Amino acid dipepetide frequency for Streptococcus phage Javan381

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.946AlaAla: 2.946 ± 1.295
0.173AlaCys: 0.173 ± 0.114
4.765AlaAsp: 4.765 ± 0.67
6.238AlaGlu: 6.238 ± 0.961
2.253AlaPhe: 2.253 ± 0.828
5.025AlaGly: 5.025 ± 0.908
1.04AlaHis: 1.04 ± 0.356
6.498AlaIle: 6.498 ± 0.78
5.805AlaLys: 5.805 ± 0.607
7.018AlaLeu: 7.018 ± 1.255
1.993AlaMet: 1.993 ± 0.382
4.592AlaAsn: 4.592 ± 0.79
2.772AlaPro: 2.772 ± 0.811
5.025AlaGln: 5.025 ± 1.066
3.639AlaArg: 3.639 ± 0.802
5.978AlaSer: 5.978 ± 1.949
4.592AlaThr: 4.592 ± 0.543
4.505AlaVal: 4.505 ± 0.708
0.953AlaTrp: 0.953 ± 0.335
2.426AlaTyr: 2.426 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
0.087CysAla: 0.087 ± 0.081
0.0CysCys: 0.0 ± 0.0
0.26CysAsp: 0.26 ± 0.207
0.173CysGlu: 0.173 ± 0.105
0.606CysPhe: 0.606 ± 0.201
0.173CysGly: 0.173 ± 0.131
0.087CysHis: 0.087 ± 0.079
0.173CysIle: 0.173 ± 0.135
0.52CysLys: 0.52 ± 0.188
0.087CysLeu: 0.087 ± 0.079
0.26CysMet: 0.26 ± 0.155
0.347CysAsn: 0.347 ± 0.138
0.433CysPro: 0.433 ± 0.186
0.173CysGln: 0.173 ± 0.107
0.26CysArg: 0.26 ± 0.193
0.433CysSer: 0.433 ± 0.175
0.087CysThr: 0.087 ± 0.079
0.173CysVal: 0.173 ± 0.106
0.087CysTrp: 0.087 ± 0.091
0.26CysTyr: 0.26 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
3.985AspAla: 3.985 ± 0.746
0.433AspCys: 0.433 ± 0.224
2.513AspAsp: 2.513 ± 0.643
5.372AspGlu: 5.372 ± 0.719
3.119AspPhe: 3.119 ± 0.581
4.592AspGly: 4.592 ± 0.691
1.126AspHis: 1.126 ± 0.323
2.339AspIle: 2.339 ± 0.33
4.419AspLys: 4.419 ± 0.67
5.458AspLeu: 5.458 ± 0.903
1.213AspMet: 1.213 ± 0.412
2.859AspAsn: 2.859 ± 0.639
2.166AspPro: 2.166 ± 0.406
2.599AspGln: 2.599 ± 0.423
2.426AspArg: 2.426 ± 0.483
3.379AspSer: 3.379 ± 0.525
3.292AspThr: 3.292 ± 0.553
3.466AspVal: 3.466 ± 0.462
1.126AspTrp: 1.126 ± 0.289
2.686AspTyr: 2.686 ± 0.561
0.0AspXaa: 0.0 ± 0.0
Glu
6.238GluAla: 6.238 ± 0.764
0.347GluCys: 0.347 ± 0.219
3.985GluAsp: 3.985 ± 0.864
7.364GluGlu: 7.364 ± 1.53
3.119GluPhe: 3.119 ± 0.525
5.025GluGly: 5.025 ± 0.654
1.126GluHis: 1.126 ± 0.377
5.545GluIle: 5.545 ± 0.861
6.411GluLys: 6.411 ± 0.803
9.53GluLeu: 9.53 ± 1.14
2.599GluMet: 2.599 ± 0.508
4.419GluAsn: 4.419 ± 0.78
1.646GluPro: 1.646 ± 0.324
4.505GluGln: 4.505 ± 0.914
4.679GluArg: 4.679 ± 0.918
2.946GluSer: 2.946 ± 0.564
4.072GluThr: 4.072 ± 0.556
4.072GluVal: 4.072 ± 0.636
1.213GluTrp: 1.213 ± 0.306
3.379GluTyr: 3.379 ± 0.577
0.0GluXaa: 0.0 ± 0.0
Phe
2.513PheAla: 2.513 ± 0.463
0.347PheCys: 0.347 ± 0.191
3.466PheAsp: 3.466 ± 0.406
4.938PheGlu: 4.938 ± 0.868
1.646PhePhe: 1.646 ± 0.366
3.119PheGly: 3.119 ± 0.525
0.173PheHis: 0.173 ± 0.139
2.079PheIle: 2.079 ± 0.337
3.206PheLys: 3.206 ± 0.512
2.426PheLeu: 2.426 ± 0.515
0.693PheMet: 0.693 ± 0.292
2.599PheAsn: 2.599 ± 0.447
1.3PhePro: 1.3 ± 0.413
1.3PheGln: 1.3 ± 0.313
1.386PheArg: 1.386 ± 0.339
2.253PheSer: 2.253 ± 0.396
3.206PheThr: 3.206 ± 0.551
1.906PheVal: 1.906 ± 0.443
0.433PheTrp: 0.433 ± 0.226
1.04PheTyr: 1.04 ± 0.291
0.0PheXaa: 0.0 ± 0.0
Gly
5.372GlyAla: 5.372 ± 0.943
0.173GlyCys: 0.173 ± 0.105
3.119GlyAsp: 3.119 ± 0.506
4.332GlyGlu: 4.332 ± 0.542
3.292GlyPhe: 3.292 ± 0.458
3.812GlyGly: 3.812 ± 0.646
0.693GlyHis: 0.693 ± 0.252
4.505GlyIle: 4.505 ± 0.776
6.845GlyLys: 6.845 ± 0.67
6.411GlyLeu: 6.411 ± 0.9
1.819GlyMet: 1.819 ± 0.448
2.859GlyAsn: 2.859 ± 0.538
1.213GlyPro: 1.213 ± 0.26
3.379GlyGln: 3.379 ± 0.63
3.379GlyArg: 3.379 ± 0.716
4.505GlySer: 4.505 ± 0.558
4.679GlyThr: 4.679 ± 0.938
4.332GlyVal: 4.332 ± 0.514
1.126GlyTrp: 1.126 ± 0.36
2.253GlyTyr: 2.253 ± 0.438
0.0GlyXaa: 0.0 ± 0.0
His
1.04HisAla: 1.04 ± 0.322
0.0HisCys: 0.0 ± 0.0
0.433HisAsp: 0.433 ± 0.204
1.04HisGlu: 1.04 ± 0.318
0.953HisPhe: 0.953 ± 0.32
1.04HisGly: 1.04 ± 0.372
0.606HisHis: 0.606 ± 0.253
0.606HisIle: 0.606 ± 0.255
1.04HisLys: 1.04 ± 0.333
0.78HisLeu: 0.78 ± 0.229
0.0HisMet: 0.0 ± 0.0
0.866HisAsn: 0.866 ± 0.218
0.26HisPro: 0.26 ± 0.133
0.347HisGln: 0.347 ± 0.164
0.693HisArg: 0.693 ± 0.211
0.866HisSer: 0.866 ± 0.218
0.78HisThr: 0.78 ± 0.245
0.693HisVal: 0.693 ± 0.246
0.173HisTrp: 0.173 ± 0.156
0.347HisTyr: 0.347 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
5.545IleAla: 5.545 ± 0.735
0.606IleCys: 0.606 ± 0.234
4.765IleAsp: 4.765 ± 0.661
7.104IleGlu: 7.104 ± 1.236
1.906IlePhe: 1.906 ± 0.441
4.505IleGly: 4.505 ± 0.74
0.866IleHis: 0.866 ± 0.205
3.119IleIle: 3.119 ± 0.461
5.545IleLys: 5.545 ± 0.653
3.899IleLeu: 3.899 ± 0.526
1.213IleMet: 1.213 ± 0.33
3.639IleAsn: 3.639 ± 0.551
1.993IlePro: 1.993 ± 0.345
1.906IleGln: 1.906 ± 0.558
2.166IleArg: 2.166 ± 0.343
3.379IleSer: 3.379 ± 0.791
3.726IleThr: 3.726 ± 0.706
3.812IleVal: 3.812 ± 0.577
0.78IleTrp: 0.78 ± 0.255
2.772IleTyr: 2.772 ± 0.607
0.0IleXaa: 0.0 ± 0.0
Lys
7.624LysAla: 7.624 ± 1.035
0.347LysCys: 0.347 ± 0.159
4.765LysAsp: 4.765 ± 0.666
6.671LysGlu: 6.671 ± 0.814
2.253LysPhe: 2.253 ± 0.352
5.372LysGly: 5.372 ± 0.62
0.52LysHis: 0.52 ± 0.191
5.458LysIle: 5.458 ± 0.641
6.151LysLys: 6.151 ± 1.21
7.364LysLeu: 7.364 ± 0.839
1.906LysMet: 1.906 ± 0.408
4.419LysAsn: 4.419 ± 0.726
2.426LysPro: 2.426 ± 0.474
3.032LysGln: 3.032 ± 0.492
3.639LysArg: 3.639 ± 0.701
4.072LysSer: 4.072 ± 0.563
5.112LysThr: 5.112 ± 0.808
4.592LysVal: 4.592 ± 0.565
0.953LysTrp: 0.953 ± 0.278
3.032LysTyr: 3.032 ± 0.607
0.0LysXaa: 0.0 ± 0.0
Leu
7.018LeuAla: 7.018 ± 0.946
0.347LeuCys: 0.347 ± 0.191
5.372LeuAsp: 5.372 ± 0.782
6.585LeuGlu: 6.585 ± 0.968
3.119LeuPhe: 3.119 ± 0.592
5.978LeuGly: 5.978 ± 0.795
0.78LeuHis: 0.78 ± 0.225
4.245LeuIle: 4.245 ± 0.667
9.011LeuLys: 9.011 ± 0.977
5.892LeuLeu: 5.892 ± 0.671
2.166LeuMet: 2.166 ± 0.478
5.112LeuAsn: 5.112 ± 0.851
3.639LeuPro: 3.639 ± 0.587
3.899LeuGln: 3.899 ± 0.577
3.466LeuArg: 3.466 ± 0.726
5.285LeuSer: 5.285 ± 0.805
4.765LeuThr: 4.765 ± 0.696
4.852LeuVal: 4.852 ± 0.642
0.433LeuTrp: 0.433 ± 0.161
2.946LeuTyr: 2.946 ± 0.44
0.0LeuXaa: 0.0 ± 0.0
Met
2.772MetAla: 2.772 ± 0.788
0.0MetCys: 0.0 ± 0.0
1.473MetAsp: 1.473 ± 0.349
1.906MetGlu: 1.906 ± 0.486
0.866MetPhe: 0.866 ± 0.266
1.56MetGly: 1.56 ± 0.418
0.0MetHis: 0.0 ± 0.0
2.166MetIle: 2.166 ± 0.478
1.473MetLys: 1.473 ± 0.375
1.3MetLeu: 1.3 ± 0.336
0.26MetMet: 0.26 ± 0.154
1.56MetAsn: 1.56 ± 0.561
0.866MetPro: 0.866 ± 0.327
1.3MetGln: 1.3 ± 0.493
1.3MetArg: 1.3 ± 0.355
2.253MetSer: 2.253 ± 0.506
1.56MetThr: 1.56 ± 0.369
1.213MetVal: 1.213 ± 0.311
0.347MetTrp: 0.347 ± 0.177
0.52MetTyr: 0.52 ± 0.219
0.0MetXaa: 0.0 ± 0.0
Asn
4.419AsnAla: 4.419 ± 1.169
0.26AsnCys: 0.26 ± 0.115
2.772AsnAsp: 2.772 ± 0.476
4.159AsnGlu: 4.159 ± 0.706
2.426AsnPhe: 2.426 ± 0.425
4.592AsnGly: 4.592 ± 0.621
1.126AsnHis: 1.126 ± 0.301
3.985AsnIle: 3.985 ± 0.479
3.466AsnLys: 3.466 ± 0.759
4.159AsnLeu: 4.159 ± 0.622
1.56AsnMet: 1.56 ± 0.384
2.859AsnAsn: 2.859 ± 0.486
1.906AsnPro: 1.906 ± 0.591
2.859AsnGln: 2.859 ± 0.601
1.906AsnArg: 1.906 ± 0.511
3.552AsnSer: 3.552 ± 0.761
2.253AsnThr: 2.253 ± 0.427
3.552AsnVal: 3.552 ± 0.574
0.866AsnTrp: 0.866 ± 0.298
2.513AsnTyr: 2.513 ± 0.536
0.0AsnXaa: 0.0 ± 0.0
Pro
3.032ProAla: 3.032 ± 0.662
0.087ProCys: 0.087 ± 0.105
2.339ProAsp: 2.339 ± 0.551
2.426ProGlu: 2.426 ± 0.615
1.56ProPhe: 1.56 ± 0.42
1.213ProGly: 1.213 ± 0.343
0.26ProHis: 0.26 ± 0.159
1.473ProIle: 1.473 ± 0.259
2.339ProLys: 2.339 ± 0.482
2.253ProLeu: 2.253 ± 0.433
0.693ProMet: 0.693 ± 0.186
1.126ProAsn: 1.126 ± 0.294
0.693ProPro: 0.693 ± 0.256
2.166ProGln: 2.166 ± 0.584
0.693ProArg: 0.693 ± 0.239
1.819ProSer: 1.819 ± 0.4
1.473ProThr: 1.473 ± 0.315
2.253ProVal: 2.253 ± 0.416
0.26ProTrp: 0.26 ± 0.135
0.953ProTyr: 0.953 ± 0.291
0.0ProXaa: 0.0 ± 0.0
Gln
4.592GlnAla: 4.592 ± 0.887
0.087GlnCys: 0.087 ± 0.086
1.646GlnAsp: 1.646 ± 0.441
3.552GlnGlu: 3.552 ± 0.966
2.166GlnPhe: 2.166 ± 0.304
2.686GlnGly: 2.686 ± 0.507
0.26GlnHis: 0.26 ± 0.171
3.206GlnIle: 3.206 ± 0.573
4.332GlnLys: 4.332 ± 0.601
3.985GlnLeu: 3.985 ± 0.932
1.56GlnMet: 1.56 ± 0.604
2.686GlnAsn: 2.686 ± 0.662
1.646GlnPro: 1.646 ± 0.542
3.206GlnGln: 3.206 ± 0.72
2.253GlnArg: 2.253 ± 0.544
1.993GlnSer: 1.993 ± 0.456
3.466GlnThr: 3.466 ± 0.564
2.686GlnVal: 2.686 ± 0.511
0.087GlnTrp: 0.087 ± 0.093
1.56GlnTyr: 1.56 ± 0.381
0.0GlnXaa: 0.0 ± 0.0
Arg
3.466ArgAla: 3.466 ± 0.694
0.087ArgCys: 0.087 ± 0.078
2.339ArgAsp: 2.339 ± 0.44
2.859ArgGlu: 2.859 ± 0.613
1.819ArgPhe: 1.819 ± 0.456
3.292ArgGly: 3.292 ± 0.572
1.126ArgHis: 1.126 ± 0.291
2.686ArgIle: 2.686 ± 0.433
3.812ArgLys: 3.812 ± 0.823
5.458ArgLeu: 5.458 ± 0.837
1.386ArgMet: 1.386 ± 0.37
1.819ArgAsn: 1.819 ± 0.498
1.126ArgPro: 1.126 ± 0.36
1.3ArgGln: 1.3 ± 0.368
1.819ArgArg: 1.819 ± 0.457
2.686ArgSer: 2.686 ± 0.445
2.079ArgThr: 2.079 ± 0.495
2.426ArgVal: 2.426 ± 0.463
0.26ArgTrp: 0.26 ± 0.169
1.646ArgTyr: 1.646 ± 0.398
0.0ArgXaa: 0.0 ± 0.0
Ser
5.632SerAla: 5.632 ± 1.724
0.347SerCys: 0.347 ± 0.214
3.639SerAsp: 3.639 ± 0.358
4.159SerGlu: 4.159 ± 0.729
2.599SerPhe: 2.599 ± 0.423
3.812SerGly: 3.812 ± 0.656
0.52SerHis: 0.52 ± 0.23
4.159SerIle: 4.159 ± 0.639
3.985SerLys: 3.985 ± 0.75
4.505SerLeu: 4.505 ± 0.792
1.906SerMet: 1.906 ± 0.474
3.292SerAsn: 3.292 ± 0.915
1.386SerPro: 1.386 ± 0.302
2.772SerGln: 2.772 ± 0.413
1.819SerArg: 1.819 ± 0.355
3.466SerSer: 3.466 ± 1.012
3.985SerThr: 3.985 ± 0.856
3.899SerVal: 3.899 ± 0.681
1.386SerTrp: 1.386 ± 0.263
1.819SerTyr: 1.819 ± 0.38
0.0SerXaa: 0.0 ± 0.0
Thr
5.112ThrAla: 5.112 ± 0.879
0.173ThrCys: 0.173 ± 0.103
3.726ThrAsp: 3.726 ± 0.684
5.025ThrGlu: 5.025 ± 0.722
2.426ThrPhe: 2.426 ± 0.469
5.198ThrGly: 5.198 ± 0.807
0.52ThrHis: 0.52 ± 0.215
4.072ThrIle: 4.072 ± 0.613
3.379ThrLys: 3.379 ± 0.618
4.332ThrLeu: 4.332 ± 0.587
1.386ThrMet: 1.386 ± 0.626
4.072ThrAsn: 4.072 ± 0.769
1.56ThrPro: 1.56 ± 0.38
2.772ThrGln: 2.772 ± 0.456
2.426ThrArg: 2.426 ± 0.41
3.206ThrSer: 3.206 ± 1.005
4.332ThrThr: 4.332 ± 0.824
4.332ThrVal: 4.332 ± 0.539
0.347ThrTrp: 0.347 ± 0.158
2.079ThrTyr: 2.079 ± 0.589
0.0ThrXaa: 0.0 ± 0.0
Val
4.245ValAla: 4.245 ± 0.659
0.26ValCys: 0.26 ± 0.156
4.245ValAsp: 4.245 ± 0.592
4.592ValGlu: 4.592 ± 0.817
1.56ValPhe: 1.56 ± 0.32
3.985ValGly: 3.985 ± 0.642
1.213ValHis: 1.213 ± 0.405
3.812ValIle: 3.812 ± 0.78
4.072ValLys: 4.072 ± 0.457
5.718ValLeu: 5.718 ± 0.696
1.386ValMet: 1.386 ± 0.382
3.466ValAsn: 3.466 ± 0.52
1.386ValPro: 1.386 ± 0.342
2.513ValGln: 2.513 ± 0.45
2.599ValArg: 2.599 ± 0.571
4.419ValSer: 4.419 ± 0.835
3.985ValThr: 3.985 ± 0.535
3.985ValVal: 3.985 ± 0.665
0.693ValTrp: 0.693 ± 0.228
1.733ValTyr: 1.733 ± 0.473
0.0ValXaa: 0.0 ± 0.0
Trp
0.953TrpAla: 0.953 ± 0.37
0.173TrpCys: 0.173 ± 0.119
1.3TrpAsp: 1.3 ± 0.381
0.953TrpGlu: 0.953 ± 0.253
0.606TrpPhe: 0.606 ± 0.242
0.606TrpGly: 0.606 ± 0.277
0.087TrpHis: 0.087 ± 0.07
0.693TrpIle: 0.693 ± 0.246
0.953TrpLys: 0.953 ± 0.272
1.473TrpLeu: 1.473 ± 0.385
0.087TrpMet: 0.087 ± 0.094
0.866TrpAsn: 0.866 ± 0.364
0.0TrpPro: 0.0 ± 0.0
0.347TrpGln: 0.347 ± 0.174
0.606TrpArg: 0.606 ± 0.245
0.78TrpSer: 0.78 ± 0.221
0.433TrpThr: 0.433 ± 0.187
0.866TrpVal: 0.866 ± 0.278
0.0TrpTrp: 0.0 ± 0.0
0.347TrpTyr: 0.347 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.646TyrAla: 1.646 ± 0.421
0.433TyrCys: 0.433 ± 0.204
1.646TyrAsp: 1.646 ± 0.412
2.772TyrGlu: 2.772 ± 0.559
1.733TyrPhe: 1.733 ± 0.426
2.513TyrGly: 2.513 ± 0.575
0.433TyrHis: 0.433 ± 0.187
2.426TyrIle: 2.426 ± 0.443
2.946TyrLys: 2.946 ± 0.448
2.859TyrLeu: 2.859 ± 0.605
0.52TyrMet: 0.52 ± 0.192
1.819TyrAsn: 1.819 ± 0.506
0.693TyrPro: 0.693 ± 0.24
2.253TyrGln: 2.253 ± 0.425
2.339TyrArg: 2.339 ± 0.578
1.819TyrSer: 1.819 ± 0.321
2.599TyrThr: 2.599 ± 0.462
2.253TyrVal: 2.253 ± 0.573
0.606TyrTrp: 0.606 ± 0.187
1.733TyrTyr: 1.733 ± 0.563
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski