Amino acid dipepetide frequency for Thalassocella blandensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.482AlaAla: 7.482 ± 0.095
1.076AlaCys: 1.076 ± 0.025
4.613AlaAsp: 4.613 ± 0.062
5.672AlaGlu: 5.672 ± 0.069
3.406AlaPhe: 3.406 ± 0.051
6.204AlaGly: 6.204 ± 0.075
1.65AlaHis: 1.65 ± 0.029
5.492AlaIle: 5.492 ± 0.063
4.649AlaLys: 4.649 ± 0.081
8.988AlaLeu: 8.988 ± 0.097
2.251AlaMet: 2.251 ± 0.037
3.866AlaAsn: 3.866 ± 0.07
2.877AlaPro: 2.877 ± 0.047
3.709AlaGln: 3.709 ± 0.075
3.731AlaArg: 3.731 ± 0.056
6.047AlaSer: 6.047 ± 0.07
4.407AlaThr: 4.407 ± 0.068
5.572AlaVal: 5.572 ± 0.066
1.064AlaTrp: 1.064 ± 0.024
2.607AlaTyr: 2.607 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.825CysAla: 0.825 ± 0.02
0.168CysCys: 0.168 ± 0.011
0.626CysAsp: 0.626 ± 0.021
0.651CysGlu: 0.651 ± 0.02
0.461CysPhe: 0.461 ± 0.017
0.892CysGly: 0.892 ± 0.028
0.319CysHis: 0.319 ± 0.016
0.622CysIle: 0.622 ± 0.019
0.413CysLys: 0.413 ± 0.018
1.031CysLeu: 1.031 ± 0.028
0.244CysMet: 0.244 ± 0.014
0.412CysAsn: 0.412 ± 0.017
0.44CysPro: 0.44 ± 0.02
0.408CysGln: 0.408 ± 0.017
0.499CysArg: 0.499 ± 0.021
0.736CysSer: 0.736 ± 0.025
0.474CysThr: 0.474 ± 0.018
0.667CysVal: 0.667 ± 0.021
0.123CysTrp: 0.123 ± 0.008
0.321CysTyr: 0.321 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.032AspAla: 5.032 ± 0.079
0.526AspCys: 0.526 ± 0.018
3.424AspAsp: 3.424 ± 0.066
3.915AspGlu: 3.915 ± 0.054
2.657AspPhe: 2.657 ± 0.042
4.374AspGly: 4.374 ± 0.105
1.094AspHis: 1.094 ± 0.025
4.328AspIle: 4.328 ± 0.055
2.953AspLys: 2.953 ± 0.048
5.281AspLeu: 5.281 ± 0.069
1.257AspMet: 1.257 ± 0.026
2.59AspAsn: 2.59 ± 0.057
2.29AspPro: 2.29 ± 0.044
2.15AspGln: 2.15 ± 0.038
2.399AspArg: 2.399 ± 0.036
3.741AspSer: 3.741 ± 0.072
3.05AspThr: 3.05 ± 0.072
4.144AspVal: 4.144 ± 0.065
0.857AspTrp: 0.857 ± 0.025
2.037AspTyr: 2.037 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.265GluAla: 5.265 ± 0.065
0.502GluCys: 0.502 ± 0.017
3.44GluAsp: 3.44 ± 0.056
4.132GluGlu: 4.132 ± 0.062
2.721GluPhe: 2.721 ± 0.041
3.84GluGly: 3.84 ± 0.058
1.525GluHis: 1.525 ± 0.032
4.134GluIle: 4.134 ± 0.055
4.187GluLys: 4.187 ± 0.07
6.299GluLeu: 6.299 ± 0.072
1.406GluMet: 1.406 ± 0.029
3.35GluAsn: 3.35 ± 0.055
1.924GluPro: 1.924 ± 0.039
3.257GluGln: 3.257 ± 0.055
3.106GluArg: 3.106 ± 0.047
4.051GluSer: 4.051 ± 0.056
3.364GluThr: 3.364 ± 0.063
4.189GluVal: 4.189 ± 0.053
0.729GluTrp: 0.729 ± 0.022
2.015GluTyr: 2.015 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.513PheAla: 3.513 ± 0.047
0.498PheCys: 0.498 ± 0.016
2.829PheAsp: 2.829 ± 0.04
2.535PheGlu: 2.535 ± 0.04
1.849PhePhe: 1.849 ± 0.041
3.051PheGly: 3.051 ± 0.046
0.913PheHis: 0.913 ± 0.024
2.699PheIle: 2.699 ± 0.048
1.966PheLys: 1.966 ± 0.035
3.595PheLeu: 3.595 ± 0.051
0.927PheMet: 0.927 ± 0.027
2.301PheAsn: 2.301 ± 0.043
1.542PhePro: 1.542 ± 0.035
1.386PheGln: 1.386 ± 0.032
1.683PheArg: 1.683 ± 0.036
3.68PheSer: 3.68 ± 0.055
2.608PheThr: 2.608 ± 0.05
2.878PheVal: 2.878 ± 0.048
0.576PheTrp: 0.576 ± 0.019
1.546PheTyr: 1.546 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
5.337GlyAla: 5.337 ± 0.089
0.778GlyCys: 0.778 ± 0.024
4.175GlyAsp: 4.175 ± 0.074
4.685GlyGlu: 4.685 ± 0.071
3.244GlyPhe: 3.244 ± 0.053
5.529GlyGly: 5.529 ± 0.128
1.444GlyHis: 1.444 ± 0.026
4.395GlyIle: 4.395 ± 0.075
3.789GlyLys: 3.789 ± 0.056
6.486GlyLeu: 6.486 ± 0.07
1.772GlyMet: 1.772 ± 0.037
3.221GlyAsn: 3.221 ± 0.078
1.856GlyPro: 1.856 ± 0.066
2.589GlyGln: 2.589 ± 0.046
2.975GlyArg: 2.975 ± 0.051
4.625GlySer: 4.625 ± 0.082
3.66GlyThr: 3.66 ± 0.081
5.155GlyVal: 5.155 ± 0.068
1.107GlyTrp: 1.107 ± 0.036
2.363GlyTyr: 2.363 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.765HisAla: 1.765 ± 0.034
0.313HisCys: 0.313 ± 0.012
1.119HisAsp: 1.119 ± 0.028
1.227HisGlu: 1.227 ± 0.027
1.136HisPhe: 1.136 ± 0.022
1.47HisGly: 1.47 ± 0.03
0.724HisHis: 0.724 ± 0.026
1.422HisIle: 1.422 ± 0.033
0.954HisLys: 0.954 ± 0.028
2.109HisLeu: 2.109 ± 0.041
0.504HisMet: 0.504 ± 0.018
0.954HisAsn: 0.954 ± 0.025
1.115HisPro: 1.115 ± 0.029
1.039HisGln: 1.039 ± 0.03
1.114HisArg: 1.114 ± 0.026
1.593HisSer: 1.593 ± 0.035
1.125HisThr: 1.125 ± 0.027
1.309HisVal: 1.309 ± 0.028
0.413HisTrp: 0.413 ± 0.017
0.957HisTyr: 0.957 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.003IleAla: 6.003 ± 0.065
0.661IleCys: 0.661 ± 0.022
4.265IleAsp: 4.265 ± 0.067
4.524IleGlu: 4.524 ± 0.051
2.472IlePhe: 2.472 ± 0.041
4.13IleGly: 4.13 ± 0.065
1.421IleHis: 1.421 ± 0.029
3.336IleIle: 3.336 ± 0.054
3.081IleLys: 3.081 ± 0.052
5.163IleLeu: 5.163 ± 0.065
1.146IleMet: 1.146 ± 0.029
3.071IleAsn: 3.071 ± 0.051
2.721IlePro: 2.721 ± 0.047
2.445IleGln: 2.445 ± 0.041
2.93IleArg: 2.93 ± 0.047
4.735IleSer: 4.735 ± 0.056
3.563IleThr: 3.563 ± 0.056
4.107IleVal: 4.107 ± 0.052
0.605IleTrp: 0.605 ± 0.022
1.835IleTyr: 1.835 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.267LysAla: 4.267 ± 0.07
0.358LysCys: 0.358 ± 0.016
2.598LysAsp: 2.598 ± 0.044
3.015LysGlu: 3.015 ± 0.055
1.766LysPhe: 1.766 ± 0.037
2.86LysGly: 2.86 ± 0.049
1.26LysHis: 1.26 ± 0.03
3.444LysIle: 3.444 ± 0.054
3.132LysLys: 3.132 ± 0.063
5.012LysLeu: 5.012 ± 0.074
1.165LysMet: 1.165 ± 0.026
2.54LysAsn: 2.54 ± 0.051
2.233LysPro: 2.233 ± 0.045
2.674LysGln: 2.674 ± 0.048
2.6LysArg: 2.6 ± 0.047
3.423LysSer: 3.423 ± 0.053
2.986LysThr: 2.986 ± 0.044
3.381LysVal: 3.381 ± 0.057
0.48LysTrp: 0.48 ± 0.018
1.448LysTyr: 1.448 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
8.863LeuAla: 8.863 ± 0.085
1.071LeuCys: 1.071 ± 0.026
5.689LeuAsp: 5.689 ± 0.065
5.869LeuGlu: 5.869 ± 0.072
3.791LeuPhe: 3.791 ± 0.049
6.37LeuGly: 6.37 ± 0.072
2.218LeuHis: 2.218 ± 0.036
5.549LeuIle: 5.549 ± 0.073
5.007LeuLys: 5.007 ± 0.075
9.23LeuLeu: 9.23 ± 0.107
2.28LeuMet: 2.28 ± 0.039
4.74LeuAsn: 4.74 ± 0.064
4.395LeuPro: 4.395 ± 0.062
4.383LeuGln: 4.383 ± 0.065
4.459LeuArg: 4.459 ± 0.058
7.43LeuSer: 7.43 ± 0.07
5.379LeuThr: 5.379 ± 0.062
6.469LeuVal: 6.469 ± 0.082
1.096LeuTrp: 1.096 ± 0.029
2.66LeuTyr: 2.66 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.07MetAla: 2.07 ± 0.041
0.214MetCys: 0.214 ± 0.011
1.227MetAsp: 1.227 ± 0.03
1.344MetGlu: 1.344 ± 0.029
0.843MetPhe: 0.843 ± 0.023
1.524MetGly: 1.524 ± 0.037
0.52MetHis: 0.52 ± 0.018
1.143MetIle: 1.143 ± 0.027
1.265MetLys: 1.265 ± 0.03
2.385MetLeu: 2.385 ± 0.041
0.558MetMet: 0.558 ± 0.018
1.049MetAsn: 1.049 ± 0.024
1.093MetPro: 1.093 ± 0.026
1.155MetGln: 1.155 ± 0.029
1.17MetArg: 1.17 ± 0.025
1.791MetSer: 1.791 ± 0.036
1.282MetThr: 1.282 ± 0.025
1.455MetVal: 1.455 ± 0.029
0.22MetTrp: 0.22 ± 0.011
0.531MetTyr: 0.531 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
4.178AsnAla: 4.178 ± 0.065
0.477AsnCys: 0.477 ± 0.018
2.652AsnAsp: 2.652 ± 0.063
2.621AsnGlu: 2.621 ± 0.04
1.99AsnPhe: 1.99 ± 0.04
3.467AsnGly: 3.467 ± 0.077
0.914AsnHis: 0.914 ± 0.024
3.306AsnIle: 3.306 ± 0.053
2.253AsnLys: 2.253 ± 0.041
4.232AsnLeu: 4.232 ± 0.063
1.019AsnMet: 1.019 ± 0.024
2.288AsnAsn: 2.288 ± 0.049
2.168AsnPro: 2.168 ± 0.041
1.899AsnGln: 1.899 ± 0.035
2.036AsnArg: 2.036 ± 0.04
3.164AsnSer: 3.164 ± 0.059
2.876AsnThr: 2.876 ± 0.05
2.975AsnVal: 2.975 ± 0.047
0.692AsnTrp: 0.692 ± 0.026
1.525AsnTyr: 1.525 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.394ProAla: 3.394 ± 0.052
0.321ProCys: 0.321 ± 0.016
2.472ProAsp: 2.472 ± 0.042
3.131ProGlu: 3.131 ± 0.053
1.634ProPhe: 1.634 ± 0.035
2.836ProGly: 2.836 ± 0.055
0.777ProHis: 0.777 ± 0.022
2.258ProIle: 2.258 ± 0.039
1.738ProLys: 1.738 ± 0.039
3.684ProLeu: 3.684 ± 0.064
0.914ProMet: 0.914 ± 0.023
1.774ProAsn: 1.774 ± 0.037
1.437ProPro: 1.437 ± 0.037
1.744ProGln: 1.744 ± 0.066
1.473ProArg: 1.473 ± 0.033
2.72ProSer: 2.72 ± 0.046
2.336ProThr: 2.336 ± 0.069
3.008ProVal: 3.008 ± 0.053
0.499ProTrp: 0.499 ± 0.018
1.183ProTyr: 1.183 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.052GlnAla: 4.052 ± 0.052
0.44GlnCys: 0.44 ± 0.017
2.209GlnAsp: 2.209 ± 0.043
2.607GlnGlu: 2.607 ± 0.043
1.766GlnPhe: 1.766 ± 0.036
2.773GlnGly: 2.773 ± 0.11
1.361GlnHis: 1.361 ± 0.036
2.416GlnIle: 2.416 ± 0.043
2.252GlnLys: 2.252 ± 0.041
4.465GlnLeu: 4.465 ± 0.065
1.01GlnMet: 1.01 ± 0.028
2.095GlnAsn: 2.095 ± 0.041
1.472GlnPro: 1.472 ± 0.031
2.795GlnGln: 2.795 ± 0.055
2.287GlnArg: 2.287 ± 0.042
2.856GlnSer: 2.856 ± 0.046
2.36GlnThr: 2.36 ± 0.043
2.703GlnVal: 2.703 ± 0.044
0.71GlnTrp: 0.71 ± 0.025
1.462GlnTyr: 1.462 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.415ArgAla: 3.415 ± 0.049
0.444ArgCys: 0.444 ± 0.015
2.663ArgAsp: 2.663 ± 0.041
3.183ArgGlu: 3.183 ± 0.046
2.279ArgPhe: 2.279 ± 0.039
2.665ArgGly: 2.665 ± 0.043
1.104ArgHis: 1.104 ± 0.029
3.123ArgIle: 3.123 ± 0.045
2.357ArgLys: 2.357 ± 0.044
4.636ArgLeu: 4.636 ± 0.061
1.165ArgMet: 1.165 ± 0.025
2.011ArgAsn: 2.011 ± 0.037
1.571ArgPro: 1.571 ± 0.033
2.162ArgGln: 2.162 ± 0.04
2.239ArgArg: 2.239 ± 0.04
2.814ArgSer: 2.814 ± 0.046
2.148ArgThr: 2.148 ± 0.039
3.187ArgVal: 3.187 ± 0.051
0.736ArgTrp: 0.736 ± 0.025
1.805ArgTyr: 1.805 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.093SerAla: 6.093 ± 0.072
0.693SerCys: 0.693 ± 0.025
4.051SerAsp: 4.051 ± 0.07
4.368SerGlu: 4.368 ± 0.05
3.154SerPhe: 3.154 ± 0.053
5.634SerGly: 5.634 ± 0.109
1.564SerHis: 1.564 ± 0.033
4.433SerIle: 4.433 ± 0.063
3.067SerLys: 3.067 ± 0.051
7.087SerLeu: 7.087 ± 0.077
1.599SerMet: 1.599 ± 0.028
3.12SerAsn: 3.12 ± 0.057
2.861SerPro: 2.861 ± 0.048
3.096SerGln: 3.096 ± 0.047
3.142SerArg: 3.142 ± 0.038
7.162SerSer: 7.162 ± 0.255
3.819SerThr: 3.819 ± 0.06
4.777SerVal: 4.777 ± 0.063
0.896SerTrp: 0.896 ± 0.025
2.161SerTyr: 2.161 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.646ThrAla: 4.646 ± 0.069
0.48ThrCys: 0.48 ± 0.018
3.038ThrAsp: 3.038 ± 0.062
3.045ThrGlu: 3.045 ± 0.043
2.264ThrPhe: 2.264 ± 0.048
4.237ThrGly: 4.237 ± 0.093
1.225ThrHis: 1.225 ± 0.031
3.433ThrIle: 3.433 ± 0.066
2.102ThrLys: 2.102 ± 0.034
6.005ThrLeu: 6.005 ± 0.069
1.072ThrMet: 1.072 ± 0.024
2.176ThrAsn: 2.176 ± 0.049
3.029ThrPro: 3.029 ± 0.067
2.447ThrGln: 2.447 ± 0.036
2.379ThrArg: 2.379 ± 0.042
3.811ThrSer: 3.811 ± 0.061
3.069ThrThr: 3.069 ± 0.057
4.022ThrVal: 4.022 ± 0.082
0.661ThrTrp: 0.661 ± 0.023
1.688ThrTyr: 1.688 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
5.832ValAla: 5.832 ± 0.069
0.733ValCys: 0.733 ± 0.021
4.433ValAsp: 4.433 ± 0.074
4.406ValGlu: 4.406 ± 0.057
3.036ValPhe: 3.036 ± 0.047
4.386ValGly: 4.386 ± 0.055
1.234ValHis: 1.234 ± 0.026
4.19ValIle: 4.19 ± 0.059
3.595ValLys: 3.595 ± 0.051
6.435ValLeu: 6.435 ± 0.079
1.611ValMet: 1.611 ± 0.034
3.262ValAsn: 3.262 ± 0.055
2.543ValPro: 2.543 ± 0.043
2.301ValGln: 2.301 ± 0.036
2.965ValArg: 2.965 ± 0.043
5.099ValSer: 5.099 ± 0.071
3.918ValThr: 3.918 ± 0.072
5.04ValVal: 5.04 ± 0.074
0.794ValTrp: 0.794 ± 0.024
2.011ValTyr: 2.011 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.84TrpAla: 0.84 ± 0.022
0.175TrpCys: 0.175 ± 0.009
0.667TrpAsp: 0.667 ± 0.021
0.713TrpGlu: 0.713 ± 0.024
0.559TrpPhe: 0.559 ± 0.02
0.802TrpGly: 0.802 ± 0.022
0.344TrpHis: 0.344 ± 0.015
0.756TrpIle: 0.756 ± 0.021
0.559TrpLys: 0.559 ± 0.022
1.535TrpLeu: 1.535 ± 0.036
0.34TrpMet: 0.34 ± 0.014
0.604TrpAsn: 0.604 ± 0.02
0.521TrpPro: 0.521 ± 0.021
0.881TrpGln: 0.881 ± 0.028
0.693TrpArg: 0.693 ± 0.019
0.897TrpSer: 0.897 ± 0.026
0.635TrpThr: 0.635 ± 0.021
0.844TrpVal: 0.844 ± 0.025
0.23TrpTrp: 0.23 ± 0.013
0.408TrpTyr: 0.408 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.493TyrAla: 2.493 ± 0.038
0.402TyrCys: 0.402 ± 0.019
1.907TyrAsp: 1.907 ± 0.061
1.793TyrGlu: 1.793 ± 0.034
1.549TyrPhe: 1.549 ± 0.031
2.141TyrGly: 2.141 ± 0.038
0.752TyrHis: 0.752 ± 0.019
1.738TyrIle: 1.738 ± 0.034
1.323TyrLys: 1.323 ± 0.032
3.29TyrLeu: 3.29 ± 0.045
0.597TyrMet: 0.597 ± 0.019
1.307TyrAsn: 1.307 ± 0.04
1.243TyrPro: 1.243 ± 0.028
1.569TyrGln: 1.569 ± 0.035
1.83TyrArg: 1.83 ± 0.037
2.403TyrSer: 2.403 ± 0.045
1.77TyrThr: 1.77 ± 0.043
1.942TyrVal: 1.942 ± 0.038
0.515TyrTrp: 0.515 ± 0.017
1.139TyrTyr: 1.139 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4758 proteins (1693339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski