Amino acid dipepetide frequency for Chelatococcus sp. CO-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.52AlaAla: 21.52 ± 0.202	1.181AlaCys: 1.181 ± 0.03	7.014AlaAsp: 7.014 ± 0.073	8.702AlaGlu: 8.702 ± 0.098	5.172AlaPhe: 5.172 ± 0.066	13.022AlaGly: 13.022 ± 0.119	2.372AlaHis: 2.372 ± 0.048	6.637AlaIle: 6.637 ± 0.072	3.297AlaLys: 3.297 ± 0.061	15.393AlaLeu: 15.393 ± 0.132	3.762AlaMet: 3.762 ± 0.06	2.518AlaAsn: 2.518 ± 0.051	6.419AlaPro: 6.419 ± 0.079	3.645AlaGln: 3.645 ± 0.053	11.097AlaArg: 11.097 ± 0.117	6.081AlaSer: 6.081 ± 0.07	6.277AlaThr: 6.277 ± 0.072	10.87AlaVal: 10.87 ± 0.097	1.546AlaTrp: 1.546 ± 0.033	2.642AlaTyr: 2.642 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.027	0.1CysCys: 0.1 ± 0.009	0.488CysAsp: 0.488 ± 0.021	0.419CysGlu: 0.419 ± 0.017	0.288CysPhe: 0.288 ± 0.015	0.934CysGly: 0.934 ± 0.028	0.233CysHis: 0.233 ± 0.016	0.366CysIle: 0.366 ± 0.019	0.133CysLys: 0.133 ± 0.01	0.821CysLeu: 0.821 ± 0.023	0.134CysMet: 0.134 ± 0.009	0.17CysAsn: 0.17 ± 0.011	0.424CysPro: 0.424 ± 0.016	0.173CysGln: 0.173 ± 0.011	0.655CysArg: 0.655 ± 0.021	0.359CysSer: 0.359 ± 0.015	0.365CysThr: 0.365 ± 0.016	0.573CysVal: 0.573 ± 0.018	0.096CysTrp: 0.096 ± 0.009	0.175CysTyr: 0.175 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.993AspAla: 6.993 ± 0.078	0.44AspCys: 0.44 ± 0.018	2.854AspAsp: 2.854 ± 0.053	3.732AspGlu: 3.732 ± 0.043	2.036AspPhe: 2.036 ± 0.035	5.236AspGly: 5.236 ± 0.068	1.112AspHis: 1.112 ± 0.029	3.033AspIle: 3.033 ± 0.052	1.511AspLys: 1.511 ± 0.037	5.919AspLeu: 5.919 ± 0.062	1.237AspMet: 1.237 ± 0.03	1.074AspAsn: 1.074 ± 0.027	3.321AspPro: 3.321 ± 0.047	1.219AspGln: 1.219 ± 0.033	4.095AspArg: 4.095 ± 0.056	1.672AspSer: 1.672 ± 0.033	2.291AspThr: 2.291 ± 0.042	4.364AspVal: 4.364 ± 0.055	0.874AspTrp: 0.874 ± 0.023	1.357AspTyr: 1.357 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.381GluAla: 9.381 ± 0.106	0.331GluCys: 0.331 ± 0.016	2.802GluAsp: 2.802 ± 0.042	3.793GluGlu: 3.793 ± 0.064	1.492GluPhe: 1.492 ± 0.037	4.728GluGly: 4.728 ± 0.061	1.125GluHis: 1.125 ± 0.026	3.159GluIle: 3.159 ± 0.051	2.144GluLys: 2.144 ± 0.043	4.958GluLeu: 4.958 ± 0.062	1.402GluMet: 1.402 ± 0.032	1.255GluAsn: 1.255 ± 0.031	2.897GluPro: 2.897 ± 0.049	1.738GluGln: 1.738 ± 0.04	6.024GluArg: 6.024 ± 0.08	2.013GluSer: 2.013 ± 0.038	3.363GluThr: 3.363 ± 0.05	4.241GluVal: 4.241 ± 0.057	0.625GluTrp: 0.625 ± 0.019	0.813GluTyr: 0.813 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	5.1PheAla: 5.1 ± 0.062	0.374PheCys: 0.374 ± 0.015	2.458PheAsp: 2.458 ± 0.045	1.966PheGlu: 1.966 ± 0.04	1.465PhePhe: 1.465 ± 0.037	3.816PheGly: 3.816 ± 0.056	0.725PheHis: 0.725 ± 0.026	1.659PheIle: 1.659 ± 0.035	0.825PheLys: 0.825 ± 0.025	3.676PheLeu: 3.676 ± 0.051	0.787PheMet: 0.787 ± 0.027	0.925PheAsn: 0.925 ± 0.023	1.612PhePro: 1.612 ± 0.032	0.812PheGln: 0.812 ± 0.024	2.38PheArg: 2.38 ± 0.046	2.041PheSer: 2.041 ± 0.04	1.931PheThr: 1.931 ± 0.038	3.163PheVal: 3.163 ± 0.052	0.527PheTrp: 0.527 ± 0.019	0.878PheTyr: 0.878 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.618GlyAla: 10.618 ± 0.103	0.852GlyCys: 0.852 ± 0.026	4.3GlyAsp: 4.3 ± 0.061	5.693GlyGlu: 5.693 ± 0.076	3.705GlyPhe: 3.705 ± 0.055	7.827GlyGly: 7.827 ± 0.103	1.992GlyHis: 1.992 ± 0.038	4.794GlyIle: 4.794 ± 0.066	2.765GlyLys: 2.765 ± 0.048	10.195GlyLeu: 10.195 ± 0.107	2.199GlyMet: 2.199 ± 0.037	1.87GlyAsn: 1.87 ± 0.052	3.888GlyPro: 3.888 ± 0.059	2.618GlyGln: 2.618 ± 0.048	7.532GlyArg: 7.532 ± 0.075	4.269GlySer: 4.269 ± 0.065	4.73GlyThr: 4.73 ± 0.061	6.255GlyVal: 6.255 ± 0.068	1.358GlyTrp: 1.358 ± 0.036	2.217GlyTyr: 2.217 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.528HisAla: 2.528 ± 0.04	0.226HisCys: 0.226 ± 0.012	1.152HisAsp: 1.152 ± 0.03	1.048HisGlu: 1.048 ± 0.026	0.778HisPhe: 0.778 ± 0.025	1.983HisGly: 1.983 ± 0.042	0.5HisHis: 0.5 ± 0.023	0.862HisIle: 0.862 ± 0.024	0.396HisLys: 0.396 ± 0.015	2.138HisLeu: 2.138 ± 0.041	0.441HisMet: 0.441 ± 0.019	0.385HisAsn: 0.385 ± 0.017	1.325HisPro: 1.325 ± 0.037	0.483HisGln: 0.483 ± 0.019	1.464HisArg: 1.464 ± 0.034	0.712HisSer: 0.712 ± 0.026	0.719HisThr: 0.719 ± 0.024	1.636HisVal: 1.636 ± 0.034	0.29HisTrp: 0.29 ± 0.015	0.5HisTyr: 0.5 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.863IleAla: 7.863 ± 0.08	0.403IleCys: 0.403 ± 0.019	3.373IleAsp: 3.373 ± 0.051	3.151IleGlu: 3.151 ± 0.048	1.609IlePhe: 1.609 ± 0.037	4.96IleGly: 4.96 ± 0.06	0.791IleHis: 0.791 ± 0.024	2.018IleIle: 2.018 ± 0.037	1.088IleLys: 1.088 ± 0.031	4.415IleLeu: 4.415 ± 0.063	0.86IleMet: 0.86 ± 0.028	1.112IleAsn: 1.112 ± 0.027	2.065IlePro: 2.065 ± 0.043	0.877IleGln: 0.877 ± 0.026	3.118IleArg: 3.118 ± 0.046	2.165IleSer: 2.165 ± 0.042	2.384IleThr: 2.384 ± 0.045	4.704IleVal: 4.704 ± 0.064	0.466IleTrp: 0.466 ± 0.018	1.042IleTyr: 1.042 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.903LysAla: 3.903 ± 0.057	0.109LysCys: 0.109 ± 0.009	1.455LysAsp: 1.455 ± 0.035	1.421LysGlu: 1.421 ± 0.035	0.695LysPhe: 0.695 ± 0.023	2.427LysGly: 2.427 ± 0.046	0.452LysHis: 0.452 ± 0.016	1.259LysIle: 1.259 ± 0.032	0.948LysLys: 0.948 ± 0.033	2.687LysLeu: 2.687 ± 0.049	0.564LysMet: 0.564 ± 0.021	0.609LysAsn: 0.609 ± 0.022	1.696LysPro: 1.696 ± 0.033	0.701LysGln: 0.701 ± 0.024	2.052LysArg: 2.052 ± 0.041	1.295LysSer: 1.295 ± 0.032	1.472LysThr: 1.472 ± 0.031	2.258LysVal: 2.258 ± 0.046	0.286LysTrp: 0.286 ± 0.014	0.475LysTyr: 0.475 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	17.14LeuAla: 17.14 ± 0.133	0.828LeuCys: 0.828 ± 0.024	6.267LeuAsp: 6.267 ± 0.075	4.887LeuGlu: 4.887 ± 0.063	3.839LeuPhe: 3.839 ± 0.062	9.056LeuGly: 9.056 ± 0.096	1.744LeuHis: 1.744 ± 0.037	4.558LeuIle: 4.558 ± 0.065	3.091LeuLys: 3.091 ± 0.048	9.716LeuLeu: 9.716 ± 0.115	2.501LeuMet: 2.501 ± 0.049	2.162LeuAsn: 2.162 ± 0.034	6.018LeuPro: 6.018 ± 0.065	2.386LeuGln: 2.386 ± 0.042	7.154LeuArg: 7.154 ± 0.078	5.806LeuSer: 5.806 ± 0.069	5.643LeuThr: 5.643 ± 0.064	9.239LeuVal: 9.239 ± 0.098	1.238LeuTrp: 1.238 ± 0.037	2.015LeuTyr: 2.015 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.15MetAla: 3.15 ± 0.045	0.125MetCys: 0.125 ± 0.009	1.024MetAsp: 1.024 ± 0.027	1.029MetGlu: 1.029 ± 0.026	0.625MetPhe: 0.625 ± 0.022	1.739MetGly: 1.739 ± 0.037	0.412MetHis: 0.412 ± 0.015	1.185MetIle: 1.185 ± 0.031	0.828MetLys: 0.828 ± 0.026	2.517MetLeu: 2.517 ± 0.045	0.595MetMet: 0.595 ± 0.026	0.645MetAsn: 0.645 ± 0.024	1.536MetPro: 1.536 ± 0.032	0.793MetGln: 0.793 ± 0.025	2.063MetArg: 2.063 ± 0.04	1.476MetSer: 1.476 ± 0.035	1.718MetThr: 1.718 ± 0.039	1.679MetVal: 1.679 ± 0.032	0.186MetTrp: 0.186 ± 0.011	0.259MetTyr: 0.259 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.712AsnAla: 2.712 ± 0.047	0.195AsnCys: 0.195 ± 0.012	1.116AsnAsp: 1.116 ± 0.035	1.148AsnGlu: 1.148 ± 0.028	0.75AsnPhe: 0.75 ± 0.022	2.048AsnGly: 2.048 ± 0.045	0.411AsnHis: 0.411 ± 0.018	1.113AsnIle: 1.113 ± 0.03	0.531AsnLys: 0.531 ± 0.021	2.292AsnLeu: 2.292 ± 0.039	0.457AsnMet: 0.457 ± 0.019	0.559AsnAsn: 0.559 ± 0.025	1.547AsnPro: 1.547 ± 0.034	0.523AsnGln: 0.523 ± 0.023	1.542AsnArg: 1.542 ± 0.031	0.822AsnSer: 0.822 ± 0.027	1.011AsnThr: 1.011 ± 0.031	1.837AsnVal: 1.837 ± 0.041	0.349AsnTrp: 0.349 ± 0.018	0.548AsnTyr: 0.548 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.441ProAla: 7.441 ± 0.089	0.313ProCys: 0.313 ± 0.016	3.543ProAsp: 3.543 ± 0.056	3.726ProGlu: 3.726 ± 0.051	2.102ProPhe: 2.102 ± 0.044	5.005ProGly: 5.005 ± 0.064	1.137ProHis: 1.137 ± 0.025	2.036ProIle: 2.036 ± 0.041	1.322ProLys: 1.322 ± 0.034	5.219ProLeu: 5.219 ± 0.058	1.191ProMet: 1.191 ± 0.029	1.121ProAsn: 1.121 ± 0.029	2.885ProPro: 2.885 ± 0.062	1.774ProGln: 1.774 ± 0.036	3.454ProArg: 3.454 ± 0.055	2.475ProSer: 2.475 ± 0.042	2.369ProThr: 2.369 ± 0.04	4.561ProVal: 4.561 ± 0.055	0.715ProTrp: 0.715 ± 0.02	1.134ProTyr: 1.134 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.728GlnAla: 3.728 ± 0.048	0.161GlnCys: 0.161 ± 0.01	1.255GlnAsp: 1.255 ± 0.03	1.449GlnGlu: 1.449 ± 0.033	0.887GlnPhe: 0.887 ± 0.026	2.072GlnGly: 2.072 ± 0.036	0.533GlnHis: 0.533 ± 0.021	1.402GlnIle: 1.402 ± 0.028	0.819GlnLys: 0.819 ± 0.029	2.583GlnLeu: 2.583 ± 0.049	0.713GlnMet: 0.713 ± 0.025	0.654GlnAsn: 0.654 ± 0.023	1.508GlnPro: 1.508 ± 0.032	1.04GlnGln: 1.04 ± 0.035	2.398GlnArg: 2.398 ± 0.045	1.309GlnSer: 1.309 ± 0.036	1.269GlnThr: 1.269 ± 0.031	1.987GlnVal: 1.987 ± 0.038	0.34GlnTrp: 0.34 ± 0.015	0.473GlnTyr: 0.473 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.304ArgAla: 9.304 ± 0.081	0.57ArgCys: 0.57 ± 0.02	4.228ArgAsp: 4.228 ± 0.059	4.828ArgGlu: 4.828 ± 0.065	3.173ArgPhe: 3.173 ± 0.046	5.565ArgGly: 5.565 ± 0.055	1.923ArgHis: 1.923 ± 0.042	4.127ArgIle: 4.127 ± 0.052	1.876ArgLys: 1.876 ± 0.039	9.431ArgLeu: 9.431 ± 0.11	1.853ArgMet: 1.853 ± 0.036	1.718ArgAsn: 1.718 ± 0.035	4.23ArgPro: 4.23 ± 0.065	2.59ArgGln: 2.59 ± 0.045	7.262ArgArg: 7.262 ± 0.087	3.613ArgSer: 3.613 ± 0.048	3.564ArgThr: 3.564 ± 0.055	5.208ArgVal: 5.208 ± 0.067	1.011ArgTrp: 1.011 ± 0.027	1.736ArgTyr: 1.736 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.625SerAla: 5.625 ± 0.066	0.352SerCys: 0.352 ± 0.016	2.359SerAsp: 2.359 ± 0.041	2.416SerGlu: 2.416 ± 0.044	2.144SerPhe: 2.144 ± 0.044	4.948SerGly: 4.948 ± 0.071	0.923SerHis: 0.923 ± 0.026	2.34SerIle: 2.34 ± 0.045	1.029SerLys: 1.029 ± 0.029	5.266SerLeu: 5.266 ± 0.064	1.058SerMet: 1.058 ± 0.025	0.985SerAsn: 0.985 ± 0.028	2.752SerPro: 2.752 ± 0.046	1.249SerGln: 1.249 ± 0.031	3.494SerArg: 3.494 ± 0.047	2.242SerSer: 2.242 ± 0.042	2.12SerThr: 2.12 ± 0.039	3.569SerVal: 3.569 ± 0.056	0.663SerTrp: 0.663 ± 0.022	1.123SerTyr: 1.123 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.274ThrAla: 6.274 ± 0.072	0.379ThrCys: 0.379 ± 0.019	2.421ThrAsp: 2.421 ± 0.044	2.305ThrGlu: 2.305 ± 0.043	1.988ThrPhe: 1.988 ± 0.047	5.081ThrGly: 5.081 ± 0.061	0.961ThrHis: 0.961 ± 0.024	2.663ThrIle: 2.663 ± 0.049	1.167ThrLys: 1.167 ± 0.028	5.787ThrLeu: 5.787 ± 0.074	1.162ThrMet: 1.162 ± 0.029	1.067ThrAsn: 1.067 ± 0.027	3.114ThrPro: 3.114 ± 0.048	1.117ThrGln: 1.117 ± 0.026	3.483ThrArg: 3.483 ± 0.054	2.483ThrSer: 2.483 ± 0.044	2.583ThrThr: 2.583 ± 0.049	4.479ThrVal: 4.479 ± 0.053	0.601ThrTrp: 0.601 ± 0.021	1.093ThrTyr: 1.093 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.148ValAla: 11.148 ± 0.094	0.615ValCys: 0.615 ± 0.021	4.261ValAsp: 4.261 ± 0.062	4.866ValGlu: 4.866 ± 0.059	3.015ValPhe: 3.015 ± 0.045	6.223ValGly: 6.223 ± 0.086	1.485ValHis: 1.485 ± 0.034	3.96ValIle: 3.96 ± 0.063	2.113ValLys: 2.113 ± 0.045	8.424ValLeu: 8.424 ± 0.084	1.971ValMet: 1.971 ± 0.037	1.804ValAsn: 1.804 ± 0.035	4.514ValPro: 4.514 ± 0.055	1.743ValGln: 1.743 ± 0.041	5.519ValArg: 5.519 ± 0.071	4.153ValSer: 4.153 ± 0.062	4.754ValThr: 4.754 ± 0.06	7.075ValVal: 7.075 ± 0.084	0.902ValTrp: 0.902 ± 0.024	1.51ValTyr: 1.51 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.225TrpAla: 1.225 ± 0.03	0.132TrpCys: 0.132 ± 0.009	0.627TrpAsp: 0.627 ± 0.022	0.507TrpGlu: 0.507 ± 0.016	0.514TrpPhe: 0.514 ± 0.021	0.893TrpGly: 0.893 ± 0.027	0.302TrpHis: 0.302 ± 0.017	0.537TrpIle: 0.537 ± 0.021	0.371TrpLys: 0.371 ± 0.016	1.666TrpLeu: 1.666 ± 0.038	0.298TrpMet: 0.298 ± 0.016	0.376TrpAsn: 0.376 ± 0.02	0.712TrpPro: 0.712 ± 0.021	0.534TrpGln: 0.534 ± 0.019	1.256TrpArg: 1.256 ± 0.034	0.732TrpSer: 0.732 ± 0.02	0.706TrpThr: 0.706 ± 0.02	0.758TrpVal: 0.758 ± 0.024	0.239TrpTrp: 0.239 ± 0.014	0.262TrpTyr: 0.262 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.53TyrAla: 2.53 ± 0.043	0.209TyrCys: 0.209 ± 0.013	1.374TyrAsp: 1.374 ± 0.033	1.196TyrGlu: 1.196 ± 0.03	0.844TyrPhe: 0.844 ± 0.024	2.112TyrGly: 2.112 ± 0.041	0.433TyrHis: 0.433 ± 0.017	0.757TyrIle: 0.757 ± 0.024	0.513TyrLys: 0.513 ± 0.019	2.188TyrLeu: 2.188 ± 0.039	0.395TyrMet: 0.395 ± 0.016	0.503TyrAsn: 0.503 ± 0.022	1.058TyrPro: 1.058 ± 0.028	0.561TyrGln: 0.561 ± 0.02	1.77TyrArg: 1.77 ± 0.042	0.938TyrSer: 0.938 ± 0.031	0.937TyrThr: 0.937 ± 0.026	1.598TyrVal: 1.598 ± 0.033	0.335TyrTrp: 0.335 ± 0.015	0.587TyrTyr: 0.587 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4557 proteins (1442732 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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