Amino acid dipepetide frequency for Saccharomycodes ludwigii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.217AlaAla: 3.217 ± 0.066	0.627AlaCys: 0.627 ± 0.021	2.418AlaAsp: 2.418 ± 0.035	2.524AlaGlu: 2.524 ± 0.04	1.93AlaPhe: 1.93 ± 0.037	2.379AlaGly: 2.379 ± 0.047	0.841AlaHis: 0.841 ± 0.019	3.486AlaIle: 3.486 ± 0.05	3.479AlaLys: 3.479 ± 0.043	4.463AlaLeu: 4.463 ± 0.056	0.96AlaMet: 0.96 ± 0.021	3.327AlaAsn: 3.327 ± 0.042	1.766AlaPro: 1.766 ± 0.034	1.534AlaGln: 1.534 ± 0.034	1.746AlaArg: 1.746 ± 0.03	4.257AlaSer: 4.257 ± 0.051	3.531AlaThr: 3.531 ± 0.046	2.635AlaVal: 2.635 ± 0.04	0.385AlaTrp: 0.385 ± 0.013	1.552AlaTyr: 1.552 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.567CysAla: 0.567 ± 0.018	0.361CysCys: 0.361 ± 0.013	0.733CysAsp: 0.733 ± 0.019	0.63CysGlu: 0.63 ± 0.017	0.747CysPhe: 0.747 ± 0.019	0.88CysGly: 0.88 ± 0.02	0.292CysHis: 0.292 ± 0.011	1.032CysIle: 1.032 ± 0.02	0.936CysLys: 0.936 ± 0.021	1.376CysLeu: 1.376 ± 0.029	0.249CysMet: 0.249 ± 0.011	0.853CysAsn: 0.853 ± 0.021	0.452CysPro: 0.452 ± 0.018	0.374CysGln: 0.374 ± 0.013	0.447CysArg: 0.447 ± 0.014	1.08CysSer: 1.08 ± 0.022	0.64CysThr: 0.64 ± 0.016	0.777CysVal: 0.777 ± 0.017	0.159CysTrp: 0.159 ± 0.009	0.569CysTyr: 0.569 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.63AspAla: 2.63 ± 0.037	0.699AspCys: 0.699 ± 0.016	5.157AspAsp: 5.157 ± 0.087	4.641AspGlu: 4.641 ± 0.062	2.901AspPhe: 2.901 ± 0.046	2.881AspGly: 2.881 ± 0.037	1.013AspHis: 1.013 ± 0.023	4.852AspIle: 4.852 ± 0.047	4.166AspLys: 4.166 ± 0.049	5.642AspLeu: 5.642 ± 0.058	1.048AspMet: 1.048 ± 0.019	4.685AspAsn: 4.685 ± 0.05	2.187AspPro: 2.187 ± 0.035	1.63AspGln: 1.63 ± 0.029	1.753AspArg: 1.753 ± 0.03	4.574AspSer: 4.574 ± 0.053	3.316AspThr: 3.316 ± 0.048	3.277AspVal: 3.277 ± 0.043	0.574AspTrp: 0.574 ± 0.018	2.488AspTyr: 2.488 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	2.657GluAla: 2.657 ± 0.043	0.647GluCys: 0.647 ± 0.019	4.123GluAsp: 4.123 ± 0.064	6.431GluGlu: 6.431 ± 0.129	2.576GluPhe: 2.576 ± 0.03	2.351GluGly: 2.351 ± 0.039	1.284GluHis: 1.284 ± 0.023	4.485GluIle: 4.485 ± 0.048	5.611GluLys: 5.611 ± 0.077	6.285GluLeu: 6.285 ± 0.078	1.197GluMet: 1.197 ± 0.022	5.077GluAsn: 5.077 ± 0.056	1.677GluPro: 1.677 ± 0.034	2.578GluGln: 2.578 ± 0.04	2.348GluArg: 2.348 ± 0.039	4.009GluSer: 4.009 ± 0.048	3.362GluThr: 3.362 ± 0.041	2.953GluVal: 2.953 ± 0.042	0.602GluTrp: 0.602 ± 0.016	2.451GluTyr: 2.451 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.086PheAla: 2.086 ± 0.036	0.549PheCys: 0.549 ± 0.017	2.732PheAsp: 2.732 ± 0.037	2.69PheGlu: 2.69 ± 0.034	2.158PhePhe: 2.158 ± 0.039	2.494PheGly: 2.494 ± 0.045	0.92PheHis: 0.92 ± 0.02	3.425PheIle: 3.425 ± 0.044	3.466PheLys: 3.466 ± 0.039	4.056PheLeu: 4.056 ± 0.053	0.861PheMet: 0.861 ± 0.021	3.1PheAsn: 3.1 ± 0.037	1.651PhePro: 1.651 ± 0.028	1.852PheGln: 1.852 ± 0.027	1.41PheArg: 1.41 ± 0.027	3.55PheSer: 3.55 ± 0.04	2.566PheThr: 2.566 ± 0.037	2.573PheVal: 2.573 ± 0.039	0.478PheTrp: 0.478 ± 0.018	1.746PheTyr: 1.746 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	2.447GlyAla: 2.447 ± 0.045	0.816GlyCys: 0.816 ± 0.019	2.728GlyAsp: 2.728 ± 0.037	2.74GlyGlu: 2.74 ± 0.035	2.296GlyPhe: 2.296 ± 0.042	3.291GlyGly: 3.291 ± 0.061	0.976GlyHis: 0.976 ± 0.023	3.613GlyIle: 3.613 ± 0.047	3.698GlyLys: 3.698 ± 0.046	4.262GlyLeu: 4.262 ± 0.05	0.888GlyMet: 0.888 ± 0.022	3.737GlyAsn: 3.737 ± 0.041	1.326GlyPro: 1.326 ± 0.028	1.266GlyGln: 1.266 ± 0.029	1.749GlyArg: 1.749 ± 0.035	4.353GlySer: 4.353 ± 0.047	3.022GlyThr: 3.022 ± 0.039	2.979GlyVal: 2.979 ± 0.038	0.51GlyTrp: 0.51 ± 0.017	1.852GlyTyr: 1.852 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	0.812HisAla: 0.812 ± 0.019	0.291HisCys: 0.291 ± 0.012	1.153HisAsp: 1.153 ± 0.022	1.1HisGlu: 1.1 ± 0.024	0.9HisPhe: 0.9 ± 0.021	1.045HisGly: 1.045 ± 0.021	0.689HisHis: 0.689 ± 0.03	1.438HisIle: 1.438 ± 0.025	1.429HisLys: 1.429 ± 0.025	1.882HisLeu: 1.882 ± 0.03	0.358HisMet: 0.358 ± 0.013	1.578HisAsn: 1.578 ± 0.026	0.875HisPro: 0.875 ± 0.019	0.724HisGln: 0.724 ± 0.023	0.805HisArg: 0.805 ± 0.021	1.624HisSer: 1.624 ± 0.03	1.085HisThr: 1.085 ± 0.021	1.03HisVal: 1.03 ± 0.022	0.192HisTrp: 0.192 ± 0.009	0.825HisTyr: 0.825 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.472IleAla: 3.472 ± 0.037	0.974IleCys: 0.974 ± 0.023	4.57IleAsp: 4.57 ± 0.045	4.257IleGlu: 4.257 ± 0.049	3.331IlePhe: 3.331 ± 0.051	3.34IleGly: 3.34 ± 0.045	1.363IleHis: 1.363 ± 0.026	5.248IleIle: 5.248 ± 0.066	5.612IleLys: 5.612 ± 0.057	7.06IleLeu: 7.06 ± 0.071	1.366IleMet: 1.366 ± 0.027	5.531IleAsn: 5.531 ± 0.059	3.351IlePro: 3.351 ± 0.042	2.402IleGln: 2.402 ± 0.037	2.573IleArg: 2.573 ± 0.033	6.349IleSer: 6.349 ± 0.058	4.498IleThr: 4.498 ± 0.044	4.025IleVal: 4.025 ± 0.042	0.673IleTrp: 0.673 ± 0.019	2.585IleTyr: 2.585 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.127LysAla: 3.127 ± 0.047	0.913LysCys: 0.913 ± 0.021	4.583LysAsp: 4.583 ± 0.057	5.576LysGlu: 5.576 ± 0.079	3.456LysPhe: 3.456 ± 0.041	2.859LysGly: 2.859 ± 0.045	1.66LysHis: 1.66 ± 0.03	6.066LysIle: 6.066 ± 0.063	8.005LysLys: 8.005 ± 0.107	7.994LysLeu: 7.994 ± 0.069	1.498LysMet: 1.498 ± 0.028	6.587LysAsn: 6.587 ± 0.065	2.735LysPro: 2.735 ± 0.04	3.041LysGln: 3.041 ± 0.042	3.592LysArg: 3.592 ± 0.041	5.697LysSer: 5.697 ± 0.055	4.399LysThr: 4.399 ± 0.051	3.855LysVal: 3.855 ± 0.044	0.744LysTrp: 0.744 ± 0.02	3.393LysTyr: 3.393 ± 0.047	0.001LysXaa: 0.001 ± 0.001
Leu	4.388LeuAla: 4.388 ± 0.048	1.39LeuCys: 1.39 ± 0.026	5.446LeuAsp: 5.446 ± 0.052	5.918LeuGlu: 5.918 ± 0.072	4.16LeuPhe: 4.16 ± 0.059	4.235LeuGly: 4.235 ± 0.051	1.881LeuHis: 1.881 ± 0.03	6.199LeuIle: 6.199 ± 0.065	8.23LeuLys: 8.23 ± 0.081	9.703LeuLeu: 9.703 ± 0.087	1.747LeuMet: 1.747 ± 0.032	6.688LeuAsn: 6.688 ± 0.065	4.283LeuPro: 4.283 ± 0.046	3.963LeuGln: 3.963 ± 0.046	3.579LeuArg: 3.579 ± 0.043	7.918LeuSer: 7.918 ± 0.066	5.229LeuThr: 5.229 ± 0.052	4.701LeuVal: 4.701 ± 0.05	0.819LeuTrp: 0.819 ± 0.02	3.409LeuTyr: 3.409 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.042MetAla: 1.042 ± 0.019	0.304MetCys: 0.304 ± 0.012	1.215MetAsp: 1.215 ± 0.024	1.22MetGlu: 1.22 ± 0.022	0.805MetPhe: 0.805 ± 0.017	1.015MetGly: 1.015 ± 0.023	0.313MetHis: 0.313 ± 0.011	1.16MetIle: 1.16 ± 0.021	1.394MetLys: 1.394 ± 0.026	1.736MetLeu: 1.736 ± 0.03	0.395MetMet: 0.395 ± 0.014	1.336MetAsn: 1.336 ± 0.028	0.658MetPro: 0.658 ± 0.02	0.533MetGln: 0.533 ± 0.016	0.609MetArg: 0.609 ± 0.017	1.707MetSer: 1.707 ± 0.03	0.998MetThr: 0.998 ± 0.022	1.063MetVal: 1.063 ± 0.021	0.158MetTrp: 0.158 ± 0.008	0.592MetTyr: 0.592 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.416AsnAla: 3.416 ± 0.046	0.906AsnCys: 0.906 ± 0.021	5.135AsnAsp: 5.135 ± 0.06	4.492AsnGlu: 4.492 ± 0.047	3.062AsnPhe: 3.062 ± 0.04	4.297AsnGly: 4.297 ± 0.043	1.441AsnHis: 1.441 ± 0.028	6.029AsnIle: 6.029 ± 0.066	6.509AsnLys: 6.509 ± 0.063	5.877AsnLeu: 5.877 ± 0.057	1.311AsnMet: 1.311 ± 0.029	12.072AsnAsn: 12.072 ± 0.216	2.509AsnPro: 2.509 ± 0.036	1.971AsnGln: 1.971 ± 0.03	2.314AsnArg: 2.314 ± 0.034	7.421AsnSer: 7.421 ± 0.087	5.819AsnThr: 5.819 ± 0.081	3.959AsnVal: 3.959 ± 0.046	0.652AsnTrp: 0.652 ± 0.018	2.716AsnTyr: 2.716 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	1.728ProAla: 1.728 ± 0.034	0.363ProCys: 0.363 ± 0.014	1.968ProAsp: 1.968 ± 0.03	2.364ProGlu: 2.364 ± 0.032	1.789ProPhe: 1.789 ± 0.031	1.627ProGly: 1.627 ± 0.031	0.768ProHis: 0.768 ± 0.017	3.006ProIle: 3.006 ± 0.038	2.726ProLys: 2.726 ± 0.036	3.651ProLeu: 3.651 ± 0.042	0.648ProMet: 0.648 ± 0.019	2.622ProAsn: 2.622 ± 0.035	1.952ProPro: 1.952 ± 0.05	1.523ProGln: 1.523 ± 0.038	1.28ProArg: 1.28 ± 0.026	3.519ProSer: 3.519 ± 0.05	2.577ProThr: 2.577 ± 0.042	2.26ProVal: 2.26 ± 0.035	0.384ProTrp: 0.384 ± 0.014	1.36ProTyr: 1.36 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	1.538GlnAla: 1.538 ± 0.032	0.384GlnCys: 0.384 ± 0.014	1.921GlnAsp: 1.921 ± 0.033	2.471GlnGlu: 2.471 ± 0.042	1.502GlnPhe: 1.502 ± 0.028	1.324GlnGly: 1.324 ± 0.027	0.867GlnHis: 0.867 ± 0.024	2.376GlnIle: 2.376 ± 0.036	2.742GlnLys: 2.742 ± 0.04	3.715GlnLeu: 3.715 ± 0.046	0.658GlnMet: 0.658 ± 0.016	2.364GlnAsn: 2.364 ± 0.035	1.312GlnPro: 1.312 ± 0.029	3.406GlnGln: 3.406 ± 0.145	1.452GlnArg: 1.452 ± 0.028	2.346GlnSer: 2.346 ± 0.03	1.729GlnThr: 1.729 ± 0.029	1.814GlnVal: 1.814 ± 0.03	0.314GlnTrp: 0.314 ± 0.012	1.473GlnTyr: 1.473 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.7ArgAla: 1.7 ± 0.031	0.503ArgCys: 0.503 ± 0.015	1.979ArgAsp: 1.979 ± 0.036	2.316ArgGlu: 2.316 ± 0.035	1.627ArgPhe: 1.627 ± 0.029	1.837ArgGly: 1.837 ± 0.036	0.761ArgHis: 0.761 ± 0.018	2.566ArgIle: 2.566 ± 0.036	3.361ArgLys: 3.361 ± 0.048	3.499ArgLeu: 3.499 ± 0.042	0.71ArgMet: 0.71 ± 0.018	2.537ArgAsn: 2.537 ± 0.036	1.181ArgPro: 1.181 ± 0.025	1.321ArgGln: 1.321 ± 0.025	2.002ArgArg: 2.002 ± 0.037	2.747ArgSer: 2.747 ± 0.037	1.908ArgThr: 1.908 ± 0.031	1.824ArgVal: 1.824 ± 0.029	0.361ArgTrp: 0.361 ± 0.012	1.378ArgTyr: 1.378 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	3.957SerAla: 3.957 ± 0.047	1.022SerCys: 1.022 ± 0.023	4.491SerAsp: 4.491 ± 0.04	3.979SerGlu: 3.979 ± 0.045	3.76SerPhe: 3.76 ± 0.051	4.223SerGly: 4.223 ± 0.055	1.56SerHis: 1.56 ± 0.032	6.364SerIle: 6.364 ± 0.064	6.518SerLys: 6.518 ± 0.053	7.709SerLeu: 7.709 ± 0.075	1.561SerMet: 1.561 ± 0.03	7.55SerAsn: 7.55 ± 0.1	3.252SerPro: 3.252 ± 0.058	2.507SerGln: 2.507 ± 0.035	2.921SerArg: 2.921 ± 0.044	10.485SerSer: 10.485 ± 0.215	6.436SerThr: 6.436 ± 0.084	4.447SerVal: 4.447 ± 0.047	0.693SerTrp: 0.693 ± 0.018	2.642SerTyr: 2.642 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	3.367ThrAla: 3.367 ± 0.046	0.781ThrCys: 0.781 ± 0.02	3.352ThrAsp: 3.352 ± 0.04	3.107ThrGlu: 3.107 ± 0.042	2.6ThrPhe: 2.6 ± 0.034	3.397ThrGly: 3.397 ± 0.054	1.165ThrHis: 1.165 ± 0.027	4.359ThrIle: 4.359 ± 0.054	4.557ThrLys: 4.557 ± 0.052	5.214ThrLeu: 5.214 ± 0.052	0.985ThrMet: 0.985 ± 0.021	5.387ThrAsn: 5.387 ± 0.074	2.929ThrPro: 2.929 ± 0.049	1.742ThrGln: 1.742 ± 0.027	2.039ThrArg: 2.039 ± 0.031	6.091ThrSer: 6.091 ± 0.088	5.586ThrThr: 5.586 ± 0.108	3.403ThrVal: 3.403 ± 0.044	0.513ThrTrp: 0.513 ± 0.015	1.783ThrTyr: 1.783 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	2.916ValAla: 2.916 ± 0.042	0.745ValCys: 0.745 ± 0.018	3.406ValAsp: 3.406 ± 0.045	3.502ValGlu: 3.502 ± 0.048	2.493ValPhe: 2.493 ± 0.032	2.682ValGly: 2.682 ± 0.037	0.999ValHis: 0.999 ± 0.023	3.669ValIle: 3.669 ± 0.043	3.742ValLys: 3.742 ± 0.042	5.219ValLeu: 5.219 ± 0.052	0.959ValMet: 0.959 ± 0.022	3.462ValAsn: 3.462 ± 0.044	2.385ValPro: 2.385 ± 0.036	1.685ValGln: 1.685 ± 0.029	1.786ValArg: 1.786 ± 0.032	4.71ValSer: 4.71 ± 0.052	3.182ValThr: 3.182 ± 0.047	3.326ValVal: 3.326 ± 0.045	0.48ValTrp: 0.48 ± 0.015	1.935ValTyr: 1.935 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.421TrpAla: 0.421 ± 0.014	0.245TrpCys: 0.245 ± 0.01	0.603TrpAsp: 0.603 ± 0.017	0.587TrpGlu: 0.587 ± 0.016	0.484TrpPhe: 0.484 ± 0.017	0.485TrpGly: 0.485 ± 0.016	0.161TrpHis: 0.161 ± 0.008	0.64TrpIle: 0.64 ± 0.02	0.796TrpLys: 0.796 ± 0.018	0.848TrpLeu: 0.848 ± 0.021	0.182TrpMet: 0.182 ± 0.008	0.645TrpAsn: 0.645 ± 0.017	0.26TrpPro: 0.26 ± 0.01	0.272TrpGln: 0.272 ± 0.012	0.397TrpArg: 0.397 ± 0.013	0.67TrpSer: 0.67 ± 0.018	0.486TrpThr: 0.486 ± 0.018	0.506TrpVal: 0.506 ± 0.014	0.138TrpTrp: 0.138 ± 0.008	0.382TrpTyr: 0.382 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.568TyrAla: 1.568 ± 0.027	0.635TyrCys: 0.635 ± 0.017	2.401TyrAsp: 2.401 ± 0.037	2.158TyrGlu: 2.158 ± 0.028	1.784TyrPhe: 1.784 ± 0.033	1.911TyrGly: 1.911 ± 0.031	0.879TyrHis: 0.879 ± 0.02	2.567TyrIle: 2.567 ± 0.042	2.801TyrLys: 2.801 ± 0.039	3.695TyrLeu: 3.695 ± 0.049	0.674TyrMet: 0.674 ± 0.016	2.769TyrAsn: 2.769 ± 0.04	1.373TyrPro: 1.373 ± 0.027	1.381TyrGln: 1.381 ± 0.026	1.318TyrArg: 1.318 ± 0.023	2.97TyrSer: 2.97 ± 0.037	1.99TyrThr: 1.99 ± 0.038	1.875TyrVal: 1.875 ± 0.033	0.38TyrTrp: 0.38 ± 0.015	1.806TyrTyr: 1.806 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.007

Statistics based on 4013 proteins (2302366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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