Amino acid dipepetide frequency for Rhodospirillales bacterium URHD0017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.479AlaAla: 17.479 ± 0.122	1.176AlaCys: 1.176 ± 0.025	6.845AlaAsp: 6.845 ± 0.059	7.057AlaGlu: 7.057 ± 0.062	4.484AlaPhe: 4.484 ± 0.046	10.847AlaGly: 10.847 ± 0.085	2.215AlaHis: 2.215 ± 0.034	6.109AlaIle: 6.109 ± 0.054	4.513AlaLys: 4.513 ± 0.046	13.165AlaLeu: 13.165 ± 0.092	3.543AlaMet: 3.543 ± 0.039	3.114AlaAsn: 3.114 ± 0.039	5.903AlaPro: 5.903 ± 0.058	3.868AlaGln: 3.868 ± 0.042	8.864AlaArg: 8.864 ± 0.07	6.184AlaSer: 6.184 ± 0.055	6.257AlaThr: 6.257 ± 0.066	8.998AlaVal: 8.998 ± 0.079	1.87AlaTrp: 1.87 ± 0.031	2.656AlaTyr: 2.656 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.021	0.137CysCys: 0.137 ± 0.007	0.566CysAsp: 0.566 ± 0.013	0.439CysGlu: 0.439 ± 0.013	0.349CysPhe: 0.349 ± 0.013	0.982CysGly: 0.982 ± 0.022	0.277CysHis: 0.277 ± 0.01	0.403CysIle: 0.403 ± 0.014	0.25CysLys: 0.25 ± 0.012	0.834CysLeu: 0.834 ± 0.02	0.175CysMet: 0.175 ± 0.008	0.226CysAsn: 0.226 ± 0.011	0.44CysPro: 0.44 ± 0.015	0.256CysGln: 0.256 ± 0.01	0.729CysArg: 0.729 ± 0.018	0.513CysSer: 0.513 ± 0.016	0.469CysThr: 0.469 ± 0.015	0.643CysVal: 0.643 ± 0.018	0.147CysTrp: 0.147 ± 0.008	0.216CysTyr: 0.216 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.298AspAla: 6.298 ± 0.058	0.5AspCys: 0.5 ± 0.016	2.94AspAsp: 2.94 ± 0.041	2.989AspGlu: 2.989 ± 0.04	2.148AspPhe: 2.148 ± 0.029	5.232AspGly: 5.232 ± 0.051	1.208AspHis: 1.208 ± 0.022	2.799AspIle: 2.799 ± 0.033	2.125AspLys: 2.125 ± 0.037	5.495AspLeu: 5.495 ± 0.06	1.301AspMet: 1.301 ± 0.022	1.315AspAsn: 1.315 ± 0.023	3.552AspPro: 3.552 ± 0.038	1.614AspGln: 1.614 ± 0.024	4.419AspArg: 4.419 ± 0.047	2.247AspSer: 2.247 ± 0.03	2.409AspThr: 2.409 ± 0.031	4.192AspVal: 4.192 ± 0.044	1.079AspTrp: 1.079 ± 0.022	1.49AspTyr: 1.49 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.887GluAla: 6.887 ± 0.068	0.344GluCys: 0.344 ± 0.011	2.111GluAsp: 2.111 ± 0.033	2.672GluGlu: 2.672 ± 0.039	1.69GluPhe: 1.69 ± 0.029	3.774GluGly: 3.774 ± 0.048	1.173GluHis: 1.173 ± 0.024	2.947GluIle: 2.947 ± 0.037	2.155GluLys: 2.155 ± 0.035	5.404GluLeu: 5.404 ± 0.056	1.395GluMet: 1.395 ± 0.025	1.228GluAsn: 1.228 ± 0.022	2.65GluPro: 2.65 ± 0.038	2.098GluGln: 2.098 ± 0.033	4.931GluArg: 4.931 ± 0.051	2.103GluSer: 2.103 ± 0.023	2.854GluThr: 2.854 ± 0.029	3.716GluVal: 3.716 ± 0.037	0.729GluTrp: 0.729 ± 0.018	1.0GluTyr: 1.0 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.682PheAla: 4.682 ± 0.045	0.409PheCys: 0.409 ± 0.013	2.588PheAsp: 2.588 ± 0.033	1.947PheGlu: 1.947 ± 0.033	1.353PhePhe: 1.353 ± 0.026	3.623PheGly: 3.623 ± 0.046	0.8PheHis: 0.8 ± 0.019	1.54PheIle: 1.54 ± 0.027	1.173PheLys: 1.173 ± 0.023	3.254PheLeu: 3.254 ± 0.039	0.774PheMet: 0.774 ± 0.015	1.11PheAsn: 1.11 ± 0.021	1.703PhePro: 1.703 ± 0.028	1.013PheGln: 1.013 ± 0.021	2.245PheArg: 2.245 ± 0.03	1.957PheSer: 1.957 ± 0.031	2.141PheThr: 2.141 ± 0.028	3.054PheVal: 3.054 ± 0.034	0.577PheTrp: 0.577 ± 0.018	0.909PheTyr: 0.909 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	9.28GlyAla: 9.28 ± 0.08	0.87GlyCys: 0.87 ± 0.019	4.269GlyAsp: 4.269 ± 0.054	4.338GlyGlu: 4.338 ± 0.048	3.636GlyPhe: 3.636 ± 0.037	7.975GlyGly: 7.975 ± 0.125	1.943GlyHis: 1.943 ± 0.03	4.254GlyIle: 4.254 ± 0.045	3.591GlyLys: 3.591 ± 0.04	8.9GlyLeu: 8.9 ± 0.063	2.299GlyMet: 2.299 ± 0.032	2.307GlyAsn: 2.307 ± 0.043	4.019GlyPro: 4.019 ± 0.04	2.993GlyGln: 2.993 ± 0.042	6.575GlyArg: 6.575 ± 0.057	4.712GlySer: 4.712 ± 0.053	4.769GlyThr: 4.769 ± 0.062	6.486GlyVal: 6.486 ± 0.053	1.62GlyTrp: 1.62 ± 0.028	2.396GlyTyr: 2.396 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.309HisAla: 2.309 ± 0.038	0.258HisCys: 0.258 ± 0.01	1.253HisAsp: 1.253 ± 0.024	1.004HisGlu: 1.004 ± 0.019	0.854HisPhe: 0.854 ± 0.021	1.981HisGly: 1.981 ± 0.034	0.597HisHis: 0.597 ± 0.017	0.955HisIle: 0.955 ± 0.02	0.564HisLys: 0.564 ± 0.018	2.083HisLeu: 2.083 ± 0.033	0.489HisMet: 0.489 ± 0.014	0.516HisAsn: 0.516 ± 0.015	1.391HisPro: 1.391 ± 0.029	0.584HisGln: 0.584 ± 0.015	1.557HisArg: 1.557 ± 0.026	0.904HisSer: 0.904 ± 0.022	0.873HisThr: 0.873 ± 0.021	1.631HisVal: 1.631 ± 0.027	0.377HisTrp: 0.377 ± 0.013	0.606HisTyr: 0.606 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.036IleAla: 7.036 ± 0.062	0.495IleCys: 0.495 ± 0.014	3.604IleAsp: 3.604 ± 0.039	3.175IleGlu: 3.175 ± 0.039	1.497IlePhe: 1.497 ± 0.027	4.758IleGly: 4.758 ± 0.045	0.87IleHis: 0.87 ± 0.02	1.703IleIle: 1.703 ± 0.029	1.58IleLys: 1.58 ± 0.025	3.802IleLeu: 3.802 ± 0.047	0.879IleMet: 0.879 ± 0.02	1.352IleAsn: 1.352 ± 0.026	2.11IlePro: 2.11 ± 0.03	1.144IleGln: 1.144 ± 0.023	2.74IleArg: 2.74 ± 0.035	2.315IleSer: 2.315 ± 0.033	2.372IleThr: 2.372 ± 0.034	4.516IleVal: 4.516 ± 0.046	0.605IleTrp: 0.605 ± 0.015	1.083IleTyr: 1.083 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.628LysAla: 4.628 ± 0.047	0.191LysCys: 0.191 ± 0.01	1.885LysAsp: 1.885 ± 0.032	1.757LysGlu: 1.757 ± 0.032	1.038LysPhe: 1.038 ± 0.022	2.895LysGly: 2.895 ± 0.037	0.659LysHis: 0.659 ± 0.017	1.673LysIle: 1.673 ± 0.029	1.515LysLys: 1.515 ± 0.032	3.611LysLeu: 3.611 ± 0.044	0.859LysMet: 0.859 ± 0.02	0.878LysAsn: 0.878 ± 0.019	2.497LysPro: 2.497 ± 0.034	1.092LysGln: 1.092 ± 0.021	2.582LysArg: 2.582 ± 0.036	1.82LysSer: 1.82 ± 0.029	1.931LysThr: 1.931 ± 0.029	2.862LysVal: 2.862 ± 0.037	0.497LysTrp: 0.497 ± 0.014	0.746LysTyr: 0.746 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.104LeuAla: 14.104 ± 0.084	0.903LeuCys: 0.903 ± 0.021	5.762LeuAsp: 5.762 ± 0.052	4.805LeuGlu: 4.805 ± 0.048	3.545LeuPhe: 3.545 ± 0.04	8.622LeuGly: 8.622 ± 0.075	1.918LeuHis: 1.918 ± 0.03	4.507LeuIle: 4.507 ± 0.043	3.846LeuLys: 3.846 ± 0.049	9.799LeuLeu: 9.799 ± 0.094	2.386LeuMet: 2.386 ± 0.036	2.412LeuAsn: 2.412 ± 0.036	5.752LeuPro: 5.752 ± 0.056	2.946LeuGln: 2.946 ± 0.037	6.883LeuArg: 6.883 ± 0.055	5.912LeuSer: 5.912 ± 0.051	4.974LeuThr: 4.974 ± 0.05	7.732LeuVal: 7.732 ± 0.069	1.299LeuTrp: 1.299 ± 0.025	2.141LeuTyr: 2.141 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	3.41MetAla: 3.41 ± 0.034	0.194MetCys: 0.194 ± 0.009	1.105MetAsp: 1.105 ± 0.022	1.001MetGlu: 1.001 ± 0.021	0.725MetPhe: 0.725 ± 0.017	1.877MetGly: 1.877 ± 0.031	0.454MetHis: 0.454 ± 0.014	1.192MetIle: 1.192 ± 0.027	1.092MetLys: 1.092 ± 0.02	2.467MetLeu: 2.467 ± 0.038	0.626MetMet: 0.626 ± 0.016	0.712MetAsn: 0.712 ± 0.015	1.628MetPro: 1.628 ± 0.026	0.78MetGln: 0.78 ± 0.016	1.839MetArg: 1.839 ± 0.029	1.589MetSer: 1.589 ± 0.027	1.798MetThr: 1.798 ± 0.027	1.779MetVal: 1.779 ± 0.029	0.268MetTrp: 0.268 ± 0.012	0.357MetTyr: 0.357 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.015AsnAla: 3.015 ± 0.04	0.24AsnCys: 0.24 ± 0.01	1.395AsnAsp: 1.395 ± 0.027	1.175AsnGlu: 1.175 ± 0.023	0.959AsnPhe: 0.959 ± 0.018	2.422AsnGly: 2.422 ± 0.041	0.525AsnHis: 0.525 ± 0.014	1.243AsnIle: 1.243 ± 0.023	0.825AsnLys: 0.825 ± 0.019	2.459AsnLeu: 2.459 ± 0.035	0.612AsnMet: 0.612 ± 0.016	0.783AsnAsn: 0.783 ± 0.023	1.813AsnPro: 1.813 ± 0.031	0.781AsnGln: 0.781 ± 0.02	1.775AsnArg: 1.775 ± 0.024	1.18AsnSer: 1.18 ± 0.025	1.289AsnThr: 1.289 ± 0.028	2.082AsnVal: 2.082 ± 0.03	0.476AsnTrp: 0.476 ± 0.012	0.697AsnTyr: 0.697 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.908ProAla: 6.908 ± 0.059	0.339ProCys: 0.339 ± 0.011	3.662ProAsp: 3.662 ± 0.043	3.297ProGlu: 3.297 ± 0.038	2.041ProPhe: 2.041 ± 0.031	4.975ProGly: 4.975 ± 0.043	1.149ProHis: 1.149 ± 0.024	2.432ProIle: 2.432 ± 0.034	1.928ProLys: 1.928 ± 0.029	5.002ProLeu: 5.002 ± 0.049	1.382ProMet: 1.382 ± 0.023	1.451ProAsn: 1.451 ± 0.025	3.507ProPro: 3.507 ± 0.058	1.806ProGln: 1.806 ± 0.036	3.337ProArg: 3.337 ± 0.04	2.983ProSer: 2.983 ± 0.038	3.026ProThr: 3.026 ± 0.036	4.227ProVal: 4.227 ± 0.045	0.887ProTrp: 0.887 ± 0.02	1.348ProTyr: 1.348 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.198GlnAla: 4.198 ± 0.044	0.244GlnCys: 0.244 ± 0.01	1.361GlnAsp: 1.361 ± 0.024	1.346GlnGlu: 1.346 ± 0.026	1.078GlnPhe: 1.078 ± 0.025	2.47GlnGly: 2.47 ± 0.034	0.653GlnHis: 0.653 ± 0.016	1.554GlnIle: 1.554 ± 0.029	1.105GlnLys: 1.105 ± 0.028	2.86GlnLeu: 2.86 ± 0.037	0.802GlnMet: 0.802 ± 0.016	0.751GlnAsn: 0.751 ± 0.019	2.0GlnPro: 2.0 ± 0.031	1.388GlnGln: 1.388 ± 0.027	2.716GlnArg: 2.716 ± 0.034	1.707GlnSer: 1.707 ± 0.025	1.641GlnThr: 1.641 ± 0.03	2.362GlnVal: 2.362 ± 0.028	0.484GlnTrp: 0.484 ± 0.013	0.65GlnTyr: 0.65 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.08ArgAla: 8.08 ± 0.058	0.653ArgCys: 0.653 ± 0.02	4.049ArgAsp: 4.049 ± 0.042	3.887ArgGlu: 3.887 ± 0.043	2.905ArgPhe: 2.905 ± 0.038	5.004ArgGly: 5.004 ± 0.044	1.881ArgHis: 1.881 ± 0.028	3.706ArgIle: 3.706 ± 0.041	2.383ArgLys: 2.383 ± 0.033	8.353ArgLeu: 8.353 ± 0.061	1.918ArgMet: 1.918 ± 0.028	1.804ArgAsn: 1.804 ± 0.03	4.038ArgPro: 4.038 ± 0.046	2.679ArgGln: 2.679 ± 0.034	6.485ArgArg: 6.485 ± 0.073	3.658ArgSer: 3.658 ± 0.041	3.646ArgThr: 3.646 ± 0.035	4.85ArgVal: 4.85 ± 0.05	1.19ArgTrp: 1.19 ± 0.024	1.826ArgTyr: 1.826 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.873SerAla: 5.873 ± 0.054	0.462SerCys: 0.462 ± 0.015	2.705SerAsp: 2.705 ± 0.037	2.364SerGlu: 2.364 ± 0.032	2.233SerPhe: 2.233 ± 0.028	5.289SerGly: 5.289 ± 0.065	1.081SerHis: 1.081 ± 0.023	2.51SerIle: 2.51 ± 0.031	1.531SerLys: 1.531 ± 0.023	5.239SerLeu: 5.239 ± 0.049	1.343SerMet: 1.343 ± 0.025	1.325SerAsn: 1.325 ± 0.026	2.919SerPro: 2.919 ± 0.032	1.472SerGln: 1.472 ± 0.026	3.483SerArg: 3.483 ± 0.038	2.775SerSer: 2.775 ± 0.037	2.766SerThr: 2.766 ± 0.039	3.882SerVal: 3.882 ± 0.047	0.851SerTrp: 0.851 ± 0.021	1.265SerTyr: 1.265 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.188ThrAla: 6.188 ± 0.056	0.446ThrCys: 0.446 ± 0.016	2.674ThrAsp: 2.674 ± 0.032	2.376ThrGlu: 2.376 ± 0.029	2.073ThrPhe: 2.073 ± 0.031	4.896ThrGly: 4.896 ± 0.057	1.0ThrHis: 1.0 ± 0.018	2.816ThrIle: 2.816 ± 0.039	1.585ThrLys: 1.585 ± 0.027	5.72ThrLeu: 5.72 ± 0.05	1.251ThrMet: 1.251 ± 0.023	1.341ThrAsn: 1.341 ± 0.024	3.375ThrPro: 3.375 ± 0.042	1.344ThrGln: 1.344 ± 0.026	3.206ThrArg: 3.206 ± 0.038	2.695ThrSer: 2.695 ± 0.039	3.085ThrThr: 3.085 ± 0.043	4.487ThrVal: 4.487 ± 0.046	0.813ThrTrp: 0.813 ± 0.019	1.261ThrTyr: 1.261 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.779ValAla: 9.779 ± 0.072	0.709ValCys: 0.709 ± 0.021	4.368ValAsp: 4.368 ± 0.047	4.404ValGlu: 4.404 ± 0.042	2.684ValPhe: 2.684 ± 0.036	6.27ValGly: 6.27 ± 0.058	1.47ValHis: 1.47 ± 0.025	3.697ValIle: 3.697 ± 0.042	2.553ValLys: 2.553 ± 0.035	7.693ValLeu: 7.693 ± 0.06	1.964ValMet: 1.964 ± 0.029	1.964ValAsn: 1.964 ± 0.029	4.314ValPro: 4.314 ± 0.042	2.148ValGln: 2.148 ± 0.035	5.303ValArg: 5.303 ± 0.047	4.069ValSer: 4.069 ± 0.041	4.257ValThr: 4.257 ± 0.042	6.702ValVal: 6.702 ± 0.066	1.042ValTrp: 1.042 ± 0.021	1.521ValTyr: 1.521 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.441TrpAla: 1.441 ± 0.028	0.149TrpCys: 0.149 ± 0.008	0.714TrpAsp: 0.714 ± 0.017	0.608TrpGlu: 0.608 ± 0.017	0.61TrpPhe: 0.61 ± 0.015	1.086TrpGly: 1.086 ± 0.025	0.431TrpHis: 0.431 ± 0.014	0.744TrpIle: 0.744 ± 0.018	0.56TrpLys: 0.56 ± 0.015	1.876TrpLeu: 1.876 ± 0.035	0.413TrpMet: 0.413 ± 0.013	0.523TrpAsn: 0.523 ± 0.015	0.887TrpPro: 0.887 ± 0.019	0.662TrpGln: 0.662 ± 0.018	1.467TrpArg: 1.467 ± 0.031	0.855TrpSer: 0.855 ± 0.021	0.94TrpThr: 0.94 ± 0.02	0.946TrpVal: 0.946 ± 0.019	0.267TrpTrp: 0.267 ± 0.011	0.341TrpTyr: 0.341 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.588TyrAla: 2.588 ± 0.033	0.294TyrCys: 0.294 ± 0.011	1.498TyrAsp: 1.498 ± 0.028	1.219TyrGlu: 1.219 ± 0.025	0.95TyrPhe: 0.95 ± 0.021	2.254TyrGly: 2.254 ± 0.029	0.484TyrHis: 0.484 ± 0.015	0.856TyrIle: 0.856 ± 0.02	0.739TyrLys: 0.739 ± 0.017	2.236TyrLeu: 2.236 ± 0.031	0.481TyrMet: 0.481 ± 0.015	0.633TyrAsn: 0.633 ± 0.015	1.187TyrPro: 1.187 ± 0.022	0.701TyrGln: 0.701 ± 0.016	1.861TyrArg: 1.861 ± 0.03	1.192TyrSer: 1.192 ± 0.023	1.135TyrThr: 1.135 ± 0.024	1.763TyrVal: 1.763 ± 0.027	0.44TyrTrp: 0.44 ± 0.013	0.626TyrTyr: 0.626 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 7953 proteins (2442273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---