHis: 1.029 ± 0.038	2.655ThrIle: 2.655 ± 0.065	1.253ThrLys: 1.253 ± 0.043	6.18ThrLeu: 6.18 ± 0.089	1.235ThrMet: 1.235 ± 0.043	1.067ThrAsn: 1.067 ± 0.036	3.56ThrPro: 3.56 ± 0.074	1.384ThrGln: 1.384 ± 0.036	3.751ThrArg: 3.751 ± 0.07	2.485ThrSer: 2.485 ± 0.057	2.726ThrThr: 2.726 ± 0.065	4.42ThrVal: 4.42 ± 0.078	0.606ThrTrp: 0.606 ± 0.024	1.08ThrTyr: 1.08 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.609ValAla: 9.609 ± 0.111	0.652ValCys: 0.652 ± 0.027	3.666ValAsp: 3.666 ± 0.067	4.217ValGlu: 4.217 ± 0.08	2.741ValPhe: 2.741 ± 0.052	5.316ValGly: 5.316 ± 0.08	1.356ValHis: 1.356 ± 0.038	4.017ValIle: 4.017 ± 0.068	2.104ValLys: 2.104 ± 0.062	8.221ValLeu: 8.221 ± 0.121	2.096ValMet: 2.096 ± 0.049	1.737ValAsn: 1.737 ± 0.042	3.985ValPro: 3.985 ± 0.065	1.996ValGln: 1.996 ± 0.041	4.569ValArg: 4.569 ± 0.075	4.251ValSer: 4.251 ± 0.071	4.828ValThr: 4.828 ± 0.077	5.608ValVal: 5.608 ± 0.099	1.025ValTrp: 1.025 ± 0.039	1.406ValTyr: 1.406 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.387TrpAla: 1.387 ± 0.04	0.12TrpCys: 0.12 ± 0.013	0.676TrpAsp: 0.676 ± 0.028	0.579TrpGlu: 0.579 ± 0.025	0.543TrpPhe: 0.543 ± 0.026	1.022TrpGly: 1.022 ± 0.032	0.328TrpHis: 0.328 ± 0.021	0.677TrpIle: 0.677 ± 0.029	0.469TrpLys: 0.469 ± 0.024	1.697TrpLeu: 1.697 ± 0.053	0.363TrpMet: 0.363 ± 0.021	0.394TrpAsn: 0.394 ± 0.02	0.755TrpPro: 0.755 ± 0.028	0.66TrpGln: 0.66 ± 0.028	1.149TrpArg: 1.149 ± 0.038	0.788TrpSer: 0.788 ± 0.03	0.755TrpThr: 0.755 ± 0.034	0.879TrpVal: 0.879 ± 0.035	0.215TrpTrp: 0.215 ± 0.017	0.254TrpTyr: 0.254 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.558TyrAla: 2.558 ± 0.058	0.198TyrCys: 0.198 ± 0.014	1.579TyrAsp: 1.579 ± 0.046	1.128TyrGlu: 1.128 ± 0.038	0.821TyrPhe: 0.821 ± 0.034	2.014TyrGly: 2.014 ± 0.051	0.44TyrHis: 0.44 ± 0.023	0.888TyrIle: 0.888 ± 0.035	0.552TyrLys: 0.552 ± 0.024	2.154TyrLeu: 2.154 ± 0.046	0.492TyrMet: 0.492 ± 0.023	0.515TyrAsn: 0.515 ± 0.022	1.074TyrPro: 1.074 ± 0.033	0.627TyrGln: 0.627 ± 0.025	1.599TyrArg: 1.599 ± 0.042	1.055TyrSer: 1.055 ± 0.037	1.029TyrThr: 1.029 ± 0.035	1.444TyrVal: 1.444 ± 0.043	0.304TyrTrp: 0.304 ± 0.02	0.553TyrTyr: 0.553 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2781 proteins (881810 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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