Amino acid dipepetide frequency for Jeongeupia sp. USM3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.757AlaAla: 17.757 ± 0.188	1.206AlaCys: 1.206 ± 0.036	7.158AlaAsp: 7.158 ± 0.096	7.076AlaGlu: 7.076 ± 0.09	4.11AlaPhe: 4.11 ± 0.066	11.61AlaGly: 11.61 ± 0.108	2.362AlaHis: 2.362 ± 0.047	5.85AlaIle: 5.85 ± 0.075	3.904AlaLys: 3.904 ± 0.074	15.006AlaLeu: 15.006 ± 0.162	3.216AlaMet: 3.216 ± 0.061	3.02AlaAsn: 3.02 ± 0.057	5.72AlaPro: 5.72 ± 0.089	5.207AlaGln: 5.207 ± 0.09	8.657AlaArg: 8.657 ± 0.095	6.424AlaSer: 6.424 ± 0.08	5.874AlaThr: 5.874 ± 0.083	8.608AlaVal: 8.608 ± 0.108	1.799AlaTrp: 1.799 ± 0.041	2.644AlaTyr: 2.644 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.03	0.12CysCys: 0.12 ± 0.009	0.496CysAsp: 0.496 ± 0.024	0.452CysGlu: 0.452 ± 0.02	0.302CysPhe: 0.302 ± 0.019	0.95CysGly: 0.95 ± 0.035	0.255CysHis: 0.255 ± 0.017	0.373CysIle: 0.373 ± 0.021	0.247CysLys: 0.247 ± 0.016	0.881CysLeu: 0.881 ± 0.029	0.168CysMet: 0.168 ± 0.013	0.265CysAsn: 0.265 ± 0.017	0.459CysPro: 0.459 ± 0.023	0.26CysGln: 0.26 ± 0.018	0.648CysArg: 0.648 ± 0.03	0.459CysSer: 0.459 ± 0.022	0.426CysThr: 0.426 ± 0.02	0.657CysVal: 0.657 ± 0.027	0.127CysTrp: 0.127 ± 0.012	0.24CysTyr: 0.24 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.196AspAla: 8.196 ± 0.113	0.527AspCys: 0.527 ± 0.022	3.737AspAsp: 3.737 ± 0.063	3.59AspGlu: 3.59 ± 0.067	2.207AspPhe: 2.207 ± 0.045	5.302AspGly: 5.302 ± 0.085	1.142AspHis: 1.142 ± 0.036	2.605AspIle: 2.605 ± 0.055	1.983AspLys: 1.983 ± 0.049	5.105AspLeu: 5.105 ± 0.069	1.014AspMet: 1.014 ± 0.029	1.414AspAsn: 1.414 ± 0.039	2.784AspPro: 2.784 ± 0.056	1.594AspGln: 1.594 ± 0.039	3.497AspArg: 3.497 ± 0.062	2.36AspSer: 2.36 ± 0.051	2.836AspThr: 2.836 ± 0.051	4.453AspVal: 4.453 ± 0.059	1.227AspTrp: 1.227 ± 0.037	1.869AspTyr: 1.869 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.754GluAla: 6.754 ± 0.099	0.368GluCys: 0.368 ± 0.02	1.909GluAsp: 1.909 ± 0.045	2.064GluGlu: 2.064 ± 0.053	1.722GluPhe: 1.722 ± 0.044	3.156GluGly: 3.156 ± 0.052	1.398GluHis: 1.398 ± 0.04	2.926GluIle: 2.926 ± 0.058	1.892GluLys: 1.892 ± 0.048	6.351GluLeu: 6.351 ± 0.088	1.237GluMet: 1.237 ± 0.042	1.298GluAsn: 1.298 ± 0.031	2.345GluPro: 2.345 ± 0.056	2.34GluGln: 2.34 ± 0.05	4.419GluArg: 4.419 ± 0.075	2.351GluSer: 2.351 ± 0.044	2.83GluThr: 2.83 ± 0.059	3.667GluVal: 3.667 ± 0.068	0.719GluTrp: 0.719 ± 0.031	1.238GluTyr: 1.238 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.517PheAla: 4.517 ± 0.074	0.394PheCys: 0.394 ± 0.02	2.73PheAsp: 2.73 ± 0.052	2.058PheGlu: 2.058 ± 0.047	1.334PhePhe: 1.334 ± 0.041	3.599PheGly: 3.599 ± 0.061	0.682PheHis: 0.682 ± 0.028	1.562PheIle: 1.562 ± 0.039	1.156PheLys: 1.156 ± 0.034	2.934PheLeu: 2.934 ± 0.056	0.725PheMet: 0.725 ± 0.024	1.188PheAsn: 1.188 ± 0.033	1.37PhePro: 1.37 ± 0.035	0.933PheGln: 0.933 ± 0.031	1.99PheArg: 1.99 ± 0.047	2.121PheSer: 2.121 ± 0.048	1.892PheThr: 1.892 ± 0.045	2.954PheVal: 2.954 ± 0.053	0.548PheTrp: 0.548 ± 0.026	0.982PheTyr: 0.982 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.645GlyAla: 8.645 ± 0.099	0.884GlyCys: 0.884 ± 0.028	4.741GlyAsp: 4.741 ± 0.071	4.964GlyGlu: 4.964 ± 0.084	3.515GlyPhe: 3.515 ± 0.061	7.099GlyGly: 7.099 ± 0.115	1.845GlyHis: 1.845 ± 0.041	4.374GlyIle: 4.374 ± 0.057	3.704GlyLys: 3.704 ± 0.067	9.021GlyLeu: 9.021 ± 0.113	2.28GlyMet: 2.28 ± 0.048	2.552GlyAsn: 2.552 ± 0.057	2.565GlyPro: 2.565 ± 0.049	3.149GlyGln: 3.149 ± 0.059	5.698GlyArg: 5.698 ± 0.084	4.309GlySer: 4.309 ± 0.073	3.936GlyThr: 3.936 ± 0.059	6.551GlyVal: 6.551 ± 0.082	1.587GlyTrp: 1.587 ± 0.04	2.484GlyTyr: 2.484 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.728HisAla: 2.728 ± 0.056	0.279HisCys: 0.279 ± 0.015	1.311HisAsp: 1.311 ± 0.041	1.01HisGlu: 1.01 ± 0.031	0.935HisPhe: 0.935 ± 0.027	2.133HisGly: 2.133 ± 0.049	0.613HisHis: 0.613 ± 0.023	0.874HisIle: 0.874 ± 0.029	0.581HisLys: 0.581 ± 0.024	2.139HisLeu: 2.139 ± 0.047	0.371HisMet: 0.371 ± 0.019	0.506HisAsn: 0.506 ± 0.022	1.36HisPro: 1.36 ± 0.042	0.712HisGln: 0.712 ± 0.025	1.509HisArg: 1.509 ± 0.048	0.955HisSer: 0.955 ± 0.031	0.936HisThr: 0.936 ± 0.026	1.502HisVal: 1.502 ± 0.037	0.417HisTrp: 0.417 ± 0.02	0.696HisTyr: 0.696 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.902IleAla: 6.902 ± 0.084	0.422IleCys: 0.422 ± 0.02	3.583IleAsp: 3.583 ± 0.068	3.16IleGlu: 3.16 ± 0.063	1.202IlePhe: 1.202 ± 0.036	4.736IleGly: 4.736 ± 0.07	0.924IleHis: 0.924 ± 0.032	1.643IleIle: 1.643 ± 0.041	1.71IleLys: 1.71 ± 0.046	3.454IleLeu: 3.454 ± 0.07	0.696IleMet: 0.696 ± 0.028	1.509IleAsn: 1.509 ± 0.041	1.998IlePro: 1.998 ± 0.046	1.283IleGln: 1.283 ± 0.036	3.016IleArg: 3.016 ± 0.052	2.373IleSer: 2.373 ± 0.047	2.393IleThr: 2.393 ± 0.046	3.966IleVal: 3.966 ± 0.068	0.502IleTrp: 0.502 ± 0.024	1.034IleTyr: 1.034 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.114LysAla: 4.114 ± 0.075	0.165LysCys: 0.165 ± 0.012	1.788LysAsp: 1.788 ± 0.053	1.377LysGlu: 1.377 ± 0.047	0.889LysPhe: 0.889 ± 0.03	2.417LysGly: 2.417 ± 0.052	0.697LysHis: 0.697 ± 0.026	1.652LysIle: 1.652 ± 0.049	1.58LysLys: 1.58 ± 0.055	4.149LysLeu: 4.149 ± 0.066	0.812LysMet: 0.812 ± 0.029	1.022LysAsn: 1.022 ± 0.039	2.154LysPro: 2.154 ± 0.058	1.621LysGln: 1.621 ± 0.041	2.254LysArg: 2.254 ± 0.045	1.746LysSer: 1.746 ± 0.039	2.043LysThr: 2.043 ± 0.051	2.618LysVal: 2.618 ± 0.061	0.408LysTrp: 0.408 ± 0.02	0.735LysTyr: 0.735 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.462LeuAla: 16.462 ± 0.198	0.945LeuCys: 0.945 ± 0.031	6.566LeuAsp: 6.566 ± 0.09	4.965LeuGlu: 4.965 ± 0.076	3.801LeuPhe: 3.801 ± 0.074	8.9LeuGly: 8.9 ± 0.093	2.141LeuHis: 2.141 ± 0.048	5.209LeuIle: 5.209 ± 0.073	4.086LeuLys: 4.086 ± 0.071	12.389LeuLeu: 12.389 ± 0.184	2.435LeuMet: 2.435 ± 0.053	3.025LeuAsn: 3.025 ± 0.045	6.493LeuPro: 6.493 ± 0.088	3.967LeuGln: 3.967 ± 0.063	7.038LeuArg: 7.038 ± 0.098	6.119LeuSer: 6.119 ± 0.073	5.672LeuThr: 5.672 ± 0.073	7.937LeuVal: 7.937 ± 0.091	1.342LeuTrp: 1.342 ± 0.037	2.358LeuTyr: 2.358 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.616MetAla: 2.616 ± 0.047	0.16MetCys: 0.16 ± 0.012	0.949MetAsp: 0.949 ± 0.028	0.73MetGlu: 0.73 ± 0.028	0.635MetPhe: 0.635 ± 0.025	1.462MetGly: 1.462 ± 0.039	0.518MetHis: 0.518 ± 0.021	1.069MetIle: 1.069 ± 0.032	1.009MetLys: 1.009 ± 0.032	2.799MetLeu: 2.799 ± 0.053	0.538MetMet: 0.538 ± 0.022	0.793MetAsn: 0.793 ± 0.031	1.352MetPro: 1.352 ± 0.04	1.051MetGln: 1.051 ± 0.031	1.441MetArg: 1.441 ± 0.035	1.491MetSer: 1.491 ± 0.036	1.384MetThr: 1.384 ± 0.039	1.533MetVal: 1.533 ± 0.038	0.202MetTrp: 0.202 ± 0.013	0.389MetTyr: 0.389 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.388AsnAla: 3.388 ± 0.064	0.211AsnCys: 0.211 ± 0.016	1.601AsnAsp: 1.601 ± 0.044	1.248AsnGlu: 1.248 ± 0.031	0.902AsnPhe: 0.902 ± 0.03	2.594AsnGly: 2.594 ± 0.054	0.513AsnHis: 0.513 ± 0.023	1.244AsnIle: 1.244 ± 0.04	0.924AsnLys: 0.924 ± 0.034	2.69AsnLeu: 2.69 ± 0.046	0.542AsnMet: 0.542 ± 0.021	0.802AsnAsn: 0.802 ± 0.032	1.861AsnPro: 1.861 ± 0.044	0.966AsnGln: 0.966 ± 0.032	1.965AsnArg: 1.965 ± 0.048	1.211AsnSer: 1.211 ± 0.039	1.362AsnThr: 1.362 ± 0.039	2.114AsnVal: 2.114 ± 0.05	0.468AsnTrp: 0.468 ± 0.021	0.78AsnTyr: 0.78 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.031ProAla: 7.031 ± 0.092	0.346ProCys: 0.346 ± 0.017	3.342ProAsp: 3.342 ± 0.052	2.998ProGlu: 2.998 ± 0.051	1.77ProPhe: 1.77 ± 0.043	4.202ProGly: 4.202 ± 0.066	1.012ProHis: 1.012 ± 0.033	1.791ProIle: 1.791 ± 0.046	1.652ProLys: 1.652 ± 0.04	5.409ProLeu: 5.409 ± 0.081	1.036ProMet: 1.036 ± 0.031	1.296ProAsn: 1.296 ± 0.039	2.209ProPro: 2.209 ± 0.05	2.205ProGln: 2.205 ± 0.048	2.648ProArg: 2.648 ± 0.057	2.234ProSer: 2.234 ± 0.049	2.365ProThr: 2.365 ± 0.073	4.331ProVal: 4.331 ± 0.068	0.714ProTrp: 0.714 ± 0.03	1.259ProTyr: 1.259 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.84GlnAla: 4.84 ± 0.08	0.273GlnCys: 0.273 ± 0.019	1.536GlnAsp: 1.536 ± 0.039	1.324GlnGlu: 1.324 ± 0.039	1.315GlnPhe: 1.315 ± 0.035	2.809GlnGly: 2.809 ± 0.051	0.986GlnHis: 0.986 ± 0.029	1.941GlnIle: 1.941 ± 0.045	1.266GlnLys: 1.266 ± 0.041	4.904GlnLeu: 4.904 ± 0.069	0.903GlnMet: 0.903 ± 0.031	0.952GlnAsn: 0.952 ± 0.03	2.184GlnPro: 2.184 ± 0.048	2.123GlnGln: 2.123 ± 0.056	3.059GlnArg: 3.059 ± 0.063	1.988GlnSer: 1.988 ± 0.049	2.067GlnThr: 2.067 ± 0.044	2.796GlnVal: 2.796 ± 0.051	0.596GlnTrp: 0.596 ± 0.027	0.996GlnTyr: 0.996 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.942ArgAla: 6.942 ± 0.086	0.586ArgCys: 0.586 ± 0.023	3.997ArgAsp: 3.997 ± 0.072	3.791ArgGlu: 3.791 ± 0.058	3.071ArgPhe: 3.071 ± 0.054	4.411ArgGly: 4.411 ± 0.066	1.957ArgHis: 1.957 ± 0.05	3.582ArgIle: 3.582 ± 0.061	2.007ArgLys: 2.007 ± 0.049	8.435ArgLeu: 8.435 ± 0.101	1.643ArgMet: 1.643 ± 0.037	1.885ArgAsn: 1.885 ± 0.043	3.068ArgPro: 3.068 ± 0.053	3.07ArgGln: 3.07 ± 0.065	4.928ArgArg: 4.928 ± 0.083	2.993ArgSer: 2.993 ± 0.061	2.928ArgThr: 2.928 ± 0.05	4.708ArgVal: 4.708 ± 0.072	1.206ArgTrp: 1.206 ± 0.033	2.338ArgTyr: 2.338 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.941SerAla: 5.941 ± 0.066	0.411SerCys: 0.411 ± 0.02	2.722SerAsp: 2.722 ± 0.055	2.37SerGlu: 2.37 ± 0.047	1.95SerPhe: 1.95 ± 0.047	4.939SerGly: 4.939 ± 0.077	1.157SerHis: 1.157 ± 0.03	2.224SerIle: 2.224 ± 0.05	1.634SerLys: 1.634 ± 0.038	5.577SerLeu: 5.577 ± 0.081	1.061SerMet: 1.061 ± 0.033	1.445SerAsn: 1.445 ± 0.036	2.616SerPro: 2.616 ± 0.056	1.879SerGln: 1.879 ± 0.05	3.346SerArg: 3.346 ± 0.062	2.582SerSer: 2.582 ± 0.061	2.615SerThr: 2.615 ± 0.056	3.843SerVal: 3.843 ± 0.061	0.74SerTrp: 0.74 ± 0.026	1.422SerTyr: 1.422 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.694ThrAla: 5.694 ± 0.075	0.392ThrCys: 0.392 ± 0.018	2.568ThrAsp: 2.568 ± 0.055	2.277ThrGlu: 2.277 ± 0.047	1.596ThrPhe: 1.596 ± 0.039	4.566ThrGly: 4.566 ± 0.067	1.018ThrHis: 1.018 ± 0.03	2.351ThrIle: 2.351 ± 0.047	1.205ThrLys: 1.205 ± 0.039	6.756ThrLeu: 6.756 ± 0.082	1.046ThrMet: 1.046 ± 0.032	1.085ThrAsn: 1.085 ± 0.043	3.464ThrPro: 3.464 ± 0.082	1.804ThrGln: 1.804 ± 0.039	3.245ThrArg: 3.245 ± 0.059	2.399ThrSer: 2.399 ± 0.055	2.599ThrThr: 2.599 ± 0.058	4.276ThrVal: 4.276 ± 0.067	0.595ThrTrp: 0.595 ± 0.022	1.037ThrTyr: 1.037 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.453ValAla: 9.453 ± 0.109	0.729ValCys: 0.729 ± 0.025	4.607ValAsp: 4.607 ± 0.067	3.956ValGlu: 3.956 ± 0.062	2.731ValPhe: 2.731 ± 0.053	5.781ValGly: 5.781 ± 0.072	1.387ValHis: 1.387 ± 0.039	3.724ValIle: 3.724 ± 0.063	2.513ValLys: 2.513 ± 0.057	8.462ValLeu: 8.462 ± 0.109	1.66ValMet: 1.66 ± 0.042	2.138ValAsn: 2.138 ± 0.047	3.778ValPro: 3.778 ± 0.06	2.543ValGln: 2.543 ± 0.051	4.752ValArg: 4.752 ± 0.07	4.365ValSer: 4.365 ± 0.063	3.885ValThr: 3.885 ± 0.067	6.046ValVal: 6.046 ± 0.092	1.031ValTrp: 1.031 ± 0.031	1.713ValTyr: 1.713 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.349TrpAla: 1.349 ± 0.038	0.167TrpCys: 0.167 ± 0.012	0.618TrpAsp: 0.618 ± 0.023	0.514TrpGlu: 0.514 ± 0.022	0.603TrpPhe: 0.603 ± 0.025	0.981TrpGly: 0.981 ± 0.034	0.436TrpHis: 0.436 ± 0.019	0.645TrpIle: 0.645 ± 0.026	0.375TrpLys: 0.375 ± 0.019	2.495TrpLeu: 2.495 ± 0.06	0.326TrpMet: 0.326 ± 0.018	0.416TrpAsn: 0.416 ± 0.019	0.721TrpPro: 0.721 ± 0.032	1.086TrpGln: 1.086 ± 0.035	1.342TrpArg: 1.342 ± 0.037	0.685TrpSer: 0.685 ± 0.025	0.624TrpThr: 0.624 ± 0.026	0.959TrpVal: 0.959 ± 0.033	0.293TrpTrp: 0.293 ± 0.018	0.351TrpTyr: 0.351 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.802TyrAla: 2.802 ± 0.059	0.281TyrCys: 0.281 ± 0.017	1.48TyrAsp: 1.48 ± 0.049	1.059TyrGlu: 1.059 ± 0.036	1.079TyrPhe: 1.079 ± 0.034	2.257TyrGly: 2.257 ± 0.054	0.525TyrHis: 0.525 ± 0.019	0.868TyrIle: 0.868 ± 0.029	0.813TyrLys: 0.813 ± 0.029	2.893TyrLeu: 2.893 ± 0.048	0.409TyrMet: 0.409 ± 0.019	0.776TyrAsn: 0.776 ± 0.027	1.35TyrPro: 1.35 ± 0.037	1.067TyrGln: 1.067 ± 0.036	2.095TyrArg: 2.095 ± 0.043	1.305TyrSer: 1.305 ± 0.033	1.305TyrThr: 1.305 ± 0.038	1.736TyrVal: 1.736 ± 0.04	0.464TyrTrp: 0.464 ± 0.02	0.746TyrTyr: 0.746 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3426 proteins (1090397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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