Amino acid dipepetide frequency for Nariva virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.402AlaAla: 4.402 ± 1.326
1.722AlaCys: 1.722 ± 0.535
1.531AlaAsp: 1.531 ± 0.632
4.019AlaGlu: 4.019 ± 0.79
1.914AlaPhe: 1.914 ± 0.548
4.402AlaGly: 4.402 ± 0.813
0.766AlaHis: 0.766 ± 0.479
5.359AlaIle: 5.359 ± 0.948
3.254AlaLys: 3.254 ± 0.664
7.656AlaLeu: 7.656 ± 1.416
2.105AlaMet: 2.105 ± 0.603
3.828AlaAsn: 3.828 ± 0.63
2.871AlaPro: 2.871 ± 1.02
2.679AlaGln: 2.679 ± 0.686
3.445AlaArg: 3.445 ± 0.632
4.211AlaSer: 4.211 ± 1.508
3.636AlaThr: 3.636 ± 0.723
4.211AlaVal: 4.211 ± 0.744
0.383AlaTrp: 0.383 ± 0.226
2.488AlaTyr: 2.488 ± 0.484
0.0AlaXaa: 0.0 ± 0.0
Cys
0.766CysAla: 0.766 ± 0.293
0.383CysCys: 0.383 ± 0.239
1.722CysAsp: 1.722 ± 0.535
0.957CysGlu: 0.957 ± 0.427
0.191CysPhe: 0.191 ± 0.12
1.34CysGly: 1.34 ± 0.728
0.574CysHis: 0.574 ± 0.359
1.148CysIle: 1.148 ± 0.297
0.191CysLys: 0.191 ± 0.248
0.766CysLeu: 0.766 ± 0.358
0.383CysMet: 0.383 ± 0.303
1.34CysAsn: 1.34 ± 0.611
1.722CysPro: 1.722 ± 0.669
1.148CysGln: 1.148 ± 0.409
0.766CysArg: 0.766 ± 0.309
1.914CysSer: 1.914 ± 0.468
0.766CysThr: 0.766 ± 0.308
1.531CysVal: 1.531 ± 0.635
0.191CysTrp: 0.191 ± 0.322
1.531CysTyr: 1.531 ± 0.395
0.0CysXaa: 0.0 ± 0.0
Asp
3.254AspAla: 3.254 ± 1.038
0.957AspCys: 0.957 ± 0.437
4.019AspAsp: 4.019 ± 0.966
4.593AspGlu: 4.593 ± 1.322
1.34AspPhe: 1.34 ± 0.492
2.297AspGly: 2.297 ± 0.41
2.679AspHis: 2.679 ± 0.562
3.445AspIle: 3.445 ± 0.951
1.531AspLys: 1.531 ± 0.373
4.785AspLeu: 4.785 ± 0.845
0.766AspMet: 0.766 ± 0.398
2.679AspAsn: 2.679 ± 0.928
5.55AspPro: 5.55 ± 1.009
2.679AspGln: 2.679 ± 0.608
2.488AspArg: 2.488 ± 0.306
4.402AspSer: 4.402 ± 0.953
2.297AspThr: 2.297 ± 0.645
2.871AspVal: 2.871 ± 0.666
0.957AspTrp: 0.957 ± 0.326
1.914AspTyr: 1.914 ± 0.468
0.0AspXaa: 0.0 ± 0.0
Glu
3.062GluAla: 3.062 ± 0.993
0.957GluCys: 0.957 ± 0.349
4.402GluAsp: 4.402 ± 1.106
3.254GluGlu: 3.254 ± 0.823
1.914GluPhe: 1.914 ± 1.128
4.402GluGly: 4.402 ± 1.851
0.957GluHis: 0.957 ± 0.475
4.019GluIle: 4.019 ± 0.933
1.531GluLys: 1.531 ± 0.662
4.402GluLeu: 4.402 ± 0.685
1.34GluMet: 1.34 ± 0.351
1.914GluAsn: 1.914 ± 0.379
2.488GluPro: 2.488 ± 0.834
1.722GluGln: 1.722 ± 0.633
3.062GluArg: 3.062 ± 0.721
6.124GluSer: 6.124 ± 2.281
4.211GluThr: 4.211 ± 0.904
3.254GluVal: 3.254 ± 1.131
0.191GluTrp: 0.191 ± 0.12
1.148GluTyr: 1.148 ± 0.639
0.0GluXaa: 0.0 ± 0.0
Phe
1.722PheAla: 1.722 ± 0.618
1.148PheCys: 1.148 ± 0.434
1.531PheAsp: 1.531 ± 0.424
1.148PheGlu: 1.148 ± 0.269
1.148PhePhe: 1.148 ± 0.541
1.531PheGly: 1.531 ± 0.656
1.34PheHis: 1.34 ± 0.471
1.722PheIle: 1.722 ± 0.676
1.148PheLys: 1.148 ± 0.562
3.445PheLeu: 3.445 ± 1.126
1.148PheMet: 1.148 ± 0.478
1.914PheAsn: 1.914 ± 0.623
0.574PhePro: 0.574 ± 0.371
2.105PheGln: 2.105 ± 0.675
1.531PheArg: 1.531 ± 0.606
1.531PheSer: 1.531 ± 0.404
1.34PheThr: 1.34 ± 0.487
0.957PheVal: 0.957 ± 0.493
0.957PheTrp: 0.957 ± 0.419
0.383PheTyr: 0.383 ± 0.318
0.0PheXaa: 0.0 ± 0.0
Gly
3.828GlyAla: 3.828 ± 1.026
1.914GlyCys: 1.914 ± 1.164
2.871GlyAsp: 2.871 ± 0.466
4.211GlyGlu: 4.211 ± 2.109
3.636GlyPhe: 3.636 ± 0.958
3.636GlyGly: 3.636 ± 0.983
2.297GlyHis: 2.297 ± 0.682
4.019GlyIle: 4.019 ± 0.699
2.105GlyLys: 2.105 ± 1.024
4.402GlyLeu: 4.402 ± 1.273
1.34GlyMet: 1.34 ± 0.61
3.636GlyAsn: 3.636 ± 0.686
2.679GlyPro: 2.679 ± 0.926
4.211GlyGln: 4.211 ± 0.646
3.445GlyArg: 3.445 ± 0.752
4.976GlySer: 4.976 ± 2.551
3.636GlyThr: 3.636 ± 0.727
5.742GlyVal: 5.742 ± 1.401
0.766GlyTrp: 0.766 ± 0.328
1.914GlyTyr: 1.914 ± 0.588
0.0GlyXaa: 0.0 ± 0.0
His
1.531HisAla: 1.531 ± 0.34
0.383HisCys: 0.383 ± 0.239
1.34HisAsp: 1.34 ± 0.537
1.722HisGlu: 1.722 ± 0.579
1.148HisPhe: 1.148 ± 0.371
1.148HisGly: 1.148 ± 0.575
0.766HisHis: 0.766 ± 0.335
1.914HisIle: 1.914 ± 0.854
0.191HisLys: 0.191 ± 0.12
3.062HisLeu: 3.062 ± 1.019
0.766HisMet: 0.766 ± 0.348
1.148HisAsn: 1.148 ± 0.482
1.531HisPro: 1.531 ± 0.317
1.148HisGln: 1.148 ± 0.586
1.531HisArg: 1.531 ± 0.688
1.914HisSer: 1.914 ± 0.662
0.383HisThr: 0.383 ± 0.239
1.148HisVal: 1.148 ± 0.4
0.191HisTrp: 0.191 ± 0.212
0.574HisTyr: 0.574 ± 0.269
0.0HisXaa: 0.0 ± 0.0
Ile
6.699IleAla: 6.699 ± 1.683
1.148IleCys: 1.148 ± 0.426
5.359IleAsp: 5.359 ± 0.794
3.062IleGlu: 3.062 ± 0.901
1.34IlePhe: 1.34 ± 0.352
3.254IleGly: 3.254 ± 1.007
0.957IleHis: 0.957 ± 0.326
4.976IleIle: 4.976 ± 1.65
4.211IleLys: 4.211 ± 1.029
5.933IleLeu: 5.933 ± 0.973
0.383IleMet: 0.383 ± 0.193
4.785IleAsn: 4.785 ± 1.415
4.593IlePro: 4.593 ± 0.594
2.679IleGln: 2.679 ± 1.381
4.402IleArg: 4.402 ± 0.706
5.55IleSer: 5.55 ± 1.617
5.167IleThr: 5.167 ± 1.502
3.828IleVal: 3.828 ± 0.882
0.574IleTrp: 0.574 ± 0.454
1.914IleTyr: 1.914 ± 0.635
0.0IleXaa: 0.0 ± 0.0
Lys
3.828LysAla: 3.828 ± 0.667
0.957LysCys: 0.957 ± 0.482
1.722LysAsp: 1.722 ± 0.338
2.679LysGlu: 2.679 ± 0.66
1.148LysPhe: 1.148 ± 0.297
4.019LysGly: 4.019 ± 1.167
0.574LysHis: 0.574 ± 0.272
2.679LysIle: 2.679 ± 0.963
0.957LysLys: 0.957 ± 0.334
4.976LysLeu: 4.976 ± 0.723
1.722LysMet: 1.722 ± 0.459
0.766LysAsn: 0.766 ± 0.39
2.488LysPro: 2.488 ± 1.085
1.914LysGln: 1.914 ± 0.574
2.297LysArg: 2.297 ± 0.472
2.679LysSer: 2.679 ± 0.715
3.445LysThr: 3.445 ± 0.886
3.445LysVal: 3.445 ± 1.565
0.0LysTrp: 0.0 ± 0.0
1.148LysTyr: 1.148 ± 0.553
0.0LysXaa: 0.0 ± 0.0
Leu
7.464LeuAla: 7.464 ± 0.625
2.105LeuCys: 2.105 ± 0.538
4.402LeuAsp: 4.402 ± 1.002
3.828LeuGlu: 3.828 ± 0.544
2.679LeuPhe: 2.679 ± 0.581
5.359LeuGly: 5.359 ± 0.723
3.445LeuHis: 3.445 ± 0.995
6.316LeuIle: 6.316 ± 1.468
4.211LeuLys: 4.211 ± 1.638
7.847LeuLeu: 7.847 ± 1.363
2.488LeuMet: 2.488 ± 0.88
4.211LeuAsn: 4.211 ± 0.879
2.871LeuPro: 2.871 ± 0.62
3.636LeuGln: 3.636 ± 0.802
5.742LeuArg: 5.742 ± 1.464
8.804LeuSer: 8.804 ± 1.166
6.316LeuThr: 6.316 ± 1.18
5.55LeuVal: 5.55 ± 1.14
1.148LeuTrp: 1.148 ± 0.478
2.871LeuTyr: 2.871 ± 0.728
0.0LeuXaa: 0.0 ± 0.0
Met
2.488MetAla: 2.488 ± 1.125
0.574MetCys: 0.574 ± 0.241
0.766MetAsp: 0.766 ± 0.348
1.914MetGlu: 1.914 ± 0.457
0.191MetPhe: 0.191 ± 0.12
1.531MetGly: 1.531 ± 0.908
0.574MetHis: 0.574 ± 0.387
2.297MetIle: 2.297 ± 0.617
0.766MetLys: 0.766 ± 0.348
2.871MetLeu: 2.871 ± 0.6
0.383MetMet: 0.383 ± 0.239
1.148MetAsn: 1.148 ± 0.393
0.957MetPro: 0.957 ± 0.475
0.191MetGln: 0.191 ± 0.322
2.105MetArg: 2.105 ± 0.689
1.914MetSer: 1.914 ± 0.535
2.297MetThr: 2.297 ± 0.598
2.679MetVal: 2.679 ± 0.883
0.383MetTrp: 0.383 ± 0.239
0.957MetTyr: 0.957 ± 0.345
0.0MetXaa: 0.0 ± 0.0
Asn
3.254AsnAla: 3.254 ± 0.811
0.574AsnCys: 0.574 ± 0.476
2.871AsnAsp: 2.871 ± 0.619
2.297AsnGlu: 2.297 ± 0.581
0.191AsnPhe: 0.191 ± 0.243
2.297AsnGly: 2.297 ± 0.677
0.574AsnHis: 0.574 ± 0.269
4.785AsnIle: 4.785 ± 1.839
1.914AsnLys: 1.914 ± 0.545
5.167AsnLeu: 5.167 ± 1.097
0.957AsnMet: 0.957 ± 0.441
1.531AsnAsn: 1.531 ± 0.43
3.828AsnPro: 3.828 ± 0.517
2.871AsnGln: 2.871 ± 0.702
2.488AsnArg: 2.488 ± 0.461
1.722AsnSer: 1.722 ± 0.676
2.488AsnThr: 2.488 ± 0.652
2.679AsnVal: 2.679 ± 0.564
0.574AsnTrp: 0.574 ± 0.359
1.914AsnTyr: 1.914 ± 0.704
0.0AsnXaa: 0.0 ± 0.0
Pro
2.297ProAla: 2.297 ± 0.872
0.574ProCys: 0.574 ± 0.55
3.828ProAsp: 3.828 ± 0.846
3.254ProGlu: 3.254 ± 0.753
0.957ProPhe: 0.957 ± 0.311
3.445ProGly: 3.445 ± 1.262
0.957ProHis: 0.957 ± 0.311
4.211ProIle: 4.211 ± 0.958
3.254ProLys: 3.254 ± 0.884
3.828ProLeu: 3.828 ± 0.901
1.914ProMet: 1.914 ± 0.662
3.445ProAsn: 3.445 ± 1.153
4.593ProPro: 4.593 ± 1.441
1.34ProGln: 1.34 ± 0.891
4.211ProArg: 4.211 ± 1.34
3.445ProSer: 3.445 ± 0.813
3.254ProThr: 3.254 ± 1.382
3.828ProVal: 3.828 ± 1.28
0.383ProTrp: 0.383 ± 0.248
3.828ProTyr: 3.828 ± 1.23
0.0ProXaa: 0.0 ± 0.0
Gln
2.488GlnAla: 2.488 ± 1.29
1.148GlnCys: 1.148 ± 0.576
2.679GlnAsp: 2.679 ± 1.329
2.297GlnGlu: 2.297 ± 0.826
0.574GlnPhe: 0.574 ± 0.346
3.254GlnGly: 3.254 ± 0.691
0.766GlnHis: 0.766 ± 0.452
2.105GlnIle: 2.105 ± 0.967
1.914GlnLys: 1.914 ± 0.624
3.828GlnLeu: 3.828 ± 0.519
0.957GlnMet: 0.957 ± 0.464
1.722GlnAsn: 1.722 ± 0.487
2.488GlnPro: 2.488 ± 0.971
2.105GlnGln: 2.105 ± 0.721
3.828GlnArg: 3.828 ± 1.088
3.254GlnSer: 3.254 ± 1.012
1.914GlnThr: 1.914 ± 0.529
3.445GlnVal: 3.445 ± 0.424
0.766GlnTrp: 0.766 ± 0.39
1.34GlnTyr: 1.34 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
3.636ArgAla: 3.636 ± 0.515
0.383ArgCys: 0.383 ± 0.213
3.828ArgAsp: 3.828 ± 0.705
4.019ArgGlu: 4.019 ± 1.003
2.297ArgPhe: 2.297 ± 0.73
5.167ArgGly: 5.167 ± 0.994
0.766ArgHis: 0.766 ± 0.385
2.679ArgIle: 2.679 ± 0.566
2.488ArgLys: 2.488 ± 1.109
6.316ArgLeu: 6.316 ± 1.704
2.488ArgMet: 2.488 ± 0.673
2.105ArgAsn: 2.105 ± 0.612
3.254ArgPro: 3.254 ± 1.548
1.722ArgGln: 1.722 ± 0.469
4.785ArgArg: 4.785 ± 1.411
1.914ArgSer: 1.914 ± 0.812
3.254ArgThr: 3.254 ± 0.918
5.933ArgVal: 5.933 ± 1.34
0.383ArgTrp: 0.383 ± 0.486
2.679ArgTyr: 2.679 ± 0.673
0.0ArgXaa: 0.0 ± 0.0
Ser
4.593SerAla: 4.593 ± 1.415
2.105SerCys: 2.105 ± 0.562
3.445SerAsp: 3.445 ± 0.716
3.828SerGlu: 3.828 ± 1.07
2.871SerPhe: 2.871 ± 0.492
6.124SerGly: 6.124 ± 1.912
2.297SerHis: 2.297 ± 0.709
5.167SerIle: 5.167 ± 0.944
3.445SerLys: 3.445 ± 0.648
6.124SerLeu: 6.124 ± 0.725
1.914SerMet: 1.914 ± 0.715
2.297SerAsn: 2.297 ± 0.494
3.636SerPro: 3.636 ± 1.18
3.636SerGln: 3.636 ± 0.799
3.445SerArg: 3.445 ± 0.887
5.933SerSer: 5.933 ± 1.032
6.124SerThr: 6.124 ± 1.781
6.316SerVal: 6.316 ± 1.105
1.34SerTrp: 1.34 ± 0.57
1.34SerTyr: 1.34 ± 0.503
0.0SerXaa: 0.0 ± 0.0
Thr
4.211ThrAla: 4.211 ± 1.226
0.574ThrCys: 0.574 ± 0.414
3.445ThrAsp: 3.445 ± 1.058
2.679ThrGlu: 2.679 ± 0.684
1.148ThrPhe: 1.148 ± 0.293
4.019ThrGly: 4.019 ± 0.673
0.957ThrHis: 0.957 ± 0.338
5.55ThrIle: 5.55 ± 1.404
3.254ThrLys: 3.254 ± 0.477
4.593ThrLeu: 4.593 ± 0.851
1.34ThrMet: 1.34 ± 0.611
3.254ThrAsn: 3.254 ± 0.453
4.211ThrPro: 4.211 ± 0.84
2.297ThrGln: 2.297 ± 0.652
4.019ThrArg: 4.019 ± 0.988
4.976ThrSer: 4.976 ± 1.446
4.593ThrThr: 4.593 ± 0.986
2.488ThrVal: 2.488 ± 0.675
0.957ThrTrp: 0.957 ± 0.439
2.871ThrTyr: 2.871 ± 1.251
0.0ThrXaa: 0.0 ± 0.0
Val
3.062ValAla: 3.062 ± 0.744
0.766ValCys: 0.766 ± 0.393
3.062ValAsp: 3.062 ± 0.47
2.871ValGlu: 2.871 ± 0.971
2.679ValPhe: 2.679 ± 0.709
5.933ValGly: 5.933 ± 1.432
1.531ValHis: 1.531 ± 0.552
6.316ValIle: 6.316 ± 1.489
3.828ValLys: 3.828 ± 0.79
6.89ValLeu: 6.89 ± 0.929
2.297ValMet: 2.297 ± 0.826
1.722ValAsn: 1.722 ± 0.358
3.254ValPro: 3.254 ± 0.593
3.062ValGln: 3.062 ± 1.239
4.785ValArg: 4.785 ± 1.02
4.785ValSer: 4.785 ± 1.49
3.445ValThr: 3.445 ± 0.503
4.976ValVal: 4.976 ± 1.114
0.574ValTrp: 0.574 ± 0.269
1.914ValTyr: 1.914 ± 0.614
0.0ValXaa: 0.0 ± 0.0
Trp
0.957TrpAla: 0.957 ± 0.338
0.191TrpCys: 0.191 ± 0.248
0.383TrpAsp: 0.383 ± 0.239
0.574TrpGlu: 0.574 ± 0.266
0.383TrpPhe: 0.383 ± 0.239
0.383TrpGly: 0.383 ± 0.355
0.191TrpHis: 0.191 ± 0.12
0.957TrpIle: 0.957 ± 0.326
1.531TrpLys: 1.531 ± 0.556
1.148TrpLeu: 1.148 ± 0.391
0.191TrpMet: 0.191 ± 0.12
0.191TrpAsn: 0.191 ± 0.12
0.191TrpPro: 0.191 ± 0.12
0.191TrpGln: 0.191 ± 0.12
0.191TrpArg: 0.191 ± 0.12
1.34TrpSer: 1.34 ± 0.516
0.957TrpThr: 0.957 ± 0.284
0.383TrpVal: 0.383 ± 0.645
0.191TrpTrp: 0.191 ± 0.12
0.574TrpTyr: 0.574 ± 0.241
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.34TyrAla: 1.34 ± 0.517
0.766TyrCys: 0.766 ± 0.296
2.297TyrAsp: 2.297 ± 0.546
1.148TyrGlu: 1.148 ± 0.418
0.574TyrPhe: 0.574 ± 0.241
1.722TyrGly: 1.722 ± 0.58
0.574TyrHis: 0.574 ± 0.241
1.148TyrIle: 1.148 ± 0.41
1.914TyrLys: 1.914 ± 0.521
3.254TyrLeu: 3.254 ± 0.299
1.914TyrMet: 1.914 ± 0.504
1.34TyrAsn: 1.34 ± 0.321
3.062TyrPro: 3.062 ± 0.682
1.531TyrGln: 1.531 ± 0.666
1.531TyrArg: 1.531 ± 0.43
4.593TyrSer: 4.593 ± 1.098
1.914TyrThr: 1.914 ± 0.458
2.488TyrVal: 2.488 ± 0.818
0.191TyrTrp: 0.191 ± 0.12
1.914TyrTyr: 1.914 ± 0.531
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (5226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski