Amino acid dipepetide frequency for Burkholderia sp. Leaf177

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.667AlaAla: 15.667 ± 0.141	1.184AlaCys: 1.184 ± 0.03	6.497AlaAsp: 6.497 ± 0.058	5.934AlaGlu: 5.934 ± 0.06	4.445AlaPhe: 4.445 ± 0.054	9.579AlaGly: 9.579 ± 0.091	2.592AlaHis: 2.592 ± 0.041	6.05AlaIle: 6.05 ± 0.067	4.255AlaLys: 4.255 ± 0.053	13.591AlaLeu: 13.591 ± 0.115	3.323AlaMet: 3.323 ± 0.042	3.565AlaAsn: 3.565 ± 0.051	5.323AlaPro: 5.323 ± 0.067	4.763AlaGln: 4.763 ± 0.066	8.04AlaArg: 8.04 ± 0.07	7.717AlaSer: 7.717 ± 0.077	6.335AlaThr: 6.335 ± 0.063	8.494AlaVal: 8.494 ± 0.067	1.491AlaTrp: 1.491 ± 0.028	2.638AlaTyr: 2.638 ± 0.036	0.004AlaXaa: 0.004 ± 0.001
Cys	1.082CysAla: 1.082 ± 0.025	0.096CysCys: 0.096 ± 0.006	0.465CysAsp: 0.465 ± 0.016	0.459CysGlu: 0.459 ± 0.014	0.338CysPhe: 0.338 ± 0.014	0.952CysGly: 0.952 ± 0.02	0.235CysHis: 0.235 ± 0.011	0.44CysIle: 0.44 ± 0.015	0.24CysLys: 0.24 ± 0.012	0.76CysLeu: 0.76 ± 0.018	0.193CysMet: 0.193 ± 0.01	0.259CysAsn: 0.259 ± 0.013	0.392CysPro: 0.392 ± 0.016	0.193CysGln: 0.193 ± 0.01	0.542CysArg: 0.542 ± 0.017	0.521CysSer: 0.521 ± 0.017	0.465CysThr: 0.465 ± 0.016	0.744CysVal: 0.744 ± 0.02	0.11CysTrp: 0.11 ± 0.007	0.205CysTyr: 0.205 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.383AspAla: 7.383 ± 0.081	0.424AspCys: 0.424 ± 0.015	3.057AspAsp: 3.057 ± 0.043	3.419AspGlu: 3.419 ± 0.042	2.084AspPhe: 2.084 ± 0.032	4.513AspGly: 4.513 ± 0.058	1.224AspHis: 1.224 ± 0.027	2.765AspIle: 2.765 ± 0.042	1.786AspLys: 1.786 ± 0.03	5.238AspLeu: 5.238 ± 0.048	1.205AspMet: 1.205 ± 0.024	1.515AspAsn: 1.515 ± 0.027	2.866AspPro: 2.866 ± 0.036	1.654AspGln: 1.654 ± 0.032	3.31AspArg: 3.31 ± 0.044	2.737AspSer: 2.737 ± 0.04	2.949AspThr: 2.949 ± 0.041	4.452AspVal: 4.452 ± 0.053	0.877AspTrp: 0.877 ± 0.022	1.494AspTyr: 1.494 ± 0.032	0.001AspXaa: 0.001 ± 0.001
Glu	6.146GluAla: 6.146 ± 0.071	0.383GluCys: 0.383 ± 0.014	2.102GluAsp: 2.102 ± 0.037	2.503GluGlu: 2.503 ± 0.04	1.851GluPhe: 1.851 ± 0.033	3.434GluGly: 3.434 ± 0.044	1.428GluHis: 1.428 ± 0.032	2.886GluIle: 2.886 ± 0.037	2.072GluLys: 2.072 ± 0.043	5.394GluLeu: 5.394 ± 0.06	1.309GluMet: 1.309 ± 0.027	1.596GluAsn: 1.596 ± 0.03	2.462GluPro: 2.462 ± 0.038	2.22GluGln: 2.22 ± 0.04	4.553GluArg: 4.553 ± 0.054	2.882GluSer: 2.882 ± 0.046	3.143GluThr: 3.143 ± 0.04	3.475GluVal: 3.475 ± 0.055	0.757GluTrp: 0.757 ± 0.021	1.142GluTyr: 1.142 ± 0.023	0.001GluXaa: 0.001 ± 0.001
Phe	4.678PheAla: 4.678 ± 0.053	0.435PheCys: 0.435 ± 0.013	2.812PheAsp: 2.812 ± 0.041	2.088PheGlu: 2.088 ± 0.035	1.538PhePhe: 1.538 ± 0.036	3.748PheGly: 3.748 ± 0.047	0.778PheHis: 0.778 ± 0.02	1.905PheIle: 1.905 ± 0.033	1.231PheLys: 1.231 ± 0.027	3.103PheLeu: 3.103 ± 0.046	0.818PheMet: 0.818 ± 0.021	1.321PheAsn: 1.321 ± 0.025	1.635PhePro: 1.635 ± 0.028	1.047PheGln: 1.047 ± 0.023	1.942PheArg: 1.942 ± 0.032	2.522PheSer: 2.522 ± 0.041	2.109PheThr: 2.109 ± 0.033	3.11PheVal: 3.11 ± 0.045	0.534PheTrp: 0.534 ± 0.02	1.001PheTyr: 1.001 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.82GlyAla: 8.82 ± 0.084	0.805GlyCys: 0.805 ± 0.02	3.911GlyAsp: 3.911 ± 0.051	4.158GlyGlu: 4.158 ± 0.051	3.563GlyPhe: 3.563 ± 0.049	6.542GlyGly: 6.542 ± 0.083	1.818GlyHis: 1.818 ± 0.035	4.566GlyIle: 4.566 ± 0.059	3.349GlyLys: 3.349 ± 0.039	7.898GlyLeu: 7.898 ± 0.068	2.269GlyMet: 2.269 ± 0.035	2.467GlyAsn: 2.467 ± 0.046	2.751GlyPro: 2.751 ± 0.036	2.553GlyGln: 2.553 ± 0.038	4.95GlyArg: 4.95 ± 0.057	4.841GlySer: 4.841 ± 0.062	4.737GlyThr: 4.737 ± 0.068	6.723GlyVal: 6.723 ± 0.07	1.28GlyTrp: 1.28 ± 0.031	2.367GlyTyr: 2.367 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.92HisAla: 2.92 ± 0.04	0.256HisCys: 0.256 ± 0.011	1.405HisAsp: 1.405 ± 0.031	1.202HisGlu: 1.202 ± 0.03	0.934HisPhe: 0.934 ± 0.024	2.043HisGly: 2.043 ± 0.039	0.602HisHis: 0.602 ± 0.021	0.949HisIle: 0.949 ± 0.025	0.615HisLys: 0.615 ± 0.02	2.108HisLeu: 2.108 ± 0.036	0.534HisMet: 0.534 ± 0.017	0.584HisAsn: 0.584 ± 0.018	1.333HisPro: 1.333 ± 0.03	0.669HisGln: 0.669 ± 0.019	1.412HisArg: 1.412 ± 0.028	1.138HisSer: 1.138 ± 0.023	1.042HisThr: 1.042 ± 0.024	1.725HisVal: 1.725 ± 0.029	0.37HisTrp: 0.37 ± 0.014	0.63HisTyr: 0.63 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.333IleAla: 7.333 ± 0.07	0.489IleCys: 0.489 ± 0.017	3.983IleAsp: 3.983 ± 0.043	3.45IleGlu: 3.45 ± 0.042	1.645IlePhe: 1.645 ± 0.036	5.141IleGly: 5.141 ± 0.07	0.952IleHis: 0.952 ± 0.023	1.925IleIle: 1.925 ± 0.037	1.654IleLys: 1.654 ± 0.031	3.661IleLeu: 3.661 ± 0.05	0.819IleMet: 0.819 ± 0.021	1.64IleAsn: 1.64 ± 0.036	2.268IlePro: 2.268 ± 0.039	1.325IleGln: 1.325 ± 0.03	2.85IleArg: 2.85 ± 0.041	2.936IleSer: 2.936 ± 0.042	2.7IleThr: 2.7 ± 0.042	4.655IleVal: 4.655 ± 0.055	0.526IleTrp: 0.526 ± 0.017	1.125IleTyr: 1.125 ± 0.024	0.001IleXaa: 0.001 ± 0.001
Lys	3.937LysAla: 3.937 ± 0.052	0.187LysCys: 0.187 ± 0.009	1.697LysAsp: 1.697 ± 0.032	1.618LysGlu: 1.618 ± 0.034	1.054LysPhe: 1.054 ± 0.023	2.399LysGly: 2.399 ± 0.036	0.805LysHis: 0.805 ± 0.023	1.888LysIle: 1.888 ± 0.035	1.561LysLys: 1.561 ± 0.037	3.78LysLeu: 3.78 ± 0.043	0.921LysMet: 0.921 ± 0.023	1.146LysAsn: 1.146 ± 0.024	2.189LysPro: 2.189 ± 0.036	1.428LysGln: 1.428 ± 0.027	2.573LysArg: 2.573 ± 0.04	2.122LysSer: 2.122 ± 0.034	2.223LysThr: 2.223 ± 0.038	2.522LysVal: 2.522 ± 0.04	0.462LysTrp: 0.462 ± 0.016	0.792LysTyr: 0.792 ± 0.022	0.002LysXaa: 0.002 ± 0.001
Leu	12.857LeuAla: 12.857 ± 0.106	0.943LeuCys: 0.943 ± 0.021	5.98LeuAsp: 5.98 ± 0.061	4.938LeuGlu: 4.938 ± 0.053	3.633LeuPhe: 3.633 ± 0.051	8.067LeuGly: 8.067 ± 0.068	2.24LeuHis: 2.24 ± 0.035	5.165LeuIle: 5.165 ± 0.056	3.79LeuLys: 3.79 ± 0.048	9.733LeuLeu: 9.733 ± 0.093	2.348LeuMet: 2.348 ± 0.038	2.99LeuAsn: 2.99 ± 0.045	5.518LeuPro: 5.518 ± 0.057	3.324LeuGln: 3.324 ± 0.046	6.543LeuArg: 6.543 ± 0.071	6.681LeuSer: 6.681 ± 0.064	5.662LeuThr: 5.662 ± 0.054	7.2LeuVal: 7.2 ± 0.073	1.059LeuTrp: 1.059 ± 0.03	2.097LeuTyr: 2.097 ± 0.033	0.002LeuXaa: 0.002 ± 0.001
Met	2.557MetAla: 2.557 ± 0.037	0.185MetCys: 0.185 ± 0.009	0.993MetAsp: 0.993 ± 0.023	0.994MetGlu: 0.994 ± 0.023	0.847MetPhe: 0.847 ± 0.024	1.593MetGly: 1.593 ± 0.033	0.564MetHis: 0.564 ± 0.019	1.305MetIle: 1.305 ± 0.026	1.127MetLys: 1.127 ± 0.024	2.759MetLeu: 2.759 ± 0.041	0.622MetMet: 0.622 ± 0.018	1.021MetAsn: 1.021 ± 0.021	1.493MetPro: 1.493 ± 0.029	1.037MetGln: 1.037 ± 0.024	1.752MetArg: 1.752 ± 0.028	1.858MetSer: 1.858 ± 0.029	1.745MetThr: 1.745 ± 0.029	1.533MetVal: 1.533 ± 0.03	0.225MetTrp: 0.225 ± 0.011	0.389MetTyr: 0.389 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	4.132AsnAla: 4.132 ± 0.054	0.255AsnCys: 0.255 ± 0.011	1.649AsnAsp: 1.649 ± 0.029	1.473AsnGlu: 1.473 ± 0.027	1.112AsnPhe: 1.112 ± 0.023	2.833AsnGly: 2.833 ± 0.048	0.617AsnHis: 0.617 ± 0.018	1.406AsnIle: 1.406 ± 0.032	0.885AsnLys: 0.885 ± 0.024	2.868AsnLeu: 2.868 ± 0.04	0.646AsnMet: 0.646 ± 0.018	0.966AsnAsn: 0.966 ± 0.028	1.909AsnPro: 1.909 ± 0.033	1.007AsnGln: 1.007 ± 0.026	1.837AsnArg: 1.837 ± 0.029	1.559AsnSer: 1.559 ± 0.038	1.786AsnThr: 1.786 ± 0.036	2.581AsnVal: 2.581 ± 0.042	0.448AsnTrp: 0.448 ± 0.016	0.766AsnTyr: 0.766 ± 0.02	0.001AsnXaa: 0.001 ± 0.001
Pro	6.086ProAla: 6.086 ± 0.071	0.31ProCys: 0.31 ± 0.012	3.199ProAsp: 3.199 ± 0.04	3.057ProGlu: 3.057 ± 0.041	1.964ProPhe: 1.964 ± 0.037	3.936ProGly: 3.936 ± 0.047	1.127ProHis: 1.127 ± 0.025	2.14ProIle: 2.14 ± 0.031	1.657ProLys: 1.657 ± 0.032	4.893ProLeu: 4.893 ± 0.058	1.134ProMet: 1.134 ± 0.026	1.55ProAsn: 1.55 ± 0.03	2.27ProPro: 2.27 ± 0.05	1.663ProGln: 1.663 ± 0.033	2.63ProArg: 2.63 ± 0.043	2.971ProSer: 2.971 ± 0.04	2.524ProThr: 2.524 ± 0.035	4.282ProVal: 4.282 ± 0.051	0.626ProTrp: 0.626 ± 0.018	1.215ProTyr: 1.215 ± 0.028	0.002ProXaa: 0.002 ± 0.001
Gln	4.175GlnAla: 4.175 ± 0.047	0.251GlnCys: 0.251 ± 0.013	1.428GlnAsp: 1.428 ± 0.028	1.372GlnGlu: 1.372 ± 0.028	1.34GlnPhe: 1.34 ± 0.027	2.348GlnGly: 2.348 ± 0.034	0.909GlnHis: 0.909 ± 0.022	2.051GlnIle: 2.051 ± 0.034	1.287GlnLys: 1.287 ± 0.028	3.55GlnLeu: 3.55 ± 0.044	1.014GlnMet: 1.014 ± 0.021	1.033GlnAsn: 1.033 ± 0.025	1.839GlnPro: 1.839 ± 0.034	1.674GlnGln: 1.674 ± 0.038	2.636GlnArg: 2.636 ± 0.039	2.13GlnSer: 2.13 ± 0.031	2.049GlnThr: 2.049 ± 0.036	2.36GlnVal: 2.36 ± 0.037	0.53GlnTrp: 0.53 ± 0.019	0.867GlnTyr: 0.867 ± 0.023	0.001GlnXaa: 0.001 ± 0.001
Arg	7.445ArgAla: 7.445 ± 0.079	0.51ArgCys: 0.51 ± 0.016	3.775ArgAsp: 3.775 ± 0.043	4.021ArgGlu: 4.021 ± 0.05	2.886ArgPhe: 2.886 ± 0.046	4.369ArgGly: 4.369 ± 0.047	1.608ArgHis: 1.608 ± 0.034	3.593ArgIle: 3.593 ± 0.041	2.141ArgLys: 2.141 ± 0.037	6.717ArgLeu: 6.717 ± 0.075	1.749ArgMet: 1.749 ± 0.033	1.922ArgAsn: 1.922 ± 0.032	2.771ArgPro: 2.771 ± 0.039	2.242ArgGln: 2.242 ± 0.035	4.574ArgArg: 4.574 ± 0.054	3.521ArgSer: 3.521 ± 0.046	3.259ArgThr: 3.259 ± 0.048	5.123ArgVal: 5.123 ± 0.052	0.953ArgTrp: 0.953 ± 0.024	1.759ArgTyr: 1.759 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.363SerAla: 7.363 ± 0.07	0.442SerCys: 0.442 ± 0.016	3.073SerAsp: 3.073 ± 0.04	2.771SerGlu: 2.771 ± 0.044	2.372SerPhe: 2.372 ± 0.038	5.57SerGly: 5.57 ± 0.066	1.253SerHis: 1.253 ± 0.026	3.263SerIle: 3.263 ± 0.045	2.073SerLys: 2.073 ± 0.036	5.916SerLeu: 5.916 ± 0.057	1.643SerMet: 1.643 ± 0.029	1.986SerAsn: 1.986 ± 0.032	2.919SerPro: 2.919 ± 0.035	1.988SerGln: 1.988 ± 0.033	3.674SerArg: 3.674 ± 0.046	3.813SerSer: 3.813 ± 0.058	3.422SerThr: 3.422 ± 0.047	4.792SerVal: 4.792 ± 0.053	0.747SerTrp: 0.747 ± 0.02	1.365SerTyr: 1.365 ± 0.027	0.001SerXaa: 0.001 ± 0.001
Thr	6.047ThrAla: 6.047 ± 0.059	0.417ThrCys: 0.417 ± 0.016	2.823ThrAsp: 2.823 ± 0.039	2.43ThrGlu: 2.43 ± 0.035	2.168ThrPhe: 2.168 ± 0.031	4.875ThrGly: 4.875 ± 0.062	1.332ThrHis: 1.332 ± 0.026	2.819ThrIle: 2.819 ± 0.044	1.576ThrLys: 1.576 ± 0.03	6.647ThrLeu: 6.647 ± 0.066	1.227ThrMet: 1.227 ± 0.024	1.651ThrAsn: 1.651 ± 0.041	3.533ThrPro: 3.533 ± 0.042	2.049ThrGln: 2.049 ± 0.032	3.509ThrArg: 3.509 ± 0.048	3.35ThrSer: 3.35 ± 0.044	3.138ThrThr: 3.138 ± 0.043	4.375ThrVal: 4.375 ± 0.047	0.688ThrTrp: 0.688 ± 0.02	1.281ThrTyr: 1.281 ± 0.028	0.001ThrXaa: 0.001 ± 0.0
Val	9.135ValAla: 9.135 ± 0.088	0.751ValCys: 0.751 ± 0.02	4.153ValAsp: 4.153 ± 0.04	4.107ValGlu: 4.107 ± 0.054	2.978ValPhe: 2.978 ± 0.041	5.461ValGly: 5.461 ± 0.06	1.541ValHis: 1.541 ± 0.029	4.306ValIle: 4.306 ± 0.049	2.739ValLys: 2.739 ± 0.039	7.898ValLeu: 7.898 ± 0.072	1.982ValMet: 1.982 ± 0.032	2.373ValAsn: 2.373 ± 0.04	3.876ValPro: 3.876 ± 0.044	2.509ValGln: 2.509 ± 0.04	4.797ValArg: 4.797 ± 0.048	4.978ValSer: 4.978 ± 0.057	4.582ValThr: 4.582 ± 0.049	6.249ValVal: 6.249 ± 0.065	0.952ValTrp: 0.952 ± 0.024	1.701ValTyr: 1.701 ± 0.029	0.002ValXaa: 0.002 ± 0.001
Trp	1.062TrpAla: 1.062 ± 0.025	0.127TrpCys: 0.127 ± 0.008	0.614TrpAsp: 0.614 ± 0.017	0.481TrpGlu: 0.481 ± 0.016	0.544TrpPhe: 0.544 ± 0.016	0.815TrpGly: 0.815 ± 0.021	0.367TrpHis: 0.367 ± 0.016	0.751TrpIle: 0.751 ± 0.019	0.47TrpLys: 0.47 ± 0.013	1.8TrpLeu: 1.8 ± 0.033	0.376TrpMet: 0.376 ± 0.013	0.501TrpAsn: 0.501 ± 0.015	0.625TrpPro: 0.625 ± 0.018	0.624TrpGln: 0.624 ± 0.02	1.109TrpArg: 1.109 ± 0.028	0.812TrpSer: 0.812 ± 0.024	0.779TrpThr: 0.779 ± 0.021	0.855TrpVal: 0.855 ± 0.02	0.199TrpTrp: 0.199 ± 0.011	0.295TrpTyr: 0.295 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.66TyrAla: 2.66 ± 0.042	0.241TyrCys: 0.241 ± 0.012	1.337TyrAsp: 1.337 ± 0.028	1.261TyrGlu: 1.261 ± 0.024	1.061TyrPhe: 1.061 ± 0.024	2.152TyrGly: 2.152 ± 0.033	0.481TyrHis: 0.481 ± 0.016	0.902TyrIle: 0.902 ± 0.024	0.795TyrLys: 0.795 ± 0.023	2.453TyrLeu: 2.453 ± 0.035	0.464TyrMet: 0.464 ± 0.015	0.648TyrAsn: 0.648 ± 0.021	1.261TyrPro: 1.261 ± 0.025	0.874TyrGln: 0.874 ± 0.019	1.702TyrArg: 1.702 ± 0.029	1.358TyrSer: 1.358 ± 0.028	1.288TyrThr: 1.288 ± 0.028	1.815TyrVal: 1.815 ± 0.032	0.374TyrTrp: 0.374 ± 0.016	0.641TyrTyr: 0.641 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5955 proteins (1921382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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