Amino acid dipepetide frequency for Thalassotalea sp. HSM 43

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.462AlaAla: 7.462 ± 0.103
0.966AlaCys: 0.966 ± 0.032
5.414AlaAsp: 5.414 ± 0.076
5.404AlaGlu: 5.404 ± 0.078
3.521AlaPhe: 3.521 ± 0.06
5.865AlaGly: 5.865 ± 0.08
1.714AlaHis: 1.714 ± 0.039
6.195AlaIle: 6.195 ± 0.072
5.449AlaLys: 5.449 ± 0.081
8.785AlaLeu: 8.785 ± 0.102
2.678AlaMet: 2.678 ± 0.052
4.503AlaAsn: 4.503 ± 0.069
2.809AlaPro: 2.809 ± 0.053
3.934AlaGln: 3.934 ± 0.061
3.119AlaArg: 3.119 ± 0.06
5.484AlaSer: 5.484 ± 0.077
4.536AlaThr: 4.536 ± 0.065
5.649AlaVal: 5.649 ± 0.072
0.966AlaTrp: 0.966 ± 0.029
2.46AlaTyr: 2.46 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.788CysAla: 0.788 ± 0.026
0.15CysCys: 0.15 ± 0.012
0.616CysAsp: 0.616 ± 0.025
0.539CysGlu: 0.539 ± 0.021
0.433CysPhe: 0.433 ± 0.02
0.811CysGly: 0.811 ± 0.03
0.351CysHis: 0.351 ± 0.022
0.594CysIle: 0.594 ± 0.027
0.422CysLys: 0.422 ± 0.021
0.95CysLeu: 0.95 ± 0.03
0.208CysMet: 0.208 ± 0.013
0.399CysAsn: 0.399 ± 0.017
0.456CysPro: 0.456 ± 0.022
0.638CysGln: 0.638 ± 0.026
0.43CysArg: 0.43 ± 0.019
0.675CysSer: 0.675 ± 0.026
0.426CysThr: 0.426 ± 0.02
0.595CysVal: 0.595 ± 0.023
0.122CysTrp: 0.122 ± 0.011
0.341CysTyr: 0.341 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.107AspAla: 5.107 ± 0.069
0.593AspCys: 0.593 ± 0.023
4.325AspAsp: 4.325 ± 0.09
3.996AspGlu: 3.996 ± 0.074
2.821AspPhe: 2.821 ± 0.055
4.384AspGly: 4.384 ± 0.076
1.112AspHis: 1.112 ± 0.03
4.812AspIle: 4.812 ± 0.061
3.933AspLys: 3.933 ± 0.064
5.268AspLeu: 5.268 ± 0.068
1.761AspMet: 1.761 ± 0.04
3.479AspAsn: 3.479 ± 0.067
1.965AspPro: 1.965 ± 0.048
2.067AspGln: 2.067 ± 0.041
2.158AspArg: 2.158 ± 0.047
3.832AspSer: 3.832 ± 0.06
2.84AspThr: 2.84 ± 0.056
4.484AspVal: 4.484 ± 0.063
0.875AspTrp: 0.875 ± 0.03
2.419AspTyr: 2.419 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.178GluAla: 4.178 ± 0.07
0.426GluCys: 0.426 ± 0.019
2.966GluAsp: 2.966 ± 0.056
3.062GluGlu: 3.062 ± 0.067
2.606GluPhe: 2.606 ± 0.051
3.05GluGly: 3.05 ± 0.063
1.741GluHis: 1.741 ± 0.047
3.577GluIle: 3.577 ± 0.062
3.342GluLys: 3.342 ± 0.061
6.317GluLeu: 6.317 ± 0.082
1.573GluMet: 1.573 ± 0.04
2.781GluAsn: 2.781 ± 0.05
1.922GluPro: 1.922 ± 0.049
5.136GluGln: 5.136 ± 0.073
2.819GluArg: 2.819 ± 0.051
3.352GluSer: 3.352 ± 0.055
2.75GluThr: 2.75 ± 0.047
3.838GluVal: 3.838 ± 0.059
0.624GluTrp: 0.624 ± 0.022
1.85GluTyr: 1.85 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
4.314PheAla: 4.314 ± 0.061
0.489PheCys: 0.489 ± 0.02
3.22PheAsp: 3.22 ± 0.056
2.445PheGlu: 2.445 ± 0.05
1.759PhePhe: 1.759 ± 0.047
3.086PheGly: 3.086 ± 0.054
0.843PheHis: 0.843 ± 0.026
3.102PheIle: 3.102 ± 0.057
2.156PheLys: 2.156 ± 0.047
3.261PheLeu: 3.261 ± 0.065
1.081PheMet: 1.081 ± 0.029
2.349PheAsn: 2.349 ± 0.048
1.352PhePro: 1.352 ± 0.034
1.214PheGln: 1.214 ± 0.033
1.42PheArg: 1.42 ± 0.036
3.391PheSer: 3.391 ± 0.063
2.41PheThr: 2.41 ± 0.047
2.932PheVal: 2.932 ± 0.052
0.523PheTrp: 0.523 ± 0.021
1.576PheTyr: 1.576 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
5.208GlyAla: 5.208 ± 0.078
0.805GlyCys: 0.805 ± 0.026
4.176GlyAsp: 4.176 ± 0.066
4.22GlyGlu: 4.22 ± 0.068
3.526GlyPhe: 3.526 ± 0.057
4.701GlyGly: 4.701 ± 0.08
1.601GlyHis: 1.601 ± 0.037
4.546GlyIle: 4.546 ± 0.069
4.159GlyLys: 4.159 ± 0.075
6.367GlyLeu: 6.367 ± 0.075
1.978GlyMet: 1.978 ± 0.043
2.866GlyAsn: 2.866 ± 0.054
1.718GlyPro: 1.718 ± 0.037
2.849GlyGln: 2.849 ± 0.055
2.733GlyArg: 2.733 ± 0.05
4.112GlySer: 4.112 ± 0.067
3.216GlyThr: 3.216 ± 0.067
4.936GlyVal: 4.936 ± 0.062
0.98GlyTrp: 0.98 ± 0.028
2.614GlyTyr: 2.614 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.598HisAla: 1.598 ± 0.036
0.328HisCys: 0.328 ± 0.017
1.233HisAsp: 1.233 ± 0.035
1.02HisGlu: 1.02 ± 0.031
1.059HisPhe: 1.059 ± 0.035
1.688HisGly: 1.688 ± 0.036
0.679HisHis: 0.679 ± 0.03
1.611HisIle: 1.611 ± 0.036
1.139HisLys: 1.139 ± 0.033
2.184HisLeu: 2.184 ± 0.052
0.55HisMet: 0.55 ± 0.025
1.077HisAsn: 1.077 ± 0.031
1.117HisPro: 1.117 ± 0.031
1.273HisGln: 1.273 ± 0.032
0.981HisArg: 0.981 ± 0.03
1.438HisSer: 1.438 ± 0.041
0.992HisThr: 0.992 ± 0.027
1.426HisVal: 1.426 ± 0.034
0.353HisTrp: 0.353 ± 0.017
0.887HisTyr: 0.887 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.709IleAla: 6.709 ± 0.084
0.72IleCys: 0.72 ± 0.027
5.153IleAsp: 5.153 ± 0.066
4.756IleGlu: 4.756 ± 0.073
2.35IlePhe: 2.35 ± 0.046
4.634IleGly: 4.634 ± 0.072
1.251IleHis: 1.251 ± 0.034
4.013IleIle: 4.013 ± 0.078
3.588IleLys: 3.588 ± 0.063
4.971IleLeu: 4.971 ± 0.085
1.374IleMet: 1.374 ± 0.038
3.561IleAsn: 3.561 ± 0.053
2.326IlePro: 2.326 ± 0.053
1.88IleGln: 1.88 ± 0.038
2.701IleArg: 2.701 ± 0.05
4.781IleSer: 4.781 ± 0.067
3.707IleThr: 3.707 ± 0.061
4.243IleVal: 4.243 ± 0.065
0.629IleTrp: 0.629 ± 0.025
1.921IleTyr: 1.921 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
5.034LysAla: 5.034 ± 0.072
0.319LysCys: 0.319 ± 0.021
3.173LysAsp: 3.173 ± 0.06
2.804LysGlu: 2.804 ± 0.052
1.754LysPhe: 1.754 ± 0.038
3.227LysGly: 3.227 ± 0.063
1.386LysHis: 1.386 ± 0.039
3.019LysIle: 3.019 ± 0.059
2.908LysLys: 2.908 ± 0.06
5.282LysLeu: 5.282 ± 0.078
1.421LysMet: 1.421 ± 0.037
2.242LysAsn: 2.242 ± 0.044
2.437LysPro: 2.437 ± 0.057
3.762LysGln: 3.762 ± 0.067
2.644LysArg: 2.644 ± 0.047
3.268LysSer: 3.268 ± 0.061
2.926LysThr: 2.926 ± 0.059
4.073LysVal: 4.073 ± 0.069
0.533LysTrp: 0.533 ± 0.02
1.651LysTyr: 1.651 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
9.86LeuAla: 9.86 ± 0.105
0.965LeuCys: 0.965 ± 0.034
5.525LeuAsp: 5.525 ± 0.064
5.039LeuGlu: 5.039 ± 0.071
4.116LeuPhe: 4.116 ± 0.069
6.314LeuGly: 6.314 ± 0.092
1.984LeuHis: 1.984 ± 0.046
6.039LeuIle: 6.039 ± 0.084
4.79LeuLys: 4.79 ± 0.076
9.832LeuLeu: 9.832 ± 0.135
2.564LeuMet: 2.564 ± 0.05
4.467LeuAsn: 4.467 ± 0.065
4.329LeuPro: 4.329 ± 0.056
4.483LeuGln: 4.483 ± 0.074
3.69LeuArg: 3.69 ± 0.065
7.283LeuSer: 7.283 ± 0.084
5.927LeuThr: 5.927 ± 0.078
6.509LeuVal: 6.509 ± 0.082
0.988LeuTrp: 0.988 ± 0.032
2.73LeuTyr: 2.73 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.732MetAla: 2.732 ± 0.05
0.223MetCys: 0.223 ± 0.015
1.318MetAsp: 1.318 ± 0.035
1.197MetGlu: 1.197 ± 0.032
0.995MetPhe: 0.995 ± 0.032
1.689MetGly: 1.689 ± 0.049
0.543MetHis: 0.543 ± 0.021
1.49MetIle: 1.49 ± 0.033
1.388MetLys: 1.388 ± 0.037
2.747MetLeu: 2.747 ± 0.054
0.792MetMet: 0.792 ± 0.027
1.062MetAsn: 1.062 ± 0.03
1.282MetPro: 1.282 ± 0.032
1.439MetGln: 1.439 ± 0.038
1.19MetArg: 1.19 ± 0.031
1.973MetSer: 1.973 ± 0.039
1.587MetThr: 1.587 ± 0.039
1.926MetVal: 1.926 ± 0.04
0.249MetTrp: 0.249 ± 0.014
0.605MetTyr: 0.605 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.828AsnAla: 3.828 ± 0.054
0.473AsnCys: 0.473 ± 0.021
3.039AsnAsp: 3.039 ± 0.057
2.607AsnGlu: 2.607 ± 0.043
1.819AsnPhe: 1.819 ± 0.041
3.241AsnGly: 3.241 ± 0.065
0.991AsnHis: 0.991 ± 0.028
3.305AsnIle: 3.305 ± 0.058
2.789AsnLys: 2.789 ± 0.055
4.083AsnLeu: 4.083 ± 0.068
1.133AsnMet: 1.133 ± 0.031
2.584AsnAsn: 2.584 ± 0.06
2.081AsnPro: 2.081 ± 0.04
2.234AsnGln: 2.234 ± 0.049
2.003AsnArg: 2.003 ± 0.046
2.872AsnSer: 2.872 ± 0.06
2.415AsnThr: 2.415 ± 0.047
3.125AsnVal: 3.125 ± 0.058
0.698AsnTrp: 0.698 ± 0.025
1.597AsnTyr: 1.597 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.891ProAla: 2.891 ± 0.057
0.285ProCys: 0.285 ± 0.018
2.393ProAsp: 2.393 ± 0.056
2.88ProGlu: 2.88 ± 0.059
1.704ProPhe: 1.704 ± 0.04
2.599ProGly: 2.599 ± 0.048
0.832ProHis: 0.832 ± 0.027
2.341ProIle: 2.341 ± 0.043
1.985ProLys: 1.985 ± 0.051
3.667ProLeu: 3.667 ± 0.06
1.009ProMet: 1.009 ± 0.028
1.626ProAsn: 1.626 ± 0.041
0.95ProPro: 0.95 ± 0.032
1.665ProGln: 1.665 ± 0.037
1.221ProArg: 1.221 ± 0.039
2.347ProSer: 2.347 ± 0.046
1.92ProThr: 1.92 ± 0.048
2.923ProVal: 2.923 ± 0.059
0.497ProTrp: 0.497 ± 0.022
1.31ProTyr: 1.31 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
4.576GlnAla: 4.576 ± 0.069
0.454GlnCys: 0.454 ± 0.024
2.416GlnAsp: 2.416 ± 0.047
2.232GlnGlu: 2.232 ± 0.053
1.952GlnPhe: 1.952 ± 0.045
3.289GlnGly: 3.289 ± 0.057
1.514GlnHis: 1.514 ± 0.042
2.882GlnIle: 2.882 ± 0.051
2.296GlnLys: 2.296 ± 0.046
5.655GlnLeu: 5.655 ± 0.093
1.227GlnMet: 1.227 ± 0.028
1.818GlnAsn: 1.818 ± 0.045
1.825GlnPro: 1.825 ± 0.044
4.957GlnGln: 4.957 ± 0.118
2.367GlnArg: 2.367 ± 0.049
3.032GlnSer: 3.032 ± 0.052
2.503GlnThr: 2.503 ± 0.045
3.427GlnVal: 3.427 ± 0.064
0.683GlnTrp: 0.683 ± 0.026
1.664GlnTyr: 1.664 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.007ArgAla: 3.007 ± 0.06
0.392ArgCys: 0.392 ± 0.018
2.479ArgAsp: 2.479 ± 0.047
2.401ArgGlu: 2.401 ± 0.055
2.144ArgPhe: 2.144 ± 0.04
2.388ArgGly: 2.388 ± 0.046
1.089ArgHis: 1.089 ± 0.036
2.787ArgIle: 2.787 ± 0.052
2.126ArgLys: 2.126 ± 0.053
4.319ArgLeu: 4.319 ± 0.068
1.109ArgMet: 1.109 ± 0.03
1.845ArgAsn: 1.845 ± 0.042
1.409ArgPro: 1.409 ± 0.032
2.255ArgGln: 2.255 ± 0.044
2.083ArgArg: 2.083 ± 0.049
2.316ArgSer: 2.316 ± 0.051
1.838ArgThr: 1.838 ± 0.036
2.875ArgVal: 2.875 ± 0.049
0.555ArgTrp: 0.555 ± 0.022
1.752ArgTyr: 1.752 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.598SerAla: 5.598 ± 0.077
0.632SerCys: 0.632 ± 0.025
4.249SerAsp: 4.249 ± 0.067
3.938SerGlu: 3.938 ± 0.059
3.081SerPhe: 3.081 ± 0.06
4.837SerGly: 4.837 ± 0.068
1.465SerHis: 1.465 ± 0.037
4.077SerIle: 4.077 ± 0.064
3.608SerLys: 3.608 ± 0.052
6.505SerLeu: 6.505 ± 0.08
1.77SerMet: 1.77 ± 0.037
2.909SerAsn: 2.909 ± 0.058
2.216SerPro: 2.216 ± 0.045
3.031SerGln: 3.031 ± 0.052
2.632SerArg: 2.632 ± 0.05
4.21SerSer: 4.21 ± 0.071
3.035SerThr: 3.035 ± 0.053
4.476SerVal: 4.476 ± 0.064
0.85SerTrp: 0.85 ± 0.028
2.279SerTyr: 2.279 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.481ThrAla: 4.481 ± 0.071
0.45ThrCys: 0.45 ± 0.019
3.265ThrAsp: 3.265 ± 0.062
2.991ThrGlu: 2.991 ± 0.047
2.171ThrPhe: 2.171 ± 0.05
3.987ThrGly: 3.987 ± 0.069
0.985ThrHis: 0.985 ± 0.029
3.491ThrIle: 3.491 ± 0.052
2.249ThrLys: 2.249 ± 0.042
5.739ThrLeu: 5.739 ± 0.07
1.273ThrMet: 1.273 ± 0.034
2.093ThrAsn: 2.093 ± 0.044
2.492ThrPro: 2.492 ± 0.047
2.053ThrGln: 2.053 ± 0.043
1.972ThrArg: 1.972 ± 0.046
3.248ThrSer: 3.248 ± 0.058
2.748ThrThr: 2.748 ± 0.05
3.783ThrVal: 3.783 ± 0.061
0.608ThrTrp: 0.608 ± 0.023
1.538ThrTyr: 1.538 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.397ValAla: 6.397 ± 0.075
0.756ValCys: 0.756 ± 0.027
4.702ValAsp: 4.702 ± 0.075
4.469ValGlu: 4.469 ± 0.066
2.944ValPhe: 2.944 ± 0.052
4.367ValGly: 4.367 ± 0.06
1.304ValHis: 1.304 ± 0.035
4.928ValIle: 4.928 ± 0.069
3.585ValLys: 3.585 ± 0.066
6.436ValLeu: 6.436 ± 0.082
1.841ValMet: 1.841 ± 0.039
3.5ValAsn: 3.5 ± 0.058
2.399ValPro: 2.399 ± 0.044
2.234ValGln: 2.234 ± 0.04
2.611ValArg: 2.611 ± 0.049
4.892ValSer: 4.892 ± 0.073
3.768ValThr: 3.768 ± 0.062
5.205ValVal: 5.205 ± 0.076
0.757ValTrp: 0.757 ± 0.032
2.068ValTyr: 2.068 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.738TrpAla: 0.738 ± 0.026
0.136TrpCys: 0.136 ± 0.01
0.621TrpAsp: 0.621 ± 0.023
0.392TrpGlu: 0.392 ± 0.019
0.603TrpPhe: 0.603 ± 0.025
0.826TrpGly: 0.826 ± 0.029
0.426TrpHis: 0.426 ± 0.018
0.582TrpIle: 0.582 ± 0.023
0.366TrpLys: 0.366 ± 0.021
1.626TrpLeu: 1.626 ± 0.05
0.331TrpMet: 0.331 ± 0.018
0.411TrpAsn: 0.411 ± 0.02
0.562TrpPro: 0.562 ± 0.026
1.262TrpGln: 1.262 ± 0.034
0.681TrpArg: 0.681 ± 0.023
0.756TrpSer: 0.756 ± 0.03
0.521TrpThr: 0.521 ± 0.021
0.748TrpVal: 0.748 ± 0.029
0.187TrpTrp: 0.187 ± 0.012
0.422TrpTyr: 0.422 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.409TyrAla: 2.409 ± 0.047
0.382TyrCys: 0.382 ± 0.019
1.946TyrAsp: 1.946 ± 0.047
1.516TyrGlu: 1.516 ± 0.036
1.566TyrPhe: 1.566 ± 0.038
2.327TyrGly: 2.327 ± 0.041
0.824TyrHis: 0.824 ± 0.024
1.878TyrIle: 1.878 ± 0.042
1.584TyrLys: 1.584 ± 0.034
3.44TyrLeu: 3.44 ± 0.071
0.752TyrMet: 0.752 ± 0.024
1.344TyrAsn: 1.344 ± 0.038
1.399TyrPro: 1.399 ± 0.034
2.402TyrGln: 2.402 ± 0.049
1.714TyrArg: 1.714 ± 0.042
2.138TyrSer: 2.138 ± 0.043
1.55TyrThr: 1.55 ± 0.049
1.996TyrVal: 1.996 ± 0.039
0.52TyrTrp: 0.52 ± 0.021
1.182TyrTyr: 1.182 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3411 proteins (1170031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski