Amino acid dipepetide frequency for Bordetella trematum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.497AlaAla: 18.497 ± 0.176
1.451AlaCys: 1.451 ± 0.036
6.687AlaAsp: 6.687 ± 0.07
6.595AlaGlu: 6.595 ± 0.087
3.96AlaPhe: 3.96 ± 0.063
12.009AlaGly: 12.009 ± 0.186
2.551AlaHis: 2.551 ± 0.046
5.405AlaIle: 5.405 ± 0.07
2.859AlaLys: 2.859 ± 0.073
15.859AlaLeu: 15.859 ± 0.162
3.596AlaMet: 3.596 ± 0.061
2.646AlaAsn: 2.646 ± 0.06
6.272AlaPro: 6.272 ± 0.085
6.537AlaGln: 6.537 ± 0.093
10.478AlaArg: 10.478 ± 0.123
6.766AlaSer: 6.766 ± 0.089
5.7AlaThr: 5.7 ± 0.076
8.806AlaVal: 8.806 ± 0.083
2.045AlaTrp: 2.045 ± 0.047
2.825AlaTyr: 2.825 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.194CysAla: 1.194 ± 0.034
0.125CysCys: 0.125 ± 0.008
0.512CysAsp: 0.512 ± 0.02
0.472CysGlu: 0.472 ± 0.019
0.328CysPhe: 0.328 ± 0.016
1.005CysGly: 1.005 ± 0.028
0.221CysHis: 0.221 ± 0.013
0.355CysIle: 0.355 ± 0.017
0.175CysLys: 0.175 ± 0.011
1.038CysLeu: 1.038 ± 0.031
0.204CysMet: 0.204 ± 0.013
0.221CysAsn: 0.221 ± 0.013
0.528CysPro: 0.528 ± 0.021
0.3CysGln: 0.3 ± 0.015
0.684CysArg: 0.684 ± 0.026
0.446CysSer: 0.446 ± 0.018
0.408CysThr: 0.408 ± 0.017
0.713CysVal: 0.713 ± 0.027
0.117CysTrp: 0.117 ± 0.01
0.234CysTyr: 0.234 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.686AspAla: 6.686 ± 0.086
0.459AspCys: 0.459 ± 0.019
2.668AspAsp: 2.668 ± 0.055
2.898AspGlu: 2.898 ± 0.054
2.01AspPhe: 2.01 ± 0.04
4.658AspGly: 4.658 ± 0.081
1.046AspHis: 1.046 ± 0.029
2.747AspIle: 2.747 ± 0.066
1.396AspLys: 1.396 ± 0.034
5.52AspLeu: 5.52 ± 0.067
1.35AspMet: 1.35 ± 0.031
1.255AspAsn: 1.255 ± 0.039
3.17AspPro: 3.17 ± 0.048
1.675AspGln: 1.675 ± 0.037
3.167AspArg: 3.167 ± 0.051
2.418AspSer: 2.418 ± 0.049
2.679AspThr: 2.679 ± 0.058
3.877AspVal: 3.877 ± 0.056
0.978AspTrp: 0.978 ± 0.031
1.529AspTyr: 1.529 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.722GluAla: 6.722 ± 0.084
0.347GluCys: 0.347 ± 0.016
2.274GluAsp: 2.274 ± 0.042
2.141GluGlu: 2.141 ± 0.05
1.635GluPhe: 1.635 ± 0.036
3.696GluGly: 3.696 ± 0.061
1.279GluHis: 1.279 ± 0.028
2.674GluIle: 2.674 ± 0.051
1.428GluLys: 1.428 ± 0.039
5.536GluLeu: 5.536 ± 0.079
1.199GluMet: 1.199 ± 0.028
1.326GluAsn: 1.326 ± 0.031
2.572GluPro: 2.572 ± 0.047
2.77GluGln: 2.77 ± 0.056
4.727GluArg: 4.727 ± 0.073
2.43GluSer: 2.43 ± 0.051
2.466GluThr: 2.466 ± 0.04
3.725GluVal: 3.725 ± 0.071
0.623GluTrp: 0.623 ± 0.022
1.086GluTyr: 1.086 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.845PheAla: 3.845 ± 0.057
0.391PheCys: 0.391 ± 0.021
2.264PheAsp: 2.264 ± 0.039
1.977PheGlu: 1.977 ± 0.045
1.256PhePhe: 1.256 ± 0.034
3.226PheGly: 3.226 ± 0.052
0.693PheHis: 0.693 ± 0.02
1.48PheIle: 1.48 ± 0.035
0.956PheLys: 0.956 ± 0.029
3.023PheLeu: 3.023 ± 0.057
0.821PheMet: 0.821 ± 0.022
0.992PheAsn: 0.992 ± 0.025
1.46PhePro: 1.46 ± 0.04
1.074PheGln: 1.074 ± 0.029
1.803PheArg: 1.803 ± 0.041
2.186PheSer: 2.186 ± 0.047
1.645PheThr: 1.645 ± 0.034
2.515PheVal: 2.515 ± 0.044
0.5PheTrp: 0.5 ± 0.022
0.876PheTyr: 0.876 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.503GlyAla: 9.503 ± 0.147
0.9GlyCys: 0.9 ± 0.028
3.854GlyAsp: 3.854 ± 0.088
4.422GlyGlu: 4.422 ± 0.059
3.067GlyPhe: 3.067 ± 0.055
7.054GlyGly: 7.054 ± 0.152
1.866GlyHis: 1.866 ± 0.034
3.855GlyIle: 3.855 ± 0.052
2.996GlyLys: 2.996 ± 0.054
10.015GlyLeu: 10.015 ± 0.104
2.577GlyMet: 2.577 ± 0.047
2.115GlyAsn: 2.115 ± 0.07
3.483GlyPro: 3.483 ± 0.054
4.104GlyGln: 4.104 ± 0.072
6.003GlyArg: 6.003 ± 0.073
4.55GlySer: 4.55 ± 0.105
4.057GlyThr: 4.057 ± 0.063
6.833GlyVal: 6.833 ± 0.082
1.507GlyTrp: 1.507 ± 0.035
2.371GlyTyr: 2.371 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.787HisAla: 2.787 ± 0.043
0.264HisCys: 0.264 ± 0.014
1.223HisAsp: 1.223 ± 0.03
1.067HisGlu: 1.067 ± 0.031
0.791HisPhe: 0.791 ± 0.023
2.075HisGly: 2.075 ± 0.04
0.531HisHis: 0.531 ± 0.02
0.94HisIle: 0.94 ± 0.025
0.446HisLys: 0.446 ± 0.022
2.116HisLeu: 2.116 ± 0.042
0.429HisMet: 0.429 ± 0.016
0.515HisAsn: 0.515 ± 0.021
1.524HisPro: 1.524 ± 0.038
0.81HisGln: 0.81 ± 0.025
1.445HisArg: 1.445 ± 0.036
0.959HisSer: 0.959 ± 0.027
0.989HisThr: 0.989 ± 0.028
1.444HisVal: 1.444 ± 0.04
0.37HisTrp: 0.37 ± 0.016
0.613HisTyr: 0.613 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.81IleAla: 5.81 ± 0.069
0.446IleCys: 0.446 ± 0.019
3.039IleAsp: 3.039 ± 0.056
3.076IleGlu: 3.076 ± 0.047
1.324IlePhe: 1.324 ± 0.036
4.164IleGly: 4.164 ± 0.068
0.817IleHis: 0.817 ± 0.025
1.745IleIle: 1.745 ± 0.044
1.35IleLys: 1.35 ± 0.039
3.796IleLeu: 3.796 ± 0.059
0.884IleMet: 0.884 ± 0.029
1.378IleAsn: 1.378 ± 0.036
2.077IlePro: 2.077 ± 0.045
1.441IleGln: 1.441 ± 0.036
2.636IleArg: 2.636 ± 0.045
2.496IleSer: 2.496 ± 0.045
2.441IleThr: 2.441 ± 0.068
3.347IleVal: 3.347 ± 0.053
0.538IleTrp: 0.538 ± 0.025
1.003IleTyr: 1.003 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
3.044LysAla: 3.044 ± 0.066
0.123LysCys: 0.123 ± 0.011
1.282LysAsp: 1.282 ± 0.039
1.257LysGlu: 1.257 ± 0.038
0.674LysPhe: 0.674 ± 0.024
2.008LysGly: 2.008 ± 0.041
0.547LysHis: 0.547 ± 0.017
1.208LysIle: 1.208 ± 0.036
0.964LysLys: 0.964 ± 0.04
2.854LysLeu: 2.854 ± 0.061
0.613LysMet: 0.613 ± 0.021
0.721LysAsn: 0.721 ± 0.024
1.755LysPro: 1.755 ± 0.045
1.142LysGln: 1.142 ± 0.036
1.97LysArg: 1.97 ± 0.042
1.397LysSer: 1.397 ± 0.037
1.594LysThr: 1.594 ± 0.04
2.099LysVal: 2.099 ± 0.052
0.323LysTrp: 0.323 ± 0.017
0.57LysTyr: 0.57 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
16.574LeuAla: 16.574 ± 0.145
1.07LeuCys: 1.07 ± 0.032
6.167LeuAsp: 6.167 ± 0.079
5.136LeuGlu: 5.136 ± 0.074
3.465LeuPhe: 3.465 ± 0.063
9.169LeuGly: 9.169 ± 0.105
2.257LeuHis: 2.257 ± 0.042
4.623LeuIle: 4.623 ± 0.081
2.982LeuLys: 2.982 ± 0.057
11.883LeuLeu: 11.883 ± 0.14
2.612LeuMet: 2.612 ± 0.051
2.828LeuAsn: 2.828 ± 0.054
6.737LeuPro: 6.737 ± 0.098
4.783LeuGln: 4.783 ± 0.066
8.757LeuArg: 8.757 ± 0.109
6.652LeuSer: 6.652 ± 0.08
5.722LeuThr: 5.722 ± 0.074
7.382LeuVal: 7.382 ± 0.083
1.283LeuTrp: 1.283 ± 0.032
2.275LeuTyr: 2.275 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.224MetAla: 3.224 ± 0.049
0.172MetCys: 0.172 ± 0.012
1.086MetAsp: 1.086 ± 0.028
0.987MetGlu: 0.987 ± 0.027
0.665MetPhe: 0.665 ± 0.025
1.91MetGly: 1.91 ± 0.043
0.504MetHis: 0.504 ± 0.02
1.01MetIle: 1.01 ± 0.027
0.818MetLys: 0.818 ± 0.027
2.907MetLeu: 2.907 ± 0.043
0.649MetMet: 0.649 ± 0.024
0.707MetAsn: 0.707 ± 0.026
1.484MetPro: 1.484 ± 0.038
1.223MetGln: 1.223 ± 0.028
1.91MetArg: 1.91 ± 0.04
1.678MetSer: 1.678 ± 0.032
1.633MetThr: 1.633 ± 0.034
1.654MetVal: 1.654 ± 0.039
0.199MetTrp: 0.199 ± 0.014
0.417MetTyr: 0.417 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.115AsnAla: 3.115 ± 0.056
0.215AsnCys: 0.215 ± 0.013
1.238AsnAsp: 1.238 ± 0.036
1.115AsnGlu: 1.115 ± 0.031
0.824AsnPhe: 0.824 ± 0.025
2.08AsnGly: 2.08 ± 0.05
0.486AsnHis: 0.486 ± 0.017
1.165AsnIle: 1.165 ± 0.038
0.712AsnLys: 0.712 ± 0.027
2.642AsnLeu: 2.642 ± 0.051
0.594AsnMet: 0.594 ± 0.023
0.697AsnAsn: 0.697 ± 0.028
1.742AsnPro: 1.742 ± 0.037
0.926AsnGln: 0.926 ± 0.03
1.67AsnArg: 1.67 ± 0.041
1.132AsnSer: 1.132 ± 0.034
1.436AsnThr: 1.436 ± 0.051
1.921AsnVal: 1.921 ± 0.044
0.357AsnTrp: 0.357 ± 0.017
0.643AsnTyr: 0.643 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.94ProAla: 7.94 ± 0.095
0.415ProCys: 0.415 ± 0.018
3.444ProAsp: 3.444 ± 0.065
3.3ProGlu: 3.3 ± 0.062
1.735ProPhe: 1.735 ± 0.034
5.084ProGly: 5.084 ± 0.077
1.058ProHis: 1.058 ± 0.026
1.843ProIle: 1.843 ± 0.041
1.234ProLys: 1.234 ± 0.036
5.492ProLeu: 5.492 ± 0.075
1.378ProMet: 1.378 ± 0.035
1.135ProAsn: 1.135 ± 0.035
2.649ProPro: 2.649 ± 0.057
2.718ProGln: 2.718 ± 0.05
3.234ProArg: 3.234 ± 0.055
2.636ProSer: 2.636 ± 0.05
2.233ProThr: 2.233 ± 0.036
4.228ProVal: 4.228 ± 0.059
0.798ProTrp: 0.798 ± 0.026
1.342ProTyr: 1.342 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
8.189GlnAla: 8.189 ± 0.113
0.307GlnCys: 0.307 ± 0.015
1.986GlnAsp: 1.986 ± 0.041
1.933GlnGlu: 1.933 ± 0.043
1.177GlnPhe: 1.177 ± 0.03
3.841GlnGly: 3.841 ± 0.071
0.959GlnHis: 0.959 ± 0.028
1.855GlnIle: 1.855 ± 0.043
0.886GlnLys: 0.886 ± 0.031
4.201GlnLeu: 4.201 ± 0.07
0.931GlnMet: 0.931 ± 0.027
0.864GlnAsn: 0.864 ± 0.025
2.5GlnPro: 2.5 ± 0.044
2.22GlnGln: 2.22 ± 0.055
3.752GlnArg: 3.752 ± 0.057
1.962GlnSer: 1.962 ± 0.04
2.162GlnThr: 2.162 ± 0.04
3.061GlnVal: 3.061 ± 0.052
0.758GlnTrp: 0.758 ± 0.025
0.879GlnTyr: 0.879 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
8.724ArgAla: 8.724 ± 0.107
0.629ArgCys: 0.629 ± 0.025
3.867ArgAsp: 3.867 ± 0.054
4.287ArgGlu: 4.287 ± 0.065
2.549ArgPhe: 2.549 ± 0.048
4.881ArgGly: 4.881 ± 0.067
2.022ArgHis: 2.022 ± 0.044
3.65ArgIle: 3.65 ± 0.053
1.927ArgLys: 1.927 ± 0.041
9.0ArgLeu: 9.0 ± 0.126
1.962ArgMet: 1.962 ± 0.04
1.966ArgAsn: 1.966 ± 0.041
3.542ArgPro: 3.542 ± 0.056
3.855ArgGln: 3.855 ± 0.071
5.882ArgArg: 5.882 ± 0.093
3.631ArgSer: 3.631 ± 0.048
2.713ArgThr: 2.713 ± 0.045
5.107ArgVal: 5.107 ± 0.071
1.197ArgTrp: 1.197 ± 0.029
2.211ArgTyr: 2.211 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.481SerAla: 6.481 ± 0.084
0.453SerCys: 0.453 ± 0.02
2.331SerAsp: 2.331 ± 0.042
2.383SerGlu: 2.383 ± 0.044
1.866SerPhe: 1.866 ± 0.039
5.36SerGly: 5.36 ± 0.092
1.15SerHis: 1.15 ± 0.031
2.287SerIle: 2.287 ± 0.048
1.254SerLys: 1.254 ± 0.033
6.23SerLeu: 6.23 ± 0.091
1.284SerMet: 1.284 ± 0.031
1.376SerAsn: 1.376 ± 0.039
2.939SerPro: 2.939 ± 0.049
2.227SerGln: 2.227 ± 0.044
3.645SerArg: 3.645 ± 0.053
2.937SerSer: 2.937 ± 0.061
2.586SerThr: 2.586 ± 0.048
3.977SerVal: 3.977 ± 0.087
0.795SerTrp: 0.795 ± 0.026
1.318SerTyr: 1.318 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
5.528ThrAla: 5.528 ± 0.07
0.389ThrCys: 0.389 ± 0.017
2.484ThrAsp: 2.484 ± 0.05
2.2ThrGlu: 2.2 ± 0.04
1.549ThrPhe: 1.549 ± 0.039
4.264ThrGly: 4.264 ± 0.07
1.081ThrHis: 1.081 ± 0.033
2.041ThrIle: 2.041 ± 0.041
0.853ThrLys: 0.853 ± 0.028
6.923ThrLeu: 6.923 ± 0.093
1.0ThrMet: 1.0 ± 0.027
0.988ThrAsn: 0.988 ± 0.032
3.497ThrPro: 3.497 ± 0.059
1.886ThrGln: 1.886 ± 0.042
3.472ThrArg: 3.472 ± 0.056
2.369ThrSer: 2.369 ± 0.054
2.409ThrThr: 2.409 ± 0.054
3.952ThrVal: 3.952 ± 0.111
0.665ThrTrp: 0.665 ± 0.023
1.065ThrTyr: 1.065 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.424ValAla: 9.424 ± 0.084
0.752ValCys: 0.752 ± 0.03
3.774ValAsp: 3.774 ± 0.07
3.658ValGlu: 3.658 ± 0.057
2.701ValPhe: 2.701 ± 0.043
5.467ValGly: 5.467 ± 0.092
1.422ValHis: 1.422 ± 0.036
3.437ValIle: 3.437 ± 0.057
1.988ValLys: 1.988 ± 0.048
8.451ValLeu: 8.451 ± 0.099
1.884ValMet: 1.884 ± 0.035
2.002ValAsn: 2.002 ± 0.041
3.908ValPro: 3.908 ± 0.065
2.934ValGln: 2.934 ± 0.053
4.926ValArg: 4.926 ± 0.069
4.268ValSer: 4.268 ± 0.088
3.867ValThr: 3.867 ± 0.086
5.905ValVal: 5.905 ± 0.092
0.879ValTrp: 0.879 ± 0.028
1.603ValTyr: 1.603 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.335TrpAla: 1.335 ± 0.037
0.14TrpCys: 0.14 ± 0.012
0.579TrpAsp: 0.579 ± 0.025
0.584TrpGlu: 0.584 ± 0.022
0.527TrpPhe: 0.527 ± 0.021
0.955TrpGly: 0.955 ± 0.028
0.353TrpHis: 0.353 ± 0.016
0.642TrpIle: 0.642 ± 0.021
0.362TrpLys: 0.362 ± 0.018
2.255TrpLeu: 2.255 ± 0.051
0.417TrpMet: 0.417 ± 0.018
0.397TrpAsn: 0.397 ± 0.019
0.77TrpPro: 0.77 ± 0.027
0.827TrpGln: 0.827 ± 0.026
1.471TrpArg: 1.471 ± 0.038
0.748TrpSer: 0.748 ± 0.025
0.607TrpThr: 0.607 ± 0.022
0.998TrpVal: 0.998 ± 0.03
0.253TrpTrp: 0.253 ± 0.016
0.325TrpTyr: 0.325 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.923TyrAla: 2.923 ± 0.049
0.235TyrCys: 0.235 ± 0.014
1.428TyrAsp: 1.428 ± 0.036
1.168TyrGlu: 1.168 ± 0.031
0.878TyrPhe: 0.878 ± 0.025
2.224TyrGly: 2.224 ± 0.043
0.494TyrHis: 0.494 ± 0.021
0.847TyrIle: 0.847 ± 0.029
0.556TyrLys: 0.556 ± 0.025
2.617TyrLeu: 2.617 ± 0.048
0.448TyrMet: 0.448 ± 0.019
0.581TyrAsn: 0.581 ± 0.022
1.285TyrPro: 1.285 ± 0.035
0.971TyrGln: 0.971 ± 0.023
1.972TyrArg: 1.972 ± 0.038
1.22TyrSer: 1.22 ± 0.027
1.269TyrThr: 1.269 ± 0.036
1.708TyrVal: 1.708 ± 0.04
0.36TyrTrp: 0.36 ± 0.017
0.63TyrTyr: 0.63 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4108 proteins (1346400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski