Amino acid dipepetide frequency for Sphingobium sp. SCG-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.124AlaAla: 17.124 ± 0.189	1.057AlaCys: 1.057 ± 0.025	7.279AlaAsp: 7.279 ± 0.123	6.889AlaGlu: 6.889 ± 0.076	4.33AlaPhe: 4.33 ± 0.062	10.547AlaGly: 10.547 ± 0.169	2.285AlaHis: 2.285 ± 0.042	6.862AlaIle: 6.862 ± 0.08	4.238AlaLys: 4.238 ± 0.079	13.232AlaLeu: 13.232 ± 0.133	3.707AlaMet: 3.707 ± 0.055	3.361AlaAsn: 3.361 ± 0.057	5.754AlaPro: 5.754 ± 0.081	4.714AlaGln: 4.714 ± 0.064	8.709AlaArg: 8.709 ± 0.103	7.043AlaSer: 7.043 ± 0.079	6.495AlaThr: 6.495 ± 0.08	8.399AlaVal: 8.399 ± 0.086	1.416AlaTrp: 1.416 ± 0.033	2.601AlaTyr: 2.601 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.033	0.091CysCys: 0.091 ± 0.01	0.527CysAsp: 0.527 ± 0.022	0.391CysGlu: 0.391 ± 0.017	0.29CysPhe: 0.29 ± 0.018	0.87CysGly: 0.87 ± 0.025	0.218CysHis: 0.218 ± 0.016	0.39CysIle: 0.39 ± 0.018	0.191CysLys: 0.191 ± 0.013	0.736CysLeu: 0.736 ± 0.022	0.177CysMet: 0.177 ± 0.011	0.212CysAsn: 0.212 ± 0.012	0.428CysPro: 0.428 ± 0.018	0.238CysGln: 0.238 ± 0.014	0.542CysArg: 0.542 ± 0.022	0.453CysSer: 0.453 ± 0.021	0.434CysThr: 0.434 ± 0.019	0.591CysVal: 0.591 ± 0.02	0.112CysTrp: 0.112 ± 0.009	0.179CysTyr: 0.179 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.605AspAla: 7.605 ± 0.089	0.467AspCys: 0.467 ± 0.021	3.299AspAsp: 3.299 ± 0.068	3.176AspGlu: 3.176 ± 0.055	2.143AspPhe: 2.143 ± 0.044	5.401AspGly: 5.401 ± 0.103	1.378AspHis: 1.378 ± 0.034	3.297AspIle: 3.297 ± 0.06	1.744AspLys: 1.744 ± 0.036	5.671AspLeu: 5.671 ± 0.076	1.451AspMet: 1.451 ± 0.032	1.521AspAsn: 1.521 ± 0.037	3.577AspPro: 3.577 ± 0.057	1.848AspGln: 1.848 ± 0.04	4.608AspArg: 4.608 ± 0.056	2.533AspSer: 2.533 ± 0.047	2.817AspThr: 2.817 ± 0.133	4.333AspVal: 4.333 ± 0.061	1.038AspTrp: 1.038 ± 0.03	1.636AspTyr: 1.636 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.16GluAla: 7.16 ± 0.092	0.338GluCys: 0.338 ± 0.018	2.785GluAsp: 2.785 ± 0.055	2.813GluGlu: 2.813 ± 0.066	1.525GluPhe: 1.525 ± 0.04	4.328GluGly: 4.328 ± 0.067	1.082GluHis: 1.082 ± 0.029	2.936GluIle: 2.936 ± 0.048	2.068GluLys: 2.068 ± 0.045	4.691GluLeu: 4.691 ± 0.064	1.459GluMet: 1.459 ± 0.036	1.48GluAsn: 1.48 ± 0.038	2.38GluPro: 2.38 ± 0.053	2.089GluGln: 2.089 ± 0.044	4.481GluArg: 4.481 ± 0.067	2.303GluSer: 2.303 ± 0.04	3.16GluThr: 3.16 ± 0.051	3.457GluVal: 3.457 ± 0.054	0.776GluTrp: 0.776 ± 0.027	1.048GluTyr: 1.048 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.6PheAla: 4.6 ± 0.067	0.367PheCys: 0.367 ± 0.018	2.684PheAsp: 2.684 ± 0.049	1.974PheGlu: 1.974 ± 0.045	1.305PhePhe: 1.305 ± 0.036	3.641PheGly: 3.641 ± 0.057	0.741PheHis: 0.741 ± 0.024	1.499PheIle: 1.499 ± 0.033	0.946PheLys: 0.946 ± 0.026	3.206PheLeu: 3.206 ± 0.056	0.795PheMet: 0.795 ± 0.029	1.115PheAsn: 1.115 ± 0.034	1.552PhePro: 1.552 ± 0.035	0.944PheGln: 0.944 ± 0.03	2.188PheArg: 2.188 ± 0.044	2.303PheSer: 2.303 ± 0.048	2.099PheThr: 2.099 ± 0.042	2.595PheVal: 2.595 ± 0.046	0.513PheTrp: 0.513 ± 0.019	0.941PheTyr: 0.941 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.61GlyAla: 9.61 ± 0.175	0.8GlyCys: 0.8 ± 0.029	4.833GlyAsp: 4.833 ± 0.155	4.479GlyGlu: 4.479 ± 0.062	3.634GlyPhe: 3.634 ± 0.057	8.28GlyGly: 8.28 ± 0.234	1.785GlyHis: 1.785 ± 0.037	4.728GlyIle: 4.728 ± 0.068	3.485GlyLys: 3.485 ± 0.056	8.3GlyLeu: 8.3 ± 0.076	2.285GlyMet: 2.285 ± 0.046	2.639GlyAsn: 2.639 ± 0.076	3.536GlyPro: 3.536 ± 0.054	2.997GlyGln: 2.997 ± 0.051	6.085GlyArg: 6.085 ± 0.072	5.234GlySer: 5.234 ± 0.112	5.145GlyThr: 5.145 ± 0.119	6.213GlyVal: 6.213 ± 0.073	1.488GlyTrp: 1.488 ± 0.033	2.373GlyTyr: 2.373 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.324HisAla: 2.324 ± 0.043	0.236HisCys: 0.236 ± 0.015	1.193HisAsp: 1.193 ± 0.03	0.974HisGlu: 0.974 ± 0.028	0.841HisPhe: 0.841 ± 0.029	1.917HisGly: 1.917 ± 0.042	0.58HisHis: 0.58 ± 0.024	1.056HisIle: 1.056 ± 0.031	0.489HisLys: 0.489 ± 0.021	1.874HisLeu: 1.874 ± 0.036	0.517HisMet: 0.517 ± 0.02	0.486HisAsn: 0.486 ± 0.02	1.293HisPro: 1.293 ± 0.033	0.585HisGln: 0.585 ± 0.022	1.431HisArg: 1.431 ± 0.035	1.07HisSer: 1.07 ± 0.029	0.674HisThr: 0.674 ± 0.021	1.546HisVal: 1.546 ± 0.034	0.364HisTrp: 0.364 ± 0.017	0.613HisTyr: 0.613 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.767IleAla: 7.767 ± 0.099	0.47IleCys: 0.47 ± 0.022	3.936IleAsp: 3.936 ± 0.056	3.489IleGlu: 3.489 ± 0.062	1.741IlePhe: 1.741 ± 0.038	5.383IleGly: 5.383 ± 0.077	0.933IleHis: 0.933 ± 0.027	2.442IleIle: 2.442 ± 0.045	1.358IleLys: 1.358 ± 0.029	4.32IleLeu: 4.32 ± 0.07	1.039IleMet: 1.039 ± 0.029	1.587IleAsn: 1.587 ± 0.038	2.329IlePro: 2.329 ± 0.05	1.26IleGln: 1.26 ± 0.029	3.317IleArg: 3.317 ± 0.055	3.065IleSer: 3.065 ± 0.054	2.768IleThr: 2.768 ± 0.046	4.376IleVal: 4.376 ± 0.064	0.629IleTrp: 0.629 ± 0.022	1.1IleTyr: 1.1 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.335LysAla: 4.335 ± 0.068	0.158LysCys: 0.158 ± 0.01	1.68LysAsp: 1.68 ± 0.045	1.305LysGlu: 1.305 ± 0.033	0.9LysPhe: 0.9 ± 0.026	2.779LysGly: 2.779 ± 0.046	0.585LysHis: 0.585 ± 0.022	1.7LysIle: 1.7 ± 0.035	1.107LysLys: 1.107 ± 0.036	3.366LysLeu: 3.366 ± 0.047	0.845LysMet: 0.845 ± 0.025	0.823LysAsn: 0.823 ± 0.027	2.024LysPro: 2.024 ± 0.048	0.977LysGln: 0.977 ± 0.029	2.302LysArg: 2.302 ± 0.044	1.829LysSer: 1.829 ± 0.038	1.826LysThr: 1.826 ± 0.042	2.259LysVal: 2.259 ± 0.045	0.422LysTrp: 0.422 ± 0.021	0.654LysTyr: 0.654 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.907LeuAla: 12.907 ± 0.125	0.851LeuCys: 0.851 ± 0.028	6.0LeuAsp: 6.0 ± 0.078	4.742LeuGlu: 4.742 ± 0.07	3.615LeuPhe: 3.615 ± 0.067	7.878LeuGly: 7.878 ± 0.095	1.81LeuHis: 1.81 ± 0.042	5.154LeuIle: 5.154 ± 0.067	3.145LeuLys: 3.145 ± 0.052	9.327LeuLeu: 9.327 ± 0.12	2.209LeuMet: 2.209 ± 0.05	2.722LeuAsn: 2.722 ± 0.047	5.523LeuPro: 5.523 ± 0.075	2.73LeuGln: 2.73 ± 0.049	6.611LeuArg: 6.611 ± 0.076	6.613LeuSer: 6.613 ± 0.083	5.724LeuThr: 5.724 ± 0.088	6.647LeuVal: 6.647 ± 0.091	1.25LeuTrp: 1.25 ± 0.032	2.048LeuTyr: 2.048 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.247MetAla: 3.247 ± 0.06	0.156MetCys: 0.156 ± 0.009	1.221MetAsp: 1.221 ± 0.032	1.136MetGlu: 1.136 ± 0.026	0.719MetPhe: 0.719 ± 0.024	1.912MetGly: 1.912 ± 0.042	0.459MetHis: 0.459 ± 0.02	1.438MetIle: 1.438 ± 0.037	0.949MetLys: 0.949 ± 0.026	2.611MetLeu: 2.611 ± 0.053	0.722MetMet: 0.722 ± 0.029	0.693MetAsn: 0.693 ± 0.021	1.452MetPro: 1.452 ± 0.036	0.803MetGln: 0.803 ± 0.028	1.815MetArg: 1.815 ± 0.039	1.557MetSer: 1.557 ± 0.039	1.764MetThr: 1.764 ± 0.038	1.673MetVal: 1.673 ± 0.038	0.221MetTrp: 0.221 ± 0.013	0.291MetTyr: 0.291 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.595AsnAla: 3.595 ± 0.061	0.266AsnCys: 0.266 ± 0.014	1.647AsnAsp: 1.647 ± 0.06	1.206AsnGlu: 1.206 ± 0.031	1.045AsnPhe: 1.045 ± 0.033	2.772AsnGly: 2.772 ± 0.071	0.51AsnHis: 0.51 ± 0.022	1.611AsnIle: 1.611 ± 0.035	0.706AsnLys: 0.706 ± 0.022	2.684AsnLeu: 2.684 ± 0.047	0.623AsnMet: 0.623 ± 0.022	0.856AsnAsn: 0.856 ± 0.033	1.757AsnPro: 1.757 ± 0.043	0.818AsnGln: 0.818 ± 0.026	1.994AsnArg: 1.994 ± 0.043	1.509AsnSer: 1.509 ± 0.043	1.245AsnThr: 1.245 ± 0.04	2.23AsnVal: 2.23 ± 0.05	0.474AsnTrp: 0.474 ± 0.02	0.785AsnTyr: 0.785 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.246ProAla: 6.246 ± 0.096	0.331ProCys: 0.331 ± 0.014	3.615ProAsp: 3.615 ± 0.049	3.349ProGlu: 3.349 ± 0.055	1.936ProPhe: 1.936 ± 0.046	4.404ProGly: 4.404 ± 0.064	1.05ProHis: 1.05 ± 0.032	2.569ProIle: 2.569 ± 0.046	1.692ProLys: 1.692 ± 0.036	4.849ProLeu: 4.849 ± 0.069	1.216ProMet: 1.216 ± 0.032	1.429ProAsn: 1.429 ± 0.036	2.518ProPro: 2.518 ± 0.063	1.761ProGln: 1.761 ± 0.042	2.889ProArg: 2.889 ± 0.047	2.938ProSer: 2.938 ± 0.048	2.691ProThr: 2.691 ± 0.054	4.155ProVal: 4.155 ± 0.064	0.688ProTrp: 0.688 ± 0.023	1.102ProTyr: 1.102 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.146GlnAla: 4.146 ± 0.062	0.236GlnCys: 0.236 ± 0.014	1.582GlnAsp: 1.582 ± 0.036	1.401GlnGlu: 1.401 ± 0.036	1.161GlnPhe: 1.161 ± 0.029	2.57GlnGly: 2.57 ± 0.045	0.677GlnHis: 0.677 ± 0.025	1.931GlnIle: 1.931 ± 0.037	1.022GlnLys: 1.022 ± 0.025	3.09GlnLeu: 3.09 ± 0.05	0.896GlnMet: 0.896 ± 0.026	0.904GlnAsn: 0.904 ± 0.027	1.778GlnPro: 1.778 ± 0.039	1.229GlnGln: 1.229 ± 0.036	2.54GlnArg: 2.54 ± 0.051	2.0GlnSer: 2.0 ± 0.044	1.767GlnThr: 1.767 ± 0.04	2.322GlnVal: 2.322 ± 0.046	0.498GlnTrp: 0.498 ± 0.02	0.716GlnTyr: 0.716 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.936ArgAla: 7.936 ± 0.097	0.506ArgCys: 0.506 ± 0.02	4.17ArgAsp: 4.17 ± 0.063	3.725ArgGlu: 3.725 ± 0.059	2.954ArgPhe: 2.954 ± 0.054	4.897ArgGly: 4.897 ± 0.069	1.644ArgHis: 1.644 ± 0.039	4.1ArgIle: 4.1 ± 0.061	2.191ArgLys: 2.191 ± 0.039	7.68ArgLeu: 7.68 ± 0.089	1.837ArgMet: 1.837 ± 0.04	1.998ArgAsn: 1.998 ± 0.047	3.456ArgPro: 3.456 ± 0.058	2.527ArgGln: 2.527 ± 0.046	5.251ArgArg: 5.251 ± 0.087	3.954ArgSer: 3.954 ± 0.064	3.602ArgThr: 3.602 ± 0.051	4.635ArgVal: 4.635 ± 0.068	1.102ArgTrp: 1.102 ± 0.036	1.897ArgTyr: 1.897 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.877SerAla: 6.877 ± 0.093	0.432SerCys: 0.432 ± 0.019	3.405SerAsp: 3.405 ± 0.057	2.797SerGlu: 2.797 ± 0.046	2.405SerPhe: 2.405 ± 0.044	6.032SerGly: 6.032 ± 0.105	1.079SerHis: 1.079 ± 0.028	3.05SerIle: 3.05 ± 0.054	1.679SerLys: 1.679 ± 0.037	5.574SerLeu: 5.574 ± 0.068	1.282SerMet: 1.282 ± 0.035	1.634SerAsn: 1.634 ± 0.04	2.99SerPro: 2.99 ± 0.057	1.706SerGln: 1.706 ± 0.042	3.738SerArg: 3.738 ± 0.055	3.245SerSer: 3.245 ± 0.06	2.929SerThr: 2.929 ± 0.053	4.041SerVal: 4.041 ± 0.063	0.847SerTrp: 0.847 ± 0.028	1.59SerTyr: 1.59 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.424ThrAla: 6.424 ± 0.078	0.404ThrCys: 0.404 ± 0.02	3.027ThrAsp: 3.027 ± 0.052	2.384ThrGlu: 2.384 ± 0.043	1.905ThrPhe: 1.905 ± 0.037	5.519ThrGly: 5.519 ± 0.118	0.99ThrHis: 0.99 ± 0.027	3.101ThrIle: 3.101 ± 0.057	1.501ThrLys: 1.501 ± 0.033	6.042ThrLeu: 6.042 ± 0.101	1.276ThrMet: 1.276 ± 0.034	1.481ThrAsn: 1.481 ± 0.036	3.482ThrPro: 3.482 ± 0.057	1.66ThrGln: 1.66 ± 0.033	3.426ThrArg: 3.426 ± 0.05	3.037ThrSer: 3.037 ± 0.058	2.89ThrThr: 2.89 ± 0.056	4.221ThrVal: 4.221 ± 0.064	0.593ThrTrp: 0.593 ± 0.02	1.231ThrTyr: 1.231 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.179ValAla: 9.179 ± 0.094	0.53ValCys: 0.53 ± 0.024	4.367ValAsp: 4.367 ± 0.063	4.319ValGlu: 4.319 ± 0.062	2.133ValPhe: 2.133 ± 0.049	5.666ValGly: 5.666 ± 0.072	1.382ValHis: 1.382 ± 0.034	3.755ValIle: 3.755 ± 0.048	2.247ValLys: 2.247 ± 0.053	6.455ValLeu: 6.455 ± 0.077	1.684ValMet: 1.684 ± 0.045	2.206ValAsn: 2.206 ± 0.055	3.861ValPro: 3.861 ± 0.063	2.232ValGln: 2.232 ± 0.045	5.034ValArg: 5.034 ± 0.07	4.311ValSer: 4.311 ± 0.067	4.504ValThr: 4.504 ± 0.066	5.138ValVal: 5.138 ± 0.069	0.773ValTrp: 0.773 ± 0.025	1.468ValTyr: 1.468 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.261TrpAla: 1.261 ± 0.033	0.114TrpCys: 0.114 ± 0.01	0.708TrpAsp: 0.708 ± 0.026	0.604TrpGlu: 0.604 ± 0.021	0.52TrpPhe: 0.52 ± 0.02	0.903TrpGly: 0.903 ± 0.028	0.358TrpHis: 0.358 ± 0.015	0.723TrpIle: 0.723 ± 0.025	0.504TrpLys: 0.504 ± 0.022	1.654TrpLeu: 1.654 ± 0.038	0.375TrpMet: 0.375 ± 0.016	0.478TrpAsn: 0.478 ± 0.017	0.69TrpPro: 0.69 ± 0.024	0.58TrpGln: 0.58 ± 0.021	1.203TrpArg: 1.203 ± 0.033	0.92TrpSer: 0.92 ± 0.029	0.873TrpThr: 0.873 ± 0.026	0.816TrpVal: 0.816 ± 0.026	0.243TrpTrp: 0.243 ± 0.013	0.27TrpTyr: 0.27 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.712TyrAla: 2.712 ± 0.046	0.245TyrCys: 0.245 ± 0.014	1.585TyrAsp: 1.585 ± 0.043	1.206TyrGlu: 1.206 ± 0.03	0.908TyrPhe: 0.908 ± 0.029	2.229TyrGly: 2.229 ± 0.041	0.515TyrHis: 0.515 ± 0.02	0.966TyrIle: 0.966 ± 0.031	0.619TyrLys: 0.619 ± 0.024	2.143TyrLeu: 2.143 ± 0.036	0.445TyrMet: 0.445 ± 0.017	0.708TyrAsn: 0.708 ± 0.028	1.051TyrPro: 1.051 ± 0.033	0.769TyrGln: 0.769 ± 0.026	1.895TyrArg: 1.895 ± 0.039	1.415TyrSer: 1.415 ± 0.045	1.185TyrThr: 1.185 ± 0.038	1.599TyrVal: 1.599 ± 0.037	0.35TyrTrp: 0.35 ± 0.017	0.663TyrTyr: 0.663 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3938 proteins (1300806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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