Amino acid dipepetide frequency for Candidatus Izimaplasma sp. ZiA1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.032AlaAla: 3.032 ± 0.102
0.474AlaCys: 0.474 ± 0.03
2.245AlaAsp: 2.245 ± 0.065
2.535AlaGlu: 2.535 ± 0.074
2.657AlaPhe: 2.657 ± 0.073
3.192AlaGly: 3.192 ± 0.093
0.843AlaHis: 0.843 ± 0.041
5.314AlaIle: 5.314 ± 0.108
4.212AlaLys: 4.212 ± 0.104
5.921AlaLeu: 5.921 ± 0.128
1.329AlaMet: 1.329 ± 0.051
2.607AlaAsn: 2.607 ± 0.076
1.246AlaPro: 1.246 ± 0.047
1.098AlaGln: 1.098 ± 0.043
1.764AlaArg: 1.764 ± 0.058
3.396AlaSer: 3.396 ± 0.078
2.866AlaThr: 2.866 ± 0.091
3.505AlaVal: 3.505 ± 0.098
0.334AlaTrp: 0.334 ± 0.031
2.148AlaTyr: 2.148 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.332CysAla: 0.332 ± 0.023
0.078CysCys: 0.078 ± 0.017
0.56CysAsp: 0.56 ± 0.035
0.494CysGlu: 0.494 ± 0.029
0.282CysPhe: 0.282 ± 0.021
0.726CysGly: 0.726 ± 0.038
0.177CysHis: 0.177 ± 0.018
0.593CysIle: 0.593 ± 0.034
0.606CysLys: 0.606 ± 0.033
0.561CysLeu: 0.561 ± 0.03
0.125CysMet: 0.125 ± 0.016
0.461CysAsn: 0.461 ± 0.029
0.374CysPro: 0.374 ± 0.029
0.169CysGln: 0.169 ± 0.018
0.214CysArg: 0.214 ± 0.019
0.447CysSer: 0.447 ± 0.03
0.393CysThr: 0.393 ± 0.029
0.474CysVal: 0.474 ± 0.028
0.024CysTrp: 0.024 ± 0.007
0.259CysTyr: 0.259 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.773AspAla: 2.773 ± 0.091
0.407AspCys: 0.407 ± 0.031
3.416AspAsp: 3.416 ± 0.093
4.916AspGlu: 4.916 ± 0.101
3.55AspPhe: 3.55 ± 0.075
3.182AspGly: 3.182 ± 0.09
0.798AspHis: 0.798 ± 0.034
6.261AspIle: 6.261 ± 0.11
4.68AspLys: 4.68 ± 0.085
6.186AspLeu: 6.186 ± 0.121
1.35AspMet: 1.35 ± 0.047
3.691AspAsn: 3.691 ± 0.087
1.47AspPro: 1.47 ± 0.054
1.46AspGln: 1.46 ± 0.045
1.562AspArg: 1.562 ± 0.055
3.425AspSer: 3.425 ± 0.083
2.951AspThr: 2.951 ± 0.087
3.95AspVal: 3.95 ± 0.103
0.335AspTrp: 0.335 ± 0.02
3.533AspTyr: 3.533 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
3.562GluAla: 3.562 ± 0.089
0.483GluCys: 0.483 ± 0.033
3.985GluAsp: 3.985 ± 0.091
5.186GluGlu: 5.186 ± 0.126
3.35GluPhe: 3.35 ± 0.068
3.33GluGly: 3.33 ± 0.087
1.058GluHis: 1.058 ± 0.041
6.965GluIle: 6.965 ± 0.123
5.934GluLys: 5.934 ± 0.121
7.102GluLeu: 7.102 ± 0.126
2.052GluMet: 2.052 ± 0.057
4.513GluAsn: 4.513 ± 0.09
1.382GluPro: 1.382 ± 0.05
1.752GluGln: 1.752 ± 0.054
2.205GluArg: 2.205 ± 0.064
3.526GluSer: 3.526 ± 0.08
3.606GluThr: 3.606 ± 0.098
5.045GluVal: 5.045 ± 0.107
0.348GluTrp: 0.348 ± 0.022
3.364GluTyr: 3.364 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.311PheAla: 2.311 ± 0.07
0.351PheCys: 0.351 ± 0.026
3.472PheAsp: 3.472 ± 0.079
3.416PheGlu: 3.416 ± 0.086
2.365PhePhe: 2.365 ± 0.071
3.161PheGly: 3.161 ± 0.088
0.627PheHis: 0.627 ± 0.032
4.98PheIle: 4.98 ± 0.108
3.959PheLys: 3.959 ± 0.093
4.381PheLeu: 4.381 ± 0.109
1.239PheMet: 1.239 ± 0.051
3.302PheAsn: 3.302 ± 0.078
1.173PhePro: 1.173 ± 0.05
0.964PheGln: 0.964 ± 0.038
1.413PheArg: 1.413 ± 0.051
3.479PheSer: 3.479 ± 0.079
3.013PheThr: 3.013 ± 0.081
3.524PheVal: 3.524 ± 0.091
0.306PheTrp: 0.306 ± 0.023
2.136PheTyr: 2.136 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
3.469GlyAla: 3.469 ± 0.095
0.601GlyCys: 0.601 ± 0.036
3.067GlyAsp: 3.067 ± 0.085
3.474GlyGlu: 3.474 ± 0.091
3.364GlyPhe: 3.364 ± 0.089
3.834GlyGly: 3.834 ± 0.115
1.086GlyHis: 1.086 ± 0.051
5.71GlyIle: 5.71 ± 0.117
4.277GlyLys: 4.277 ± 0.089
5.862GlyLeu: 5.862 ± 0.113
1.63GlyMet: 1.63 ± 0.052
2.871GlyAsn: 2.871 ± 0.064
1.289GlyPro: 1.289 ± 0.048
1.255GlyGln: 1.255 ± 0.047
1.823GlyArg: 1.823 ± 0.066
3.536GlySer: 3.536 ± 0.082
3.316GlyThr: 3.316 ± 0.088
4.742GlyVal: 4.742 ± 0.106
0.375GlyTrp: 0.375 ± 0.027
3.048GlyTyr: 3.048 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.794HisAla: 0.794 ± 0.035
0.125HisCys: 0.125 ± 0.016
0.954HisAsp: 0.954 ± 0.044
1.004HisGlu: 1.004 ± 0.04
0.78HisPhe: 0.78 ± 0.04
1.022HisGly: 1.022 ± 0.045
0.391HisHis: 0.391 ± 0.029
1.533HisIle: 1.533 ± 0.053
1.22HisLys: 1.22 ± 0.048
1.63HisLeu: 1.63 ± 0.05
0.374HisMet: 0.374 ± 0.025
1.018HisAsn: 1.018 ± 0.041
0.712HisPro: 0.712 ± 0.039
0.537HisGln: 0.537 ± 0.026
0.551HisArg: 0.551 ± 0.033
1.048HisSer: 1.048 ± 0.04
0.787HisThr: 0.787 ± 0.04
0.921HisVal: 0.921 ± 0.041
0.071HisTrp: 0.071 ± 0.011
0.773HisTyr: 0.773 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.54IleAla: 5.54 ± 0.105
0.652IleCys: 0.652 ± 0.032
6.367IleAsp: 6.367 ± 0.121
6.659IleGlu: 6.659 ± 0.131
4.278IlePhe: 4.278 ± 0.097
5.856IleGly: 5.856 ± 0.115
1.371IleHis: 1.371 ± 0.05
9.688IleIle: 9.688 ± 0.176
8.494IleLys: 8.494 ± 0.151
8.574IleLeu: 8.574 ± 0.155
2.207IleMet: 2.207 ± 0.073
6.849IleAsn: 6.849 ± 0.13
2.935IlePro: 2.935 ± 0.077
1.851IleGln: 1.851 ± 0.054
2.81IleArg: 2.81 ± 0.068
6.816IleSer: 6.816 ± 0.135
5.752IleThr: 5.752 ± 0.101
6.381IleVal: 6.381 ± 0.129
0.398IleTrp: 0.398 ± 0.024
3.9IleTyr: 3.9 ± 0.096
0.0IleXaa: 0.0 ± 0.0
Lys
4.066LysAla: 4.066 ± 0.101
0.507LysCys: 0.507 ± 0.032
5.742LysAsp: 5.742 ± 0.123
7.789LysGlu: 7.789 ± 0.136
2.895LysPhe: 2.895 ± 0.075
4.119LysGly: 4.119 ± 0.088
1.467LysHis: 1.467 ± 0.054
7.394LysIle: 7.394 ± 0.127
7.768LysLys: 7.768 ± 0.149
7.233LysLeu: 7.233 ± 0.119
2.516LysMet: 2.516 ± 0.066
5.521LysAsn: 5.521 ± 0.116
1.814LysPro: 1.814 ± 0.058
2.273LysGln: 2.273 ± 0.064
3.182LysArg: 3.182 ± 0.091
4.767LysSer: 4.767 ± 0.095
4.949LysThr: 4.949 ± 0.102
5.33LysVal: 5.33 ± 0.101
0.521LysTrp: 0.521 ± 0.03
4.117LysTyr: 4.117 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
5.147LeuAla: 5.147 ± 0.092
0.591LeuCys: 0.591 ± 0.036
6.157LeuAsp: 6.157 ± 0.13
6.741LeuGlu: 6.741 ± 0.123
5.013LeuPhe: 5.013 ± 0.111
6.07LeuGly: 6.07 ± 0.119
1.439LeuHis: 1.439 ± 0.054
8.981LeuIle: 8.981 ± 0.152
8.194LeuLys: 8.194 ± 0.152
9.645LeuLeu: 9.645 ± 0.159
2.356LeuMet: 2.356 ± 0.062
6.286LeuAsn: 6.286 ± 0.145
2.817LeuPro: 2.817 ± 0.071
1.887LeuGln: 1.887 ± 0.064
3.243LeuArg: 3.243 ± 0.083
7.417LeuSer: 7.417 ± 0.142
5.194LeuThr: 5.194 ± 0.092
6.836LeuVal: 6.836 ± 0.116
0.447LeuTrp: 0.447 ± 0.029
3.913LeuTyr: 3.913 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.376MetAla: 1.376 ± 0.051
0.146MetCys: 0.146 ± 0.016
1.373MetAsp: 1.373 ± 0.052
1.524MetGlu: 1.524 ± 0.05
1.373MetPhe: 1.373 ± 0.055
1.458MetGly: 1.458 ± 0.061
0.367MetHis: 0.367 ± 0.022
2.469MetIle: 2.469 ± 0.069
2.421MetLys: 2.421 ± 0.062
2.198MetLeu: 2.198 ± 0.066
0.721MetMet: 0.721 ± 0.04
1.656MetAsn: 1.656 ± 0.057
0.706MetPro: 0.706 ± 0.037
0.598MetGln: 0.598 ± 0.034
0.824MetArg: 0.824 ± 0.038
1.733MetSer: 1.733 ± 0.058
1.253MetThr: 1.253 ± 0.054
1.517MetVal: 1.517 ± 0.056
0.127MetTrp: 0.127 ± 0.016
1.044MetTyr: 1.044 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.073
0.452AsnCys: 0.452 ± 0.027
4.059AsnAsp: 4.059 ± 0.096
4.727AsnGlu: 4.727 ± 0.095
2.582AsnPhe: 2.582 ± 0.065
3.21AsnGly: 3.21 ± 0.085
1.107AsnHis: 1.107 ± 0.044
6.362AsnIle: 6.362 ± 0.116
5.745AsnLys: 5.745 ± 0.124
5.924AsnLeu: 5.924 ± 0.125
1.505AsnMet: 1.505 ± 0.047
4.638AsnAsn: 4.638 ± 0.127
1.96AsnPro: 1.96 ± 0.056
2.061AsnGln: 2.061 ± 0.061
2.004AsnArg: 2.004 ± 0.059
3.571AsnSer: 3.571 ± 0.091
3.166AsnThr: 3.166 ± 0.068
3.986AsnVal: 3.986 ± 0.08
0.327AsnTrp: 0.327 ± 0.022
3.119AsnTyr: 3.119 ± 0.089
0.0AsnXaa: 0.0 ± 0.0
Pro
1.185ProAla: 1.185 ± 0.05
0.198ProCys: 0.198 ± 0.017
1.269ProAsp: 1.269 ± 0.043
1.722ProGlu: 1.722 ± 0.06
1.541ProPhe: 1.541 ± 0.052
1.564ProGly: 1.564 ± 0.057
0.497ProHis: 0.497 ± 0.029
2.473ProIle: 2.473 ± 0.072
2.028ProLys: 2.028 ± 0.065
2.852ProLeu: 2.852 ± 0.065
0.521ProMet: 0.521 ± 0.035
1.614ProAsn: 1.614 ± 0.054
0.499ProPro: 0.499 ± 0.032
0.643ProGln: 0.643 ± 0.031
0.82ProArg: 0.82 ± 0.037
1.83ProSer: 1.83 ± 0.067
1.618ProThr: 1.618 ± 0.054
1.931ProVal: 1.931 ± 0.064
0.163ProTrp: 0.163 ± 0.017
1.218ProTyr: 1.218 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.347GlnAla: 1.347 ± 0.053
0.155GlnCys: 0.155 ± 0.017
1.256GlnAsp: 1.256 ± 0.047
1.686GlnGlu: 1.686 ± 0.056
1.097GlnPhe: 1.097 ± 0.043
1.411GlnGly: 1.411 ± 0.051
0.368GlnHis: 0.368 ± 0.026
2.289GlnIle: 2.289 ± 0.057
2.136GlnLys: 2.136 ± 0.073
2.25GlnLeu: 2.25 ± 0.059
0.636GlnMet: 0.636 ± 0.032
1.587GlnAsn: 1.587 ± 0.052
0.506GlnPro: 0.506 ± 0.031
0.567GlnGln: 0.567 ± 0.035
0.872GlnArg: 0.872 ± 0.043
1.336GlnSer: 1.336 ± 0.046
1.303GlnThr: 1.303 ± 0.05
1.713GlnVal: 1.713 ± 0.059
0.156GlnTrp: 0.156 ± 0.017
0.999GlnTyr: 0.999 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
1.521ArgAla: 1.521 ± 0.053
0.247ArgCys: 0.247 ± 0.021
1.731ArgAsp: 1.731 ± 0.055
2.131ArgGlu: 2.131 ± 0.069
1.545ArgPhe: 1.545 ± 0.061
1.823ArgGly: 1.823 ± 0.059
0.57ArgHis: 0.57 ± 0.032
3.074ArgIle: 3.074 ± 0.074
2.902ArgLys: 2.902 ± 0.075
2.916ArgLeu: 2.916 ± 0.078
0.838ArgMet: 0.838 ± 0.04
2.021ArgAsn: 2.021 ± 0.063
0.784ArgPro: 0.784 ± 0.036
0.855ArgGln: 0.855 ± 0.048
1.331ArgArg: 1.331 ± 0.053
1.844ArgSer: 1.844 ± 0.057
1.654ArgThr: 1.654 ± 0.054
2.362ArgVal: 2.362 ± 0.07
0.158ArgTrp: 0.158 ± 0.015
1.526ArgTyr: 1.526 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
2.86SerAla: 2.86 ± 0.075
0.492SerCys: 0.492 ± 0.035
3.594SerAsp: 3.594 ± 0.086
4.025SerGlu: 4.025 ± 0.092
3.458SerPhe: 3.458 ± 0.079
4.101SerGly: 4.101 ± 0.096
1.143SerHis: 1.143 ± 0.04
6.421SerIle: 6.421 ± 0.112
5.634SerLys: 5.634 ± 0.105
6.73SerLeu: 6.73 ± 0.135
1.493SerMet: 1.493 ± 0.057
3.907SerAsn: 3.907 ± 0.09
1.5SerPro: 1.5 ± 0.053
1.413SerGln: 1.413 ± 0.053
2.134SerArg: 2.134 ± 0.057
4.35SerSer: 4.35 ± 0.107
3.427SerThr: 3.427 ± 0.074
4.398SerVal: 4.398 ± 0.089
0.36SerTrp: 0.36 ± 0.029
2.834SerTyr: 2.834 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
2.681ThrAla: 2.681 ± 0.072
0.398ThrCys: 0.398 ± 0.027
2.996ThrAsp: 2.996 ± 0.068
3.088ThrGlu: 3.088 ± 0.078
2.82ThrPhe: 2.82 ± 0.075
3.422ThrGly: 3.422 ± 0.085
1.037ThrHis: 1.037 ± 0.039
5.328ThrIle: 5.328 ± 0.099
4.635ThrLys: 4.635 ± 0.098
5.816ThrLeu: 5.816 ± 0.109
1.161ThrMet: 1.161 ± 0.046
3.307ThrAsn: 3.307 ± 0.085
1.771ThrPro: 1.771 ± 0.055
1.168ThrGln: 1.168 ± 0.044
1.609ThrArg: 1.609 ± 0.056
3.717ThrSer: 3.717 ± 0.082
3.277ThrThr: 3.277 ± 0.099
3.915ThrVal: 3.915 ± 0.093
0.311ThrTrp: 0.311 ± 0.026
2.515ThrTyr: 2.515 ± 0.083
0.0ThrXaa: 0.0 ± 0.0
Val
3.571ValAla: 3.571 ± 0.087
0.606ValCys: 0.606 ± 0.033
4.212ValAsp: 4.212 ± 0.099
4.31ValGlu: 4.31 ± 0.106
3.875ValPhe: 3.875 ± 0.101
4.252ValGly: 4.252 ± 0.111
0.933ValHis: 0.933 ± 0.041
6.862ValIle: 6.862 ± 0.126
5.177ValLys: 5.177 ± 0.108
7.102ValLeu: 7.102 ± 0.119
1.67ValMet: 1.67 ± 0.046
4.0ValAsn: 4.0 ± 0.089
1.792ValPro: 1.792 ± 0.058
1.315ValGln: 1.315 ± 0.052
1.92ValArg: 1.92 ± 0.064
4.76ValSer: 4.76 ± 0.083
3.835ValThr: 3.835 ± 0.088
5.119ValVal: 5.119 ± 0.122
0.396ValTrp: 0.396 ± 0.028
2.947ValTyr: 2.947 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.297TrpAla: 0.297 ± 0.023
0.04TrpCys: 0.04 ± 0.007
0.391TrpAsp: 0.391 ± 0.026
0.327TrpGlu: 0.327 ± 0.024
0.37TrpPhe: 0.37 ± 0.026
0.398TrpGly: 0.398 ± 0.03
0.094TrpHis: 0.094 ± 0.012
0.504TrpIle: 0.504 ± 0.027
0.335TrpLys: 0.335 ± 0.022
0.499TrpLeu: 0.499 ± 0.032
0.153TrpMet: 0.153 ± 0.017
0.311TrpAsn: 0.311 ± 0.028
0.162TrpPro: 0.162 ± 0.016
0.149TrpGln: 0.149 ± 0.017
0.156TrpArg: 0.156 ± 0.018
0.311TrpSer: 0.311 ± 0.023
0.252TrpThr: 0.252 ± 0.021
0.349TrpVal: 0.349 ± 0.026
0.057TrpTrp: 0.057 ± 0.009
0.271TrpTyr: 0.271 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.018TyrAla: 2.018 ± 0.065
0.344TyrCys: 0.344 ± 0.026
3.052TyrAsp: 3.052 ± 0.087
2.996TyrGlu: 2.996 ± 0.079
2.376TyrPhe: 2.376 ± 0.073
2.501TyrGly: 2.501 ± 0.078
0.872TyrHis: 0.872 ± 0.036
4.176TyrIle: 4.176 ± 0.101
3.613TyrLys: 3.613 ± 0.079
4.991TyrLeu: 4.991 ± 0.107
1.004TyrMet: 1.004 ± 0.049
3.182TyrAsn: 3.182 ± 0.09
1.296TyrPro: 1.296 ± 0.05
1.656TyrGln: 1.656 ± 0.055
1.394TyrArg: 1.394 ± 0.051
2.966TyrSer: 2.966 ± 0.079
2.36TyrThr: 2.36 ± 0.072
2.657TyrVal: 2.657 ± 0.073
0.212TyrTrp: 0.212 ± 0.018
2.212TyrTyr: 2.212 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1828 proteins (575450 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski